The compounds are PDE7 inhibitors and have a number of therapeutic applications, particularly in the treatment of pain, especially neuropathic pain. The SPIROCYCLIC DERIVATIVES of the present invention are cAMP and cGMP hydrolyzed to the corresponding inactive 5'-monophosphate nucleotides. There are at least 11 families of PDE's, some (PDE3, 4, 7, 8) being specific for cAMP (PDE5, 6, and 9),
The compounds are PDE7 inhibitors and have a number of therapeutic applications, particularly in the treatment of pain, especially neuropathic pain. The SPIROCYCLIC DERIVATIVES of the present invention are cAMP and cGMP hydrolyzed to the corresponding inactive 5'-monophosphate nucleotides. There are at least 11 families of PDE's, some (PDE3, 4, 7, 8) being specific for cAMP (PDE5, 6, and 9),
The compounds are PDE7 inhibitors and have a number of therapeutic applications, particularly in the treatment of pain, especially neuropathic pain. The SPIROCYCLIC DERIVATIVES of the present invention are cAMP and cGMP hydrolyzed to the corresponding inactive 5'-monophosphate nucleotides. There are at least 11 families of PDE's, some (PDE3, 4, 7, 8) being specific for cAMP (PDE5, 6, and 9),