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.

1 ) (LIFE 2,3
1.1

)(

. :
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. :1 . .
. . :1
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.1.3

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COMMUNITY

.1.4
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.2 ) (LIFE 4
2.1
)(
. , . 2 ) (CAPSULE .
. .
2.2
) - , , (
. , 5 . . .
. .
2.3
.
.PROTOBIONTS ,
.
2.4
,
, .
DNA . .
2.5 ?
. DNA RNA .
.
.

.3 ) (LIFE 4
-CELLULAR FRACTIONATION .
.
3.1
. .
. . .
, .
.
.
-CENTRIOLES . .
) -(VESICLES , , ) . :-
(. .
, . ,,
.
-(CILIUM) CILIA . .
. .
) -(FLAGELLA .
. .
- DNA- . .
. )(
.
)-(NUCLEOLUS . .
DNA , . DNA-
DNA.
- . 23
+ X .Y
) -(PEROXISOME .
3.2 ,
* ER-.
-ROUGH ENDOPLASMIC RETICULUM ,
. ) ( VESICLES
.
-SMOOTH ENDOPLASMIC RETICULUM .
. . .

-GOLGI APPARATUS . ER- ,,


, .VESICLES .
3.3
ATP- . :
, , .MATRIX ,CRISTAE ,
.CRISTAE CRISTAE-
CRISTAE .ATP .ATP
DNA .
- . - .
. . .
STROMA DNA- .
)-(THYLAKOIDS- .
GRANA .GRANUM ,
.LUMEN .
3.4
:
- ) ( . ,
. , . ,
.
-PLASMODESMATA . .
-VACUOLE . ) (TURGOR .
, .
.
- . .
) -(LEUCOPLAST .
:
-EXTRACELLULAR MATRIX .
EM .EM .
, " .EM EM
, ,
, , .
3.5
. . .
. ,INTERMEDIATE FILAMENTS ,MICROFILAMENTS :
.MICROTUBULES
-MICROFILAMENTS . . .

-INTERMEDIATE FILAMENTS - . .
. , .
-MICROTUBULES . .MOTOR PROTEINS
. " .
) (CILIA ).(FLAGELLA
-MOTOR PROTEINS " .ATP
MICROTUBULES . )(VESICLE
) ( MICROTUBLE .

.4 ) . (LIFE 5
-4.1 .
).
. .(SEMI PERMIABILITY-
- . ,
- )( )( . ,
- , . )
( 25% ) .(FLUID MOSAIC MODEL
, .
.
)( ) ( ,
, .
-LIGAND .
, .
-4.2
, . )(,
.
-
. .
.
.
.
-4.3 ,
, . .
. .
) (ISOTONIC . .
) (HYPERTONIC ,

. ) (HYPOTONIC , .
.
-4.4
. )FACILITATED
.(DIFFUSION
-4.5
) (CARRIER PROTEIN . ) (CHANNELS
. ) (VOLTAGE GATED\LIGAND GATED \ .
.
.
-4.6 ,
. .
) (PRIMARY .ATP ) -(SECONDARY
, . "
. . .
.- .

) . .(SODIUM POTASSIUM PUMP
-4.7
, ) .(CARRIER PROTEINS .FACILITATED DIFFUSION
," ,"
. -PHAGOCYTOSIS :
." ).(ENDOCYTOSIS
-PINOCYTOSIS ) . (EXOCYTOSIS

.5 ) (LIFE 6
-5.1
,
.
-5.2
, , .
.
-

Ea

- , .
: . .
. .
-5.3
-1 . .
2 ,
.
,
) . " T S(.

H = G + T S
-T S- .
-5.4 ,

- .

G reaction = G products G reac tan ts

G > 0

. .

G < 0

. .

G = 0

- .

.
.

ATP-5.5
. ATP
:

A TP + H 2 O ADP + PI + G
- G ( G < 0 ).

