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Sensory Inflammatory

Impede blood flow

Oxygen

Release of chemical mediators

Blood flow

Hypoxia

Migration of WWBC (neutrophils) in the site of injury

Anaerobic metabolism

Phagocytosis
Prostaglandins

Lactic acid production

Bradykinins

Pus
Vasodilatation

Irritation of nerve endings

PAIN
Loss of Appetite Compression of nerve ending

Swelling

PATHOPHYSIOLOGY

Hard mass of feces (fecalith) Foreign body in the lumen of appendix Fibrous disease of bowel wall Adhesion/parasitic infestation Calcium phosphate-rich mucus In organic Tumors Viral /bacterial infestation

Malfunction of the appendix

Small lumen of the appendix

Obstruction accumulation of mucus inside the appendix

Continues accumulation of mucus inside appendix

Swelling of the appendix

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