FOCIS Program May 2005

Photograph by Peter Vanderwarker
2005
ANNUAL MEETING
FINAL PROGRAM May 12-16, 2005 • Westin Copley Place, Boston, Massachusetts
• Satellite Programs • Plenary Session

• Exhibit Hall • Thematic Symposia
• Poster Hall • Oral Abstract
• Thematic Symposia Sessions
• Oral Abstract
Session
• Industry Tutorials
• Oral Abstract
Session
• Speaker Ready
Room
2005
ANNUAL MEETING
TABLE OF CONTENTS
Table of Contents
Westin Copley Place ......................................................................... inside cover
Supporting Organizations ................................................................................ 2
Mission Statement & Strategic Plan .................................................................... 3
Member Societies ........................................................................................... 5
FOCIS Centers of Excellence ............................................................................ 6
Steering Committee ......................................................................................... 7
FOCIS Committees and Executive Office Staff ..................................................... 8
Faculty ........................................................................................................ 11
General Information ...................................................................................... 16
CME Information .......................................................................................... 16
Program-At-a-Glance .................................................................................... 18
Satellite Symposia ........................................................................................ 19
Industry Tutorials ........................................................................................... 34
Business Meetings ........................................................................................ 38
Program Schedule ........................................................................................ 39
Exhibitor Information ..................................................................................... 58
Travel Award Recipients ................................................................................. 66
Abstracts in Order of Presentation ................................................................... 67
CME Self-Reporter ...................................................................................... 133
FOCIS
555 East Wells Street Future Meetings
Suite 1100
Milwaukee, WI 53202 FOCIS 2006
Phone (414) 918-3192
Fax (414) 276-3349 June 1-5, 2006
focis@focisnet.org San Francisco
www.focisnet.org
Marriott
FOCIS 2007
June 7-11, 2007
Sheraton San Diego
Hotel & Marina
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2005
ANNUAL MEETING
Supporting Organizations
FOCIS gratefully acknowledges the continued support of its funders. This support allows FOCIS
to continue to fulfill its mission to foster interdisciplinary approaches to both understand and treat
immune-based diseases, and ultimately, to improve human health through immunology.
Thank you to the 2005 Industr

Industryy Liaison Council...
Thank you to the FOCIS 2005 Major Supporters...
National Institutes of Health
Thank you to the FOCIS 2005 Contributing Supporters...
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2005
ANNUAL MEETING
Mission Statement
Federation of Clinical Immunology Societies, Inc. (FOCIS) has been created to engender cross-
fertilization among the many specialty societies that are included in the broad field of clinical
immunology. A major role of the Federation is to organize an annual meeting involving clinician
scientists from many different constituent societies, which share an interest in clinical immunology.
An additional principal purpose of the Federation is to educate the community, physicians, train-
ees, and patients in the broad discipline of clinical immunology as well as to promote an
understanding of the field of clinical immunology.
FOCIS Annual Meeting

The FOCIS Annual Meeting provides a scientific forum to foster the cross-disciplinary approach
required to understand and treat immune-based diseases. The evolution of clinical immunology is
a reflection of the shared pathophysiology of many diseases including: autoimmune diseases,
cancer, allergy/asthma, infectious diseases, immune deficiency, and transplant rejection. While
clinicians necessarily remain linked to diseases associated with their own specialty, the immuno-
logical sciences underlying recent advances in diagnosing and treating these diverse
diseases are multi-disciplinary and cut across traditional clinical boundaries.
The ultimate goal of the FOCIS Annual Meeting is to create a better understanding of the shared
pathophysiological underpinnings of clinical immunology and the new therapeutic approaches
suggested by these novel relationships, including the increasingly widespread use of biologics in
therapy. In addition to highlighting the best science in the field, the FOCIS Annual Meeting is an
incubator for developing scientists and practitioners alike to meet with one another and represen-
tatives of the relevant biotech and pharmaceutical industries whose combined support is invalu-
able to the success of the field of clinical immunology.
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2005
ANNUAL MEETING
2005-2008 Strategic Plan

Core Purpose:
To improve human health through immunology.
Mission:
To foster interdisciplinary approaches to both understand and treat immune-based diseases.
Core Values:
Values:
Interdisciplinar y:
Interdisciplinary:
Believing in the importance of interdisciplinary approaches in education, research, and patient
care; translating new knowledge from basic science into multiple clinical disciplines.
Leadership:
Embracing active and committed leadership to ensure a successful future.
Collaboration:
Strengthening relationships by proactively reaching out to related groups.
Training and Education:
Supporting basic and clinical scientists to perform the best research, to create new tools and
provide new insights.
Goals
I. Education of Clinical TTrainees
rainees and Investigators
Create educational programs that maintain, develop and increase the knowledge, under-
standing, skills and professional performance of trainees and investigators in the broad field
of clinical immunology.
II. Education of Basic Scientists
Enable basic scientists to understand the pathogenesis of immunological disease and the
principles of clinical research.
III. FOCIS Centers of Excellence (FCE)
Establish a variety of diverse of FCE that are fully functional as interdisciplinary “umbrella”
programs that bring a unique approach to research and patient care.
IV
IV.. Annual Meeting
Establish the FOCIS Annual Meeting as the premier venue for clinical immunology in the
world.
V. Endowment
Establish an ample endowment to support the FOCIS infrastructure, Annual Meeting, educa-
tional, and research initiatives.
VI. Committee Structure
Develop and appoint membership to committees designed to support FOCIS mission.
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2005
ANNUAL MEETING
Member Societies
American Academy of Allergy, Asthma, and Immunology (AAAAI)
American College of Rheumatology (ACR)
American Society for Blood and Marrow Transplantation (ASBMT)
American Society for Histocompatibility and Immunogenetics (ASHI)
American Society of Transplantation (AST)
American Uveitis Society (AUS)
America’s Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS)
Association of Medical Laboratory Immunologists (AMLI)
Clinical Immunology Society (CIS)
Crohn’s and Colitis Foundation of America (CCFA)
Immunology of Diabetes Society (IDS)
International Complement Society (ICS)
International Cytokine Society (ICS)
International Society for Interferon and Cytokine Research (ISICR)
International Society for Neuroimmunology (ISNI)
International Society for the Biological Therapy of Cancer (ISBTC)
Society for Investigative Dermatology (SID)
Society for Mucosal Immunology (SMI)
Affiliate Societies
Australasian Society of Clinical Immunology and Allergy (ASCIA)
Clinical Immunology Chapter of the Sociedad Mexicana de Inmunologia
Commonwealth of Independent States Society of Allergology and Clinical Immunology
Israel Association of Allergy and Clinical Immunology
The Italian Society of Allergology and Clinical Immunology
Pan American Group for Immunodeficiency
Section of Clinical Immunology and Allergy of the Royal Society of Medicine
The International Society for NeuroImmunoModulation
World Allergy Organization (WAO)
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2005
ANNUAL MEETING
FOCIS Centers of Excellence

Albert Einstein College of Medicine Medical School University of Southern California
Director: Chaim Putterman Director: Alice B. Gottlieb Director: Chaim Oscar Jacob
Baylor College of Medicine University of Alabama - Stanford University
Director: David P. Huston Birmingham Medical Center
Director: Robert P. Kimberly Director: C. Garrison Fathman
Brigham & W omen’
omen’ss Hospital
Women’
Director: Paul Anderson University of California - Yale University
Los Angeles Director: Jordan S. Pober
Children’
Children’ss Hospital Boston
Director: Raif S. Geha Director: Bevra Hahn Washington University
Cincinnati Children’ University of California - Director: Wayne M. Yokoyama
Children’ss Hospital
Director: Alexandra H. Filipovich San Diego
Director: Arthur Kavanaugh International FCE
Cleveland Clinic Foundation
University of Chicago Ghent University Hospital
Director: Brian Mandell
Director: Stephen Hanauer Director: Eric Veys
Columbia University
University of Colorado Health Giannina Gaslini Institute
Director: Betty Diamond
Sciences Center Director: Lorenzo Moretta
Dartmouth Medical School
Director: George S. Eisenbarth Institute of Immunology of Central
Director: Lloyd H. Kasper
University of Florida University Medical School, V enezuela
Venezuela
Duke University Medical School Director: Nicolas E. Bianco
Director: John F. Valentine
Director: E. William St. Clair
University of Iowa Institute of Immunology
Emor
Emoryy Clinic Czech Republic (pending)
Director: Elizabeth H. Field
Director: Jorg Josef Goronzy Director: Jirina Bartunkova
University of Miami
FOCIS Center of Seattle Oxford Radcliffe Hospitals
Director: Jay Skyler
Director: Keith B. Elkon Director: Helen M. Chapel, MD
University of North Carolina
Hospital for Special Surger
Surgeryy Rostov-on-Don State
Director: Dhavalkumar D. Patel
Director: Mary K. Crow Medical University
University of Pennsylvania
Mayo Clinic Director: Lyudmila P. Siziakina, MD
Medical School
Director: Hirohito Kita Shiraz University of
Director: Arnold I. Levinson
McGill University Medical Sciences
University of Pittsburgh
Director: Emil Skamene Director: Sara Kashef
Director: Scott Plevy
Robarts Research Institute University Hospital of Freiburg
University of Rochester Medical Center
&W ester
Wester
estern n University Director: Hans-Hartmut Peter
Director: Christopher H. Ritchlin
Director: Joaquin Madrenas Universite Libre de Bruxells
University of California -
Rober
Robertt Wood Johnson
Wood Hopital Erasme
San Francisco
Director: Michael Goldman
Director: Jeffrey A. Bluestone
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2005
ANNUAL MEETING
Steering Committee
Grant J. Anhalt T. Mohanakumar
Johns Hopkins University School of Medicine Washington University-School of Medicine
Society for Investigative Dermatology (SID) International Cytokine Society (ICS)
Jack PP.. Antel William J. Murphy
Montreal Neurology Hospital & Institute University of North Virginia Medical School
International Society for Neuroimmunology (ISNI) American Society for Blood and Marrow Trans-
& America’s Committee for Treatment and plantation (ASBMT)
Research in Multiple Sclerosis (ACTRIMS)
Maurice R.G. O’Gorman
Richard S. Blumberg The Children’s Memorial Hospital
Brigham & Women’s Hospital Association of Medical Laboratory Immunologists
Crohn’s and Colitis Foundation (AMLI)
of America (CCFA)
Charles G. Orosz
Jeffrey A. Bluestone Ohio State University
University of California-San Francisco American Society for Histocompatibility and
TrialNet Immunogenetics (ASHI)
Mar
Maryy K. Crow Lanny J. Rosenwasser
Hospital for Special Surgery National Jewish Medical Research Center
American College of Rheumatology (ACR) American Academy of Allergy, Asthma and
Immunology (AAAAI)
Charlotte Cunningham-Rundles
The Mount Sinai Medical Center Daniel Rotrosen
Clinical Immunology Society (CIS) National Institute of Allergy and Infectious
Diseases
Mohamed R. Daha
Federal Liaison
Leiden University Medical Center
International Complement Society (ICS) Kendall A. Smith
Cornell University Medical College
Lynn K. Gordon
International Society for Interferon and Cytokine
Jules Stein Eye Institute-UCLA
Research (ISICR)
American Uveitis Society (AUS)
Warren Strober
Vijay Kuchroo
Society for Mucosal Immunology
Harvard Medical School
International Society for Neuroimmunology (ISNI) Matthias G. V on Herrath
Von
La Jolla Institute Allergy & Immunology
Peter E. Lipsky
Immunology of Diabetes Society (IDS)
Federal Liaison
Adriana Zeevi
Michael TT.. Lotze
University of Pittsburgh Medical Center
University of Pittsburgh
American Society of Transplantation (AST)
International Society for the Biological Therapy
of Cancer (ISBTC)
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2005
ANNUAL MEETING
FOCIS Executive Committee

Chair Secretar y/T
Secretary/T reasurer
y/Treasurer
C. Garrison Fathman Jonathan Braun
Stanford University UCLA Medical Center
Vice-Chair
David A. Hafler
FOCIS Committee Chairs

FOCIS Centers of Excellence Development Committee
Chair Lanny J. Rosenwasser
Rosenwasser,, Chair
David PP.. Huston National Jewish Medical Research Center
Baylor College of Medicine Emil Skamene, Vice-Chair
Education Committee McGill University Health Centre
Paul J. Utz, Chair Accreditation Committee
Stanford University School of Medicine George S. Eisenbarth, Chair
Abul K. Abbas, Vice-Chair University of Colorado Health Science Center
University of California-San Francisco Communication Advisors
International Committee Lynn K. Gordon
Stefan Meuer
Meuer,, Chair Jules Stein Eye Institute-UCLA
University of Heidelberg Andrew Saxon
Research Committee UCLA School of Medicine
Dhaval Patel, Chair
University of North Carolina
Bill St. Clair
Clair,, Vice-Chair
Vice-Chair
Duke University Medical Center
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2005
ANNUAL MEETING
2005 Program Committee

Chairs Members
Richard S. Blumberg Abul K. Abbas
Brigham & Women’s Hospital University of California-San Francisco
Vijay Kuchroo Jeffrey A. Bluestone
Harvard Medical School University of California-San Francisco
Megan Sykes Mar
Maryy K. Crow
Massachusetts General Hospital Hospital for Special Surgery
Thomas A. Fleisher
National Institutes of Health
Lynn K. Gordon
Jules Stein Eye Institute-UCLA
Norma Sue Kenyon, PhD
University of Miami
Gerald TT.. Nepom
Virginia Mason Research Center
Benaroya Research Institute
John D. Rioux
Whitehead Institute
Lanny J. Rosenwasser
National Jewish Medical Research Center
Warren Strober
National Institutes of Allergy and Infectious Dis-
eases/National Institutes of Health
Paul J. Utz
Stanford University
Matthias G. V on Herrath
Von
La Jolla Institute Allergy & Immunology
Adriana Zeevi
University of Pittsburgh Medical Center
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2005
ANNUAL MEETING
2005 Program Committee

Abstract Review Committee
Abul K. Abbas Cathr yn Nagler
Cathryn -Anderson
Nagler-Anderson
University of California-San Francisco Massachusetts General Hospital
Deborah Anderson Maurice R.G. O’Gorman
Brigham and Women’s Hospital The Children’s Memorial Hospital
Jack PP.. Antel Trevor Owens
Montreal Neurology Hospital & Institute McGill University
Ken Beaman Jerome Ritz
Rosalind Franklin University Medical Center Harvard Medical School
Jeffrey A. Bluestone Kendall A. Smith
University of California-San Francisco Cornell University Medical College
Richard S. Blumberg Terr
erryy Strom
Brigham & Women’s Hospital Beth Israel Deaconess Medical Center
Jonathan Braun Megan Sykes
UCLA Medical Center Massachusetts General Hospital
Rachel Caspi Dale Umetsu
National Institutes of Health Stanford University School of Medicine
Mar
Maryy K. Crow Paul J. Utz
Hospital for Special Surgery Stanford University School of Medicine
Charlotte Cunningham-Rundles Matthias G. V on Herrath
Von
The Mount Sinai Medical Center La Jolla Institute Allergy & Immunology
Mohamed R. Daha
FOCIS Executive Office Staff
Raif S. Geha Gail L. Bast
Children’s Hospital Boston Executive Director
Lynn K. Gordon Megan M. Kelley
Jules Stein Eye Institute-UCLA Meetings Manager
David PP.. Huston Sarah J. Krause
Baylor College of Medicine Program Manager
Vijay Kuchroo Jennifer D. Warpool
Warpool
Harvard Medical School Program Coordinator
Thomas S. Kupper
Brigham and Women’s Hospital 555 East Wells Street, Suite 1100
Milwaukee, WI 53202
Michael TT.. Lotze
Phone (414) 918-3192
University of Pittsburgh Fax (414) 276-3349
T. Mohanakumar focis@focisnet.org
Washington University-School of Medicine www.focisnet.org
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2005
ANNUAL MEETING
2005 Faculty
Abul Abbas, MD Jane Buckner

Buckner,, MD
Department of Pathology, University of California—San Francisco Assistant Member, Benaroya Research Institute; Clinical Assistant
Salvatore Albani, MD PhD Professor, University of Washington, Department of Medicine
Professor of Medicine and Pediatrics, University of California Michael Carroll, PhD
San Diego Professor of Pediatrics (Pathology), Harvard Medical School
Disclosure: Scientific Founder, Androclus Therapeutics Rober
Robertt Car ter,, MD
ter
Carter
Jack Antel, MD Professor of Medicine, Division of Clinical Immunology & Rheu-
McGill University, Montreal matology, Department of Medicine, University of Alabama Bir-
K. Frank Austen, MD mingham
AstraZeneca Professor of Respiratory and Inflammatory Diseases,
Disclosure: Paid consultant for Genentech.
Harvard Medical School; Director, Inflammation & Allergic Dis- Andrew C. Chan, MD PhD
eases Research Section, Brigham and Women’s Hospital Vice President, Research Immunology, Genentech, South San
Jean Francois Bach, MD DSc Francisco, CA
Professory of Immunology, Rne Descartes Paris V University; Head, Disclosure: Employee of Genentech
Laboratory Immunology Lieping Chen, MD PhD
Tim Behrens, MD Johns Hopkins University School of Medicine
Professor of Medicine, University of Minnesota Medical School Chris Contag, PhD
Nina Bhardwaj, MD PhD Assistant Professor, Departments of Pediatrics, Radiology and
Professor of Medicine, Director, Tumor Vaccine Program, NYU Microbiology and Immunology
Cancer Institute Cathleen Cooper
Cooper,, MD
Christine A. Biron, PhD Scientific Review Administrator, Transplantation, Tolerance, and
Esther Elizabeth Britzenhoff Professor of Medical Science; Chair- Tumor Immunology Study Section and Referral; Officer, Division
person, Department of Molecular Microbiology & Immunology; of Receipt and Referral, Center for Scientific Review
Brown University Michael Croft, PhD
Jeffrey Bluestone, PhD La Jolla Institute for Allergy and Immunology, Division of Mo-
A.W. and Mary Clausen Distinguished Professor of Medicine, lecular Immunology
Pathology, Microbiology & Immunology; Director, Diabetes Center Mar y K. Crow
Mary Crow,, MD
Disclosure: Potential financial gain from topics discussed, IP and Hospital for Special Surgery
Co-Founder of XCYTE Therapies. Chella S. David, PhD
Richard S. Blumberg, MD Mayo Clinic College of Medicine
Associate Professor of Medicine, Brigham and Women’s Hospital Glen Dranoff, MD
Jonathan Braun, MD PhD Associate Professor of Medicine, Dana-Farber Cancer Institute,
Department of Pathology and Lab Medicine, David Geffen Harvard Medical School
School of Medicine at UCLA
Disclosure: Equity in Santarus Corporation (San Diego, CA) and
Prometheus Corporation (San Deigo, CA)
11
2005
ANNUAL MEETING
2005 Faculty
David Fiorentino, MD PhD Juha Kere, MD PhD

