DRUG STUDY GENERIC / BRAND NAME Mefenamic acid ApoMefenamic (CAN), Ponstel CLASSIFI CATION NSAID DOSAGE MODE

OF ACTION Antiinflammatory, analgesic, and antipyretic activities related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known. INDICATIONS CONTRAINDICA DRUG TIONS INTERACTION Contraindicated with hypersensitivity with mefenamic acid, aspirin allergy, and as treatment of preoperative pain with coronary artery bypass grafting. Use cautiously with asthma, renal or hepatic impairment, peptic ulcer disease, GI bleeding, hypertension, heart failure, pregnancy, lactation. Drug to drug: increased risk of GI bleeds with ASA, anticoagulants, other NSAIDs. Drug-lab test: false positive reaction for urinary bile using the Diazo tablet test. SIDE EFFECTS / ADVERSE EFFECT CNS: headache, dizziness, somnolence, insomnia, fatigue,tiredness,tin nitus, ophthalmic effects DERMATOLOGIC: rach, pruritus, sweating, dry mucous membranes, stomatitis GI: nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence, ulcers, GI bleed. GU: dysuria, renal impairment HEMATOLOGIC: bleeding,platelet inhibition with higher doses, neutro0penia, eosinophilia,leukope NURSE CONSIDERATI ON HISTORY: allergies, renal hepatic of GI considerations: pregnancy, lactation. PHYSICAL: skin color and lesions; orientations, reflexes, ophthalmologic anf audiometric evaluation, peripheral sensation; P,edema, R, adventitious sounds; liver evaluation, CBC, clotting times , LFTs, renal function tests; serum electrolytes, stool guaiac

Adults and patients older than 14 yr Acute pain: initially, 500mg PO followed by 250 mg every 6 hr as needed. Do not exceed 1 wk of therapy. Primary dysmenorrhea: initially, 500mg PO followed by 250 mg every 6 hr starting with the onset of bleeding. Can be initiated at start of menses and should not be necessary for longer than 2-3 days. Pediatric patients Safety and efficacy for patients younger than 14 yr old not

Relief of moderate pain when therapy will not exceed 1 wk. Treatment of primary dysmenorrhea.

established.

nia, pancytopenia, thrombocytopenia, agranulocytosis, granuocytopenia,apl astic anemia, decreased Hgb or Hct, bone marrow depression, menorrhagia. RESPIRATORY: dyspnea, hemoptysis, pharingitis, bronchospam, rhinitis. OTHER: peripheral edema, anaphylactoid reactions to anaphylactic shock.