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PREFACE An issue told that a 56 years old man has come to the dental clinic with white plaque

as complaint within right back of cheek since 5 years ago. At last 6 months, the plaque has been whiten, thick, unpain, with aperture form of surface. Some unpain stomatitis occured in some parts of oral cavity. Patient has been treated at Public Health Center and has been given antibiotic each time but hes not going to be healed even the white plaque increasingly extended. Some discusses were done to find about the right diagnose by identifying patients symptoms. From one characteristic, white plaque, firstly it was suspected as leukoplakia. Generally, white plaque in humans oral cavity is identified as leukoplakia with characteristic such as looks like white lession with ceratinisation in some epitel layers (It differs from nevus pigmentosus or black lession erythroplakia or red lession). By attending time of event that the illnes has come since 5 years ago and last 6 months, the plaque has been whiten, thick, unpain, and with aperture form of surface, leukoplakia is not final diagnose. We considered that it developed to be carcinoma in situ (consist of cancer cells but they dont cross basal lamina)

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