Cell Cycle

RNA, Protein
Lamin H1 Abl

Mitosis, Cytokinesis

Cyc B/A CDK1 DNA, RNA, Protein Cyc A CDK2

G2 M 3-4 h 1 h S 6-8 h
G1

Cyc Ds G0 CDK4,6 RNA, Protein Cyc E CDK2

Eric Niederhoffer SIU-SOM

6-12 h

p53 pRb

Variation in Cell Cycle Cyclins

Cyclin-dependent kinases

Cdk4
cyclins

Cdk2
D E A

Cdk1
B(A)

G1 Start

G2

M G1

Cell cycle phases

Cell Cycle Regulation

1. CDK phosphorylation 2. C degradation DNA damage

3. C & CDK synthesis

4. CDK inhibition CDK2

Active p53

CE

p21 P

pRb pRb E2F Enzymes for DNA synthesis

Passage from G1 to S

Review Questions

What are and what happens during the phases of the cell cycle? Which proteins are involved in the regulation of the cell cycle? Which cyclins and cyclin-dependent kinases are most important in individual phases of the cell cycle? What are four mechanisms for regulating cyclin-dependent kinase activity? What role do p53, p21, and pRb play in the G1 to S transition?