Basic Clinical Study Designs

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 (Basic clinical study designs)
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2
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Future
Time period
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oral cancer
(case)

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(control)

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(exposure)
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(outcome)
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Future

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case

Control

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odds ratio (OR) = 6 odds  J@ 94 2 :
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6 (ratio) 34 odds 
34 case-control study 01? M
Odds ratio (OR)

odds 34 exposure :6 case


odds 34 exposure :6 control

(a/a+c)
(c/a+c)

ad/bc

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(d/b+d)

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b/d

 4

B49
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? 2= (rare event) 6 OR H   RR
46 
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:

? Endometrial cancer > >20:S

Exposure

Outcome
? Endometrial cancer

<6? Endometrial cancer

:62:

77

64

:62<6:

42

11

119

75



Odds ratio (OR) =

=
OR = 0.32   6

77 x 11
42 x 64
0.32

- 94 34? Endometrial cancer > >20:S2:


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JA!A345 randomized controlled trials 


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B446 6 ? 6
4:5

?  0R>> (IQ)

-10 =C, 0 =C, 32 =F, 98.6 =F 01 


90, 120, 180
01 

70
4:5 
J ?<?01 327?J@4:55 2= 7 
J0
<?6
4:5 80 =C 56 4:5 60 =C 01  7 6
? 
6 K_;  B4 6 35 016 2
85H = ??4 <666 5 27H
 B24H 6 5 34
? 6
   7?J@6
34 70
 M456 <6<6 46 6 4:5 0 =C 
B4 0 =F <6<? J@<64:5
4. 4
6
(ratio scale)
01
? 
 ?34 70
252:?
70
 
J ?44 01 3 G@2:  
  

J 7?6  6 46 <? 7  6 5 016 5 27H
 (absolute zero) B4<6
 6 M=  015  J@<6 M=   70
2 
J ?<?
? 4
6
 01
01 70
2 234  3   
:3 ; 6 M=  65 4 :  ? 9 5
? M= 
B4? 01 
4H ?34 70
7

H  34345A012H= 01
B4J    

@K  M N G@2

H 343457601 2  K B4


1. Parametric data 013452

H  70  (normal distribution)

502 11 3452

H  70 

2. Non parametric data 013452

H  7<60 

502 12 3452

H  7<60 
! Y;D
 Z
[





:0
B4J ;BMC  H 
Type of data
Non parametric data
Nominal
Ordinal
Describe one
group
Compare one
group
Compare two
independent
groups
Compare two
dependent
groups
Compare three
or more
independent
groups
Compare three
or more
matched groups
Correlation
between two
variables

Proportion
Chi-square or
Binomial test
Fisher's test
(chi-square
for large
samples)

Parametric data

Survival time

Median,
interquartile range

Mean, SD

Kaplan Meier
survival curve

Wilcoxon test

One-sample t test

Mann-Whitney test

Unpaired t test

Log-rank test or
Mantel- Haenszel

McNemar's test

Wilcoxon test

Paired t test

Conditional
proportional
hazards regression

Chi-square test

Kruskal-Wallis test

One-way ANOVA

Cox proportional
hazard regression

Cochrane Q

Friedman test

Contingency
coefficients

Spearman
correlation

Repeated
measures
ANOVA
Pearson
correlation

Conditional
proportional
hazards regression
-

;;3
3434: 8.?
. P
 > : ;K 7
.?
. >: 02   = 
345
4
0
4
4  = 
  
,   
 ? = 
  
7

PH   

0 

1.  7H64:
 .
 ? ;BMC . 3 : 9G;
 ; 2540.
2. Fletcher RH, Fletcher SW, Wagner EH. Clinical Epidemiology: the essentaials. 3 rd ed.
Maryland: William&Wilkins; 1996.
3. Grimes DA, Schulz KF. Cohort studies: marching towards outcomes. Lancet 2002 Jan 26;
359: 34145.
4. Schulz KF, Grimes DA. Case-control studies: research in reverse. Lancet 2002 Feb 2; 359:
43134.

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