Professor, Karolinska Institute, Stockholm, Sweden
Assistant Professor; Director, Cutaneous Autoimmunity Clinic,
Stanford University School of Medicine, Department of Derma-Disclosure: Member of Board of Directors of Geneos Ltd, a com-
tology pany holding patent applications on the use of GPRA, an asthma
Alexander Flugel, MD candidate gene that is the subject of this speaker’s presenta-
Laboratory for Cellular and Molecular Neuroimmunology, Max- tion. Speaker is one of the inventors of these patent applications
Planck Institute for Neurobiology, Martinried/Munich and a minority shareholder of Geneos Ltd.
Stephen J. Galli, MD Samia Khour

Khoury y, MD
Professor of Pathology and of Microbiology and Immunology, Co-Director, Partners MS Center; Associate Professor of Neurol-
Stanford University School of Medicine ogy, Harvard Medical School
Raif Geha, MD Hirohita Kita, MD

J. Gambles Professor of Pediatrics, Harvard Medical School; Professor of Medicine, Mayo Clinic College of Medicine
Chief, Division of Immunology, Children’s Hospital Boston Lars Klareskog, MD PhD
Ronald N. Germain, MD PhD Rheumatology Unit, Department of Medicine, Karolinska Insti-
Deputy Chief, Laboratory of Immunology; Chief, Lymphocyte tute, Stockholm
Disclosure: Served as an expert consultant to several pharmaceu-
Biology Section, Laboratory of Immunology, National Institute of
tical companies, with no financial interest in these companies
Allergy and Infectious Diseases, National Institutes of Health
Dwight Kono, MD
Joan Goverman, PhD
Associate Professor, The Scripps Research Institute, Department
Department of Immunology, University of Washington, Seattle
of Immunology
David A. Hafler
Hafler,, MD
Art Krieg, MD
Jack, Sadie and David Breakstone Professor of Neurology, De-
Chief Scientific Officer, Coley Pharmaceutical Group
partment of Neurology, Brigham and Women’s Hospital,
Disclosure: Founder and stockholder of Coley Pharmaceutical
Harvard Medical School Group
Mar
Martintin Hemler
Hemler,, PhD
Matthew Krummel, PhD
Professor, Department of Pathology, Harvard Medical School,
Assistant Professor, Department of Pathology, UCSF
and Department of Cancer, Immunology, and AIDS, Dana
Farber Cancer Institute Vijay K. Kuchroo, PhD DVM
Professor of Neurology, Brigham and Women’s Hospital, Harvard
Steve Jacobson, PhD
Medical School
Chief, Viral Section, National Institutes of Health
Eric Lander
Lander,, PhD
Dan Kastner
Kastner,, MD PhD
Director, Broad Institute of MIT and Harvard Medical School
Chief, Genetics and Genomics Branch, National Institute of Ar-
thritis and Muscoloskeletal and Skin Diseases Antonio Lanzavecchia, MD
Institute for Research in Biomedicine
12
2005
ANNUAL MEETING
2005 Faculty
David Lee, MD PhD Lorenzo Moretta, MD

Division of Rheumatology, Immunology, and Allergy, Brigham Full Professor of General Pathology and Pathophysiology, Uni-
and Women’s Hospital, Harvard Medical School versity of Genova; Scientific Director, Giannina Gaslini Institute,
Andrew Lichtman, MD PhD Genova, Italy
Associate Professor of Pathology, Brigham and Women’s Hospi- Gar
Garyy Nabel, MD PhD
tal and Harvard Medical School Director of Vaccine Research Center, National Institutes of Health
Peter Lipsky
Lipsky,, MD Robert Negrin, MD
Chief, Autoimmunity Branch, National Institute of Arthritis and Professor of Medicine, Stanford University School of Medicine
Musculoskeletal and Skin Diseases, National Institutes of Health Lindsay B. Nicholson, MD PhD
Youn-Jun Liu, MD PhD Clinical Sciences, Pathology and Microbiology, University of Bristol
Professor and Chairman, Department of Immunology; Director, Hans Ochs, MD
Center for Cancer Immunology Research, M.D. Anderson Can- Professor of Pediatrics; University of Washington, School of
cer Center Medicine; Department of Pediatrics
Roy Lobb, PhD John O’Shea, MD
Advisor, Abingworth Ventures Molecular Immunology and Inflammation Branch, National In-
Disclosure: Consultant to Biogen IDEC on VLA-4 stitutes of Health
Michael TT.. Lotze, MD Disclosure: CRADA with Pfizer
University Pittsburgh Molecular Medicine Institute Drew Pardoll, MD PhD
Andrew Luster
Luster,, MD PhD Seraph Professor; Co-Director, Cancer Immunology & Hemato-
Chief, Division of Rheumatology, Allergy and Immunology, Mas- poiesis Program
sachusetts General Hospital Virginia Pascual, MD
Ann Marshak-Rothstein, PhD Associate Investigator, Baylor Institute for Immunology Research
Professor of Microbiology, Boston University School of Medicine Dhaval Patel, MD PhD
Diane Mathis, PhD Director, Thurston Arthritis Center; Chief, Rheumatology, Allergy
Head, Section on Immunology and Immunogenetics; Joslin Dia- and Immunology; Professor of Medicine
betes Center/ Professor of Medicine; Harvard Medical School University of North Carolina at Chapel Hill
Stephan Meuer Karl Peggs
Chairman, Department of Immunology, University of Heidelberg Senior Lecturer, Royal Free and University College, London Medi-
Stephen D. Miller
Miller,, PhD cal School; Visiting Investigator, MSKCC, NY
Cong. John E. Porter Professor of Biomedical Sciences, Depart- J. Theodore Phillips, MD PhD
ment of Microbiology-Immunology, Northwestern University Medi- Clinical Associate Professor, Department of Neurology, Univer-
cal School, Chicago sity of Texas Southwestern Medical Center, Dallas, Texas
Branch Moody
Moody,, MD Shiv Pillai, MBBS PhD
Department of Medicine, Brigham and Women’s Hospital, Associate Professor of Medicine, Massachusetts General Hospi-
Harvard Medical School tal and Harvard Medical School
13
2005
ANNUAL MEETING
2005 Faculty
Jeffrey V
V.. Ravetch, MD PhD Federica Sallusto
Theresa and Eugene Lane Professor; Head, Laboratory of Mo- Institute for Research in Biomedicine
lecular Genetics and Immunology, The Rockefeller University Jane Salmon, MD
Paul Ridker
Ridker,, MD Professor of Medicine, Weill Medical College, Cornell Univer-
Brigham and Women’s Hospital sity, Attending Physician and Senior Scientist, Hospital for Spe-
John D. Rioux, PhD cial Surgery
Director, Inflammatory Disease Research, Broad Institute of MIT Mohamed Sayegh, MD
and Harvard; Assistant Professor of Medicine, Harvard Medi- Brigham and Women’s Hospital
cal School, Brigham and Womens Hospital; Associate Professor Kathy Siminovitch, MD FRCP
Medicine, University of Montreal, Montreal Heart Instutite Professor, Department of Medicine, University of Toronto, Mount
Jerome Ritz, MD Sinai Hospital/University Health Network
Professor of Medicine, Dana-Farber Cancer Institute, Harvard Arlene H. Sharpe, MD PhD
Medical School Harvard Medical School
William Robinson, MD PhD Grace Shen
Division of Immunology and Rheumatology, Stanford University Director, Ocular Immunology Program, Division of Extramural
School of Medicine, GRECC, Palo Alto VA Health Care System Research, National Eye Institute
Kenneth Rock, MD Kendall A. Smith, MD
Professor and Chair, Department of Pathology, UMass Medical Cornell University Medical College
School
Jean-Paul Soulillou, PhD
Derr
Derryy Roopenian, PhD Nantes University
Senior Staff Scientist, The Jackson Laboratory Disclosure: Member of Scientific Board of TcLAND
Alexander Rudensky
Rudensky,, PhD Larr
Larryy Steinman, MD
Professor and Investigator, HHMI/University of Washington Stanford University School of Medicine
David Sachs, MD Ralph Steinman, MD
Director, Transplantation Biology Research Center, Massachu- Rockefeller University
setts General Hospital; Professor of Surgery (Immunology),
Megan Sykes, MD
Massachusetts General Hospital, Harvard Medical School
Steve Sacks, MD PhD
Cox TTerhorst,
erhorst, PhD
Head of the Department of Nephrology & Transplantation, Guy’s
Chief, Division of Immunology, Beth Israel Deaconess Medical
Kings’ & St. Thomas School of Medicine, Kings College London
Center; Professor of Medicine, Harvard Medical School
Shimon Sakaguchi, MD PhD
Professor, Institute for Frontier Medical Sciences, Kyoto University
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2005
ANNUAL MEETING
2005 Faculty
Angus Thomson, PhD DSc FRCPath Sander J. van Deventer

Deventer,, MD
Professor of Surgery and Immunology, University of Pittsburgh, Laboratory of Experimental Internal Medicine
Director of Transplant Immunology, Starzl Transplant Institute Edward W akeland, PhD
Wakeland,
Disclosure: Member, Scientific Advisory Board, Therakos Director, Center for Immunology, University of Texas Medical
John TTodd,
odd, PhD Center
Professor of Medical Genetics, Cambridge Institute for Medical Hanspeter W aldner
aldner,, PhD
Waldner
Research; Director, JDRF/WT Diabetes and Inflammation Labo- Brigham and Women’s Hospital and Harvard Medical School
ratory
Howard W einer
einer,, MD
Weiner
urley
urley,, PhD
Shannon J. TTurley Robert L. Kroc Professor of Neurology, Harvard Medical School
Assistant Professor, Department of Cancer, Immunology and
David S. Wilkes, MD
AIDS, Dana Farber Cancer Institute; Assistant Professor, Depart-
Calvin H. English Professor of Medicine, Microbiology and Im-
ment of Pathology, Harvard Medical School
munology; Director, Center for Immunobiology
Dale TT.. Umetsu, MD PhD
David W ofsy
ofsy,, MD
Wofsy
The Prince Turki al Saud Professor of Pediatrics, Childrens Hos-
Professor of Medicine and Microbiology/Immunology, Univer-
pital Boston, Harvard Medical School
sity of California, San Francisco
Paul J. Utz, MD Disclosure: Consultant for Genentech, Aspreva, Bristol-Myers
Stanford University Squibb, Serono
Inder V er
Ver ma, MSc PhD
erma, John B. W ong, MD FFACD
Wong, ACD
Salk Institute for Biological Sciences Professor of Medicine; Chief, Division of Clinical Decision Mak-
Matthias von Herrath, MD ing, Tufts-New England Medical Center, Tufts University School
Associate Professor with Tenure, Division of Developmental Im- of Medicine
munology, La Jolla Institute for Allergy and Immunology, San Disclosure: Grants NIH National Library of Medicine; Schering-
Deigo, CA Ploegh, Honoraria for speaking, Schering-Ploegh, Centocor
Kathr yn W
Kathryn ood, PhD
Wood,
Professor of Immunology, University of Oxford
Anette Ziegler
Ziegler,, MD
Professor of Internal Medicine, Ludwig-Maximilians University,
Munich; Senior Physician, Internal Medicine, Schwabing Hos-
pital; Director, Immunology and Diabetes Department, Diabe-
tes Research Institute
15
2005
ANNUAL MEETING
General Information
• Dates: The meeting begins Thursday, May 12 and adjourns Monday, May 16, 2005.
• Venue: Westin Copley Place
10 Huntington Avenue
Boston, Massachusetts 02116
www.westin.com
Registration Information
Name badges will be mailed to pre-registrants prior to the meeting. Final programs and
registration bags will be distributed at the registration desk, located at the Westin Copley Place.
Registration will be open during the following hours:
3 rd Floor- Essex Foyer:
Thursday, May 12 8:00 am-8:00 pm
4 Floor- America Foyer:
th
Friday, May 13 7:00 am-5:00 pm

Saturday, May 14 7:00 am-5:00 pm
Sunday, May 15 7:00 am-5:00 pm
CME Information
Target Audience:
The target audience for this meeting is a multi-disciplinary group of individuals with an interest in
clinical immunology:
• Researchers
• Clinical investigators
• Clinicians
• Postdoctoral fellows
• Pre-doctoral students
• Graduate students
Learning Objectives:
At the completion of the meeting, participants should be able to:
• Discuss the current research and/or clinical topics relevant to the session topics.
• Demonstrate a gained level of insight into the methods being used by researchers and practitioners.
• Describe a personal exposure to several stimulating areas of inquiry with faculty and presenters.
Accreditation Statement:
The Clinical Immunology Society is accredited by the Accreditation Council for Continuing Medical
Education (ACCME) to provide continuing medical education for physicians.
Credit Designation:
The Clinical Immunology Society (CIS) designates this educational activity on an hour-for-hour
basis in Category 1 credit toward the Physicians Recognition Award of the American Medical
Association. Each physician should only claim those hours of credit he/she actually spends in the
educational activity.
16
2005
ANNUAL MEETING
Program At-a-Glance
Thursday Friday Saturday Sunday Monday
7:00 a.m. Industry Tutorials Industry Tutorials

7:30 a.m Poster Session 1
8:00 a.m. (7:30-8:30 am)
8:30 a.m. Planary Session Planary Session Planary Session

