BRONCHIAL ASTHMA IN ACUTE EXACERBATION PATHOPHYSIOLOGY

Predisposing Factors Gender, Age, Family History, Race dander, dust, pollen, etc.)

Precipitating Factors Viral Respiratory Infections, Allergen Exposure (animal

Change in Weather, Smoking, Exercise

Exposure to different pathogens

Entry of the allergen

Release of immunoglobulin E (IgE)

Release of different chemical mediators

Mast cell degranulation

Release of the different inflammatory chemical mediators

Leukotrienes mediators

Prostaglandins

Histamine, bradykinin, & other inflammatory

Release of eosinophils (to combat allergen)

Opening of the mucosal inrtracellular junction

Inflammatory process

Mucus production efferents

Increase vascular permeability

Direct stimulation of the vagal

Mucosal edema

Bronchoconstriction

More release of other inflammatory mediators

Decrease ciliary function

Epithelial damage

Further edema

Mucus hypersecretion

Increased airway responsiveness

Wheezing, continuous coughing, feelings of chest tightness

dypnea, moist skin, tachypnea

fatigue, anxiety

View more pathophysiology and schematic diagrams at Nurseslabs.com