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( Homeotic genes ; Hox genes)

1
2
3
4
5
6
7
8
9
10
11
12

6.7

DNA

1DNA

[1]

[2]

(transcription factor) DNA

60

(Drosophila melanogaster) (Antennapedia)

2 .

(realisator genes)
(segment polarity genes)
[3]

DNA TAAT 5' T

DNA
TAAT
9Bicoid
Bicoid

[4]

[5]

(gap genes) (pair-rule

genes) RNA
RNA

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(gap genes) (pair-rule

genes) RNA
RNA

2 Bicoid Hunchback
Giant Kruppel 2 Bicoid Hunchback Giant Kruppel

miRNA (1RNA)
()
RNA (ncRNA) 231 RNA
HOTAIR Polycomb-group (PRC2) (
HOXC HOXD )
PCR (en:Collinearity)

[6]

[7]

[8]

[9]

[10]

1894
()

1940

3 Ultrabithorax
11 () Ultrabithorax 3
2 (11)

[11]

:L-fly-mouse.gif

(Ecdysozoa ) (Antennapedia complex)

(Bithorax complex) 2 HOM-C (Homeotic Complex) (Deuterostome
) Hox HoxaHoxbHoxc Hoxd 4
Hox hox

10HoxaHoxbHoxc Hoxd 104

( paralogue) 42
(Cnidaria) (Bilateria) 2
[12]

[13]

Hoxa Hoxd Hox 2

Hoxd 8 13 Hoxd 13 5 ()
[14]

(body plan)
15 (
)
1995

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(body plan)
15 (
)
1995

1. ^ Lutz, B., H.C. Lu, G. Eichele, D. Miller, and T.C. Kaufman (1996). Rescue of Drosophila labial null mutant by the chicken ortholog Hoxb-1 demonstrates
that the function of Hox genes is phylogenetically conserved. Genes & Development 10: pp. 176-184.
2. ^ Ayala, F.J., A. Rzhetskydagger (1998 January). Origin of the metazoan phyla: Molecular clocks confirm paleontological estimates. Proc Natl Acad Sci 95
(2): pp. 606-11.
3. ^ Cesares and Mann 1998; Plaza et al 2001
4. ^ Gilbert, Developmental Biology, 2006
5. ^ Hanes and Brent 1989, 1991
6. ^ Small S, 1992. Regulation of even-skipped stripe 2 in the Drosophila embryo. EMBO J. 1992 Nov;11(11):4047-57
7. ^ Lempradl A, Ringrose L. 2008 How does noncoding transcription regulate Hox genes? Bioessays. 30(2):110-21.
8. ^ Rinn JL et al, 2007. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 129(7):1311-23
9. ^ Fraser P, Bickmore W. 2007. Nuclear organization of the genome and the potential for gene regulation. Nature. 447(7143):413-7.
10. ^ Montavon et al. 2008. Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness. Genes Dev. 22(3):346-59
11. ^ Pierce, Benjamin A. Genetics:A Conceptual approach.2nd edition
12. ^ Dehal P, Boore JL (2005) Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate. PLoS Biol 3(10): e314
13. ^ (http://www.sdbonline.org/fly/aimain/hox2.jpg)
10 4
104
14. ^ Deschamps J. 2007. Ancestral and recently recruited global control of the Hox genes in development. Curr Opin Genet Dev. 17(5):422-7

The Homeotic Selector Genes (http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=Homeotic%20gene&rid=dbio.section.1971#2009) in

Developmental Biology, 6th Edition by Scott F. Gilbert (2000) Published by Sinauer Associates, Inc. ISBN 0-87893-243-7.

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