Plenary Session
9:00 a.m.
(8:30-10:00 am)
9:30 a.m.
10:00 a.m. Break Break Break Break
10:30 a.m Concurrent Thematic Symposia
11:00 a.m. Concurrent Thematic Symposia
11:30 a.m. (10:30 am - 12:30 pm)
Member
12:00 p.m.
Society
12:30 p.m. Satellite Lunch, Industry Tutorials Lunch, Industry Tutorials Lunch
NIH Grants
1:00 p.m. Programs Information Session
(12:30 - 2:00 pm)
1:30 p.m.
Industry Symposia
2:00 p.m.
(1:30 - 3:00 pm)
2:30 p.m.
3:00 p.m. Break Break Break
3:30 p.m. Concurrent Oral Abstract Sessions
4:00 p.m.
Concurrent Oral Abstract Sessions
4:30 p.m.
(3:30 - 5:30 pm)
5:00 p.m.
5:30 p.m. Poster Session 2 Poster Session 2
6:00 p.m. Poster Session 2
(5:30-7:30 pm)
6:30 p.m.
7:00 p.m.
Welcome Reception
7:30 p.m.
(7:00 - 9:00 pm)
8:00 p.m.
8:30 p.m.
9:00 p.m
18
2005
ANNUAL MEETING
Satellite Symposia
Thursday
Thursday,, May 12, 2005
American Academy of Allergy
Allergy,, Asthma and Immunology
Eosinophil Biology in Health and Disease
1:15-4:30 pm Essex North-East, 3rd Floor
Moderator: Lanny J. Rosenwasser, MD FAAAAI
Co-Moderator: Peter F. Weller, MD FAAAAI
1:15-1:20pm Introduction
Lanny J. Rosenwasser, MD FAAAAI and Peter F. Weller, MD FAAAAI
1:20-2:00 pm Hypereosinophilic Syndromes
Peter F. Weller, MD FAAAAI
2:00-2:40 pm Eosinophils in Asthma
Criag Gerard, MD PhD
2:40-3:10 pm Break
3:10-3:50 pm Eosinophil Biology in Animal Models
James J. Lee, PhD
3:50-4:30 pm GI in Eosinophilia: Basic and Clinical Mechanisms
Marc Rothenberg, MD PhD FAAAAI
American College of Rheumatology
Rheumatoid Arthritis Scientific Forum:
A Forum to Identify Opportunities for Advances in Rheumatoid Arthritis Research
8:00 am-5:00 pm Essex Nor th-Center
th-Center,, 3rd Floor
North-Center
8:00-8:30 am Welcome
Introduction and Overview of RA Scientific Forum Goals
Opportunities and Challenges in RA Research
Speakers:
Michael Brenner, MD
Harvard Medical School, Boston, MA
David Fox, MD
University of Michigan, Ann Arbor, MI
Session I
Epidemiology and Genetics: Defining Environmental and Inherited Risk Factors for RA
8:30-8:50 am Epidemiology of RA: What Questions Can We Answer
in the Next Decade?
Alan J. Silman, MD
University of Manchester, Manchester England
8:50-9:10 am Strategies to Define Links Between Environmental
Triggers and Autoimmunity in RA
Lars Klareskog, MD
Karolinska Hospital, Stockholm Sweden
19
2005
ANNUAL MEETING
Satellite Symposia
American College of Rheumatology (Session 1 continued...)
9:10-9:30 am Genetics of RA: MHC and Non-MHC Loci
Peter Gregerson, MD
Biology I Human Genetics, North Shore Univ. Hospital
9:30-9:50 am Genetic Determinants of Lymphocyte Function in RA
Shimon Sakaguchi, MD
Kyoto University, Institute for Frontier Medical Sciences
9:50-10:20 am Panel Discussion, Question and Answer
Peter Gregerson, MD
Lars Klareskog, MD
Shimon Sakaguchi, MD
Alan Silman, MD
10:20-10:40 am Break
Session II
Synovium, Cartilage and Bone in RA: Identifying Molecular Control Points of Disease
Progression and Novel Therapeutic TTargets
argets
10:40-11:00 am Synovial Fibroblasts: Instigators or Targets?
Gary Firestein, MD
University of California – San Diego
11:00-11:20 am Development of the Synovial Lining and its Role in Inflammatory Arthritis
Michael Brenner, MD
11:20-11:40 am Synovial Angiogenesis – How Can it Be Reversed?
Alisa Koch, MD
University of Michgan, Ann Arbor, MI
11:40 am-12:00 pm Events at the Interface of Pannus with Cartilage and Bone
Steffen Gay, MD
Center of Experimental Rheumatology, Zurich, Switzerland
12:00-12:20 pm The Response of Cartilage and Bone to Synovitis: How Can Repair of
Damaged Joints be Promoted?
Steven Goldring, MD
Beth Israel Deconess Medical Center, Boston, MA
12:20-1:00 pm Panel Discussions, Question and Answer
William Arend, MD, University of Colorado, Denver, CO
Gary Firestein, MD
Steffen Gay, MD
Steven Goldring, MD
Alisa Koch, MD
1:00-2:00 pm Lunch on your own
20
2005
ANNUAL MEETING
Satellite Symposia
American College of Rheumatology (continued...)
Session III
Redefining the Contributions of Innate and Adaptive Immune Mechanisms to RA
2:00-2:20 pm Understanding Lymphocyte Function in RA
Cornelia Weyand, MD
Emory University, Atlanta, GA
2:20-2:40 pm Autoantibodies and the Joint – Unique Immune and
Inflammatory Mechanisms
Diane Mathis, MD
Harvard Medical School, Boston, MA
2:40-3:00 pm Cytokine Networks in RA Synovium
Iain McInnes, MD, University of Glasgow, Glasgow, United Kingdom
3:00-3:20 pm Reversing the Roles of Innate and Adaptive Immune Components in RA
David Fox, MD
3:20-3:40 pm Panel Discussion, Question and Answer
Cornelia Weyand, MD
Diane Mathis, MD
Peter Lipsky, MD, National Institute of Arthritis Musculoskeletal and Skin
Diseases
Michael Holers, MD, University of Colorado, Denver, CO
3:40-4:00 pm Break
Session IV
Achieving and Measuring Remission and Cure of RA
4:00-4:20 pm Developing Better Approaches to Measuring the Clinical Activity of RA
and the Utility of Novel Therapeutics
David Felson, MD
Boston University School of Medicine, Boston, MA
4:20-4:40 pm Measuring and Mitigating the Total Impact of RA: Medical,
Economic and Social Aspects
Edward Yelin, MD
University of Texas, Houston, TX
4:40-5:00 pm Defining Better Targets and Better Strategies for Treating RA
William Arend, MD
5:00-5:25 pm Panel Discussion, Question and Answer
David Felson, MD
Edward Yelin, MD
William Arend, MD
James O’Dell, MD, University of Nebraska, Omaha, NE
William St. Clair, MD, Duke University Medical Center, Durham, NC
5:25-5:30 pm Concluding Remarks and Adjournment
Michael Brenner, MD
David Fox, MD 21
2005
ANNUAL MEETING
Satellite Symposia
American Uveitis Society
Bench to Bedside: TTranslational
ranslational approaches to ocular Inflammation Webster/Courier
ebster/Courier,,
An American Uveitis Society Sponsored Meeting 7th Floor
Organizers: Reza Dana, LLynn
ynn Gordon, Rober
Robertt Nussenblatt for the AUS
Despite significant research efforts and advances in diagnostic and therapeutic capabilities, ocu-
lar inflammatory diseases remain a significant cause of ocular morbidity and legal blindness. The
purpose of this symposium is to explore some of the major concepts in pathogenesis of ocular
inflammatory disease and discuss new approaches to understanding immune regulation as it
relates to the eye. The format is a combined short presentation followed by open discussion.
Specific aspects of the ocular microenvironment will be considered throughout the symposium. This
symposium is presented in three parts. First, an overview of the current models of ocular inflamma-
tory diseases will be presented followed by an active discussion regarding the strengths and
weaknesses of these models. Second, aspects of innate and adoptive immunity will be consid-
ered as they relate to ocular inflammatory diseases. Finally, concepts relating to immune regula-
tion or modulation, including soluble and cellular mediators will be discussed.
The goal of this meeting is to maximize discussion. The presentations by our speakers will set the
stage for an active discussion which will be stimulated by questions which will be posed to the
audience. The discussions will have three goals: understanding the current state of the art, identi-
fication of important future directions, and development of strategic goals in investigation of ocu-
lar inflammatory disease.
1:00-1:05 pm Welcome
1:05- 2:00 pm Animal Models- Anterior and Posterior
Robert Hendricks and Rachel Caspi
2:00-2:20 pm Break
2:20-3:20 pm Innate and Adaptive Immunity
Ralph Levinson and Howard Weiner
3:20-3:40 pm Break
3:40-4:40 pm Immunoregulation
Andrew Tayler and Arlene Sharpe
4:40-5:00 pm Wrap Up
22
2005
ANNUAL MEETING
Satellite Symposia
Clinical Immunology Society
Emerging Lab TTechnologies
echnologies
9:00 am-12:30 pm Essex Nor th-W
North-W est, 3rd Floor
th-West,
CME A vailable
Available Program Organizers
Registration fee: $15.00 Jonathan Braun, MD PhD
On-Site Registration Available Matthias G. Von Herrath, MD
William Robinson, MD PhD
9:00 am Introduction and Overview
Jonathan Braun, UCLA
9:05 am Multibead Array Analysis of HLAs and KIRs in Transplantation
Elaine Reed, UCLA
Proteomic Analysis of Signal TTransduction
ransduction Pathways:
9:25 am Reverse Phase Protein Array Analysis of Phospho-proteins
Steven Chan, Stanford University
Imaging TTechnologies:
echnologies:
9:45 am PET: Anti-Tumor T Cell Marking
Jonathan Braun, UCLA
Glycomics:
10:05 am Mass Spectrometry Identification of Immunostimmulatory Oligosaccharides
Rudolf Grimm, Agilent Technologies
Human Proteome Arrays:
10:25 am Human Proteome Array Analysis of Autoimmune Disease and Cancer
Paul Predki, Invitrogen
10:45 am Break
Technologies to Characterize the Specificity of Immune Responses:
11:00 am Antigen Microarray Analysis of Antibody Responses in Infection and Autoimmunity
William Robinson, Stanford University
11:20 am Peptide:MHC Microarray for Profiling T Cell Specificity and Function
Daniel Chen, Stanford University
11:40 am Flow Cytometry Analysis of Antigen-Specific T Cell Responses
Amit Bar-Or, Montreal Neurologic Institute
The Road Ahead:
12:00 pm Roundtable Discussion: Translating Diagnostic Technologies Into the Clinic:
Promise and Pitfalls
Vicki Seyfert, Immune Tolerance Network
Thomas Fleisher, NIH
Bruce Sands, Massachusetts General Hospital
23
2005
ANNUAL MEETING
24
2005
ANNUAL MEETING
Satellite Symposia
Clinical Immunology Society
Primar
Primaryy Immunodeficiency Diseases Consor tium Conference
Consortium
8:00 am-5:00 pm (Reception to follow) Staffordshire, 3rd Floor
CME A vailable
Available Program Organizers
Registration Fee $25.00 Charlotte Cunningham-Rundles, MD PhD
On-Site Registration Available Kathleen E. Sullivan, MD PhD
Helen Chapel, MD
Jordan Orange, MD PhD
This intensive one-day conference will provide an opportunity to capitalize on the diagnosis and
treatment of primary immunodeficiency diseases in a setting that encourages interactive participa-
tion amongst presenters and attendees that will facilitate the exchange of information.
The target audience for this conference is a multi-disciplinary group of individuals with an interest
in clinical immunology focusing on Primary Immune Deficiency. Themes of the day will include:
• Antibody Deficiency Diseases: Cases/ Diagnosis/ Molecular Defects in B Cell Differentiation/
Isotype Switch, Somatic Hypermutation, etc.
• Combined Immune Defects: Cases/ Diagnosis/ Molecular Defects/ Signaling Pathways/
Treatment Strategies
• Pathways in Innate Immunity: Natural Killer Cells
• Monocyte Neutrophil Disorders: Analysis/ Treatment
• Cytokine and Signaling Defects: Common Themes, Infections, Toll Receptors and Signaling
• Laboratory Evaluation of Primary Immunodeficiency
• Immune Reconstitution: Gene Therapy Strategies/ Stem Cell/ Bone Marrow/ Measures of Term
Reconstitution
• Use of Standard and Novel Therapies: Cytokines, Immune Modulation, Monoclonal Antibodies
Both research and case-based presentations will be made. The sessions will start with a keynote
presenter, giving details of the latest research work in their respective fields. Following this, a
second block will include the research presentations given by new investigators, fitting into the
themes just introduced. These sessions will be laboratory based but in each case, elucidating
facets of the Primary Immune Deficiencies. Laboratory Investigations will include data handling
and genetics.
25
2005
ANNUAL MEETING
Satellite Symposia
Federation of Clinical Immunology Societies
Basic Immunology for Clinicians: Update 2005
8:00am-5:00 pm Conference Center at Har vard Medical School, Rotunda
Harvard
Sponsored by Abbott Laboratories (www.abbott.com)

This one-day course will review fundamental principles of adaptive immunity and immunological
tolerance, with an emphasis on recent advances. Topics to be discussed include: antigen process-
ing and presentation (including dendritic cell biology); T lymphocyte activation and homeostasis
(including costimulation and apoptosis); innate immunity (including Toll receptors and the biology
of NK cells); cytokines and helper T Cell subsets; and self-tolerance and its breakdown. Ample
time will be scheduled for discussions and interactive exchanges with the faculty. Outlines of
lectures and illustrations will be provided in a course syllabus and on CD-ROM for each student.
Faculty
Abul K. Abbas, MD
University of California - San Francisco
San Francisco, CA
Hidde L. Ploegh, PhD
Boston, MA
Schedule
Lecture 1: Innate Immunity
Lecture 2: Antigen Presentation
Lecture 3: Activation and Regulation of T Lymphocytes
Lecture 4: Effector Mechanisms of Cell-Mediated Immunity
Lecture 5: Lymphocyte Development
Lecture 6: Tolerance and Autoimmunity
Shuttles will run from the Westin Copley Place to the Conference
Center from 7:00 - 8:00 am, returning at 5:00 pm.
26
2005
ANNUAL MEETING
Satellite Symposia
Federation of Clinical Immunology Societies
FOCIS Centers of Excellence TTrainee
rainee Satellite Symposium
8:00 am- 5:00 pm Essex Center & Essex South, 3rd Floor
7:00 -8:00 am Continental Breakfast
8:00-8:15 am Welcome
David P. Huston, MD, Baylor College of Medicine
8:15-9:00 am The Expanding Scope of Clinical Immunology - Cardiovascular Disease
Keynote Speaker: Cornelia Weyand, MD, PhD, Emory University
9:05-10:20 am Trainee Abstract Minisymposium
9:05-9:20 am Antibodies to Citrulline-Modified Proteins Enhance Tissue Injury in
Inflammatory Arthritis
Kristine Kuhn, University of Colorado
9:20-9:35 am B-Cell and Dendritic Cell Perturbations in the Fingerprinting of SLE
Meghavi Kosboth, MD, University of Florida
9:35-9:50 am Presence of Interferon-a in Systemic Lupus Erythematosus Plasma is Highly
Correlated with Expression of Interferon Target Genes in SLE PBMC
Jing Hua, MD PhD, Hospital for Special Surgery
9:50-10:05 am Plasma Cell Differentiation of CD27- and CD27+ Human B Cells
Jennifer Huggins, MD, University of Rochester
10:05-10:20 am Characterization of an Immunodeficient Patient with TLR7, 8, 9 Defects
Douglas McDonald, MD PhD, Children’s Hospital Boston
10:20-10:35 am Break
10:35-11:35 am Plenary Session
10:35-11:05 am FMF and Beyond: Misadventures in the Genomics of Inflammation
Dan Kastner, MD PhD, NIH/NIAMS
11:05-11:35 am New Insights into the Mechanism of Disease and Targets for Treatment
of the Antiphospholipid Syndrome
Jane Salmon, MD, Hospital for Special Surgery
11:35 am-1:15 pm Lunch & Poster Presentations with Authors Present
1:30-2:30 pm Plenary Session
1:30-2:00 pm Genetic Control of Autoimmunity by Aire
Mark Anderson, MD PhD, University of California – San Francisco
2:00-2:30 pm Mast Cells and Inflammatory Arthritis
David Lee, MD PhD, Brigham & Women’s Hospital
2:35-3:50 pm Trainee Abstract Minisymposium
2:35-2:50 pm Targeting of Antigen-Specific T Cells With Macromolecular Conjugates
Tarek Fahmy, PhD, Yale University
27
2005
ANNUAL MEETING
Satellite Symposia
Federation of Clinical Immunology Societies (continued...)
2:50-3:05 pm High-Throughput Analysis of Autoantibodies Recognizing Myelin Anti-
gens in Acute Disseminated Encephalomyelitis.
Kevin O’Connor, PhD, Brigham & Women’s Hospital
3:05-3:20 pm De Novo Generation of Antigen-Specific CD4+CD25+ Regulatory T Cells
from Human CD4+CD25- Cells
Mindi Walker, PhD, Benaroya Research Institute
3:20-3:35 pm Differential Expression of Phosphorylated NF-kB/RelA in Normal and
Psoriatic Epidermis and Downregulation of NF-kB in Response to Treat
ment with Etanercept.
Paul Lizzul, MD, PhD, Robert Wood Johnson
3:35-3:50 pm Binding of the Green Tea Polyphenol, Epigallocatechin Gallate, to the
CD4 Receptor on Human CD4+ T Cells Resulting in Inhibition of HIV-1-
gp120-Binding
Christina Nance, PhD, Baylor College of Medicine
3:50-4:00 pm Break
4:00-4:30 pm Closing Plenary: The Intersection of Science and Architecture
Peter Vanderwarker
4:30-4:40 pm Closing Remarks
David Huston
28
2005
ANNUAL MEETING
Satellite Symposia
International Complement Society
Complement in Health and Disease
8:00 am-12:00 pm Webster/Courier
ebster/Courier,, 7th Floor
Chairs: John Lambris and Moh Daha
Organized by: International Complement Society
Sponsored by Biovista (www.biovista.com)
8:00-8:30 am Novel Elisa-Based Methods for the Diagnostic Assessment of Complement
Mohamed R. Daha
Leiden, The Netherlands
8:30-9:00 am Cleaning the Bloodstream: A Complement-Erythrocyte Dependent Process
Anne Nicholson – Weller
Harvard Medical School and Beth Israel Deaconess Medical Center
Boston, USA
9:00-9:30 am Protective Role of Innate Immunity in Autoimmune Disease
Marat Alimzhanov
CBR Institute for Biomedical Research and Dept. of Pediatrics,
Boston, USA
9:30-10:00 am Gastrointestinal and/or Myocardial Schemia/Reperfusion Models in Mice
Gregory L. Stahl
Brigham and Womens Hospital and Harvard Medical School
Boston, USA
10:00-10:30 am Coffee Break
10:30-11:00 am Signaling of Human T Cells Through CD46
John Atkinson
Washington University School of Medicine
St. Louis, USA
11:00-11:30 am From Atoms to Systems: a Multidisciplinary Approach to
Study Complement Functions
John Lambris
University of Pennsylvania
Philadelphia, USA
11:30 am-12:00 pmExtended Discussion
29
2005
ANNUAL MEETING
Satellite Symposia
International Society for Neuroimmunology - Immunology of Diabetes Society
Early Clinical TTrials
rials in Multiple Sclerosis and TType
ype 1 Diabetes: A Look Down the Pipeline
8:00am-5:00 pm St. George, 3rd Floor
9:00-11:45 am Antigen Specific Inter ventions and TT-/or
Interventions -/or B-Cell TTargeted
argeted Approaches
Chairs: Amit Bar-Or and George Eisenbarth
Speakers:
9:00 – 9:15 am Introduction: Questions that Mice Pose to the Clinician
Matthias von Herrath
9:15 – 9:35 am Antigen Specific DNA Vaccine and Altered Peptide Ligands in MS and T1D
Hideki Garren
9:35 – 9:55 am Anti-CD25 Therapy/Daclizumab and Deletion of Aggressive T Cell with ECDI
Stephen Miller
9:55 – 10:35 am Autoantibodies in MS and Anti-CD20/B Cell Targeted Therapy
Kevin O’Connor
Amit Bar-Or
10:35 – 10:45 am Break
10:45 – 11:00 am The European Anti-CD3 Results
Lucienne Chatenoud
11:00 – 11:15 am Statins in the Treatment of Autoimmunity
Scott Zamvil
11:15 – 11:45 Two selected abstract presentations from FOCIS submissions
11:45 am– 1:00 pm Lunch (provided)
1:00 – 4:30 pm Systemic Immune Modulators, Combination Therapies and Failed Thera
pies in TType
ype 1 Diabetes and MS
Chairs: Kevan Herold and Jerr y Palmer
Jerry
Speakers:
1:00 – 1:20 pm Introduction: Clinical Caveats When Using Systemic Immune Modulation
David Harlan
1:20 – 1:40 pm CTLA-4-Ig/Costimulatory Blockade
Samia Khoury
1:40 – 2:00 pm Islet Regeneration Therapy – Novel Avenues
Jacob Petersen
2:00 – 2:20 pm Anti-VLA-4/Adhesion Molecules/Trafficking
Benoit Lapointe
2:20 – 2:40 pm The Trial Net Experience
Jerry Nepom
2:40 – 3:00 pm Break
30
2005
ANNUAL MEETING
Satellite Symposia
International Society for Neuroimmunology - Immunology of Diabetes Society
(continued...)
3:00 – 3:30 pm Combination Therapies in MS and T1D
Peter Calabresi
Kevan Herold
3:30 – 3:50 pm Lessons from Negative Trials – MS
Jack Antel
3:50 – 4:10 pm Lessons from Negative Trials – Type 1 Diabetes
George Eisenbarth
4:10 – 5:00 pm Panel Discussion: Future Avenues and Strategies

George Eisenbarth, Jack Antel, David Harlan, David Hafler, Carla
Greenbaum, Jerry Nepom, Vicki Seyfert, Jerry Palmer, Dick Insel
Idea, Goals and Synopsis:

The idea for this symposium was jointly conceived by the International Neuroimmunology and
Diabetes Societies. This event is organized in a similar fashion as last year’s joint-symposium,
which was focused on more basic aspects of pathogenesis and was successful and well-received.
The focus this year is on agents already introduced into early phase studies in patients, especially
those, where human immune-monitoring and mechanistic data are available. The morning session
is focused on antigen specific therapies and interventions that directly target T- and B-cells. In the
afternoon, the aspects of systemic immune modulation and possible combinatorial therapies will
be discussed. We will close with two talks highlighting past failures, which directly lead into a
panel discussion that will suggest and debate future avenues and optimal strategies. We believe
that this topic is highly relevant for refining future immune based interventions in multiple sclerosis
(MS) and type 1 diabetes (T1D) and several other autoimmune disorders. Identifying parallels as
well as differences between MS and T1D will allow us to better to fully realize the potential of
novel treatments. The symposium, which already features international experts, will also serve as
a forum for the most outstanding abstracts to be chosen from work submitted to ICI/FOCIS 2004.
In summary, bridging the knowledge and experience across two disciplines is timely and a good
strategy to further our understanding into autoimmune disease mechanisms and prospective thera-
peutics. Sharing data during the early phase trials in both diseases will allow us to identify
parallels and differences and help to optimally design future interventions. Furthermore, lessons
learned from one disease might be helpful for the other and vice versa. Clinicians, basic scientists,
pharmaceutical industry and, ultimately, patients, will all profit from this satellite meeting.
31
2005
ANNUAL MEETING
Satellite Symposia
International Society for Neuroimm unology
Neuroimmunology
Immune-Mediated Disease in Non-Human Primates: Critical Models for Preclinical Studies
PRIMOCID (non human PRimate MOdels of Chronic Imm une Disorders)
Immune
2:00-5:00 pm Essex Nor th-W
North-W est, 3rd Floor
th-West,
Organized by the Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands
An EU-Sponsored Research Infrastructure
Chairpersons: Dr. Sandra Amor and Dr. Margreet Jonker
Invited Speakers:
Dr. Sandra Amor Preclinical Models of Multiple Sclerosis in Non-Human Primates
Dr. Marc de Beats Myastenia Gravis Model in Rhesus Monkeys
Prof. Stuart Knechtle Non-Human Primate Models of Transplantation
Dr. Mark de Boer Costimulation Blockade: The Benefits of Non-Human Primate Models
Prof. Avi Ben-Nun A New Model of Optic Neuritis in Rhesus Monkeys
Dr. Thomas Hanke Pre-Clinical Therapy Evaluation for Arthritis
Dr. Margreet Jonker Summing Up
This symposium will highlight the non-human primate models of immune disorders as essential
steps toward the clinical development of new therapies and drugs. The BPRC offers the opportu-
nity to the EU research community to use the institutes animals and scientific expertise for studies
requiring non-human primates, an activity which sponsored by the EU as Research Infrastructure.
Contact Inf ormation:

