Name of Drug

Classification

Mechanism of Action Mechanism of action not conclusively demonstrated; probably due to drugs metabolism to alpha-methyl norepinephrine, which lowers arterial BP by stimulating CNS alpha2-adrenergic receptors, which in turn decreases sympathetic outflow from the CNS

Indications

Contraindications

Adverse Reactions CNS: Sedation, headache, asthenia, weakness (usually early and transiet), dizziness, lightheadedness, symptoms of Cerebrovascular insufficiency CV: Bradycardia Endocrine: Breast enlargement, gynecomastia, lactation, hyperprolactine mia GI: Nausea and vomiting, distention, constipation

Nursing Responsibilities Before: Take drug this drug as prescribed; it is important not to miss

Generic Name: Methyldopa Brand Name: Nu-Medopa (CAN) Patients Dose: Minimum Dose: Maximum Dose:

General Classification: Sympatholytic (centrally acting) Functional Classification: Antihypertensive

>Hypertension >IV methyldopate: Acute hypertensive crisis; not drug of choice of slow onset of action >Unlabeled use: Hypertension of pregnancy

>Contraindicated with hypersensitivity to methyldopa, active hepatic disease, previous methyldopa therapy associated with liver disorders >Use cautiously with liver disease, renal failure, dialysis, bilateral Cerebrovascular disease, pregnancy lactation

During: Monitor patient closely in any situation or any adverse effects After: Report unexplained, prolonged general tiredness; yellowing of the skin or eyes; fever; bruising; rash