Integumentary System

, , 15-20% .

:
Epidermis , .

Dermis ,

, . .
Hypodermis .

skin appendages

Stratified Keratinized (cornified) Squamous Epithelium 5:

(. Stratum Basale (stratum germinativum ,
. ),(keratinocytes
90%- .
. ,
.
- . Startum Spinosum
. .
.
. Stratum Granulosum - 3-5 . :
-Keratohyalin granules

)(.
Lamellar bodies

.
v. Stratum Lucidum .
) ( ,
. .
v. Stratum Corneum , .
.
:

St. Lucidum
St. Corneum

 :
Keratinocytes - 2

:
,
.1

.2
, ,
.tonofilaments ,
) ,(keratohylin granules .
, , .
, , ,
) (.
Melanocytes , .

.
. "
.thyrosinase UV
. ) ,(melanosome .
) cytocrine secretion-
" (.
:



UV






.
:
.1
.2
.3
Langerhan`s Cells

. 2-8% .
.
Merkel`s Cells

.
. .dense cored neurosecretory granules

2:
Epidermal Ridges .1 .
) ,
(.
Dermal Papillae .2

 : .
,
. , - .
2- :
Papillary Layer , loose connective-

.tissue .
) .(dermal papillae-
Reticular Layer . .

,dense irregular connective tissue- ,

) .(Langer`s lines , ,
, .
,
.

Epidermal Skin Appendages :

) (Hair Follicles and Hair
.1
, .
.
) (glassy membrane .
, Arrector pili muscles
) " - "(.
-hair bulb .dermal papilladermal-
papilla . bulb-
.Matrix cells . dermal papilla-
, . .
internal root sheath-
. .external root sheath
. 3:
Medulla . .

Cortex .

.
Cuticle of the hair shaft

.
) (Sebaceous Glands
.2
: , , , .
: ) ( .
, , , ,
.
- Sebum : .
: .
.3

) (Sweat Glands 2- :
Eccrine sweat glands

.
. 2:

 secretory segment 3
)(1
:pseudostratified epithelium
. Clear cells
.
. Dark cells .
. Myoepithelial cells .
duct segment stratified cuboidal epithelium
)(2
. .
.
.
Apocrine sweat glands .

, " , ,
. .
, , )
- (.
2:
) secretory segment (1
. .
simple cuboidal/low culomnar
epithelium myoepithelial cells .
,
)= .(Merocrine
) . duct segment stratified cuboidal epithelium (2
.
.4 ) - (Nails . nail
,beds .
nail root .
.
. lunula
, .
.eponychium .
. hyponychim ,
.

:
:
.1

Cornification

, 2-:

. ) (Loricrin, involucrin
, .cell envelope-
.
.) lamellar bodies- (
.
.
.

.2
.1 ,:


.
.
.
.2 ) , '(:
)=
(.
- , :
:
Mast cells

(Macrophages (Histiocytes

:

) (
.3 ,UV ":
" UV

UV ,D
DNA-



.3
. .
.
. ' . '
.
.iv
:
'

'

'

.4


D
.5

.6
,
.
Merkel`s Disk merkel
. - .
Meissner`s Corpuscle -
dermal papillae ) ,( . -
.

 Pacinian Corpuscle
. .
, . -
)(.
Ruffini`s Corpuscle-
, .
:
Basal cell carcinoma 78% .1 .
," . .
Squamous cell carcinoma 20% .2 .
. .
Melanoma 2% .3 . .
.

 ' " 2003-2004