Information:
Dr
Dr.. Sandra Amor or Dr
Dr.. Margreet Jonker
Biomedical Primate Research Centre
PO Box 3306
2280GH Rijswijk
Netherlands
+31152842699
amor@bprc.nl
jonker@bprc.nl
32
2005
ANNUAL MEETING
Industr
Industryy TTutorials
utorials
Friday
Friday,, May 1
133
Cytometric Bead Array Cytokine and Gene Expression Profiling of Host Immune Responses to
Emerging Infectious D iseases
Diseases
David Kelvin, PhD
12:30-1:30 pm Adams Room, 7th Floor
Lunch served
Presented by BD Biosciences
Severe acute respiratory syndrome (SARS) is a notable example of a recently-emerging infectious
disease. The highly variable pathogenesis of SARS may be the result of unabated proinflammatory
host responses against the SARS coronavirus (CoV). To model host gene expression during SARS
CoV infection, we collected longitudinal samples from mild and critical care SARS patients from
the onset of symptoms through convalescence or, in some cases, death. Using Cytometric Bead
Array (CBA) system (BD Bioscience) and high-density cDNA microarray analysis of peripheral
blood RNA, we uncovered multiple gene pathways whose expression patterns associated with
different disease courses of SARS. For example, persistent increased expression of the chemokine
CXCL10 in the periphery and lungs was linked to uncontrolled immune responses against the
SARS CoV. Moreover, signatures of other interferon-associated genes identified deviated adap-
tive immune responses in patients who were at risk for poor outcome in SARS. In this regard, CBA
and gene expression analysis may represent a powerful prognostic tool in differentiating patients
on the basis of their host immune responses and immune-mediated injury due to serious infections.
Clinical Genomics - IT Strategies to Enable TTranslational

ranslational Research
12:30-1:30 pm Flying Cloud Room, 7th Floor
Presented by IBM
The healthcare and pharmaceutical industries have been buzzing with the promise of personal-
ized medicine since the inception of the human genome project. As this decade unfolds, contin-
ued advances in science, technology and information technology will accelerate the translation of
research discoveries into clinical practice. In order to achieve this goal of information based
medicine, an advanced information infrastructure will be required across the healthcare con-
tinuum. This presentation will explore the factors and technologies enabling the move towards
information based medicine. Specifically, it will explore the emerging area of Clinical Genomics,
where the integration of phenotypic and genotypic data will present a host of opportunities for
identifying and validating novel disease markers, enabling more focused clinical research and
ultimately transforming the delivery of healthcare.
34
2005
ANNUAL MEETING
Industr
utorials
Saturday
Saturday,, May 14
Advances in Immune Monitoring and Epitope Discover y: A SARS Case Study
Discovery:
Kur tis Bray
Kurtis Bray,, Ph.D., Director
Director,, Research and Development, Beckman Coulter
Coulter,, Inc.
7:00-8:00 am Webster Room, 7th Floor
Breakfast Served
Presented by Beckman Coulter

Objective: SARS is a severe infectious disease caused by a virus identified through gene sequenc-
ing and serological analysis as a new strain of human Coronavirus. SARS coronovirus (SARS-CoV)
causes severe acute respiratory symptoms in patients and results in a high mortality rate. Antigenic
peptides recognized by SARS virus specific CTL’s are useful tools for studying the CTL responses
during infection enabling researchers to better monitor disease and develop T-Cell mediated
vaccines. In order to identify potential immunogenic epitopes from the SARS N protein, we used
Beckman Coulter’s iTopia™ Epitope Discovery System to analyze the protein across 8 MHC Class
I alleles. This technology identifies and ranks candidate epitopes across 8 class I alleles based on
true experimental binding, affinity and off rate determinations in an in vitro 96-well format
Results: Identification of SARS candidate epitopes were as follows: 6 epitopes for HLA*A0101,
30 epitopes for HLA*A0201, 18 epitopes for HLA*A0301, 28 epitopes for HLA*A1101, 37
epitopes for HLA*A2402, 18 epitopes for HLA*B0702, 7 epitopes for HLA*B0801 and 27
epitopes for HLA*B1501. Based on iTopia rankings of candidate epitopes, SARS iTAg™ MHC
Tetramers for two of the candidate epitopes of the A1101 allele were manufactured and used to
stain cryopreserved PBMC’s from an A1101+ convalescent SARS patient. Both tetramers showed
strong staining, confirming the biologic activity of these two epitopes.
Conclusion: Using the iTopia Epitope Discovery System, the SARS N protein (422 amino acids)
was screened and potential immunogenic epitopes were identified based on true experimental
binding, affinity and off rate determinations. SARS results demonstrate the capacity of the iTopia
system to screen large number of MHC Class I restricted peptides and prioritize the epitopes with
greatest potential for producing an immune response. Biologic activity of two of the identified
epitopes was confirmed by in vitro staining with MHC tetramers of cells from a convalescent SARS
patient.
35
2005
ANNUAL MEETING
Industr
utorials
A Method for Analyzing Gene Expression Using RNA Isolated From Whole Blood
12:30-1:30 pm Adams Room, 7th Floor
Lunch Served
Presented by Agilent Technologies

With the recent advances of diagnostic tools such as microarray analysis and quantitative ampli-
fication technologies, including real-time reverse transcriptase – polymerase chain reaction (RT-
PCR), there is an increasing need for rapid and inexpensive methods to purify high quality RNA.
Agilent Technologies has developed a “whole solution” platform for the analysis of differential
gene expression experiments, and RNA isolation is often the critical first step for these applica-
tions. In many research and clinical assays whole blood is the desired source of cellular RNA.
However, isolation of RNA from blood is frequently compromised by instability of the mRNA profile
and the presence of interfering compounds such as hemoglobin and heparin. We have devel-
oped a method for isolating high- purity, intact cellular RNA from whole blood by combining our
Total RNA Isolation Mini Kit with PreAnalytiX PAXgeneâ blood collection tubes. PAXgene tubes
enable the collection and stabilization of whole blood samples. Agilent’s RNA isolation technol-
ogy ensures purification of total cellular RNA that is essentially free of interfering components,
including genomic DNA, and does not require the use of toxic chemicals such as phenol or
chloroform. In preliminary experiments using the RNA as input in Agilent’s Low RNA Input Fluores-
cent Linear Amplification Kit, ample yield of high specific activity cRNA was synthesized. The
labeled cRNAs were further utilized in hybridizations to Agilent Human 1A Oligo Microarrays.
Multiplex Serum Cytokine Analysis for Immunogenicity and Immune Competence

Meeta Patnaik, MD, Vice President, Pathway Diagnostics
12:30-1:30 pm Webster Room, 7th Floor
Webster
Lunch Served
36
2005
ANNUAL MEETING
Industr
utorials
Fine Mapping Solutions to the MHC and Beyond
Sarah Shaw-Murray
Shaw-Murray,, PhD
12:30-1:30 pm Flying Cloud Room, 7th Floor
Presented by Illumina
For almost 20 years, researchers have been using genome-wide linkage analysis to search for
genes conferring susceptibility to inflammatory diseases. The results of these linkage studies have
been difficult to replicate. One exception is linkage of most inflammatory disorders to the MHC
region. Unfortunately, the MHC region is also one of the most difficult regions to fine map in order
to determine the associated gene and the underlying etiologic variant conferring susceptibility to
disease. Illumina has developed two high density SNP genotyping products that overcome these
challenges. The Illumina MHC panel consists of two multiplexes, each with ~1,200 SNPs that are
designed for use with Illumina’s GoldenGate® assay and can be used either independently or in
conjunction with one another. The first multiplex is “exon-centric” and contains SNPs within 10 kb
of coding sequences of genes in the MHC region spanning from ret finger protein (RFP) to motilin
(MLN). The second multiplex consists of SNPs evenly spaced across the region with an emphasis
on tag SNPs. For genome-wide fine mapping studies, Illumina’s new InfiniumTM assay provides a
whole genome genotyping solution that enables investigators to more precisely identify inflamma-
tory disease susceptibility genes.
Sunday
Sunday,, May 15
Monitoring Vaccine Response: Standardization of Functional Cell Assays
Vaccine
Enrique Rabellino, MD, Medical Officer
Officer,, Beckman Coulter
Coulter,, Inc.
7:00-8:00 am Webster Room, 7th Floor
Webster
Breakfast Served
37
2005
ANNUAL MEETING
Business Meetings
Clinical Immunology Society Council Meeting
Wednesday, May 11
4:00 -11:00 pm
Flying Cloud Room
FOCIS Centers of Excellence Directors Meeting

Friday, May 13
5:30-7:00 pm
Adams Room
FOCIS Inter national Advisor

International Advisoryy Committee Meeting
Friday, May 13
11:30 am-12:30 pm
Adams Room
FOCIS 2006 Organizing Committee Meeting

Saturday, May 14
5:30-7:30 pm
Ambassador Suite
Clinical Immunology Society Annual Business Meeting

Saturday, May 14
6:30-7:45 pm
Turner’s Fisheries
FOCIS Steering Committee Meeting

