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  • Pathopysiology

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    Jonathan Cruz Talon
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    This document summarizes risk factors for gallstone formation. Higher estrogen levels during pregnancy in females aged 40 and above increase risk. A high fat diet raises fat and cholesterol levels in the liver, reducing bile acid production and increasing cholesterol in the gallbladder, leading to supersaturation and crystallization of cholesterol and calcium stones.

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    This document summarizes risk factors for gallstone formation. Higher estrogen levels during pregnancy in females aged 40 and above increase risk. A high fat diet raises fat and cholesterol levels in the liver, reducing bile acid production and increasing cholesterol in the gallbladder, leading to supersaturation and crystallization of cholesterol and calcium stones.

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    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
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    10 views1 page

    Pathopysiology

    Uploaded by

    Jonathan Cruz Talon
    This document summarizes risk factors for gallstone formation. Higher estrogen levels during pregnancy in females aged 40 and above increase risk. A high fat diet raises fat and cholesterol levels in the liver, reducing bile acid production and increasing cholesterol in the gallbladder, leading to supersaturation and crystallization of cholesterol and calcium stones.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
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    of 1

    PATHOPYSIOLOGY

    Gender (Female) Estrogen level related to pregnancy (G10, P6)

    Age (40 & above) Body organ function deterioration

    Diet (High Fat) Fats level in the body Synthesis of cholesterol in the liver

    Reduces bile acid uptake by hepatocytes Bile acid production

    Production of bile by hepatocytes

    Excretion of cholesterol in the gallbladder level of cholesterol in the gallbladder

    Bile acid level in gallbladder

    Insoluble ratio of bile salts and cholesterol Super saturation of bile with cholesterol and calcium Nucleation, precipitation of solution and crystallization Fusion of crystals Gallstone formation

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