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NON MODIFIABLE FACTORS: Age Gender (more common in men) Hypertension

Large artery thrombosis

Vasoconstriction (Inc. BP)

Disruption of cerebral blood flow *Impaired Physical Mobility

Inc. BP weakens vessel wall and vessel erupts Intracerebral Bleeding

Hypoxia

Energy Failure

Increased Hmg and Hct to compensate = Inc. 02 carrying capacity

Acidosis

Ion Imbalance Increase intracellular calcium

Intracellular calcium increased

Depolarization

Cell membranes and proteins break down

Formation of free radicals

Protein production decreased

Cell injury and death

Decreased Hmg and Hct due to Dec. Blood Flow = Dec. 02 also

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