Monday, May 16
1:00-3:00 pm
Webster/Courier
Lunch served @ 12:30
38
2005
ANNUAL MEETING
Program Schedule
Friday
Friday,, May 13, 2005
7:00 am-5:00 pm Registration Open
7:30-8:30 am Poster Session 1 St. George, 3rd Floor
8:30-10:00 am Plenar
Plenaryy Session America Ballroom, 4th Floor
Regulation of T Cell Differentiation
Chair: Vijay K. Kuchroo, DVM PhD
Signals for T and B Cell Activation
Antonio Lanzavecchia, MD
Antigen Specific Control of the Immune System by Dendritic Cells
Ralph Steinman, MD
10:00-10:30 am Break
10:30 am-12:30 pm Concurrent Thematic Symposia
I. Regulator
Regulatoryy T Cells in TTransplant
ransplant & Autoimmunity America North, 4th Floor
Chair: Shimon Sakaguchi, MD PhD
Preventing Rejection with Alloantigen Reactive Regulatory T Cells
Kathryn Wood
Generation of Regultory T Cells: Induction and Isolation of Antigen Specific TR
Jane Buckner, MD
Naturally Arising CD25+CD4+ Regulatory T Cells in Immunologic Tolerance
Shimon Sakaguchi, MD PhD
Foxp3 as a Dedicated Genetic Mechanism of Dominant Tolerance
Alexander Rudensky, PhD
(OR-01) Distinct Regulatory Functions are Defined by HLA-DR Expression on Human CD4+CD25 T Reg
Cells
C.M. Baecher-Allan
II. FCR and Complement America Center
Center,, 4th Floor
Chair: Michael Carroll, PhD
Blockade of Locally Acting Complement in Renal Transplantation
Steve Sacks
The Antiphospholipid Syndrome Revisited: A Disorder Initiated by Inflammation
Jane Salmon, MD
FC Receptor Function in Immunity and Tolerance
Jeffrey V. Ravetch, MD PhD
Functions of the Novel MHC Class I Like Fc Receptor, FcRn
Derry Roopenian, PhD
39
2005
ANNUAL MEETING
Program Schedule
Friday
Friday,, May 13, 2005 (continued)
III. Dendritic Cells (Transplant)
(Transplant) America South, 4th Floor
Chair: Mar
Maryy K. Crow
Crow,, MD
Dendritic Cells as Modulators of Transplant Outcome
Angus Thomson, PhD DSc FRCPath
Dendritic Cells and the Modulation of Immunity
Nina Bhardwaj, MD PhD
GM-CSF Based Cancer Vaccines
Glen Dranoff, MD
Dendritic Cells and Immunity
Youn-Jun Liu, MD PhD
(OR-02) CNS Dendritic Cells Drive Naïve T Cell Proliferation and Epitope Spreading in Relapsing
Experimental Autoimmune Encephalomyelitis
S.D. Miller
IV
IV.. Antibodies in Disease Pathogensis and Therapy Staffordshire, 3rd Floor
Chair: Paul J. Utz, MD
Role of Autoimmunity in the Pathogenesis of Lung Allograft Rejection
David S. Wilkes, MD
Overcoming Natural Antibodies in Xenotransplantation
David Sachs, MD
B Cell Immunity After Allogeneic Stem Cell Transplantation
Jerome Ritz, MD
Natural History of Islet Autoimmunity in Type 1 Diabetes
Anette Ziegler, MD
(OR-03) A New Spontaneous Mouse Model for Human Devic’s Disease
E. Bettelli
12:30-1:30 pm Lunch
Industr
utorials presented by BD Biosciences and IBM (see page 34) 7 th Floor
Poster Session 1 (continued) St. George, 3rd Floor
40
2005
ANNUAL MEETING
Program Schedule
Friday
1:30-3:00 pm Industr
Industryy Symposium Presented by Biogen IDEC America Ballroom, 4th Floor
This session is programmed by FOCIS and supported by an unrestricted educational grant from Biogen IDEC.
Selective Adhesion Molecule Inhibition in Autoimmune Disease
Moderator: Roy Lobb, PhD
How Does VLA-4 Work? Mechanistic Insights—Past, Present, and Future
Martin Hemler, PhD
Clinical Results of Selective VLA-4 Blockade with Natalizumab in Relapsing Multiple Sclerosis
J. Theodore Phillips, MD PhD
Speaker TBA
3:00-3:30 pm Break
3:30-5:30 pm Concurrent Oral Abstract Sessions
I. Antibodies and B Cells America North, 4th Floor
Chair: Shiv Pillai, MBBS PhD
(OR-04) Elucidating the Mechanism of Anti-MOG Antibody –Mediated Demyelination.
C. B. Marta
(OR-05) Synovial Intracellular Citrullinated Proteins Colocalizing with Peptidyl Arginine Deiminase are
Pathophysiologically Relevant Antigenic Determinants of Rheumatoid Arthritis-Specific Humoral Autoim
munity.
L. De Rycke
(OR-06) Antibodies to Citrulline-Modified Proteins Enhance Tissue Injury in Inflammatory Arthritis.
K. A. Kuhn
(OR-07) T to B Epitope Spreading is Responsible for the Diversification of Autoantibody Responses
Within the Small Nuclear Ribnucleoprotein Complex.
U. S. Deshmukh
(OR-08) In Sjogren’s Syndrome Serum Autoantibodies Recognize Tear Lipocalin and Alpha-Fodrin.
Riccardo Navone
(OR-09) Microarray Profiling of Anti-Lipid Antibodies in MS.
J. L. Kanter
(OR-10) High-Throughput Analysis of Autoantibodies Recognizing Myelin Antigens in Acute Dissemi
nated Encephalomyelitis.
K. C. O’Connor
(OR-11) Role of CD38 in Human B Cells: Evidence of a Functional and Physical Association with CD 19.
S. Deaglio
41
2005
ANNUAL MEETING
Program Schedule
Friday
II. Innate Immune System Regulating Disease America Center
Center,, 4th Floor
Chair: Hanspeter Waldner
aldner,, PhD
Waldner
(OR-12) Toll-Like Receptor 2 Regulates Cellular Responses to Axonal Degeneration in the Central
Ner vous System.
A. A. Babcock
(OR-13) Linking Innate Immunity to Autoimmunity Through the Role of TLRs and the MyD-88 Signaling
Pathway.
P. P. Ho
(OR-14) Transcription Factor T-Bet Regulates Inflammatory Arthritis Through Linking the Innate and
Adaptive Immunity.
J. Wang
(OR-15) Three Different TLR9 CpG Stimulants Exhibit Diverse Effects in Murine Graft-Versus Host Disease
(GVHD).
R. A. Puliaev
(OR-16) HSP60 Inhibits Th1-Mediated Hepatitis Model Via Innate Regulation of Th1/Th2 Transcription
Factors and Cytokines.
Alexandra Zanin-Zhorov
(OR-17) Toll Receptor Ligands Potently and Broadly Enhance the Immune Response of Immunodepressed
Cutaneous T-Cell Lymphoma Patients.
M. Wysocka
(OR-18) Beta-Adrenergic and Toll-Like Receptor 2 Signalling in Epidermal Keratinocytes Drive the Skin
Immune Response to a Soluble Protein.
Georges J.M. Maestroni
III. T Regs and Regulation of Immune Response America South, 4th Floor
Chair: Joan Goverman, PhD
Oral Anti-CD3 Suppresses Autoimmunity by Inducing TGF-b Dependent LAP+ Regulatory T Cells
Howard Weiner, MD
(OR-19) Regulatory Function Is Deficient in CD4+CD25+ T Cells from Patients with Systemic Lupus
Erythematosus.
M. I. Vargas-Rojas
(OR-20) IL-2 Mediates Expansion but Not Maintenances of TGF Induced T Regs in Inflammation: A
Novel Role of IL-10.
M. C. Fantini
(OR-21) Identification of Important Functional Domains of FOXP3 by Analysis of Mutations Present in
Patients with IPEX Syndrome.
T. R. Torgerson
(OR-22) GRAIL Expression Is Associated with the Biological Activity of CD25+ T Regulatory Cells.
D. A. MacKenzie
42
2005
ANNUAL MEETING
Program Schedule
Friday
IV
IV.. New Pathways of Immune Regulation Staffordshire, 3rd Floor
Chair: Marie Wahren, MD PhD
Wahren,
(OR-27) Requirement for the Adipocyte Fatty Acid Binding Protein aP2 in Allergic Airway Inflammation.
B. Shum
(OR-28) Transcriptional Regulation of Autoimmune Diseases by Tumor Suppressor p53.
Xiaochun Wan
(OR-29) The Sjögren’s Syndrome Associated Autoantigen Ro52 Is a RING-Dependent E3 Ligase That
Suppresses Cellular Proliferation.
A. Espinosa
(OR-30) Graft-Versus-Leukemia Target Antigens in Chronic Myelogenous Leukemia (CML) are Expressed
on Myeloid Progenitor Cells.
J. Wu
(OR-31) BAFF-but Not LT-Dependent B Cell Expansion Contributes to the Suppression of Lethal Intestinal
Inflamation.
Yasuyo Shimomura
(OR-32) Increased Constitutive Activation of NF-B in Patients with Multiple Sclerosis.
J. Yan
(OR-33) Control of Macrophage Activation Via Myeloid CD200R Signaling During Experimental
Autoimmune Uveoretinitis.
J. Calderm
(OR-34) Role of Fgl2 Prothrombinase/Fibroleukin in Experimental and Human Allograft Rejection.
Qin Ning
43
2005
ANNUAL MEETING
Program Schedule
Friday
V. NK and NK T Cells Webster/Courier
Chair: TBA
(OR-35) Glycolipid Mediated Activation of iNKT Cells is Sufficient to Induce Airway Hyperreactivity
Independent of Conventional CD4 T Cells.
E. H. Meyer
(OR-36) The Involvement of CD1-Restricted NKT Cells in the Pathogenesis of Collagen-Induced and
Antibody-Induced Arthritis.
S. Kaieda
(OR-37) Effects of Natural Killer (NK) Cells on Allogeneic Bone Marrow Transplantation.
Swati Bhattacharyya
(OR-38) - NK-Mediated Protection in CFA-Injected NOD Mice ig
I.F. Lee
(OR-39) Microsomal Triglyceride Transfer Protein Regulation of CD1d-Mediated Glycolipid Antigen
Presentation.
S. K. Dougan
(OR-40) Exogenous IL-2 Promotes IL-5 Production by Human CD4+ NKT Cell Clones: The Role of IL-2 in
the Immune Regulation.
K. Sakuishi
(OR-41) - Specificity of NK T Cells Against GD3 Ganglioside.
Dianna Y. Wu
(OR-42) CD4+ Invariant T Cell Receptor+ NKT Cells and the Development of Bronchial Asthma in Humans.
Omid Akbari
5:30-7:30 pm Poster Session 2 (Wine and Cheese Ser
(Wine ved)
Served) St. George, 3rd Floor
7:00-9:00 pm Welcome Reception Essex Ballroom, 3rd Floor
Open to all delegates
44
2005
ANNUAL MEETING
Program Schedule
Saturday
Saturday,, May 14, 2005
7:00 am-5:00 pm Registration Open
7:00 am-8:00 am Industr
utorials presented by Beckman Coulter (see page 35) 7th Floor
7:30-8:30 am Poster Session 1 St. George, Essex, 3rd Floor
Genetics & Gene Therapy
Chair: Megan Sykes, MD
Edward Wakeland, PhD
Gene Therapy: Medicine of the 21st Century
Inder Verma
10:00-10:30 am Break
I. Genetics of Immune-Mediated Diseases & TTransplantation
ransplantation America North, 4th Floor
Chair: Jack PP.. Antel, MD
Towards a Taxonomy of Type 1 Diabetes
John Todd
Inflammatory Bowel Disease-A Genetics Success Story
Kathy Siminovitch, MD FRCP
GPRA, A Susceptibility Gene for Allergy and Asthma
Juha Kere, MD PhD
The SLAM Family of Cell Surface Receptors Controls Immune Responses to Viruses and Bacteria
Cox Terhorst, PhD
(OR- 43) TIM-1 Induces T Cell Activation and Inhibits the Development of Peripheral Tolerance.
S. E. Umetsu
II. TLR, NK, Innate Immunity America Center
Center,, 4th Floor
Chair: Stephan Meuer
Meuer,, MD
Checkpoints in Human NK Cell Activation and Function
Lorenzo Moretta, MD
Endogenous TLR Ligands and Systemic Autoimmune Disease
Ann Marshak-Rothstein, PhD
Danger Signals and the Initiation of Immune Responses
Kenneth Rock, MD
Active Control of CDI Antigen Processing in Human Dendritic Cells
Branch Moody, MD
(OR-44) In Vivo Homeostatic Proliferation of Naive CD4+ T-Cells Restrains the TCR Repertoire in Healthy
Human Adults.
S. Kohler
45
2005
ANNUAL MEETING
Program Schedule
Saturday
Saturday,, May 14, 2005 (continued)
III. Immunodysregulation and Immunoreconstitution America South, 4th Floor
Chair: Matthias vonHerrath, MD
Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX): A Model of Foiled Peripheral
Self-Tolerance
Hans Ochs, MD
Innate Autoimmunity
Michael Carroll, MD
Immune Deficiency Due to Defects in Isotype Switching
Raif Geha, MD
Alemtuzumab in Allogeneic Transplantation: Between Scylla and Charybdis
Karl Peggs, MD
(OR-45) Intragraft Foxp3 Expression is Associated with Rejection and is Suppressed by CsA.
K. G. Haanstra
46
2005
ANNUAL MEETING
Program Schedule
Saturday
IV
IV.. Disease Regulation: Role of Antigens, Cytokines, Chemokines Staffordshire, 3rd Floor
Chair: Andrew Luster
Luster,, MD PhD
Fevers, Genes, and Pathways: The Systemic Autoinflammatory Diseases
Dan Kastner, MD PhD
Chemokines and Lipid Chemoattractants in Disease
Andrew Luster, MD PhD
Cytokine Signal: Basic and Applied
John O’Shea, MD
Cytokines in Viral Infections
Christine A. Biron, PhD
(OR-46) Insulin with Native B:9-23 Sequence is an Essential Autoantigen in the NOD Mouse.
M. Nakayama
12:30-1:30 pm Lunch
Industr
Industry utorials presented by
y TTutorials
Agilent TTechnologies,
echnologies, Beckman Coulter
Coulter,, Illumina (see page 36) 7th Floor
Poster Session 1 (continued) St. George, Essex, 3rd Floor
Industryy Symposium Presented by Centocor
This session is programmed by FOCIS and supported by an unrestricted educational grant from Centocor.
Immune-Mediated Inflammator y Disorders: Elucidating Patter
Inflammatory ns in Immune Disease Concomitancy
Patterns
and Connectivity America Ballroom, 4th Flooor
Moderator: John B. W ong, MD
Wong,
Patterns of Immune Disease: Exploring the Biologic Underpinnings
Abul Abbas, MD
The Gastroenterology Perspective
Sander J. van Deventer, MD
The Clinical Immunology Perspective
Speaker TBA
Current Implications and Future Direction
David F. Fiorentino, MD, PhD
Closing
3:00-3:30 pm Break
3:30-5:30 pm Oral Abstract Sessions
I. Genetics and Genomics America North, 4th Floor
Chair: John Rioux, PhD
(OR-47) Differential Transcript Profiling Identifies Candidate Genes in the New Zealand Model of
Systemic Lupus Erythematosus, Including the B-Cell Transcription Factor, Bach2.
R. J. Rigby
47
2005
ANNUAL MEETING
Program Schedule
Saturday
(OR-48) Impact of the Lupus Susceptibility Locus, Sle1 on B Cell Tolerance.
K. Raman
(OR-49) Insulin-VNTR Modulate Functional Phenotypes of T-Cell Responses to Proinsulin in HLA-DRB1*04
Positive Subjects with and without Type 1 Diabetes.
I.Durinovic-Bello
(OR-50) A Toll Receptor Pathway Polymorphism Affects Susceptibility to Inflammatory Bowel Disease.
P. L. De Jager
(OR-51) Finally Found: Human BAFF-R Deficiency Causes Hypogammaglobulinemia.
K. Warnatz
(OR-52) Polymorphisms in CTLA4 and CD28 Are Associated with SLE.
D. S. Cunninghame Graham
(OR-53) Building an Admixture Map for Disease Gene Discovery in African Americans.
A.Waliszewska
II. Immunodiagnosis America Center
Center,, 4th Floor
Chair: TBA
(OR-54) Detection of Allergen-Antibody Complexes on Murine B Cells Using Flow Cytometry.
P. A. Wachholz
(OR-55) Novel Candidate Markers for Multiple Sclerosis Using Phage cDNA Display.
V.Somers
(OR-56) Phenotypic and Functionnal Ex Vivo Profiling of Human CMV Specific CD8+ T-Cell Responses
After Allo-HSCT.
V.Bajzik
(OR-57) A Compliant Solution for Monitoring Proteins Using a Lab-on-a-Chip Instrument.
P. Barthmaier
(OR-58) Correlation of Clinical Outcome with Immunophenotype in Islet Transplant Recipients.
N. S. Kenyon
(OR-59) Autoimmunity in Children with Atypical Type 1 and Type 2 Diabetes.
L. K. Gilliam
(OR-60) Development of a Clinical Assay Evaluating Toll-Like Receptor Function.
R. P. Deering
(OR-122) Identification of Disease Profiles for Rheumatoid Arthritis Using Antibody and Antigen Arrays.
D. Hirschberg
48
2005
ANNUAL MEETING
Program Schedule
Saturday
III. TTolerance
olerance America South, 4th Floor
Chair: Stephen D. Miller
Miller,, PhD
(OR-61) Tolerance to Inhaled Proteins Does Not Develop in the Presence of Proteinase-Activated Recep
tor-2 (PAR-2) Activation.
C. Ebeling
(OR-62) Nasal Vaccination with a Proteosome-Based Adjuvant and Glatiramer Acetate Clears Alzheimer’s
Amyloid in an Antibody-Independent Fashion.
Dan Frenkel
(OR-63) Collaboration between Central Tolerance and Peripheral Regulation to Control Autoimmunity.
Z. Chen
(OR-64) Mechanisms of Retinal Immune Privilege.
C. H. Lau
(OR-65) - Treatment with a Donor-Specific Transfusion and Anti-CD154 mAb Induces Non-Responsive
ness in a Population of T Cells That Recognize Alloantigen Via Indirect Antigen Presentation.
N. E. Phillips
(OR-66) Successful Induction of Mixed Chimerism and Tolerance with Non-Myeloablative Conditioning
in Mice Presensitized with Fully Mismatched Skin Grafts.
P. D. Bardwell
IV
IV.. Dendritic Cells and Regulation of Disease Staffordshire, 3rd Floor
Chair: Shannon TTurley
urley
urley,, PhD
(OR-67) Dendritic Cell Response to Necrosis is Defective in Atopy.
H. Kandil
(OR- 68) CD150 (SLAM) Modulates TLR and CD40 Pathways in Monocyte-Derived Dendritic Cells.
B. Rethi
(OR-69) Activation of Human NK Cells by Plasmacytoid DC and Its Modulation by CD4+ T Cells and
CD25hi T Regulatory Cells.
C. Romagnani
(OR-70) Hepatitis C Virus Core Protein Induced, Monocyte-Mediated Mechanisms of Reduced IFN and
Plasmacytoid Dendritic Cells Loss in Patients with Chronic HCV Infection.
A.Dolganiuc
(OR-71) Delayed IL-10 Induced Human Tolerogenic DC Inhibit Naive T Cell Proliferation by Mechanisms
Other Than Their Exaggerated PD-L1/2 Induction.
F. Li
(OR-72) Induction of Heme Oxygenase-1 (HO-1) Inhibits Dendritic Cell Differentiation and Adaptive
Immunity.
J. J. Listopad
(OR-73) Donor-Specific Allograft Tolerance by Administration of Recipient-Derived Immature Dendritic
Cells and Suboptimal Immunosuppression.
49
G. Beriou
2005
ANNUAL MEETING
Program Schedule
Saturday
(OR-74) - Impact of Plasmacytoid Dendritic Cell (PDC) Recovery on Outcome after Allogeneic Stem Cell
Transplantation (allo-SCT).
M. Mohty
V. Immunodeficiency Webster/Courier
Chair: Dale Umetsu, MD PhD
(OR-75) Functional Interaction of Common Gamma Chain and Growth Hormone Receptor Signaling
Apparatus.
M. Adriani
(OR-76) Novel Humoral Immunodeficiency in Humans Associated with Deleterious Homozygous Muta
tion in CD19.
D. Castano
(OR-77) Mutations in TACI Are Associated with Immunodeficient Phenotypes in Humans.
U. Salzer
(OR-78) Expansion of Maternally Derived Monoclonal T Cells with a CD3 + CD8 + TCR Phenotype in
Two Children with Severe Combined Immunodeficiency.
E. Hodges
(OR-79) Semi-Nested Degenerate rtPCR Allows Rapid Identification of TCR-beta Rearrangement on the
Single Cell Level.
Dun Zhou
5:30-7:30 pm Poster Session 2 (Wine and Cheese Ser
(Wine ved)
Served) St. George, Essex, 3rd Floor
Sunday
Sunday,, May 15, 2005
7:00am-5:00 pm Registration Open
7:00-8:00 am Industr
Industry utorials presented by Beckman Coulter (see page_)
y TTutorials 7 th Floor
Tracking Pathogenic & Therapeutic Immune Responses
Chair: Richard Blumberg, MD
Imaging Inflammation in Type-1 Diabetes
Diane Mathis, PhD
Imaging Cell Fates and Function Noninvasively
Chris Contag
I. In Vivo Imaging America North, 4th Floor
Chair: Jeffrey Bluestone, PhD
Multicellular Synapse Dynamics In Vivo
Matthew Krummel, PhD
Trafficking of Immune Populations with Biolumenescence
50 Robert Negrin, MD
2005
ANNUAL MEETING
Program Schedule
Sunday
Sunday,, May 15, 2005 (continued)
II. Costimulation and TTolerance
olerance
Chair: TBA
High Resolution Dynamic Visualization of Immune Cell Function In Vivo in Health and Disease
Ronald N. Germain, MD PhD
Live Imagine of Autoaggressive T Cells Attacking the CNS
Alexander Flugel, MD
(OR-80) Expanded T Cells from Human Type 1 Diabetic Pancreatic Draining Lymph Nodes React with
Insulin A Chain 1-15.
S. C. Kent
The Roles of the New Negative T-Cell Costimulatory Pathways in Regulating Autoimmunity
Samia Khoury, MD
CD137 and HVEM in the Control of Transplantation Tolerance
Lieping Chen, MD PhD
OX40: OX4OL in T Cell Immunity and Disease
Michael Croft, PhD
Novel T Cell Costimulatory Pathways in Transplantation
Mohamed H. Sayegh, MD
(OR-81) Anti-CD28 Antibodies-Induced Transplant Tolerance Involving TCR- Class II- CD80/86+ Regula
tory Cells and Tryptophan Degradation.
F. Haspot
III. Mast Cell, Eosinophils, Allergic Reactions America South, 4th Floor
Chair: Stephen J. Galli, MD
Mast Cells as Effector and Potential Immunoregulatory Cells in Acquired Immune Responses
Stephen J. Galli, MD
Mast Cells and Inflammatory Arthritis
David Lee, MD PhD
Homing/Recruitment and Function of Peripheral Tissue Mast Cell
K. Frank Austen, MD
Role of Eosinophils in Innate Immunity and Allergic Inflammation
Hirohita Kita, MD
IV
IV.. Living with the Bugs: Good or Bad Staffordshire, 3rd Floor
Chair: Kendall A. Smith, MD
Immunopathology in HTLV-I Associated Neurologic Disease
Steve Jacobson, PhD
How Viruses Enhance or Abrogate Type 1 Diabetes
Matthias von Herrath, MD
Infection and Immunity in Atheroclerosis
Andrew Lichtman, MD PhD 51
2005
ANNUAL MEETING
Program Schedule
Sunday
How Did Infections Protect Us from Allergic and Autoimmune Diseases?
Jean Francois Bach
(OR-82) - Immature Myeloid Dendritic Cells Induce Intestinal Granulomas under Certain Environmental
Conditions.
K. Sugimoto
12:30-1:30 pm Lunch
Poster Session 1 (continued) St. George, Essex, 3rd Floor
Industryy Symposia Presented by Genentech America Ballroom, 4th Floor
This session is programmed by FOCIS and supported by an unrestricted educational grant from Genentech.
Linking B Cells and Autoimmune Diseases
Moderator: Dhaval Patel, MD PhD
Pathways of B Cell Activation
Robert Carter, MD
B Cells and Autoimmunity
Peter E. Lipsky, MD
Therapeutic Targeting of B Cells
Dhaval Patel, MD PhD
3:00-3:30 pm Break
3:30-5:30 pm Oral Abstract Sessions
I.New Animal Models: Defining Antigens Recognition by Animal Models America North,
Chair: Chella David, PhD 4th Floor
(OR-83) HLA-A11/KboDbo Transgenic Mice are Susceptible to PLP41-60 Induced Experimental Autoim
mune Encephalomyelitis (EAE).
A.K. Mangalam
(OR-84) Fibrinogen-Induced Arthritis in Mice as a Novel Model for Rheumatoid Arthritis.
P. P. Ho
(OR-85) Murine Model of Mixed Connective Tissue Disease in HLA-DR4 Transgenic Mice Induced with
U1-70kD Small Nuclear Ribonucleoprotein Autoantigen.
R. W. Hoffman
(OR-86) Proteoglycan-Induced Arthritis: A New and Unique TCR Transgenic Arthritis Model.
S. E. Berlo
(OR-87) BDC 12-4.1 (Anti-Insulin B:9-23) T Cell Receptor Transgenic Mice Are Lymphopenic but Entrain
Early Insulitis and Can Cause Early Diabetes Modified by Insulin 2 Gene Expression.
J. M. Jasinski
(OR-88) Implication for the Pathogenesis and Immunoregulation in a Murine Model of Sarcoidosis.
B.Wei
(OR-89) A New Model of Endogeneous AML Following Irradiation and Allogeneic Bone Marrow Trans-
plantation.
52 B.Van Wijmeersch
2005
ANNUAL MEETING
Program Schedule
Sunday
II. Costimulation America Center
Center,, 4th Floor
Chair: Arlene Sharpe, MD PhD
(OR-90) Monoclonal Antibody Targeting of TIRC7 Results in Significant Therapeutic Effects on T and B
Cell Response in Collagen-Induced Arthritis in Mice.
N. Utku
(OR-91) Transgenic Expression of Program Death Ligand 1 Protects Islets from Autoimmune Diabetes in
Nonobese Diabetic Mice.
Huey-Kang Sytwu
(OR-92) PD-L1/PD-L2 Expression Protects Against the Development of Autoimmune Diabetes.
Mary E. Keir
(OR-93) ICOS Engagement of CD4 T-Cells Following Pulmonary Influenza Infection: Evidence for Nega
tive Regulation of T-Cell Effector Function.
M. E. Dahl
(OR-94) Tim-4 Is the Ligand for Tim-1, and the Tim-1/Tim-4 Interaction Regulates T Cell Expansion.
J. Hartt Meyers
(OR-95) Evidence for Early Anergy Followed by Rapid Peripheral Deletion of Donor-Specific CD8 T Cells
after Non-Myeloablative BMT with Anti-CD154: In Search of a Tolerogenic Donor Cell.
T. Fehr
(OR-96) TIM-3 Mediated Enhancement of Anti-Tumor Immune Responses.
Brian K. Helmich
III. Immunotherapy America South, 4th Floor
Chair: TBA
(OR-97) Apoptosis Induction as a Therapeutic Intervention To Eliminate Encephalitogenic T Cells; Antisense
XIAP (AEG35169) in Murine Models of EAE.
S. P. Zehntner
(OR-98) Blockade of TNF Preferentially Inhibits Proliferation of Anti - CD3, Recall - Antigen Responsive
and Autoreactive Human VLA-1+CD45RO+CD4+ T Cells.
S. Ben-Horin
(OR-99) An Immunization Strategy for Generation of T Cell Receptor Mimics.
Vaughan P. Wittman
(OR-100) Differential Expression of Phosphorylated NF-kB/RelA in Normal and Psoriatic Epidermis and
Downregulation of NF-kB in Response to Treatment with Etanercept.
P. F. Lizzul
(OR-101) Anti-IL-2R Therapy: An Alternative Strategy for Regulating CD40L Expression.
J. Shen
(OR-102) Prophylactic Administration of Abatacept (CTLA4-Ig; BMS-188667) Prevents Disease Induc
tion and Bone Destruction in a Rat Model of Collagen-Induced Arthritis.
B.Kliwinski
53
2005
ANNUAL MEETING
Program Schedule
Sunday
(OR-103) Abatacept (CTLA4Ig) Modulates Human T-Cell Proliferation and Cytokine Production but Does
Not Affect TNF Production by Monocytes.
P. M. Davis
(OR-104) Essential Role of IL-10 in Restricting Immunity during a Chronic Viral Infection.
Mette Ejrnaes
IV
IV.. Trafficking and Adhesion Staffordshire, 3rd Floor
Chair: TBA
(OR-105) Effects of Natalizumab (anti-VLA-4 Antibody) on Immune Cell Adhesion and Migration in
Patients with MS.
Masaaki Niino
(OR-106) Molecular Imaging of Adhesion Molecules in Experimental Autoimmune Encephalomyelitis
(EAE).
R. A. Linker
(OR-107) Immunotherpy of Relapsing Experimental Autoimmune Encephalomyelitis (EAE) by Neutral
ization of CD4+ T Cell Chemoattractant Cytokine IL-16.
D. S. Skundric
(OR-108) High Resolution Dynamic Visualization of Immune Cell Function In Vivo in Health and Disease.
R. N. Germain
(OR-109) Migration Matters: Regulatory T Cell Compartmentalization Determines Suppressive Activity In
Vivo.
K. Siegmund
(OR-110) The Anti-Inflammatory Action of Methotrexate is Not Mediated by Lymphocyte Apoptosis, but
by the Suppression of Activation and Adhesion Molecules.
A.Johnston
(OR-111) Conditional Deletion of Alpha (v) Integrins Causes Inflammatory Bowel Disease.
A.Lacy-Hulbert
V. Cytokine Mediated Immunoregulation Webster/Courier
Chair: Lindsay B. Nicholson, MD PhD
(OR-112) Phenotype of Cytokine Expressing Cells in Peanut Allergen-Primed Mice.
P. A. Wachholz
(OR-113) Foxp3+ Regulatory T Cells Can Be Induced from CD4+CD25- TGF Transgenic Cells and Are
Able To Condition Dendritic Cells To Suppress Naïve T Cells.
Y. Carrier
(OR-114) Atorvastatin Prevents the Th1 Differentiation of Myelin-Reactive T Cells During EAE by Interfer
ing with the Prenylation of Ras and the Activation of ERK.
S. E. Dunn
54
2005
ANNUAL MEETING
Program Schedule
Sunday
(OR-115) Regulation of T Cell Differentiation by IL-4R-Chain Single Nucleotide Polymorphisms.
A. Skapenko
(OR-116) Diverging Roles for the IL-12 Family in T Cell Immunity: IL-12 and IL-27-EBI3 Have Similar
Contributions to Pathogen Responses While IL-23 Is Unique to Certain Autoimmune Pathways.
Jacqueline M. Benson
(OR-117) IL-4 Can Be a Key Positive Regulator of Inflammatory Arthritis.
Koichiro Ohmura
(OR-118) IL-12/23-Deficient Genotype Reveals Two Distinct Pathways Leading to Arthritis in Mice.
H. Hess
(OR-119) Systemic Onset Juvenile Idiopathic Arthritis is an IL-1 Mediated Disease.
F. Allantaz
5:30-7:30 pm Poster Session 2 St. George, Essex, 3rd Floor
Monday
Monday,, May 16, 2005
8:30-10:00 am Distinguished Lecture: Genetics and Genomics America Ballroom, 4th Floor
Chair: David A. Hafler
Hafler,, MD
HIV Vaccines Epitope Diversity and T Cell Memory
Gary Nabel, MD PhD
Genomic Information: Implications for Medicine
Eric Lander, PhD
10:00- 10:30 am Break
I. Therapeutic V accines
Vaccines America North, 4th Floor
Introduction
Chair: Lucienne Chatenoud, MD PhD
Enhancing Tumor Vaccination Through In Vivo Plasmacytoid Dendritic Cell Activation Via TLR9
Art Krieg, MD
Breaking Tumor-Induced Tolerance with Therapeutic Intent
Drew Pardoll, MD PhD
The Quest for Antigen Specific Therapy for Autoimmune Disease
Larry Steinman, MD
Modulation of Adaptive Immunity in Rheumatoid Arthritis
Salvatore Albani, MD PhD
55
2005
ANNUAL MEETING
Program Schedule
Monday
Monday,, May 16, 2005 (continued)
II. Development of Immune-Based Therapeutics America Center
Center,, 4th Floor
Chair: Michael Lotze, MD
B Cell Immunotherapy
Andrew C. Chan, MD PhD
On the Horizon: Better Therapies for Systemic Lupus Erthematosus
David Wofsy, MD
Monoclonar Antibody and Cellular Therapy in Type 1 Diabetes
Jeffrey Bluestone, PhD
Molecular Pathogensis of RA and Mode of Action of TNF-Blocking and Other Target Therapies
Lars Klareskog, MD PhD
(OR-120) - A High Affinity, Soluble T Cell Receptor for Targeting Tumours Expressing NY-ESO and HLA-
A2.
R. Ashfield.
III. Roles of Interferons in Defense & Disease America South, 4th Floor
Chair: Tim Behrens, MD
Role of Interferon-alpha in Systemic Lupus Erythematosus
Virginia Pascual, MD
The Interferon Pathway and Human Lupus
Tim Behrens, MD
The Role of Interferons in Systemic Autoimmunity
Dwight Kono, MD
Control of T-Cell Immunity by Dendritic Cells
Frederica Sallusto
IV
IV.. Immunodiagnostic Disease Predictors Staffordshire, 3rd Floor
Chair: Jonathan Braun, MD PhD
Proteomic Analysis Reveals Molecular Subtypes of Rheumatoid Arthritis
William Robinson
Molecular and Microbial Disease Markers in Inflammatory Bowel Disease
Jonathan Braun, MD PhD
Paul Ridker, MD
Can We Detect Tolerance Following Allograft Transplantation?
Jean-Paul Soulillou
(OR-121) GAD65- and Proinsulin-Specific CD4+ T-Cells Detected by MHC Class II Tetramers in the
Peripheral Blood of Type 1 Diabetic Patients and Prediabetic Subjects.
V. Oling
56
2005
ANNUAL MEETING
Program Schedule
Monday
Monday,, May 16, 2005 (continued)
12:30-2:00 pm NIH Grants Information Session America North, 4th Floor
This session will inform applicants about the NIH peer review and program funding processes. The
session is directed at all academic investigators. The topics will include the receipt and referral process,
the review process, as well as the funding mechanisms and NIH program initiatives available to clini
cian-scientists.
Dr. Cathleen Cooper
Scientific Review Administrator, Transplantation, Tolerance, and Tumor Immunology Study Section and
Referral; Officer, Division of Receipt and Referral, Center for Scientific Review
Dr. Grace Shen
Director, Ocular Immunology Program, Division of Extramural Research, National Eye Institute
57
2005
ANNUAL MEETING
Exhibit Hall - Essex Ballroom, 3 rd

