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Maturation Process for Immune Cells Attack Bacteria & Viruses APC Activates IgE binds to allergens and

parasites IgG binds to viruses and bacteria IL-4 Th2 IL-4 B cells IL-5; IL-13 IL-10 Threg IL-10

Pre Th IL-2 M IL-2 NK Th1 CTL IFN Th0 IL-2*

Local cells near infection site stimulate production of cytokines IL 1 activates T cells IL 6 activates B Cells IL -12 activates NK cells

Humoral CMI *: IL-2 levels have to be abnormally high for this pathway to take effect

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