DkUG kA1ICNALL SnLL1

C|ass|f|cat|on Chem|ca| Act|on at|ent 1each|ng Adverse effects

AldosLerone recepLor anLagonlsLs


Lplerenone (lnspra)





8locks aldosLerone blndlng aL Lhe
mlneralocorLlcold recepLor slLes ln
Lhe kldney hearL blood vessels
and braln
8ecommended dosage ls 30 mg
dally can be lncreased Lo 100 mg

1each paLlenLs grapefrulL [ulce
and SL !ohn's WorL can also
lncrease adverse effecLs
*PyperLryglycerldemla
hyponaLremla hyperkalemla
*uslng ACL or A88's aL Lhe same
Llme lncreases rlsk of
hyperkalemla
*MonlLor k++ lnlLlally every Lwo
weeks for flrsL few monLhs Lhen
monLhly
*Avold lLraconazole and
keLoconazole
*Ls Laklng eryLhromycln
saqulnavlr and verapamll wlLh a
reducLlon by half 23 mg


8enln lnhlblLors

Allsklren (1ekLurna)
roduced ln Lhe kldneys causes
vasoconsLrlcLlon lncreases
perlpheral reslsLance and
lncreases cardlac ouLpuL prevenL
renln from produclng Lhls acLlon
8esplraLory dlsLress may occur
CenLral Alpha agonlsL

Clonldlne( CaLapres)
revenLlng reupLake of
noreplnephrlne and resulLlng ln
lower perlpheral vascular
reslsLance and blood pressure
usually glven as a Lransdermal
paLch ConLrols blood pressure for
up Lo 7 days
SedaLlon posLural hypoLenslon
and lmpoLence
Alphaandregenlc anLagonlsLs

Lnd ln sln

(razosln)Mlnlpress (Cardura)
doxazosln (PyLrln)Lerazosln

ullaLes arLerloles and velns
Lowers blood pressure qulckly
use llmlLed b/c of frequenL and
boLhersome slde effecLs
Cardura and PyLrln prescrlbed ln
8P b/c dllaLlng effecLs Lhe
vessels decreaslng hyperLrophy
and lmprovlng blood flow