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Bhn Kulit Lola 11 Feb

Bhn Kulit Lola 11 Feb

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Published by Soeklola Mulyadi

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Published by: Soeklola Mulyadi on Sep 15, 2011
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kelompok fibrous structural protein. Keratin merupakan struktur utama penyusun lapisan teratas kulit manusia, maupun komponen utama rambut dan kuku. Macam–macam Keratin Di dalam kulit serta apendiksnya terdapat dua macam keratin, yaitu keratin lunak dan keratin keras. Keratin lunak selain terdapat pada folikel rambut juga terdapat di permukaan kulit. Keratin lunak dapat diikuti terjadinya pada epidermis yang dimulai dari stratum granulosum dengan butir-butir keratohyalinnya, kemudian sel-sel menjadi jernih pada stratum lucidum dan selanjutnya menjadi stratum korneum yang dapat dilepaskan. Sedangkan keratin keras terdapat pada cuticula, cortex rambut dan kuku. Keratin keras dapat diikuti terjadinya mulai dari sel-sel epidermis yang mengalami perubahan sedikit demi sedikit dan akhirnya berubah menjadi keratin keras yang lebih homogen. Keratin keras juga lebih padat dan tidak dilepaskan, serta tidak begitu reaktif dan mengandung lebih banyak sulfur.1,2

Gambar 1. Gambar Mikroskopis struktur filament keratin di dalam sel.2

DAFTAR PUSTAKA 1. Anonymous. Histologi Kulit. Diakses dari: http://blogs.unpad.ac.id/histologi/2010/ 07/18/10-kulit/ pada tanggal 12 februari 2011. 2. Hickman, Cleveland Pendleton; Roberts, Larry S.; Larson, Allan L. (2003). Integrated principles of zoology. Dubuque, IA: McGraw-Hill. p. 538. ISBN 0-07-243940-8.

and 250A°. 150A°. mitochondria. respectively.. keratin is the main structural protein of the epidermis. the largest acidic keratin is expressed with the largest basic. M. nucleic acids. intracytoplasmic system of filaments. In addition. keratin accounts for up to 85% of the cellular protein. The components of this system include actin. and keratin in epithelial cells. in essentially all situations. enzymes. myosin. and antigenic properties. biophysical. glial fibrillary acidic filaments in glial cells.000 micrograms. Intermediate filaments form a major part of the cytoskeleton of most cells and fulfill a variety of roles related to cell shape. whose diameters average approximately 60A°. The two members of each pair are in the same size rank order within their respective family.e. neurofilaments in neurons. there are two keratin subfamilies. e. while in stratum corneum. Kamel. The molecular weight of the members of one (the basic subfamily) is relatively larger than that of the members of the other (the acidic subfamily). a number of classes of intermediate filaments can be recognized in different cell types: desmin (skeletin) in muscle cells.htm judul: ANATOMY OF THE SKIN. keratins account for up to 30% of the cellular protein.D. and since the diameter of these latter structures was found to be between 70 and 100A°. According to this catalogue. the keratins are expressed as pairs containing one member of each subfamily. and tubulin.000 to 68.g. and perhaps informational transfer. and simple epithelium of the epidermal glands. Based on their biochemical. In cultured epidermal cells. corneal epithelium. and cyclic nucleotides are attached to the cytoskeleton. The type of keratin differs in different tissues. they were called intermediate filaments. Moll and his coworkers published their human keratin catalogue in 1982. Keratin Electron microscopical examination of cells from all tissues reveals that they contain a complex. At least 19 keratin proteins can be identified ranging in molecular weight from approximately 40.org/anatomy/anatomy. i. other intracytoplasmic filaments were noted. spatial organization. Maged N. As mentioned before. The nucleus contains structures related to these intermediate filaments and many intracellular components including polyribosomes.Diambil dari: http://www. hyperproliferative epidermis of palms and soles. .telemedicine. heterogenous. Each of the keratins is the product of a unique gene and. there are different types of keratin for keratinized epidermis. stratified epithelium of the esophagus and cervix. vimentin in mesenchymal cells.

Epidermal keratinization results in the production of a barrier which is relatively impermeable to substances passing in or out of the body. in the cells of the stratum corneum. The matrix is derived from the keratohyaline granules of the granular layer. these bundles of keratin filaments form a complex intracellular network embedded in an amorphous protein matrix. Eventually. .The keratinocytes in the basal layer and prickle cell layer synthesize keratin filaments (tonofilaments) which aggregate into bundles (tonofibrils).

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