C ch tc dng Tc dng khng khun ca tetracyline rt phc tp thng qua nhiu cch khc nhau.

c ch tng hp protein vi khun, gn vo tiu phn 30s, bao vy s kt hp ca nhiu cation kim loi: Ca++, Mg ++, Mn++, Zn++, Fe++, Al+++ iu ny ct ngha c tnh ca thuc trn h xng, rng. Khng dng thuc cng cc ch phm ca sa, thuc khng acid, vitamin, kim loi hay thuc ty cha cc kim loi trn. Chng s lm gim s hp th tetracyline. Cc tetracyline to phc vi nhng cht chuyn ha ct yu: cc vitamin, cc amino acid gy ri loi qu trnh chuyn ha ca vi khun gy bnh s ng vi khun trong qu trnh sng cn acid glutamic trong h hp m bo. Tetracyline lm ri lon s tch acetate trong trao i cht, dn n vi khun b c ch, khng pht trin c v b thc bo. V vy, tetracyline khng sinh ph rt rng. Oxytetracyline (tetramycine) Tn ha hc: 4-(dimethylamino)-1,4,4A,5,5A,6,11a-octahydro3,5,6,10,12,12a-exahydroxy-6-mehtyl-1,11-dioxo-2naphthacencecarboxamide Cng thc cu to

Oxytetracyline tn ti dng bt, tetracyline dng dung dich du vi dung mi propylic glicol. Oxytetracyline c ph khng khun rng ging Aureomycin. nng thp c kh nng c ch vi khun, nhng dng nng cao c th dit khun. vi khun c th khng vi Oxytetracyline nu dng thi gian di v dng lp li nhiu ln. thuc Oxytetracyline hp thu vo c th nhanh, nhng t lwj hp thu khng cao, nn c lc vi vt nui thp, d lng ca loi khng sinh ny trong c th vt nui thp, nhng tc ng ca n vi mi trng khng nh. trong mi trng kim lm cho tn hiu nghim gim kks ny

c tc dng vi nhiu cu khun v trc khun Gram(-) v Gram(+), xon khun v Rickettsia. Trong nui trng thy sn, dng Oxytetracyline phng tr cc bnh nhim vi khun Vibrio nh bnh pht sng, bnh dc thn u trng, bnh thn, bnh n mn v kitin, bnh m nu tm cng xanh, bnh ng rut, bnh hoi t ph b ca tm s, bnh nhim trng mu v xut huyt c cc loi c nc ngt c gi tr kinh t nh: c tra, c basa, c trm c c 3 loi thng c dng trong nui trng thy sn Vit Nam l: Oxytetracyline v Chlortetracyline trong nui nc mn v Tettracyline trong nui trng thy sn nc ngt. Cch dng: Trng vo thc n cho tm, c n lin rc trong 5- 7 ngy, t ngy th 2 gim bt thuc, liu dng 10- 12 gam thuc vi 100kg trng lng tm, c/ ngy. y l loi khng sinh c th thay th cho cc khng sinh b cm dng trong nui trng thy sn Vit Nam: Chloramphenicol, Furazolidone, Nitrofuran, Furazon, Metrodidazole.