.6 , ) . (LIFE 6
-6.1 ,
: )( , )( ,
, ).R .(R
, .
R
" 20 .

COO-

NH3

H
.1 : .
.2 .
.3 .
.4 :
.SH , .DISULFIDE BRIDGE
.
. , .
- , . . .
- . ,
) (CONDENSATION .
) (N TERMINUS
) (C TERMINUS .
) (
: ,
: )( ,
)( , )( .
-6.2
.
.
, .

- .
- , ,PH
.
- .
-.
-6.3
)( " . !G
) (SUBSTRATE .
- .
: , , \
. , . "
, .
COFACTORS COENZYMES -.
-6.4
" ) ,(INHIBITORS .
) .(IRREVERSIBLE INHIBITION
.REVERSIBLE INHIBITION- )COMPETITIVE
(INHIBITORS .
) (NONCOMPETITIVE \ ALLOSTERIC ,
) . S
(. FEEDBACK INHIBITION PATHWAY
,METABOLIC , .
.PH-

.7 ) (LIFE 7
7.1
: , , .
.
. :
* .
* " .
* .
* , .
* " .KEY ENZYMES
- .
: ATP- .
, 3 ).(G3P
* ADP- " SUBSTRATE-LEVEL
.PHOSPHORYLATION
7.2
:

C6H12O6 + 6O2 6CO2 + 6H2O+ free energy


.ATP-

ADP + Pi + free energy ATP


:

m o le

G = 686 kcal

, , .ATP O2)
( 4 , :
* , , PYRUVATE ) (
) ( . O2 PYRUVATE ,
)(.


) (

)(

PYRUVATE

)(


PYRUVATE

. 10 " .
2 : 4 ,PYRUVATE 2 ,ATP .NADH
: 2 .ATP
7.3 -
- .
- " .
- .
* .
. .OXIDIZING AGENT
.REDUCING AGENT
, ,REDUCING AGENT- O2 - .OXIDIZING AGENT-
. REDUCING AGENT- NAD COENZYME .
. :
NAD+
NADH + H +

NAD + + 2H NADH + H

H H +.
:NADH-

NADH + H + + 1 O2 NAD+ + H2O


2
:

m ole

G = 52.4 kcal

) O2 (OXIDIZING AGENT-
7.4 ) (
, ) ( .
.
, .
7.5 ,
, .
PYRUVATE " NADH + H + NAD + -.
- , PYRUVATE . .ACETALDEHYDE-
ACETALDEHYDE . CO2 " NAD + , NADH + H + .
7.6
-PYRUVATE , PYRUVATE .
, acetyl CoA - PYRUVATE CO2-
NAD + NADH + H + -
) (- acetyl CoA- Oxaloacetate -
acetyl CoA . 2 6 ,ATP NADH + H + 2- ) FADH 2
COENZYME, NADH + H + ( .
, , .
ATP -OXIDATIVE PHOSPHORYLATION . O2
: .
7.7
4 . Ubiquinone , Cytochrome C ,
, .
. ) ( H +
. 4
)( )" ( .
, , Cytochrome C
Ubiquinone .

-1 H + ATP ?
.1 .8 PH H +
.
+
.2 ) .4 PH .( H
- ATP .
+
: , H ATP"
.
7.8 ATP
- ATPsyntase - ATPsyntase .
ATP ADP- . Pi -
ATPsyntase .
- ) (PROTON-MOTIVE FORCE .ATP

* ) ( ATPsyntase , H +
.
*" :
2 ATP
2 ATP -
28 ATP -OXIDATIVE PHOSPHORYLATION
:

C6H12O6 + 6O2 6CO2 + 6H2O + 32ATP


-2 ATP ?ATP
.1 .
.2 H + .
ATP.3 , ATP- .
H + .4 ATP-" ATP.
ATP : , , .ATP
:
.
.1 :
.
) DAP- ( , .acetyl CoA-
- , .
.2 :
.
-GLUCONEOGENESIS .

