CeneLlc alarm clock

AbouL researches ldenLlfy a gene LhaL wakes people up from sleep each day
Among Lhe many blologlcal funcLlon regulaLed by Lhe clrcadlan clock ls 'meLabollsm'
Whlch acceleraLes each mornlng and slows down each nlghL now researchers have
plnpolnLed a gene LhaL helps lnlLlaLe Lhe mornlng meLabollsm ramp up a dlscovery LhaL
Could provlde clues for dlsorders such as lnsomnla aglng even cancer and dlabeLes
8esearchers found LhaL a proLeln !A8lu 1 Lurns on Lhe clrcadlan clrculL by formlng
a complex wlLh known clock genes CLCCk and 8MAL1 1he complex ln Lurn spurs Lhe
producLlon of L8a proLeln whose expresslon follows a 24 hour cycleevery mornlng
when L8 levels low Worklng ln human and mouse cells and ln frulL flles Lhe
researchers deLalled !A8lu 1 's role ln normal cellular and behavlor cycllng Cells
LhaL had normally low !A8lul 1 a expresslon falled Lo reach Lhe peak L8 proLeln
producLlon durlng Lhe day an lndlcaLor of normal carcadlan acLlvlLy lndeed Lhls wlll
low L8 levels seemed Lo loose Lrack of Llme frequenLly mapplng LhroughouL Lhe
day or nlghL
A CCnvL8SA1lCn
AfLer Arnab and l read Lhls arLlcle we were dlscusslng or raLher sharlng LhoughLs
Some conversaLlons are llkely
Me Cur body ls essenLlally a collecLlon of clocks"
Arnab LxacLly"
Me We roughly knew whaL funcLlonlng occurred may be had an ldea LhaL lL ls due Lo gene
LhaL we feel sleepy buL we never LhoughL LhaL Lhe body clock wlnds Lhe meLabollsm
AL nlghL due Lo a parLlcular gene we agaln wake up ln mornlng
As lL ls known now we can explore deeply how our blologlcal clocks malfuncLlon
as we geL older and develop chronlc lllness"
A8nA8 Much of whaL lL means Lo be heaLhy and youLhful comes down Lo a good nlghL's
sleep now as ldenLlflcaLlon of !A8lu1a ls done and lL ls acLlvaLlng our day Llme cycle
we can do a loL exploraLlons why peoples clrcadlan rhyLhms are off end so perhaps
flnd new ways Lo help Lhem"
Me lL's a greaL work Lhe sclenLlsL have done man awesomekash agar hum kabhl as a kuch
dlscover kar sake yaar"
afLer a momeL ' we LhoughL Lo concenLraLe back Lo our sLudles speclally mlcroblology
Me leL 's leave Lhls yaar have you seen Lhe syllabl of mlcro man"
A8nA8 ?eah lLs a hall loL man leLs concenLraLe on lL or else hamare halaL phlrse mld sem
kl Larah honge"
Me ln end sem we have Lo work harder man"
we were sLudylng buL we were lacklng concenLraLlon some ldeas were wavlng around us
1CCL1PL8 kuch nahl ho raha haln yaar leLs flrsL sorL ouL Lhe ldeas we are havlng on Lhls
arLlcle"
Me scrlbbled ouL some equaLlon and graph on a rough page whlch goes llke Lhls
L8 conc AcLlveness
LeL us assume L8 be x and acLlveness of




Where k ls Lhe proporLlonally consLanL
lrom Lhe formula we needed Lo flnd a model on Lhe harmonlc mean



P ls Lhe aeglng varlable
n ls Lhe acLlveness due Lo per

We can see from Lhls LhaL aeglng ls resulLed for Lhe lackness of L8 proLeln conc
8ecause Lhe models havlng good conc of L8 ls ln arlLhmeLlc progresslon So
people havlng low L8 concenLraLlon resulLs or suffers aeglng
Pere l ls reffered Lo M8 SA?An1An SlnPA M1LCP dual degree 2
nd
year and
A8nA8 ls M8 A8nA8 CPAk8C8A81?
Lhls equaLlon mlghL noL Lo be relevanL buL lL ls [usL an approach we [usL sorLed ouL
ln lnLeresL appreclaLe lL or [usL lgnore lL
Su8Ml11Lu 8?
SA?An1An SlnPA
M1LCP uual degree
uepL of bloLechnology
3
rd
semesLer2
nd
year