CELL BASED DRUG CELL BASED DRUG

DELVERY AND DELVERY AND

TARGETNG SYSTEMS TARGETNG SYSTEMS
$$# $$#
Cells as carriers Cells as carriers
Erythrocytes Erythrocytes
- Oligonucleotides
-Peptides
Methods o drug loading
Osmotic shock
Turbulenceshock
Erythrocyte Sedimentation Rate (ESR)
Use of red cell loader
Hypotonic dilution
Chemical perturbation of the membrane
Entrapment by endocytosis:
Loading by lipid fusion
Loading by electric cell fusion
Oligonucleotides & Peptides
Modified oligonucleotides are used
where the analogues areencapsulated
Peptide is stable in the erythrocytes
and efficiently competes with
endogenous substances in
macrophages. Thus, the delivery of
peptides is feasible
ADVANTAGES
An easily controllable life span from
minutes to months
Desirable size range & uniform shape
endogenous factors
. Relatively inert intracellular environment
Protection of the loaded compound from
W Possibility of targeted drug delivery to the RES
organs
W Possibility of ideal zero-order kinetics of drug
release
WModification of the pharmacokinetic and
pharmacodynamic parameters of the drug
DRAWBACKS DRAWBACKS
'he rapid leakage of certain encapsulated 'he rapid leakage of certain encapsulated
substances from the loaded erythrocytes substances from the loaded erythrocytes
Several molecules may alter the physiology of the
erythrocyte
Possible contamination due to the origin of the
blood
&$
The use of resealed erythrocytes looks
promising for a safe and sure delivery of various
drugs for passive and active targeting

"golden eggs in novel drug

delivery systems
At present it is concluded that erythrocyte
carriers are
ACKNOWLEDGEMENTS
CH.SHVA REDDY
Smt.N.K.D.DEV
KVSR Siddhartha College of
Pharmaceutical Sciences
Vijayawada-10
CH.NAGABHUSHANAM
77t/ /