a

Dark/Black Light/White Dark/Black

( 24 hr) ( 30 min) ( 30 min)

b Light/White Dark/Black
( 24 hr) ( 30 min)

Light/White
( 30 min)

c
Dark/Black-adapted Light/White-adapted
Pigmented area (%)

Light/White Light/White Dark/Black

or Dark/Black (30 min) (30 min)
(24 hr)

Supplementary Figure 17