Drug name AMITRIPTYLINE General details A tricyclic antidepressant drugs used to treat long-term depression (elevates mood, increases

physical activity, improves appetite and restores interest in NDA). Useful if depression is accompanied by anxiety and insomnia. It may also be used to treat neuralgia. In overdose, amitriptyline may cause coma, fits, and abnormal heart rhythms. How taken Tablets SR capsules Liquid Dosage Duration of action 50-200 mg/day Anti-depressant effect may last for 6 weeks considerations May be useful to liaise with GP and local mental health officer to find out how is best to deal with someone who is clinically depressed. Dietary advice Drug class Tricyclic antidepressant Trade names

Availability POM

Side effects Result of anti-cholinergic action and its blocking action on the transmission of signals through the heart. Symptom Drowiness Sweating Drymouth/constipation Blurred vision Dizziness/fainting Difficulty passing urine Sore throat Palpitations Occurrence Common Common Common Common Common Rare Rare Rare

Other drug interactions Reduces the effects of anti-epileptics. Drugs with sedative effects intensify those of amitriptyline. There is an increased risk of abnormal heart rhythms when anti-arrhythmic drugs are taken with amitriptyline.

Special precautions An abrupt stop can cause withdrawal symptoms. Alcohol increases the drugs sedative effect. Not recommended for under 16 years for depression or under 6 years for enuresis.