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Risk Factors Genetic Factors Environment Age Predisposing Factors S.

aureus Stress Anxiety Systemic illness

Dysregulation of islets of Langerhan cells, epidermal cells, macrophages

Predominance of TH2 cells over TH1 cells

Increase TH1 cytokines & decrease of TH2 cytokines & IL-2

Desaturase activity is deficient

Increase in IgE synthesis

ALLERGIC REACTION

Decrease linoleic and linoleic acid metabolite

Colonization on skin due to deficiencies to endogenous antimicrobial peptides

Loss of ESSENTIAL FATTY ACID

Increased in trans epidermal water loss

ATOPIC DERMATITIS

Xerosis, dry skin, cracking skin, itchiness, pruritus, lichenification

Impaired skin integrity r/t inflammatory process. Disturbed sleep pattern r/t itchiness

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