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  • Seth Y. Ablordeppey and Donald M.N. Sikazwe - Haloperidol Analogs

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    Seth Y. Ablordeppey and Donald M.N. Sikazwe- Haloperidol Analogs

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    3 views9 pages

    Seth Y. Ablordeppey and Donald M.N. Sikazwe - Haloperidol Analogs

    Uploaded by

    Lonkes

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF or read online from Scribd
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    of 9
    2) United States Patent Ablordeppey et al. (54) HALOPERIDOL ANALOG (75) Inventors: Seth Y. Ablordeppey, Tallaassee, PI (US); Donald M. N. Sikuzwe, Tallahassee, FL (US) Florida A&M University, Tallahassee, FLQUS) (93) Assignee: Notice: Subject to any disclaimer, the term ofthis pateat is extended of adjusted under 35 USC. 154(b) by 372 days. an Appl. No 101934,769 (22) Filed: Sep. 7, 2004 (65) Prior Publication Data S 2006005236341 Mar. 9, 2006 (1) Ineck AGIP 3518 AGIK 3155 AAGIK 31/445 AGIK 31/40 coz 20710 corp 20746 coz 21100 cor 2120 CozD 2254 07D 24308 coz 295/00 corp 48700 a silat (200601) (200601) (2006.01), (2006.01) (200601) (2006.01), (200601) (2006.01), (200601) (200601), (200601), (2006.01) 514/218; 514/317; 5141327 S14i424; 514/428; S40/461; 840/575: ‘4/217: SA6/247, 48/556, 548/571 Field of Classification Search ‘514/218, SLA/317, 327, 412, 424, 428; 540/46, ‘546/217, 287; SAN/SS See application file for complete search history. 650) References Cited US. PATENT DOCUMENTS BaSK9O1 A 411969 Ianssen ‘602987 AS09573 A AL97O Schima ta 260.268. S2m0382 A 711993 Chakra et als wo $14220 OTHER PUBLICATIONS Abloreppey et al Design and Synthesis of Novel Analogs of Haloperdol Incapable of Fomning MPP+-Like Species, Medicinal Chomisry Research, (7), pp 459-467, 19952 Iyles- Eggleston etal. Design, Symes, and Evaluation of Metabo- lismBasod Analogues of Haloperidel Incapable of Forming MPP. like Species dourmal of Metisinal Chemistry, Jan. 29,2004, vol 7, No.3: pp 497-508, especially p 498 —relvan to claims 1-5, 'US007700587B2 (10) Patent No. 4s) Date of Patent: US 7,700,587 B2 Apr. 20, 2010 vets ea, Seience 192-481-485, 1976 Rows Metal Mad. Chem, 2001, 4(8), 477 Jaber M, etal, Nawyphara, 1096, 3511) 1803, Eyles, Da, Life Se, 19,4, 529, Boy, Dee a, ur J Pharmacol, 2000, 91, 63. Missle et aly Physio Rev, 1998, 78,189, 6 tal Biorganie & Medicinal Chery Letter, 13,203, mid al, Eu J Pharmacol, 2001, 425, 197 Newham ota, Pychophormacl Bull 1996, 321), 123 * cited by examiner Primary Examiner (73) Attorney rend [Coleman Agent, or Firm—Dennis . Clarke on ABSTRACT Haloperidel analo _ o wherein: Ris H, or (CH), OH, nnisan integer from 0 to 2, and \ isabetercyclic bridging group, consisting essentially of earbon and atleast one nitrogen atom, which eff tively maintains the distance between the moieties connected theeeby sk thatthe compound (1 isinca pable of metabolizing to BCPP" lke species, (2) has in affinity’ forthe D2 receptor subtype of 15

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