Predisposing Factor: Race Age Geographical Areas- tropical Island in the Pacific (Philippines) and Asia

Precipitating Factor: Environmental conditions (open spaces with water pots, and plants) Immunocompromise

Aedes Aegypti (Dengue Virus Carrier); 8 12 days of viral replication on mosquitoes salivary glands

Bite from Mosquito (Portal of Entry in the Skin)

Stimulates secondary defenses including B lymphocytes that produces and secretes Immunoglobulins (anitbodies), monocyte/macrophages, and neutrophils

Virus rapidly replicates in the blood cell

Activates interleukins, urokinase, platelet activating factor which stimulates WBCs and Pyrogen release

Dengue Fever

Leukopenia

Thrombocytopenia

Increase capillary permeability

If Treated DENGUE HEMORRHAGIC FEVER

If Not Treated:

Mainstay of treatment is supportive therapy:

Further Shifting and leakage of fluid from intravascular to interstitial spaces

supplementation with intravenous fluids to prevent dehydration immediate blood transfusion Pleural Effusion as ordered good compliance to drugs as ordered strict monitoring for hemoconcentration stability adequate rest and sleep Signs and Symptoms: confirms to the prescribed Profuse non-productive diet throughout the therapy cough with white sputum with blood

Ascites

Signs and Symptoms: Abdominal distention with increasing abdominal girth Hypoactive bowel sound

Complications: Intense bleeding Pulmonary Edema Shock Very low blood pressure Liver cirrhosis

DENGUE HEMORRHAGIC SHOCK

DEATH