" , .NEGATIVE\ POSITIVE FEEDBACK


phosphofructokinase - .ATP
-isocitrate dehydrogenase ATP-
+
. NADH + H

.8 ) . (LIFE 9
- . -
4 . :
.1 (REPRODUCTIVE SIGNAL) .
.2 .DNA
.3 )-(SEGREGATION DNA .
.4 )-(CYTOKINESIS .
8.1

. , DNA" .
:
-Ori
-Ter
DNA REPLICATION COMPLEX . Ori
. ;
. ,
.
8.2
- , ) N(.
- ) 2N(.
, - . .
- N.
- 2N.
2- , .
)-(KARYOTYPE , .

- - .
) ( .
, . ,
-GROWTH FACTORS . PLATELET-DERIVED .
GROWTH FACTOR , .
INTERLEUKINS ERYTHROPOETIN .
, - .
GROWTH FACTORS GROWTH FACTOR- .
" . .
. .
. . .
-ASEXUAL REPRODUCTION . : -
- , .
-CLONES .
-SEXUAL REPRODUCTION ) . ,
(. , .
* . : ) ,(3N
) . ... (4N .
* .
) (3N
I .
:SEXUAL LIFE CYCLES
-HAPLONTIC LIFE CYCLE .PROTISTS- .
SPORES SPORES . ) ,(GAMETOPHYTE
" . ).(SPOROPHYTE
-DIPLONTIC LIFE CYCLE . .
. .
.
:
-NECROSIS " . .
. .
-APOPTOSIS . (.1: (.2 .
, .
, .
. " (.1 :
) (.2 .(GROWTH FACTOR- .DNA-


) (CASPASES .
8.3
- , .
," .
)-(INTERPHASE . . 3--
:
-S PHASE .DNA )(CHROMATIDS
.
-G1 ) (GAP .S
-G2 ,S .
. :
) .(PHOSPHORYLATION " .
CYCLIN-DEPENDENT KINASE Cdk .Cdk "
) ,(ALLOSTERIC REGULATION . Cdk-
G1- .S- Cdk- .
RESTRICTION POINT G1- .
RESTRICTION POINT- RETINOBLASTOMA PROTEIN- RB .RB" ,
, .RESTRICTION POINT
P53 ,P21 RB-" . , DNA
,G1 P21 P21 . -Cdk G1- . DNA
. .Cdk-,
,P53 ,P21 Cdk .
P53 .
8.4
) 2N 4N ,( DNA ,
CONDENSINS . , DNA .
" . , CENTROMERE
) ) CENTROSOME .(X- CENTRIOLES , ( ,
DNA- . G2- MITOSIS) M- ( CENTROSOMES
. " "
. .CENTRESOMES-
, ) .(SPINDLE CENTROSOMES
. :
- , ) KINETOCHORES . (
CENTROSOMES.CENTROMERE- ,
.
- ) (NUCLEOLI . .

- CENTROMERES- .
* . ,
, ,CENTROMERE-.
- - ) .
2N 2N ,(.
MOTOR PROTEINS KINETOCHORES- .
, MOTOR PROTEINS .
.
- . . .
.
)CONTRACTILE
(RING MICROFILAMENTS . ,
, .
.
8.5
, DNA .
. . :
* .
* ) N(.
* .
:
* - I .
* -I , .II
,I S DNA .
, " . ,I .
SYNAPTONEMAL COMPLEXProteinscaffold.SYNAPSIS 4 .
TETRAD .BIVALENT : 46 23- . :I
TETRAD 23 " 92 . I- :I
. , " ) CHIASMATA(
. CHIASMATA- OVER .OVER CROSSING
CROSSING . I . :
I . : I ,
. :I . KINETOCHORES ,
.
. :I , " .CHIASMATA
:I , ) .(N
) 2N "( . II :

* DNA .II
* II .CROSSING OVER-
II . 4 .
CROSSING OVER .I ,
-INDEPENDENT ASSORTMENT .I
, .
: 23 (8,388,608) 223 , INDEPENDENT-
.ASSORTMENT
:
-NONDISJUNCTION ,I
, . :ANEUPLOIDY .
ANEUPLOIDY .
50% .
. : , 21 ,
TRISOMIC .21 .
,21 , .MONOSOMIC
-TRANSLOCATION .
+ 21 21 .