Floor
Booth # Company
1-2 Agilent Technologies 28 EFORE (USA), Inc.
3-4 DakoCytomation 29 ALPCO Diagnostics
5-6 DynalBiotech ASA 30 BioLegend, Inc.
7-8 Whatman/Schleicher & Schuell 31 Jackson ImmunoResearch Laboratories, Inc.
9 National Institute of Allergy and Infectious Diseases 32 KRONUS, Inc.
10 Journal of Experimental Medicine 33 LINCO Research, Inc.
11-12 Centocor, Inc. 34 Luminex Corporation
13 Immune Tolerance Network 35 Miltenyi Biotec, Inc.
14 Elsevier 36 ProImmune, Inc.
15 American Autoimmune Related Diseases Association 37 Bristol-Myers Squibb
16-18 Grifols International SA 38 SeraCare Life Sciences
19-23 Beckman Coulter, Inc. 39 THERAKOS
24 BD Biosciences 40 Upstate
25 Autoimmun Diagnostika GMBH/Cell Technology, Inc. 41 Blackwell Publishing
26 Biacore, Inc. 42 IgG America
27 Cellular Technology, Ltd. CTL
58
2005
ANNUAL MEETING
Exhibit Hall
Exhibit Hall Hours
Friday, May 13 Opening Reception 7:00-9:00 pm
Saturday, May 14 7:00 am-7:30 pm
Sunday, May 15 7:00 am-7:30 pm
Exhibit Hall hours are designed to correspond with Poster Sessions also being held in the Essex Ballroom. Poster viewing hours are
7:30-8:30 am, 12:30-1:30 pm, and 5:30-7:30 pm. However, the Exhibit Hall and poster areas will be accessible from 7:30 am
to 7:30 pm.
13th International Congress of Immunology ALPCO Diagnostics

Sociedade Brasileira de Imunologia PO Box 451
Apuiar 44 Windham, NH 03087
Sao Paulo Booth Number: 29
Brasil
ALPCO Diagnostics offers a comprehensive range of over 600
high-quality immunoassay kits to both the research and clinical
The 13 International Congress of Immunology, sponsored by
th
laboratory communities. ALPCO is featuring kits in the areas of
the International Union of Immunological Societies (IUIS), the
Allergy Research, Autoimmunity, Rheumatology, Thyroid Func-
Brazilian Society of Immunology (SBI) and the Latin American
tion, and Hepatology. Please visit us to receive our full product
Society of Immunology (ALAI) will be held in Rio de Janeiro,
catalog, Immunoassay Kits Beyond the Ordinary.
August 12th-17 th, 2007. The Scientific Program will be outstand-
ing; there will be a full social program to allow delegates to AutoImmun Diagnostika GMBH/Cell Technology
echnology,,
Technology
experience the charm of Rio de Janeiro, one of the most beauti- Inc.\Cell T echnology
echnology,, Inc.
Technology
ful cities in the world, nicknamed “Cidade Maravilhosa” (Won- 8980 Old Annapolis Road
derful City). Suite L
Columbia, MD 21045
American Autoimmune Related Booth Number: 25
Diseases Association Cell Technology, Inc. (www.celltechnologyinc.com) is the North
22100 Gratiot Ave. American Distributor of Image Analyzers (for EliSpot / Viral
E. Detroit, MI 48021 Plaque/ IFA assay) and test kits manufactured by AutoImmun
Booth Number: 15 Diagnostika, Strassberg, Germany (www.aid-diagnostika.com).
Additionally, Cell Technology Inc. provides storage and distri-
Agilent TTechnologies
echnologies bution services for biological materials.
2850 Centerville Road
Wilmington, DE 19808 BD Biosciences
Booth Number: 1-2 2350 Qume Drive
San Jose, CA 95131
Agilent Technologies is a leading supplier of life science tech-
Booth Number: 24
nologies, providing solutions for gene expression, proteomics
and informatics that optimize sensitivity and workflow productiv- BD Biosciences, a business segment of BD (Becton, Dickinson
ity. Key products include: whole genome and custom microarrays, and Company), has four business units: Clontech, Discovery
scanners; HPLC, LC/MS/MS and HPLC-Chip/MS; ion trap and Labware, Immunocytometry Systems, and Pharmingen. As one
TOF mass spectrometers; lab-on-a-chip products; reagents; and of the largest companies supporting the life sciences, BD Bio-
data analysis software. sciences provides integrated, high value products and services
for genomics, proteomics, drug discovery and development, and
cell analysis.
59
2005
ANNUAL MEETING
Exhibit Hall
Beckman Coulter Blackwell Publishing
7330 Carroll Road Booth Number: 41
San Diego, CA 92121
Blackwell Publishing is one of the world’s leading medical pub-
Booth Number: 19-23 lishers, representing the very best in academic research, profes-
From Epitope Discovery to Patient Monitoring. Your Immune sional development and student learning. Our Immunology
Monitoring Partner: Beckman Coulter. Come see the latest solu- portfolio contains some of the leading journals in the field, in-
tions from Beckman Coulter that help you innovate, simplify and cluding Immunological Reviews, the official journals of the Brit-
automate your immune monitoring processes. From our revolu- ish Society for Immunology: Clinical and Experimental Immunol-
tionary iTopia Epitope Discovery System and iTAg MHC Tetram- ogy and Immunology , and the Scandinavian Journal of Immu-
ers to the IC 100 cellular imaging system, Quanta and FC 500 nology . Visit us at booth# 41, or browse our website
Series flow cytometry systems, as well as the A2 MicroArray at: www.blackwellimmunology.com
System, Beckman Coulter delivers complete Immune Monitoring
solutions. Learn more by visiting our booth. Bristol-Myers Squibb
345 Park Ave
Biacore, Inc. New York, NY 10154
200 Centennial Ave, Suite 100 Booth Number: 37
Piscataway, NJ 08854
Bristol-Myers Squibb welcomes you to Boston! We invite you to
Booth Number: 26 visit our exhibit and learn more about T-Cell Co-Stimulation. Bristol-
Biacore supplies analytical systems that improve productivity of Myers Squibb is a pharmaceutical and related health care prod-
research and development in the life science and pharmaceuti- ucts company whose mission is to extend and enhance human
cal markets. Unique data on protein interactions give insights life.
into protein functionality, the role of proteins in normal and dis-
eased states, and the influence of potential drug candidates. Cellular T echnology
echnology,, Ltd.-CTL
Technology
The company also provides ready-to-use solutions to determine 10515 Carnegie Ave.
food quality and safety. For more information, visit Cleveland, OH 44106
www.biacore.com Booth Number: 27
BioLegend, Inc. From academic roots, CTL has grown to become the world leader
8395 Camino Sante Fe, Suite E in ELISPOT development and automated image analysis. We
San Diego, CA 92121 provide scientifically validated ELISPOT products for all needs
Booth Number: 30 and budgets including the ImmunoSport Analyzer line,
ImmunoSpot Software with dual color, scanning, and analysis
At BioLegend, we are committed to providing world-class qual-
services, and contracted research. Seeing is believing! Visit our
ity research reagents and outstanding value. BioLegend fea-
booth and witness how CTL’s products can be an asset to your
tures antibodies/conjugates against human, mouse, and rat
laboratory. www.immunospot.com
covering the areas of cell immunophenotyping, cytokines and
chemokines, adhesion, phosphorylation, cancer research, cell-
cycle analysis, and apoptosis. BioLegend reagents’ applications
include flow cytometry, ELISA, ELISPOT, immunoprecipitation,
Western blotting, immunofluorescence microscopy, immunohis-
tochemistry, and in vitro/in vivo functional assays. BioLegend
offers a wide range of custom conjugation services to meet our
customers’ specific needs.
60
2005
ANNUAL MEETING
Exhibit Hall
Centocor
Centocor,, Inc. Dynal Biotech ASA
200 Great Valley Parkway Ullernchausjeen 52
Malvern, PA 19355 N-0379 OS6
Booth Number: 11-12 Norway
Centocor, a wholly owned subsidiary of Johnson & Johnson, Booth Number: 5-6
creates, acquires and markets biomedicines that benefit patients Dynal Biotech is the leading supplier of basic and clinical re-
and the healthcare community. Centocor is dedicated to research grade magnetic beads for human and mouse cell sepa-
searching and developing treatments for a wide range of im- ration and expansion. By coupling your own antibodies, you
mune mediated inflammatory disorders (I.M.I.D.) to help physi- can also isolate or deplete cells from a variety of samples.
cians deliver innovative treatments to improve health and re- Dynabeads bridge the gap from basic research methods, through
store quality of life. research & validation to routine applied ex-vivo immunotherapy.
Clinical-grade Dynabeads are versatile tools in clinical research
Clinical Immunology Society to separate viable cell populations. Come and see us at our
555 E. Wells Street booth.
Suite 1100
Milwaukee, WI 53202 EFORE (USA), Inc.
Booth Number: Foyer 6029 W. Campus Circle Drive
Irving, TX 75063
The Clinical Immunology Society (CIS) is the key inter-disciplin-
ary organization for the field of clinical immunology with the Booth Number: 28
mission to support and advance the community of immunologic EFORE (USA), Inc. is the distributor for Bio-Sys Bioreader and
scholars and physicians in education, research, and patient care. Biocount(r) in the United States and Canada. Bioreader’s are
Established in 1986, CIS is devoted to fostering developments used for counting Elispot and Colony Forming Units (CFU) as
in the science and practice of clinical immunology. CIS is an well as Plaque Assays. Bioreader@efore.com
international professional organization which includes 700 cli- Elispot:
nicians, investigators, and trainees. CIS has various program- * Diagnosis of genetic defects
ming objectives and is known worldwide for Educational Resi- * Allergic diseases
dential Seasonal Schools. * Autoimmune diseases
* Transplantation
DakoCytomation * Cancer research
4850 Innovation Drive * Acute inflammation, acute infectious diseases and septic shock
Fort Collins, CO 80525 Elsevier
Booth Number: 3-4 655 Avenue of the Americas
DakoCytomation A/S, headquartered in Copenhagen, Denmark, New York, NY 10010
is a leading cancer diagnostics company with a focus on per- Booth Number: 14
sonalized medicine. DakoCytomation offers systems solutions for
Elsevier publishes journals, books and reference works across
clinical laboratories and life science researchers, providing tests
immunology. Come to the booth to: Claim conference discounts
and instruments so that physicians can link diagnostic results to
on key book titles such as Measuring Immunity or the new edi-
specific therapies and optimize patient care. The privately held
tion of Mucosal Immunology; Discover the benefits to authors of
company has significant R&D and manufacturing activities in
publishing in our prestigious journals, such as Clinical Immunol-
Denmark, UK and USA, with operations in 20 countries, dis-
ogy; Human Immunology or Cytokine and pick up a free sample
tributors in 50+ countries and more than 1,300 employees.
of Trends in Immunology or Current Opinion in Immunology.
www.dakocytomation.com
61
2005
ANNUAL MEETING
Exhibit Hall
Grifols International SA Jackson ImmunoResearch Laboratories, Inc.
Department of Inflammation 872 West Baltimore Pike
200 Cambridge Park Drive PO Box 9
Cambridge, MA 02140 West Grove, PA 19390
Booth Number: 16-18 Booth Number: 31
Grifols has been working for health since 1940 creating inno- Affinity-purified secondary antibodies (many absorbed against
vative products and services based on the values of ethics and other species for multiple labeling) (see also our new anti-mouse
responsibility. The Bioscience Division develops quality plasma- IgG subclass specific antibodies), anti-digoxin, anti-biotin, anti-
derived therapies with outstanding records of safety and effi- FITC, streptavidin, and purified immunoglobulins are conjugated
cacy. Grifols’ plasma derivative production uses the most ad- with fluorophores (including Cy2, Cy3, and Cy5), enzymes, Bi-
vanced technology by a highly-qualified team— and all of this otin-SP , colloidal gold, phycoerythrin, and allophycocyanin.
with complete traceability of the entire process. Grifols plasma Monovalen Fab fragments are available for blocking endog-
derivatives are accompanied by PediGri: a commitment of com- enous Ig and for lableing two antibodies from the same host.
pletely transparent information to health professionals. Journal of Experimental Medicine
IgG America 1114 First Ave
34 Flint Street New York, NY 10021
Marblehead, MA 01445 Booth Number: 10
Booth Number: 42 The Journal of Experimental Medicine provides broad cover-
IgG America is a national specialty pharmacy that provides age in all research areas encompassing the host’s response to
immune globulin (IgG) services. IgG America provides immune disease. The topics covered include: hematopoiesis; infectious
globulin, supplies, pump/pole, pharmacy clinical monitoring, disease; inflammation; microbial pathogenesis; oncology; stem
and all nursing services required to administer IgG in the home cells; vaccines; vascular biology; and virology. With a high im-
and or alternate site settings. Please visit us at pact factor of 15.302 (2003 ISI® Journal Citation Reports®),
www.iggamerica.com or call toll-free 877-674-9700. the JEM is a leading life sciences journal in two ISI categories:
Immunology and Research & Experimental Medicine. The JEM
Immune TTolerance
olerance Network now has a free open archive of full-text, searchable PDF ver-
Suite 300 sions of all articles dating back to 1896, a new design, and
4800 Montgomery Lane new features including In This Issue overview and commentar-
Bethesda, MD 20814 ies/news.
Booth Number: 13
KRONUS, Inc.
The Immune Tolerance Network (ITN) aims to accelerate the 12554 W. Bridger St.
development of immune tolerance therapies in kidney, liver and Suite 108
islet transplantation, autoimmune diseases and allergy & asthma. Boise, ID 83713
The ITN solicits proposals for clinical trials and associated toler-
Booth Number: 32
ance assay studies from academic and industry-based research-
ers in a year-round, open call for proposals. The ITN is jointly KRONUS will be showcasing a variety of immunoassay test kits
sponsored by the NIAID, NIDDK and JDRF. More information for use by clinical and research laboratories to aid in the differ-
may be found at www.immunetolerance.org ential diagnosis and management of various autoimmune dis-
eases in the areas of Type 1 Diabetes, Celiac Disease, Addison’s
Disease, thyroid autoimmunity (including Grave’s Disease) and
Myasthenia Gravis/Lambert-Eaton Myasthenic Syndrome. Please
visit our exhibit to learn more about the complete line of KRONUS
products!
62
2005
ANNUAL MEETING
Exhibit Hall
LINCO Research, Inc. National Institute of Allergy and Infectious Dis-
14 Research Park Drive eases/National Institutes of Health
Saint Charles, MO 63304 4900 Seminary Road
Booth Number: 33 Suite 1100
LINCO Research is a recognized leader in the development Alexandria, VA 22311
and commercialization of multiplexed immunoassays for the Booth Number: 9
Luminex xMAP platform. LINCOplex multi-analyte panels are With nationwide responsibility for improving the health and well
available for cytokines/chemokines, as well as biomarkers for being of all Americans, the Department of Health and Human
the study of metabolic diseases (diabetes, obesity, cardiac dis- Services, (DHHS), oversees the biomedical research programs
ease). Several specialty panels are also available for analytes of the National Institutes of Health, (NIH), and those of NIH’s
related to bone, sepsis/apoptosis and skin. LINCO is also a research Institutes. NIAID is the second largest of 27 Institutes
well known provider of traditional RIA and ELISA kits for diabe- and Centers of the world-renowned National Institutes of Health,
tes and obesity. DHHS, the U.S. Government’s premier biomedical research in-
Luminex Corporation stitution. The 317-acre NIH campus is located in Bethesda,
12212 Technology Blvd. Maryland.
Austin, TX 78727 ProImmune, Inc.
Booth Number: 34 Oxford BioBusiness Center
Luminex Corporation develops, manufactures and markets pro- Littlemore Park
prietary biological testing technologies, with applications through- Littlemore, Oxford OX4 4SS
out the life-sciences industry. This industry depends on a broad Booth Number: 36
range of tests, known as “bioassays,” to discover new drugs, ProImmune is a leading provider of products and services for
identify new genes or simply monitor blood cholesterol levels. monitoring the state of the immune system, including recombi-
The experts at Luminex have developed an innovative approach nant Pro5TM MHC Pentamers, custom peptide libraries and
to bioassays, known as xMAP technology. This groundbreaking antibodies. Pro5TM MHC Pentamers can be used to evaluate T
technology, enables companies and laboratories to perform bio- cell immunity in disease and in response to therapy, enabling
assays more quickly and cost-effectively than with other systems, investigators to accelerate their research and the discovery and
without sacrificing accuracy. development of new biopharmaceutical drugs in areas of ma-
Miltenyi Biotec, Inc. jor unmet need, such as cancer, infectious diseases, autoimmu-
251 Auburn Ravine Road nity, and in transplantation.
Suite 208 SeraCare Life Sciences
Auburn, CA 95603 1935 Avenida Deloro
Booth Number: 35 Suite F
Miltenyi Biotec, manufacturer of MACS Separation Technology, Oceanside, CA 92056
supplies equipment and reagents for the immunomagnetic isola- Booth Number: 38
tion of specific cell types, organelles, and molecules from hetero- SeraCare offers a broad range of biological based materials
geneous samples. The CliniMACS system, approved in the Euro- and services, including clinical specimens used for target iden-
pean Union since December of 1997, is indicated for the purifi- tification, culture and media components, blood-derived base
cation of stem cells for the use in bone marrow transplantation. matrices, positive and negative control sera, and various puri-
fied proteins. Products featured will include our extensive bank
of specimens obtained from apparent ADR cases, with poten-
tial use in toxicogenomic and protein identification, and viable,
well-characterized cryopreserved human PBMC’s.
63
2005
ANNUAL MEETING
Exhibit Hall
THERAKOS Whatman/Schleicher & Schuell BioScience, Inc.
437 Creamery Way PO Box 2012
Exton, PA 19341 10 Optical Avenue
Booth Number: 39 Keene, NH 03431
Booth Number: 7-8
THERAKOS, Inc., an immune cell therapy company, is a world-
wide leader in extracorporeal disease management. THERAKOS Whatman/Schleicher & Schuell BioScience will feature the
Photopheresis, including the UVAR ® XTS ™ System and UVADEX company’s full line of protein array products and services, in-
® Methoxsalen Sterile Solution, IS approved for the palliative cluding the new S&S Two-Color Labeling and Fluorescent De-
treatment of skin manifestations in Cutaneous T-Cell Lymphoma, tection Kit. FAST Quant protein array kits and software for multi-
and is currently being studied in other immune mediated dis- plex cytokine quantification, FAST Slides and protein arraying
eases. kits, and a complete menu of protein arraying, processing and
scanning services.
Upstate
706 Forest Street
Charlottesville, VA 22903
Booth Number: 40
Upstate is a leading provider of cell signaling products and
services for research and drug discovery. Products include anti-
bodies, enzymes, siRNA and assay kits for signaling pathway
analysis, as well as a complete offering of cytokine, chemokine
and growth factor multiplex kits for the Luminex System.
64
2005
ANNUAL MEETING
FOCIS 2005 TTravel

