Cell Wall Agents Beta-Lactams (prevents x-linking via transpeptidase) -penicillin -cephalosporins -carbapenems Glycopeptide (prevents x-linking at another

step) -Vancomycin b-lactamase inhibitors -clavulanic acid -tazobactam DNA Agents Quinolones (-floxacin) -Gyrase and Topoisomerase Sulfonamides -Folic Acid Metronidazole -reduced within bacteria, will fragment DNA Protein Synthesis Macrolides 50s (mainly static) -Erythromycin, clarithromycin, azitrhomycin -Clindamycin Aminoglycosides 30s (cidal) -Gentamycin, tobramycin, streptomycin Antifungals Cell membrane -electrolyte imbalances Polyene (AmphoB, nystatin) -targets ergosterol Azoles (fluconazole, itraconazole, voriconazole) -targets a P450 enzyme that makes ergosterol Cell Wall

Echinocandins (Caspofungin, Mecafungin) -inhibits glucan synthesis, leading to weaker cell wall and osmotic lysis Nucleoside Analog Flucytosine