Tablet Coating

Why

coat tablets?

Types

of coatings

sugar coating film coating press coating (compression coating)

CHEE 440

Sugar Coating

stages involved

sealing of tablet core subcoating smoothing colouring

polishing
printing

CHEE 440

Film Coating

involves spraying a solution of polymer + pigments + plasticizers onto a rotated, mixed tablet bed forms a thin, uniform film on tablet surface
materials

polymers solvents plasticizers colorants

CHEE 440

Film Formation
latex particles dispersed in aqueous phase

formation of thin film with water evaporation through film

continuous film

CHEE 440

Coating Process
coating

pans

CHEE 440

Coating Process
fluid

beds

CHEE 440

Important Processing Parameters

inlet

and bed temperatures relative humidity atomization air pressure liquid spray rate droplet size drying time

CHEE 440

Coating Problems
picking/chipping
roughness sticking

film

cracking/peeling

CHEE 440

Normal Coating
Description
HPMC based Aqueous system HPMC based Organic solvent system HPMC based Aqueous/ Organic Solvent/ Hydro Alcoholic system PVA based Aqueous system

Average Reconstitution weight level gain

11% to 15% 2.5 %

Application examples
Amoxycillin, Azithromycin, Atenolol, Amlodipine, Amitriptyline, Ampicilin Ciprofloxacin, Cephadroxil , Cimitidine, Calcium Tablets, Citrizine , Chloroquine Phosphate, Clarithromycin, Erythromycin, Ferrous Fumarate, Famotidine, Ferrous Sulphate, Ibuprofen, Indapamine, Losartan Potassium, Levamisole, Methyl-Dopa, Metronidazole+Tinidazole, Metronidazole, Methyl Coblamine, Mefenamic Acid, Metoprolol Tartrate, Norfloxacin, Nifidipine, Norfloxacin+Tinidazole, Ofloxacin, Paracetamol, Quinine Sulphate, Roxythromycin, Secnidazole, Sildenafil Citrate, Trimetazidine, Tinidazole, Tinidazole-Doxycycline, Tinidazole + Tetracycline, Verapamil

5%

2.5%

Aqueous 11% Organic Solvent 5% Hydro Alcoholic 9% 2.5%

20% to 25%

2.5%

CHEE 440

Enteric-coated
coating

resists dissolution or disruption in stomach but not in intestines used for drugs that are unstable, irritating to stomach

CHEE 440

10

Enteric Coating
Description
Organic Enteric Coating system, Cellulose Acetate Phthalate based Aqueous coating system & Organic enteric coating system. Hydroxy Propyl Methyl Cellulose Phthalate based system. Methacrylic acid copolymer type "C" USP/NF based system

Average Reconstitution weight level gain

Application ** examples

5%

8%

Aspirin, Bisacodyl Diclofenac Sodium Doxylamine Succinate

Organic: 5% Aqueous: 10%

8% Garlic Tablets, Omeprazol, Pentaprazole,

Aqueous 20% Hydro Alcoholic 10% Organic System 10% Pentoxyfyline, Rabeprazol , 9% Serrosipeptadise

CHEE 440

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Press Coating
use

of compression to form coat around a preformed core

used

mainly to separate chemically incompatible materials

also dual release patterns possible

CHEE 440

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