ravel Award Recipients
Award
Biogen IDEC Bristol-Myers Squibb
Daniel Bandari Robert Axtell Anjelica Gonzalez
Halima El-Mouslimany Alicia Babcock Xiaonan Han
Steve Brass Estelle Bettelli Henry Hess
Ritika Jaini Tarek Fahmy Ali Jabbari
Anjali Shah Lisa Gilliam Andrew Johnston
Olaf Stuve Peggy Ho H. Kandil
Greg Wu Jing Hua Sonja Kierstein
Jennifer Huggins Brent Koehn
Boehringer Ingelheim Meghavi Kosboth Subramaniam Krishnan
Phillip Bardwell Kristi Kuhn Adam Lacy-Hulbert
S. Ben-Horin Paul Lizzul F. Li
Gilles Benichou Douglas McDonald Julie Lin
Swati Bhattacharyya Maki Nakayama Ralf Linker
Claudia Calder Christina Nance J. Listopad
V. Cotta-de-Almei Mindi Walker Peng Liu
P. Davis Kefei Yu Dalam Ly
Cory Ebeling Emma Masteller
Alexander Espinosa Dana Foundation Laurie Minns
Massimo Claudio Fantini Rebecca Ashfield Mohamad Mohty
Thomas Fehr Clare Baecher-Allen Koichiro Ohmura
Dan Frenkel K. Haanstra Georgios Papachristou
R. Gorczyski Fabienne Haspot B. Rethi
Brian Helmich Sally Kent Khaja Rheman
S. Kaieda Siegfried Kohler Chiara Romagnani
C. Kliwinski Stephen Miller Pedro Ruiz
Chun Lau Vivetka Oling Michael Shakarijan
I-Fang Lee Ken Sugimoto Nicole Sherry
D. MacKenzie Dale Umetsu Alla Skapenko
Everett Meyer Dusanka Skundric
Qin Ning FOCIS Jason Song
N. Phillips Marsilio Adriani Peter Sziglieti
J. Shen Florence Allantaz Henrik Toft-Hansen
Yasuyo Shimomura Jacqueline Benson Yue Wang
B. Shum Gaelle Beriou Bo Wei
Phillipe Stock Yijun Carrier Kristy Wolniak
Troy Torgerson D. Castano
M. Vargas-Rojas Miguel de La Fuente
Xiaochun Wan Scott DeGregorio
Vaughan Wittman F. Dolganiuc
Dianna Wu S. Dunn
Jun Yan Anna Eriksson
Simone Zehntner Ronald Germain
65
2005
ANNUAL MEETING
FOCIS 2005 TTravel

ravel Award Recipients
Award
Juvenile Diabetes National Multiple Sclerosis Society
Research Foundation Alexandra Degenhart
Damien Bresson Susan Gauthier
Christopher Moore Adil Javed
Yu Feng Peng Salvatore Napoli
Govinda Rajagopalan
Immune TTolerance
olerance Network
National Institutes Omid Akbari
of Health Martin Dahl
V. Bajzik Stephanie Dougan
Peter Barthmaier J. Harrt Meyers
S. Berlo Mary Keir
D. Cunningham-Graham Masaaki Niino
Silvia Deaglio Huey-Kang Sytwu
Raquel Deering Nalan Utku
Phillip DeJager Bart Van Wijmeersch
Leen DeRycke C. Wu
Umesh Deshmukh
Ivana Durinovic-Bello Novartis
R. Hoffman Elena Yarmola
Jean Jasinski Linda Wu
Jennifer Kanter
Norma Sue Kenyon Teva
Georges Maestroni Elizabeth Hodges
Cecilia Marta Ashutosh Mangalam
Riccardo Navone Kevin O’Connor
Roman Puliaev Daniel Li
K. Raman K. Sakuishi
Robert Rigby U. Salzer
Veerle Anne-Marie Somers Alicja Waliszewska
W. Walchholz Dun Zhou
J. Wang
Klau Warnatz
Maria Wysocka
Alexandra Zanin-Zhorov
FOCIS 2005 Par ticipation A

Participation ward Recipients
Award
Jeffrey Modell Foundation
Clara Bueno
Eva Carmona
Audrey Chen
66
2005
ANNUAL MEETING
Abstracts in Order of Presentation

