We examined the usefulness of brief neuropsychological tests and serum A as a pre dictive test for detecting MCI/AD in older

adults. Serum A levels were measured f rom 208 subjects who were cognitively normal at enrollment and blood draw. Twent y-eight of the subjects subsequently developed MCI (n = 18) or AD (n = 10) over the follow-up period. Baseline measures of global cognition, memory, language fl uency, and serum A(1-42) and the ratio of serum A(1-42)/A(1-40) were significant pr edictors for future MCI/AD using Cox regression with demographic variables, APOE 4, vascular risk factors, and specific medication as covariates. An optimal sens itivity of 85.2% and specificity of 86.5% for predicting MCI/AD was achieved usi ng ROC analyses. Brief neuropsychological tests and measurements of A(1-42) obtai ned via blood warrants further study as a practical and cost effective method fo r wide-scale screening for identifying older adults who may be at-risk for patho logical cognitive decline. for more information on the Roskamp Institute and Alzheimers please visit: http://www.mullanalzheimer.com http://www.mullanalzheimer.info http://www.michaelmullan.us www.rfdn.org