RESULTS AND DISCUSSION

MOUSE ONSET DURATION

DIAZEPAM (A)
PHENOBARBITAL (B) THIOPENTAL (C)

5 mins
5 mins 40 sec

--30 mins 40 mins

EXPECTED RESULTS
DRUGS ONSET DURATION

DIAZEPAM

PHENOBARBITAL
THIOPENTAL

IV 1-5mins Oral 1545mins 5 mins

30-60 sec

IV 15-60 mins
Oral 7-8 H

4-6 hours
20-30 mins

What other factors will determine the onset and the intensity and the duration of drug effect aside from route of administration? Dosage of drug Half life Pharmacokinetic (absorption, distribution, metabolism and excretion

What were you able to prove with the above procedure and results? all three drugs give the same effect (sedative, hypnotics). Based on our experiment thiopental has the fastest onset (40 sec.) thiopental has also a longer duration (40 mins)

3. Suggest possible modification of this experiment.

Longer time to do the experiment, to observe it more accurately

RESULTS AND DISCUSSION

MOUSE ONSET DURATION

Diphenhydramine (A)
Phenobarbital (B) Diphenhyhdramine + Pb (C)

4 mins
10 mins 20 mins

30 mins
70 mins > 2 hrs

EXPECTED RESULTS
DRUGS ACTION DURATION

Diphenhydramine
Phenobarbital Diphenhyhdramine + Pb

30 mins
5 mins

3-6 H
4-6 H

 1. What are you trying to prove in this experiment?

 2. What are the drugs give the same effects? Give at least 5 examples.