NURSING IMPLICATIONS Assessment & Drug Effects Determine previous hypersensitivity reactions to penicillins, cephalosporins, an d other allergens prior

to therapy. Lab tests: Baseline C&S tests prior to initiation of therapy, start drug pending results; periodic assessments of renal, hepatic, and hematologic functions shou ld be made during prolonged therapy. Monitor for S&S of an urticarial rash (usually occurring within a few days after start of drug) suggestive of a hypersensitivity reaction. If it occurs, look fo r other signs of hypersensitivity (fever, wheezing, generalized itching, dyspnea ), and report to physician immediately. Report onset of generalized, erythematous, maculopapular rash (ampicillin rash) to physician. Ampicillin rash is not due to hypersensitivity; however, hypersens itivity should be ruled out