DRUG STUDY

GENRIC / TRADE NAME Rifampicin Dosage 2.8 mL Rifampicin 10mg/kg (200mg/5 mL) CLASSIFICATION Antibiotic, Antituberculotic (first line) INDICATION >Treatment of Pulmonary TB CONTRAINDICATION >Contraindicated with allergy to any rifampicin, acute hepatic disease, lactation. >Use cautiously with pregnancy SIDE EFFECTS >headache, drowsiness, rash pruritis,muscle weakness, urticaria, flashing

16 NURSING RESPONSIBILITIES >Administer on an empty stomach, 1 hr before or 2 hr after meals. >Administer in a single daily dose. >Consult pharmacist for rifampicin suspension for patients unable to swallow capsules. >Prepare patient for the reddishorange coloring of body fluids (urine, sweat, sputum, tears, feces, saliva); soft contact lenses may be permanently stained; advise patients not to wear them during therapy. >Warning: arrange for follow-up visits for liver and renal function tests, CBC, and ophthalmic examinations. >Take the drug in single daily dose. Take on an empty stomach., 1 hour before or 2 hours after meals >Take this drug regularly; avoid missing any doses; do not discontinue this drug without consulting your health care provider. >Have periodic medical checkups, including eye examinations and blood tests, to evaluate the drug effects. >Do not drink alcohol, or drink as little as possible. there is an increased risk of hepatitis >Can cause peripheral neuropathy which is manifested by tingling sensation on extremities. It can be

Pyrazinamide

5.5 mL antibiotic Pyrazinam ide 25mg/kg (250mg/5 mL)

>used with other drugs to treat tuberculosis

>severe hepatic damage; who have shown hypersensitivity to it; with acute gout.

>an allergic reaction, fever, unusual weakness or fatigue, nausea, vomiting, or loss of appetite, yellow skin or eyes, dark urine, difficult or painful urination, painful or swollen joints

Isoniazid

1.4 mL Isoniazid 5mg/kg

Antituberculotic

>Tuberculosi s of all forms >Prophylaxis

>severe hypersensitivity reactions, including

>Peripheral neuropathy, Nausea and

17 (200mg/5 mL) in specific patients who are tuberculin reactors (positive Mantoux test)) or who are considered to be high risk for TB. drug -induced hepatitis >severe adverse reactions to isoniazid such as drug fever, chills, arthritis; and acute liver disease of any etiology vomiting, Thrombocytopenia , Local irritation at IM site, Epigastric distress prevented through use of supplemental vitamin B6 (pyridoxine). >Give in an empty stomach 1 hr before or 2 after meals; may be given with food if GI UPSET OCCURS. >Give in a single daily dose. Reverse parenteral dose for pt unable to take oral meds. >Dec. foods containing tyramine or histamine in pt diet.