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BPH-A: A Potentially Useful New Marker for Benign Prostatic Hyperplasia

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Nama : Albertus Sri Agseyogi NIM : 201020401011181

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BPH

PSA

CA PROSTA T

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BPH
BPH (also referred to as Benign Prostatic Hypertrophy) is a

condition in which the prostate gland becomes very enlarged and may cause problems associated with urination

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BPH

theory focuses on dihydrotestosterone (DHT), a substance derived from testosterone in the prostate, which may help control prostate growth
Testosteron 5Reduktase DHT M-RNA

Growth Factor Proliferas i Sel-Sel Kelenjar Prostat

CA PROSTAT

Prostate cancer is a malignant (cancerous) tumor (growth) that consists of cells from the prostate gland.

Generally, the tumor usually grows slowly and remains confined to the gland for many years. During this time, the tumor produces little or no symptoms or outward signs

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PSA (Prostatic-Specific Antigen)

Immunoassay test underdevelopment By

Beckman Caulter

(2005)

The test called BPH-A (or BPSA), detects an isoform of prostate-specific antigen (PSA) that exists in abnormally high level in blood of men with enlargement of Prostate Gland.

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PSA (Prostatic-Specific Antigen)

The rationale for the test is as follows: in its normal physiological pathway, PSA passes into the seminal plasma, where it promotes sperm motility by dissolving the seminal coagulum. When either BPH or prostate cancer exists, significant amounts of PSA leak from the prostate gland into the bloodstream. The leaked PSA can be found in the blood in a form bound to serum proteins or in an unbound form, also known as fPSA

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What Condition may Cause PSA Level Elevated ?

BPH Prostatitis Prostate Biopsy Recent Ejaculation Digital Rectal Exam (DRE) Bicycle Riding Ca Prostat

PROSTATE ENLARGEME NT ???

PSA

4 ng/mL

410ng/m L FOLLOW UP

>10ng/ mL

Digital Rectal Exam (DRE)

Unusual Prostat/ LUMP Detected / Enlarge Prostat

CA ?? ? 25%
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BIOPSI

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Transrectal Ultrasound

REFFERENCES

B.Cook, Mikolajczyk, Weinzierl, 2005, BPH-A: a potentially usefull new marker for benign prostatic hyperplasia, USA.

Joana Lins Medical and Cancer Clinic, 2009, NonCancerous Cause of an elevated PSA, accessed 13 September 2011, http://prostatecancer.about.com/od/symptomsanddiagnos .

NCI, 2009, Prostate-Specific Antigens (PSA) Test, accessed 13 September 2011, http://www.cancer.gov/cancertopics/factsheet/detection/P .4/29/12

RDamiano, 2003, Prostate Cancer and Prostatic Diseases, accessed 14 September 2011, http:// www.nature.com/pcan/journal/v6/n3/full/4500671a.html .

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Results of biopsies according to clinical and PSA indications

Pts Indicatio ns PSA >4 PSA<4 PSA >4 Cancer 39 6 21 Detection rate (%) 64 21 28

61 (37%) DRE+ 28 (17%) DRE+ 76 (46%) DRE(RDamiano,

2003) 4/29/12

Chen et al : The addition of biopsy of the anterior TZ, midline PZ and inferior portion of the AH of the PZ reliably detected cancer in 96% of 4/29/12

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