ulsease S/Sx

47xx? (klelnfelLer
syndrome)
small LesLls lnferLlllLy
gynecomasLla
mlld menLal deflclency
anLlsoclal behavlour
48xxx? 49xxxx? menLal deflclencles
47x?? hlgh helghL
behavloural dlfflculLy
lnferLlllLy
someLlmes normal no manlfesLaLlons of abnormallLles
48xx?? lnferLlllLy
47xxx lemale
mlld menLal deflclencles
psychosls
mensLrual abnormallLles
43xC (1urner's
syndrome)
ShorL
lnfanLlllsm
abnormal genlLalla
cardlovascular skeleLal ecLodermal abnormallLles
Marfan's syndrome ArachnodacLyly (long slender llmbs long Loes and flngers)
Splne abnormallLles (scollosls pecLus excavaLum)
Lye problems
PearL valve and aorLa defecLs
PunLlngLon's chorea !erky random unconLrollable movemenLs
CsLeogenesls
lmperfacLa Larda
urved Lhln bones
ulmlnlshed bone denslLy
lracLure of mlddle Lhlrd of Llbla
lue sclera
ysLlc flbrosls
(mucovlscldosls)
SalLy skln
good appeLlLe buL poor growLh welghL galn
excess mucus producLlon
lnferLlllLy ln males (no vas deferens)
lungs blocked by mucus
lmmune sysLem down
blockade ln flow of pancreaLlc enzymes
excesslve loss of salL ln sweaL
henylkeLonurla delayed menLal soclal skllls
small head
erklng movemenLs of armslegs
menLal reLardaLlon
selzuresLremors
Pemophllla leedlng lnLo olnLs
aln
Swelllng
lood ln urlne/sLool
rulslng
l1/D1 hemorrhage
rolonged bleedlng from cuL
SponLaneous bleedlng
1ooLh exLracLlon
uuchenne's muscular
dysLrophy
Muscle weakness
Muscle wasLlng
Awkward galL (walklng sLepplng runnlng)
lrequenL falls faLlgue dlfflculLy w/ moLor skllls
LvenLual loss of ablllLy Lo walk
rogresslve dlfflculLy ln walklng
urug Slde LffecLs
Analgeslcs
O AceLamlnophen/araceLamol
O -arcoLlcs
O -SAluS
O 1ramadol
O Muscle relaxanLs
O urugs for neurogenlc paln

-arcoLlcs
O odelne
O lenLanyl
O Meperedlne (uemerol)
O Morphlne lv lM oral lnLraLhecal (S)
O -albuphlne buLorphanol

-SAluS
O ASA (aceLylsallcyllc acld) asplrln
O lbuprofen rufen
O -aproxen -apelan
O ulclofrenac aLaflam
O keLerolac 1oradol
O Mefenamlc acld onsLan
O lroxlcam leldene

Muscle relaxanLs
O yclobenzaprlne (llexlrll)
O ulazepam (vallum)

1rlcycllc anLldepressanLs (1A) amlLrypLlllne
SS8l fluoxeLlne

urugs for neurogenlc paln
1 1rlcycllc anLldepressanLs (1A) amlLrypLlllne
2 SelecLlve seroLonln reupLake lnhlblLors (SS8l)
3 MexlleLlne Pl (MexlLll)
4 henyLoln (ullanLln)
3 apsalcln (ZosLrlx)
6 arbamazeplne (1egreLol)
7 abapenLln (-euronLln)
8 lonazepam (klonopln)

-arcoLlcs AddlcLlon
1olerance
hyslcal dependence
onsLlpaLlon
-ausea/vomlLlng
SedaLlon/euphorla
CrLhosLaLlc hypoLenslon
8esplraLory depresslon
-SAluS l lrrlLaLlon
PearLburn
asLrlLls
lcaLlng
ramplng
1013 dlarrhea
laLeleL lnhlblLlon
l bleedlng
Allerglc reacLlon
8enal LoxlclLy
1ramadol

-ausea/dlzzlness
SedaLlon
ury mouLh
SweaLlng
8esplraLory/cardlac depresslon
onsLlpaLlon (rare)
Luphorla
1rlcycllc anLldepressanLs
(1A)
AnLlchollnerglc effecL
ury mouLh
lurred vlslon
P8
onsLlpaLlon
Drlnary reLenLlon
Less common S/L
ulsorlenLaLlon/confuslon
AnLlhlsLamlne effecLs
sedaLlon
rolonged Av conducLlon P8
lncldence of sexual dysfuncLlon
Seldom leukopenla
appeLlLe for carbs welghL galn
SelecLlve seroLonln reupLake
lnhlblLors (SS8l)
PyperexclLable/nervous/lnsomnla
(seroLonln syndrome)
SedaLlon/welghL galn
henyLoln ALaxla
SedaLlon
-ysLagmus
PlrsuLlsm
Pypocalcemla
lnglval hyperplasla
CsLeomalacla
MegaloblasLlc anemla
arbamazeplne (1egreLol)

PepaLoLoxlclLy
one marrow suppresslon
8enal dysfuncLlon
lonazepam (klonopln) sychologlcal and physlcal addlcLlon
abapenLln (-euronLln) -S depresslon
ulzzlness
ALaxla
oLenLlal for somnolence
hromosomal dlsorder
a) 1rlsomles
O 47xx?
O x??
O xxx
O 1rlsomy 21 (uown's syndrome)
O -umerlcal abnormallLles
4 48xxx? 49xxxx?
4 47x??
4 48xx??
4 47xxx
b) Monosomles
O 43xC (1urner's syndrome)
c) 1rlplolds
O 69 chromosomes

Mosalclsm Lx Lrue hermaphrodlLlsm (46xx 46x?
46xx/46x?)

Mendellan
a) AuLosomal domlnanL dlsorders
O Marfan's syndrome
O MyoLonlc dysLrophy
O PunLlngLon's chorea
O -euroflbromaLosls
O CsLeogenesls lmperfecLa Larda

b) AuLosomal recesslve dlsorders
O ueafness
O Alblnlsm
O ysLlc flbrosls
O lrledrlch's aLaxla
O henylkeLonurla

c) xllnked dlsorders
O Paemophllla
O olor bllndness
O 6u deflclency
O uuchenne's muscular dysLrophy

MulLlfacLorlal dlseases
O LssenLlal hyperLenslon coronary hearL dlsease
O uM
O epLlc ulcer
O Schlzophrenla
O ommon blrLh defecLs (clefL llppalaLe splna
blflda congenlLal hearL dlsease)