Drug name Generic name: Diazepam Brand name: Diaepam Intensol, Valium Classification: Sedative/hypnotic; skeletal muscle relaxant;

antiepileptic; anxiolytic; benzodiazepine Dosage: 10 mg IM

Therapeutic actions Exact mechanisms of action not understood; acts mainly at the limbic system and reticular formation; may act in spinal cord and at supra spinal sites to produce skeletal muscle relaxation; anxiolytic effects at does well below those necessary to cause sedation

Indications -management of anxiety disorders/for short term relief of symptoms of anxiety -muscle relaxant: adjunct for relief of reflex skeletal muscle spasm due to local pathology -antiepileptic: adjunct in status epilepticus and severe recurrent convulsive seizures

Contra-indications - Hypersensitivity - Cross-sensitivity with other benzodiazepines may occurs - Comatose patients - Pre-existing CNS depression - Uncontrolled severe painUse cautiously in: 1) Hepatic dysfunction 2) Severe renal impairment 3) History of suicide attempt or drug dependence

Adverse effects - CNS: 1) dizziness 2) drowsiness 3) lethargy 4) hangover 5) headache 6) depression - RESP: 1) respiratory depression - CV: 1) hypotension - GI: 1) constipation 2) diarrhea 3) nausea 4) vomiting

Generic name: Methylergometrine Brand name: Methergine

Acts directly on the smooth muscle of the uterus and increases the tone, rate and amplitude of rhythmic contractions through binding and the resultant antagonism

-post-partum hemorrhage and uterine atony, subinvolution -for routine management after delivery of placenta

-hypertension, toxemia, pregnancy

-hypo or hypertension, nausea, vomiting, chest pain, dyspnea, headache, hematuria, thrombophlebitis, water intoxication, hallucination, leg cramps, dizziness, tinnitus, nasal congestion, diarrhea, diaphoresis

Nursing considerations - Monitor BP, PR,RR prior to periodically throughout therapy and frequently during IV therapy. - Assess IV site frequently during administration, diazepam may cause phlebitis and venous thrombosis. - Caution patient to avoid taking alcohol or other CNS depressants concurrently with this medication. - Change from IV therapy to oral therapy as soon as possible. -evaluate patients medical history -assess patient condition -monitor BP and PR before administration -assess allergic reaction like GI disturbances -assess for toxicity -safety measures