Post-doctoral position: microuidic drops for cell biology

Charles Baroud, LadHyX, Ecole Polytechnique. baroud@ladhyx.polytechnqiue.fr October 2011

In the framework of a European Research Council (ERC) starting grant, I have an opening for a post-doctoral fellow at the Laboratoire dHydrodynamique at Ecole Polytechnique (LadHyX), starting on or after February 1st 2012. The project objective is to build on our recent work on droplet microuidics [1, 2] and move further into applications to cellular biology. In particular, we wish to extend the methods we have developed for producing two-dimensional arrays of nano-liter drops, control of gas exchange through diusion, generation of drops on demand, etc. However, the emphasis will be shifted from developing devices to performing biological or biophysical studies. Possible avenues to be explored include the migration of adherent cells in polymerized drops, interactions in cellular co-cultures, or the activation of cells by chemical signals.

Figure 1: Array of 96 drops displaying a gradient of uorescence concentration. Scale bar is 300 m [3]. Our microuidics group consists of a multidisciplinary and international group of students and post-docs and is set to grow in the coming years. The project will be based at LadHyX and the mechanics and living systems consortium at Ecole Polytechnique. It will also benet from many collaborations with research groups at Polytechnique and elsewhere in the Paris area. More information about the group can be found here: www.o-ladhyx.polytechnique.fr/people/baroud/ We are looking for someone who can help kick-start this activity in the group. The ideal candidate will have at least some experience in cell manipulation in microuidics. Knowledge of basic biological protocols is necessary, as well as familiarity with physical and chemical concepts. The post-doc will work with graduate students on dierent sub-projects which will address biology, physics, and technology. Knowledge of French is not required. Please send a CV as well as a list of three persons who can recommend the candidate by email.

References
[1] P. Abbyad, R. Dangla, A. Alexandrou, and C.N. Baroud. Lab Chip, 11:813821, 2011. [2] R. Dangla, S. Lee, and C.N. Baroud. Physical Review Letters, 107(12):124501, 2011. [3] E. Fradet, C. McDougall, P. Abbyad, R. Dangla, D. McGloin, and C.N. Baroud. Lab Chip, In Press, 2011.