1

JOURNAL OF SUPERCRITICAL FLUIDS, 47, 537-545 (2009)

Manufacture of submicron drug particles with enhanced dissolution behaviour by
rapid expansion processes
()
Michael Turk*
Institut fur Technische Thermodynamik und Kaltetechnik, Universitat Karlsruhe (TH), Engler-Bunte-Ring
21, 76131 Karlsruhe, Germany

2.7 m 10 m
(bioavailibility) RESS
RESS

(acentric factor)

RESS

RESS 20 (
)()

(1) (pre-expansion temperature)

(2) (pre-expansion pressure) CO2

(3) (nozzle diameter)CO2

(4)
RESS CO2
( < 500 nm) RESS

(1) RESS (RESS in aqueous solution, RESSAS or

RESOLV)

(2) RESS (RESS with a solid co-solvent, RESS-SC)

()

(3) RESS (RESS with a biocompatible

polymer)(PLA) RESS
PLA
PLA

(4) / (drug/carrier inclusion complexes)

pH
RESS

CO2 RESS