.9 ) (LIFE 11,12
9.1 RNA ,DNA -
-DNA : )( , 4 - .:
.1GUANINE (G) ,ADENINE (A) -
.2) THYMINE (T) ,CYTOSINE (C) - RNA- ,THYMINE ) .(URACIL (U
= A T
= C G
)( = )(
DNA . A T C .G
. A T , C G .
...
,DNA .
.
.

DNA 5 ) ,(5 5 ,
3 ,(3) ) OH- (.
- ) 5( 3
. DNA ).(ANTIPARALLEL

' 5' 3
' 3' 5

DNA , .
\ .
.
-RNA :DNA- , , .URACIL RNA .DNA
) URACIL ( . RNA ,"
. .
9.2 DNA-
- , Rstrain ,
) ( , Sstrain , )( .
, ,
, , .
, .
" " . , DNA-Sstrain -
" " . Sstrain ,DNA -
Rstrain .
- - . ,
DNA )P32 (DNA
.S35
, . .DNA
, . ,
. ,
, DNA DNA
.
9.3 ,DNA- -
" . .
.1
, .
.2 ,
.
.3 "" .
.
- - 20 . DNA N15
DNA . , 20 DNA ,
. , 40 DNA )( ,

.N15- , DNA - .
. ,
,
.
-DNA
. DNA helicase .
DNA polimerase 3-
. ) ( , DNA
,polymerase .DNApolymerase RNA
DNA DNApolymerase
.DNA- RNA DNA
, .
, .
, 5 3 . ,
,
. . leadingstrand
.laggingstrand
.dATP,dGTP,dCTP,dTTP
: . :
.1 .
.2 DNA .
.
-PCR- .DNA DNA " .
) 15-20 , , ( , )
(dATP,dGTP,dCTP,dTTP DNA- ) (900C- . DNA .
3 - DNA , .
- DNA mRNA .premRNA
9.4 - -
. ,
,RNA . .
:
- .RNA
RNA- .
- .

RNA

DNA

(.1 : ? (.2
RNA- ?

RNA) mRNA( - DNA- ) .


(.
(ADAPTER) tRNA , ,
.mRNA- mRNA
)(.
* , DNA .TEMPLATE STRAND .rRNA ,tRNA ,mRNA
RNA - .
RNA
- -

RNA
RNA

RNA
) DNA DNA RNA- (REVERSE TRANSCRIPTION

:
-INITIATION ) RNA ,(DNA- .
, DNA . .INITIATION SITE-
RNA -ELONGATION ,DNA 10 3-.5-
RNA ANTIPARALLEL ,DNA- 5- .3- " DNA"
. DNA , RNA
. , .
.DNA
) TERMINATION( - " .DNA-
* ,premRNA mRNA- .

- tRNA ) ( . 3
, . .CCA
- .mRNA .tRNA : DNA-
.3GCC5mRNA .3CGG5 : tRNA .3GCC5:tRNA .
3 . : GCC,GCA- GCU- "
.tRNA .wobble ,tRNA
- . tRNA "-
tRNA- . tRNA- .
: tRNA , .ATP-
tRNA-" ,
. .
tRNA- .
.
- mRNA tRNA .
. - . ,-
RNA ) ,(rRNA 45- .-
rRNA 33- .- " )

