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  • Benzylpenicillin, Commonly Known As Penicillin G: Bond Formation Inhibited by Penicillin

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    Shamsuzzaman Tanim
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    Benzylpenicillin, commonly known as penicillin G, works by inhibiting the bacterial transpeptidase enzyme involved in synthesizing the cell wall. The beta-lactam ring in penicillin allows it to become covalently linked to the active site of this enzyme, irreversibly inhibiting it. This prevents bacteria from forming peptide cross-links needed to assemble the cell wall, leading to cell death.

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    Benzylpenicillin, commonly known as penicillin G, works by inhibiting the bacterial transpeptidase enzyme involved in synthesizing the cell wall. The beta-lactam ring in penicillin allows it to become covalently linked to the active site of this enzyme, irreversibly inhibiting it. This prevents bacteria from forming peptide cross-links needed to assemble the cell wall, leading to cell death.

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    5 views2 pages

    Benzylpenicillin, Commonly Known As Penicillin G: Bond Formation Inhibited by Penicillin

    Uploaded by

    Shamsuzzaman Tanim
    Benzylpenicillin, commonly known as penicillin G, works by inhibiting the bacterial transpeptidase enzyme involved in synthesizing the cell wall. The beta-lactam ring in penicillin allows it to become covalently linked to the active site of this enzyme, irreversibly inhibiting it. This prevents bacteria from forming peptide cross-links needed to assemble the cell wall, leading to cell death.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
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    Benzylpenicillin, commonly known as penicillin G

    Mechanism of action Penicillins inhibit a bacterial enzyme called the transpeptidase enzyme which is involved in the synthesis of the bacterial cell wall The b-lactam ring is involved in the mechanism of inhibition Penicillin becomes covalently linked to the enzymes active site leading to irreversible inhibition Mechanism of action - bacterial cell wall synthesis
    NAM
    L-Ala D-Glu L-Lys D-Glu L-Ala L-Lys D-Glu L-Lys D-Glu L-Lys

    NAG NAM
    L-Ala

    NAM
    L-Ala NAG D-Glu

    NAG NAM
    L-Ala D-Glu

    NAM
    L-Ala NAG D-Glu L-Lys

    NAM
    L-Ala

    NAM
    L-Lys

    NAG

    NAM
    L-Ala

    NAG
    D-Glu

    NAM
    L-Ala

    L-Lys D-Glu L-Lys

    Bond formation inhibited by penicillin

    L-Lys

    Mechanism of action - bacterial cell wall synthesis


    NAM L-Ala D-Glu L-Lys D-Ala D-Ala Gly Gly Gly Gly Gly NAG NAM L-Ala D-Glu L-Lys D-Ala D-Ala Gly Gly Gly Gly Gly NAG

    SUGAR BACKBONE

    PENICILLIN TRANSPEPTIDASE D-Alanine

    NAM L-Ala D-Glu L-Lys D-Ala

    NAG

    NAM L-Ala D-Glu

    NAG

    SUGAR BACKBONE

    Gly Gly Gly Gly Gly

    L-Lys D-Ala

    Gly Gly Gly Gly Gly

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