( . ,- .-
:tRNA
-A tRNA.
-P tRNA .
-E tRNA .
tRNA rRNA .mRNA -
, ,tRNA-
.
:
-INITIATION tRNA-initiationcomplex - , .mRNA-
rRNA ,ShineDalgarnosequence -mRNA .
,AUG , .-
tRNA , Initiationfactors .P- initiation
.complex
tRNA -ELONGATION .A- (.1 :
tRNA P (.2 .
tRNA .A tRNA , E -
ELONGATION . ,
.elongationfactors
-TERMINATION .A proteinrelease
-factor tRNA- .P C
terminus Nterminus) . ( .
,mRNA . mRNA
.
:
. .
. - .
" : " " , ,ER- " .
.
. :ER- signalreceptorparticle-
. ,ER- .
. - ,
. :
-Proteolysis " .
-Glycosylation .
-Phosphorylation " . .

9.5
.
- . .
AUG- .
.

, . ,
- . ,
. : - . .
3 ?
20 ) ( ) U ,A,C,G .(T
64=4X4X4 - .
?
mRNA- ) (UUUUU
.

9.6
-Somaticmutations . ,
" .
-Germlinemutations . .
.
:
- , , . ,
.
:DNA
- , " .
- .
-INVERSION .
-TRANSLOCATION DNA .
. , .

.
-Missense .
-Nonsense . .
-Frameshift " .
. :
* -tautomers Tautomers .
. ) ( . -
.
* NONDISJUNCTION.
.
) ( ) ( . ,
.
. ,
. 2 2 ,
, .
.
.
. , , ,
) . (.transposableelements-
:
* ) . (.
* .
* DNA .
* .

* . , .
RNA )(TERMINAROR SEQUENCE
. . mRNA-
.
, .INTRONS
EXTRONS .EXONS INTRONS premRNA INTRONS .mRNA-,
DNA . EXONS ,
. .
, . .
premRNA ) Gcap . (GTP , 5 ,
" PolyAtail . .3 ,
.mRNA - AAUAAA ,
,premRNA , 100 300 "").(AAAAAAAA...
RNA INTRONS- EXONS- premRNA . smallnuclear-
) .ribonucleoproteinparticles(snRNPs EXONS) INTRONS-
5 snRNP .(INTRON- , 3 .INTRON- ,ATP
RNAproteincomplex .spliceosome ,premRNA
,INTRONS EXONS.

mRNA , TAP 5 ,mRNA


.
" .
. INITIATION ) ,
RNA ( . , : -
RNA . -TATA .DNA , )
( RNA - TFIID :
,TATA- , .Transcriptioncomplex
, " .
" . -
.DIFFERENTIATION " repressor
) .proteins DNA (. repressorproteins
-Alternativesplicing . EXONS- .
. -mRNA Alternative-
mRNA .splicing " .-mRNA -
. .
,ubiquitin . ubiquitin ubiquitin- .
.polyubiquitincomplex Ubiquitin .proteasome- ,
. .
, .

.10 . ) . (LIFE 19
10.1
- . 4 :
-DETERMINATION .
-DIFFERENTIATION .
) -(MORPHOGENESIS .
" .
1\3 - .
10.2
, , .
) .(DIFFERENTIAL GENE EXPRESSION ,
. DIFFERENTIATION
. DNA , "
DIFFERENTIATION mRNA . : ,
DIFFERENTIATION . MyoD
MyoD .MyoD PROMOTERS- PROMOTER-
. MyoD ,

. , MyoD , " "


).(DEVELOPMENTAL GENES
10.3
) ( , .
, .DETERMINED ,
. " .
DIFFERENTIATION , CLONE .
)= , ( .
, , .
. .G1
. 8
) ( . , .
10.4 ""
, ) .
(.
,
. , , .DIFFERENTIATION-
10.5
DIFFERENTIATION , .
, - .
)-(MERISTEMS ,DIFFERENTIATION
.
, ,.
, .PHARMING-
.
.
. DIFFERENTIATE . , A
. ,
" ).(THERAPEUTIC CLONING
?
.
, , .
. ,
. .

" ) (c

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