Poster Session 1 F1.05 - Increased Experession in CD30+ and CD57+ Mol-
Friday
Friday,, May 13, 2005 ecules on CD4+ T Cells in Atopic Asthmatic Children: A Pre-
7:30 am - 1:30 pm liminar
liminaryy Repor t.
Report.
N. E. Martinez-Jimenez,1 E. Rojas-Ramos,1 Y. B. Garfias,2 E. G.
Allergy/Asthma Zenteno,2 R. L. Lascurain.2 1Clinical Immunology and Allergy,
F1.01 - Prevalence of Aeroallergens in Allergic Rhinitis. ISSSTE, Mexico, Mexico City, Mexico; 2Biochemistry, INER, SSA,
Mohammad Amin Kashef,1 Sara Kashef,2 Fardin Eghtedari.3 Mexico, Mexico City, Mexico.
1
Allergy Research Center, Shiraz University of Medical Sciences,
Shiraz, Fars, Islamic Republic of Iran; 2Immunology and Allergy, F1.06 - CCR3 Expressed on CD4+ T Cells Correlations with
Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Re- IL-4 Production in Allergic Rhinitis Patients. Preliminar
Preliminaryy Re-
public of Iran; 3Otolaryngology, Shiraz University of Medical port.
Sciences, Shiraz, Fars, Islamic Republic of Iran. E. Rojas-Ramos,1 M. N. Martinez-Jimenez,1 E. G. Zenteno,2 Y.
B. Garfias,2 R. L. Lascurain.2 1Clinical Immunology and Allergy,
F1.02 - Modulation of Immunological Functions of Mast Cells ISSSTE, Mexico, Mexico City, Mexico; 2Biochemistry, INER,SSA,
by Heat Shock. Mexico, Mexico City, Mexico.
E. Mortaz, F. A. Redegeld, M. W. Heijden, F. P. Nijkamp, H. R.
Wong, F. Engels. 1Dept. Pharmacology & Pathophysiology, F1.07 - Mugwort-Pollen Allergy Represents an Ideal Candi-
Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht, date for Peptide Immunotherapy
Immunotherapy..
Netherlands; 2Dept. Pharmacology & Pathophysiology, Institute B. Jahn-Schmid,1 G. F. Fischer,2 B. Bohle,1 F. Ferreira,3 C. Ebner.1
for Pharmaceutical Sciences (UIPS), Utrecht, Netherlands; 3Dept. 1Dept. of Pathophysiology, Medical University of Vienna, Vienna,
Pharmacology & Pathophysiology, Institute for Pharmaceutical Austria; 2Dept. of Blood Serology, Medical University of Vienna,
Sciences (UIPS), Utrecht, Netherlands; 4Dept. Pharmacology & Vienna, Austria; 3Department of Immunology and Allergology,
Pathophysiology, Institute for Pharmaceutical Sciences (UIPS), University of Salzburg, Salzburg, Austria.
Utrecht, Netherlands; 5Critical Care, Division of Critical Care
Medicine, Children’s Hospital Medical Center and Children’s
F1.08 - Characterization of Human Cord Blood-Derived In
Hospital, Cincinnati, OH, USA; 6Dept. Pharmacology & Patho-
physiology, Institute for Pharmaceutical Sciences (UIPS), Utrecht, Vitro Generated Mast Cells: Hemopoietic Antigens,
Netherlands. Chemokine Receptors, Activation Markers, TTetraspanins.
etraspanins.
I. Mirkina, T. Schweighoffer. RD-ADV, Novartis Institutes for
1
F1.03 - Naive CD4+ T Cell Activation by Antigen-Present- Biomedical Research, Vienna, Austria.
ing Air way Eosinophils.
Airway
H. Wang,1 P. F. Weller.1 1Division of Allergy and Inflammation, F1.09 - IL-4Ra Single Nucleotide Polymorphisms in Aller-
Beth Israel Deaconess Medical Center, Harvard Medical School, gic Bronchopulmonar
Bronchopulmonary y Aspergillosis.
Boston, MA, USA. Alan P. Knutsen,1
Barbara Kariuki,1 Manoj R. Warrier.2 1Al-
lergy/Immunology, Saint Louis University, St. Louis, MO, USA;
ming Growth Factor Beta-1 May Up Regulate Allergy/Immunology, Cincinnati Children’s Hospital, Cincinnati,
2
F1.04 - TTransfor
ransfor
ransforming
Interferon Gamma Production by Peripheral Blood Mono- OH, USA.
nuclear Cells from Asthmatics and Normal Controls.
J. Joseph,1 S. Benedict,1 M. Joseph,2 B. Al-Ramadi.3 1Internal
Medicine, Faculty of Medicine & Health Sciences, Al Ain,
Abudhabi, United Arab Emirates; 2Pediatrics, Al Ain Hospital,
Al Ain, Abudhabi, United Arab Emirates; 3Microbiology & Im-
munology, FAculty of Medicine & Health Sciences, Al Ain,
Abudhabi, United Arab Emirates.
67
=Poster of Distinction. Scored in TTop
op 10% of Poster Submissions.
2005
ANNUAL MEETING
F1.10 - House Dust Mite Allergen (Der p1 and Blo t5) Levels F1.15 - Exposure to Monomeric Human Myeloma IgE in the
in Asthmatics’ Home in Hong Kong. Absence of Known Specific Antigen Can Enhance Chemokine
Baoqing Sun, Adrian Wu, Nanshan Zhong. 1Dept of Medi- Production in In Vitro-Derived Human Mast Cells.
cine, Guangzhou Institute of Respiratory Deseases, Guangzhou, Adrian M. Piliponsky,1 Kentaro Matsuda,1 Motoyasu Iikura,1
GuangDong, China; 2Dept of Medicine, The University of Toshiaki Kawakami,2 Evelyn Wang,1 Mindy Tsai,1 Stephen J.
HongKong, HongKong, Hong Kong; 3Dept of Medicine, Galli.1,3 1Pathology, Stanford University School of Medicine,
Guangzhou Institute of Respiratory Deseases, Guangzhou, Stanford, CA, USA; 2Division of Cell Biology, La Jolla Institute for
GuangDong, China. Allergy and Immunology, San Diego, CA, USA; 3Microbiology
and Immunology, Stanford University School of Medicine,
F1.11 - House Dust Mite Allergen Der f Increase Bronchial Stanford, CA, USA.
Epithelial Cell Cytokine Expression.
Baoqing Sun, Nanshan Zhong. 1Dept of Medicine, Guangzhou F1.16 - Comparison of the Efficacy of Intranasal Phototherapy
Institute of Respiratory Diseases, Guangzhou, GuangDong, and Fexofenadine Hydrochloride for the TTreatment reatment of Sea-
China; 2Dept of Medicine, Guangzhou Institute of Respiratory sonal Allergic Rhinitis.
Diseases, Guangzhou, GuangDong, China. A. Koreck, Zs Csoma, M. Boros-Gyevi, L. Kemeny. 1Department
of Dermatology and Allergology, University of Szeged, Szeged,
F1.12 - D. pteronyssinus Extract-Treated Confluent A549 Cells Hungary..
Extract-Treated
(cA549) Secrete Mediators That Stimulate Human Pulmonar
Pulmonaryy F1.17 - Inhibition of the Peptidyl-prolyl Isomerase (PPIase)
Fibroblasts TTo
o Increase Secretion of V ascular Endothelial Pin1 Induces Caspase-3-Mediated Apoptosis of Human Pe-
Vascular
Growth Factor (VEGF). ripheral Blood Eosinophils.
A. Capetandes,1 M. Frieri.1 1Dept of Pathology, Division of Z. J. Shen,1 S. J. Esnault,1 J. S. Malter.1 1Pathology and Labora-
Allergy Immunology, Nassau University Medical Center, East tory Medicine, Waisman Center for Developmental Disabilities,
Meadow, NY, USA. University of Wisconsin, Madison, WI, USA.
F1.13 - Skin Reactivity for Aeroallergens and Peripheral Eosi- F1.18 - Natural CD25+CD4+ Regulator
Regulatoryy Cells Inhibit Pro-
nophilia in Children with Otitis Media with Effusion. liferation of CD25-CD4+ Cells from Naive or Immunized BALB/
Fardin Eghtedari,1 Hossein Mohammadi-Nik,1 Sara Kashef,1 c Mice When Stimulated by Dendritic Cells Pulsed with Fel d
Mohammad Hadi Imanieh,1 Farhad Handjani,1 Eskandar
1 or Major Fel d 1 T Cell Epitopes.
Kamali-Sarvestani,1 Marzieh Orouj.1 1Allergy Research Cen-
F. R. Hentges,1 C. A. Leonard,1 C. P. Le Pogam.1 1Laboratory of
ter, Shiraz University of Medical Sciences, Shiraz, Fars, Islamic
Immunogenetics and Allergology, CRP-Sante, Luxembourg, Lux-
Republic of Iran.
embourg.
F1.14 - Recurrent Angioedema by Blastocystis Hominis Suc-
F1.19 - Omalizumab Improves Asthma Outcomes Irrespec-
cessfully TTreated
reated with Paromomycin.
tive of Leukotriene Receptor Antagonist (LTRA) Use.
(LTRA)
D. Micheloud,1 J. Jensen,1 E. Fernandez-Cruz,1 J. Carbone.1
M. Massanari,1 Y. Deniz,2 R. Maykut,1 C. Reisner,3 G. Geba.1
1
Clinical Immunology Unit, University Hospital Gregorio Maranon, 1
US Clinical Development and Medical Affairs, Novartis Phar-
Madrid, Spain.
maceuticals Corporation, East Hanover, NJ, USA; 2Clinical De-
velopment, Genentech, South San Francisco, CA, USA; 3Clini-
cal Development, Novartis Pharmaceuticals, East Hanover, NJ,
USA.
68
2005
ANNUAL MEETING
F1.20 - Administration of Chitin Down-Regulate Serum IgE F1.25 - Anaphylaxis to Intravenous and Oral Cyclosporin in
Levels and Lung Eosinophilia in Ova-Albumin Allergic Mouse. a Child and Successful Desensitization.
C.-L. Kao,1 C.-R. Shen,1,2 C.-J. Lin,1 J.-K. Chen,3 M.-L. Kuo,2 C.-L. Sara Kashef,1 Mojhgan Kiani,2 Habib Nourani-Khojasteh,3 Mani
Liu.4 1Graduate Institute of Medical Biotechnology, Chang Gung Ramzi.3 1Allergy Research Center, Pediatric Immunology & Al-
University, Kweishan, Taoyuan, Taiwan; 2Graduate Institute of lergy, Shiraz University of Medical Sciences, Shiraz, Fars, Is-
Basic Medical Sciences, Chang Gung University, Kweishan, lamic Republic of Iran; 2Pediatric Immunology & Allergy, Shiraz
Taoyuan, Taiwan; 3Department of Environment and Biotechnol- University of Medical Sciences, Shiraz, Fars, Islamic Republic of
ogy, Refine and Manufacture Research Center, Chinese Petro- Iran; 3Department of Hematology & Oncology, Shiraz University
leum Company, Chiayi, Chiayi, Taiwan; 4Graduate Institute of of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran.
Engineering and Department of Biochemical Engineering, Ming-
Chi University of Technology, Taishan, Taipei, Taiwan. F1.26 - Skin Reactivity to Aeroallergens Is Not Related to the
Nasal Polyp Tissue Eosinophil Inflammation.
F1.21 - Allergic /T oxic Manifestations Associated with In-
/Toxic Fardin Eghtedari,1 Seyed Reza Cheraghzadeh,2 Sara Kashef,3
gestion of Stir-Fried/ Cooked Mushrooms. Ahmad Monabati,4 Elham Shoraka.5 1Allergy Research Cen-
M. Ishaq, I. M. Sameera, M. Taj. 1Allergy/Pulmonology, Al- ter, Department of Otolaryngology, Shiraz University of Medi-
Junaid Hospital, Nowshera, Pakistan. cal Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Depart-
ment of Otolaryngology, Shiraz University of Medical Sciences,
F1.22 - Effects of TTacrolimus
acrolimus Upon TT-L
-Lymphocyte, NK Cell,
-Lymphocyte, Shiraz, Fars, Islamic Republic of Iran; 3Allergy Research Center,
and Eosinophil Activation. Pediatric Immunology & Allergy, Shiraz University of Medical
C. N. Huynh,1 E. S. Lee,1 Q. N. Chung,1 M. A. Gibson,1 R. L. Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Department of
Roberts.1 1Department of Pediatrics, David Geffen School of Pathology, Shiraz University of Medical Sciences, Shiraz, Fars,
Medicine at UCLA, Los Angeles, CA, USA. Islamic Republic of Iran; 5Department of Obstetrics & Gynecol-
ogy, Shahid Beheshti Hospital, Shiraz, Fars, Islamic Republic of
Iran.
F1.23 - Hemopoietic Cells Accumulate in Murine Lungs in
Response to Ectopic Grafts of Lung Tissue from Allergic and
F1.27 - Superior Safety of Polymerized Allergen VVaccines:
accines:
from IL-5 TTransgenic
ransgenic Donors.
Zero Systemic Reactions during 55,000 Injections of Polymer-
M. I. Gaspar-Elsas, E. S. Maximiano, T. Q. Souza-Pinto, D. Jo-
seph, B. B. Vargaftig, P. Xavier Elsas. 1Pediatrics, Instituto ized Ragweed and Grass V accines in 500 Allergy Patients.
Vaccines
Fernandes Figueira - FIOCRUZ, Rio de Janeiro, RJ, Brazil; 2Im- S. Kagen, J. Zondlo, R. Muthiah, M. Kagen. 1Allergy - Immu-
munology, Inst. Microbiol. Prof. Paulo de Goes - UFRJ, Rio de nology, Kagen Allergy Clinic, Appleton, WI, USA.
Janeiro, RJ, Brazil; 3Pharmacology, Instituto de Ciencias
Biomedicas - USP, Sao Paulo, SP, Brazil; 4Unite Pharmacol. F1.28 - TTrans
rans Fatty Acid and Atopic Eczema/Der matitis Syn-
Eczema/Dermatitis
Cellulaire - U485 INSERM, Institut Pasteur Paris, Paris, Ile-de- drome: The Relationship with a Free Radical cis-trans Isomer-
France, France. ization of Membrane Lipids TTrans
rans LIPIDS in Atopic Der matitis.
Dermatitis.
L. Chini,1 F. Angelini,1 C. Chatgilialoglu,2 S. Dellonte,2 V.
F1.24 - Intracellular Stores of Interleukin-4 (IL-4) Receptor a Moschese,1 S. Corrente,1 R. Iannini,1 M. Chianca,1 P. Rossi,1 C.
L. A. Spencer,1 R. C.N. Melo,1,2 S. A.C. Perez,1 A. M. Dvorak,3 Ferreri.2 1Pediatrics, Policlinico Tor Vergata, University of Rome
P. F. Weller.1 1Department of Medicine, Beth Israel Deaconess Tor Vergata, Rome, Italy; 2ISOF, Consiglio Nazionale delle
Medical Center, Boston, MA, USA; 2Department of Biology, Fed- Ricerche, Bologna, Italy.
eral University of Juiz de Fora, Juiz de Fora, MG, Brazil; 3De-
partment of Pathology, Beth Israel Deaconess Medical Center,
Boston, MA, USA.
69
2005
ANNUAL MEETING
F1.29 - Proinflammator
Proinflammatoryy Cytokines and Nitric Oxide in Ex- F1.35 - Interleukin-4 and Its Alter natively Spliced V
Alternatively ariant
Variant
haled Breth Condensate in Monitoring of Exacerbation δ2) in Healthy Donors and Patients with Atopic Asthma.
(IL-4δ2)
(IL-4
Asthma in Children. A. A. Babakhin,1 E. I. Bateneva,1 S. M. Andreev,1 M. R. Khaitov,1
Boleslaw Kalicki,1 Anna Jung,1 Wanda Stankiewicz,2 Marek D. Y. Trofimov,1 L. P. Alekseev,1 L. M. DuBuske.2 1National Re-
Dabrowski,2 Janusz Zuber.1 1Paediatric, Military Medical Insti- search Center, Institute of Immunology, Moscow, Russian Fed-
tute, Warsaw, Poland; 2Immunology, Institute of Hygiene and eration; 2Immunology Research Institute of New England,
Epidemiology, Warsaw, Poland. Gardner, MA, USA.
F1.30 - Combined Skin Prick, Immediate Patch and Specific- F1.36 - B Epitope Assay of hIL-4 δ2, an Alternative Splicing
hIL-4δ2,
IgE TTesting
esting in the Diagnosis of Peanut Allergy in Children. Variant of hIL-4.
S. M. Andreev,1 I. V. Dubinkin,1 A. O. Petrukhina,1 A. M. Vasiliev,2
B. K. Wainstein,1 A. Yee,1 M. Ziegler,1 D. Jelley,1 J. B. Ziegler.1
1
Immunology and Infectious Diseases, Sydney Children’s Hospi- I. V. Kosarev,2 N. V. Tokhtamysheva,2 G. Y. Puchkova,2 A. A.
tal, Sydney, New South Wales, Australia. Babakhin,1 L. M. DuBuske.3 1NRC Institute of Immunology,
Moscow, Russian Federation; 2Institute of Immunological Engi-
F1.31 - Cow’
Cow’ss Milk Allergy in Infantile Colic. neering, Lyubuchany, Moscow Region, Russian Federation; 3Im-
Mohammad Hadi Imanieh,1 Hosein Moravej,1 Sara Kashef,1 munology Research Institute of New England, Gardner, MA,
Farhad Handjani, 1 Eskandar Kamali-Sarvestani, 1 Fardin USA.
Eghtedari,1 Marzieh Orouj.1 1Allergy Research Center, Shiraz
University of Medical Sciences, Shiraz, Fars, Islamic Republic of F1.37 - LPS Differentially Modulates Th2 Cell Responses to
Iran. Antigen during Acute and Relapse Allergic Asthma in Mice.
M. Zerbs,1 R. Bankoti,1 G. Dekan,2 G. Stingl,1 M. M. Epstein.1
F1.32 - 5-Lipoxygenase Locolization to Cytosolic Lipid Bod- 1Dermatology, Medical University of Vienna, Vienna, Austria;
ies in Rat Basophil Leukemia Cells.
2
Clinical Pathology, Medical University of Vienna, Vienna, Aus-
Z. Jin, D. Wan, H. B. Wang, I. Ghiran, R. J. Soberman, P. F.
1 1 1 1 2 tria.
Weller.1 1Division of Allergy and Inflammation, Beth-Israel Dea-
coness Medical Center, Harvard Medical School, Boston, MA, F1.38 - Differential Th2 Immune Responses in C57BL/6 and
USA; 2Massachusetts General Hospital, Harverd Medical School, BALB/c Mice in a Novel Model of Milk-Induced Allergic
Boston, MA, USA. Asthma.
M. Zerbs,1 G. Dekan,2 G. Stingl,1 M. M. Epstein.1 1Dermatol-
F1.33 - Approaches to Immunogenicity of Human Protein ogy, Medical University of Vienna, Vienna, Austria; 2Clinical
Products. Pathology, Medical University of Vienna, Vienna, Austria.
H. S. Ko.1 1Division of Hematology, Office of Blood Research
and Review, Center for Biologics Evaluation and Research, Food F1.39 - Response of Older Patients with Asthma to
and Drug Administration, Rockville, MD, USA. Omalizumab: A Pooled Analysis across 5 Clinical TTrials. rials.
R. J. Maykut,1 Y. Deniz,2 M. Massanari,1 C. Reisner,3 F. Kianifard,1
F1.34 - Plasma Concentration of Soluble IL-4 Receptor in G. P. Geba.1 1&2Clinical Development, Genentech, Inc., South
Asthma Patients during Specific Bronchial Challenge with San Francisco, CA, USA; 3CRD, Novartis Pharmaceuticals Cor-
Dermatophagoides Pteronyssinus(Dp) Allergen. poration, East Hanover, NJ, USA.
K. Kowal,1 A. Pampuch,1 L. M. DuBuske,2 A. Bodzenta-
Lukaszyk.1 1Department of Allergology and Internal Medicine, F1.40 - Development of a CD154-Dependent Model of IL-13
University Medical School of Bialystok, Bialystok, Poland; 2Im- Producing B Cells.
munology Research Institute of New England, Gardner, MA, O. Hajoui,1 J. Guay,1 S. Al-Tamemi,1,2 B. D. Mazer.1,2 1Meakins
USA. Christie Laboratories, McGill University, Montreal, QC, Canada;
2
Division of Allergy and Immunology, Montreal Children’s Hos-
pital, Montreal, QC, Canada.
70
2005
ANNUAL MEETING
F1.41 - Daclizumab Does Not Alter the Function of Healthy F1.48 - Vitamin E Supplementation Augments the Levels of
Human CD4+CD25+ Regulator y T Cell In V
Regulatory itro.
Vitro. Endogenous Antioxidants and Improves Lung Function in Asth-
T. Sornasse,1 Y. Zhang,1 W. Hong,1 D. Polakoff,1 V. V. Vexler.1 matic Patients.
1
Research, Translational Medicine, Protein Design Labs, Inc., Ahmed Nadeem, Sunil K. Chhabra, Hanumanthrao G. Raj.
Fremont, CA, USA. 1
Department of Biochemistry, Vallabhbhai Patel Chest
Institute,University of Delhi, Delhi, India; 2Department of Cardio-
F1.42 - Respirator
Respiratory y Exposure to OV OVAA Induce Functional Ef- respiratory Physiology, Vallabhbhai Patel Chest Institute,University
fector CD4 T Cells. of Delhi, Delhi, India.
B. Chiu,1 V. R. Stolberg,2 S. W. Chensue.1,2 1Pathologh, Univer-
sity of Michigan Medical School, Ann Arbor, MI, USA; 2Pathol- Bone Marrow or Stem Cell TTransplantationransplantation
ogy and Laboratory Medicine, VA Ann Arbor Healthcare Sys-
tem, Ann Arbor, MI, USA. F1.49 - Recover
Recovery y of CD4 and CD8 LLymphocyte
ymphocyte Subsets and
Their Impact on Acute Graft-vs. Host Disease (GVHD) after
F1.43 - A-317491 Inhibits the Activation of Guinea-Pig Pul- Reduced Intensity Conditioning (RIC) Allogeneic Stem Cell
monar
monary yV agal Sensor
Vagal Sensoryy Ner
Nerve er
ve TTer minals by α,β−
erminals methylene- Transplantation (allo-SCT).
α,β−methylene-
ATP
TP.. M. Mohty,1 D. Blaise,1 C. Faucher,1 D. Olive,1 B. Gaugler.1
A. Pelleg,1 B. J. Undem.2 1&2Asthma Center, Johns Hopkins Immunologie des Tumeurs, Insitut Paoli-Calmettes, Marseille,
1
University, Baltimore, MD, USA. France.
F1.44 – Abstract Withdrawn F1.50 - Cross-Presentation of Minor Histocompatibility Anti-

gens Requires Dendritic Cells and Immunoproteasomes.
F1.45 - Sodium Sulfite Activates Mast Cells and Basophils T. M. Hill,1 L. Van Kaer,1 J. W. Yewdell,2 D. C. Roopenian,3 S.
through Induction of Oxidative Stress. Joyce.1 1Microbiology and Immunology, Vanderbilt University
C. R. Collaco,1 D. J. Hochman,1 R. M. Goldblum,1 E. G. Brooks.1 School of Medicine, Nashville, TN, USA; Laboratory of Viral
2
1
Pediatrics, The University of Texas Medical Branch, Galveston, Diseases, National Institute of Allergy and Infectious Diseases,
TX, USA. National Institutes of Health, Bethesda, MD, USA; 3
The Jackson
Laboratory, Bar Harbor, ME, USA.
F1.46 - Structural Basis for Epitopes Sharing between Group
F1.51 - Permanent Mixed Chimerism in Mice by Short, Low
1 Allergens of Cedar Pollen.
Toxicity
oxicity,, Radiation Free TTreatment
reatment Allows Myoblast Allograft
T. Midoro-Horiuti,1 C. H. Schein,2 V. Mathura,2 W. Braun,2 E.
W. Czerwinski, 2 A. Togawa, 1 Y. Kondo, 1 T. Oka, 3 M. Tolerance across Fully MHC-Mismatched Barriers.
Watanabe,4 R. M. Goldblum.1 1Pediatrics, University of Texas L. Stephan,1 J. P. Tremblay.2 1Human Genetic, CRCHUL, Que-
Medical Branch, Galveston, TX, USA; 2Human Biological Chem- bec, QC, Canada; 2Human Genetic, CRCHUL, Quebec, QC,
istry and Genetics, University of Texas Medical Branch, Canada.
Galveston, TX, USA; 3Oka Pharmacy, Tamano, Okayama, Ja-
pan; 4Tokyo Research Laboratories, Kowa Co., Ltd., Noguchi, F1.52 - Neonatal CD4+ CD25+ T Cells – Age Restricted De-
Tokyo, Japan. olerance.
velopment of Immune TTolerance.
R. Reibke,1 B. Arnold,2 G. J. Hammerling.2 1Dept. of Internal
F1.47 - Food Allergy Related Hospitalizations New Y ork State Medicine III, University of Munich, Klinikum Grosshadern,
York
Hospitals from 1994-2003. Munich, Germany; 2Molecular Immunology, German Cancer
L. R. Forbes,1 R. Y. Lin.2 1Pediatrics, St. Vincent’s Medical Cen- Research Center, Heidelberg, Germany.
ter Manhattan, New York, NY, USA; 2Medicine, St. Vincent’s
Medical Center Manhattan, New York, NY, USA.
71
2005
ANNUAL MEETING
F1.53 - In Vivo Neutralization of Both Interferon Gamma (IFN- F1.59 - Distinct Effects of Early and Delayed CTLA4-Blockade
g) and Interleukin-2 (IL-2) Accelerates Anti-Host Cytotoxic T after Murine miHC-Disparate Allogeneic Bone Marrow TTrans- rans-
Lymphocyte (CTL) Development and Acute Graft-V ersus-Host
Graft-Versus-Host plantation: Graft-V ersus-Host Disease V
Graft-Versus-Host ersus Auto-Immunity
Versus Auto-Immunity..
Disease (GVHD) in the Parent-Into-F1 Model. S. Fevery,1 P. Vandenberghe,2 B. Sprangers,1 O. Rutgeerts,1 C.
I. A. Puliaeva,1 R. A. Puliaev,1 F. D. Finkelman,2 C. S. Via.1 Lenaerts,1 J. Goebels,1 C. Segers,1 W. Landuyt,3 L. Boon,6 A.
1
Pathology, Uniformed Services University of Health Sciences, Kasran,4 C. De Wolf-Peeters,5 M. Waer,1 A. D. Billiau.1 1Lab.
Bethesda, MD, USA; 2Medicine, University of Cincinnati Col- Experimental Transplantation, University of Leuven, Leuven, Bel-
lege of Medicine, Cincinnati, OH, USA. gium; 2Center of Human Genetics; 3Lab. Experimental Radio-
therapy; 4Lab. Experimental Immunology; 5Dep. Pathology, Uni-
y versity of Leuven, Leuven, Belgium; Bioceros NV, Amsterdam,
6
F1.54 - Role of Apoptotic Cells in the Induction of Regulator
Regulatory
Netherlands.
T Cells.
Kim A. Campbell, Amy Krutsick, Janine Huber, David Peritt.
1 1 1 1
1
Research & Clinical Development, Therakos, Inc., Exton, PA, F1.60 - Successful Bone Marrow TTransplantation
ransplantation in a Patient
USA. with WHIM Syndrome.
Y. Kamachi,1 Y. Nakamura,1 A. Hama,1 K. Kudo,1 A. Yoshimi,1
F1.55 - Distribution of CD4+25+ Cells in Fetal Sheep Early in N. Watanabe, I. Tsuge, S. Kojima. Pediatrics, Nagoya
1 2 1 1
University Graduate School of Medicine, Nagoya, Aichi, Ja-

Gestation.
pan; 2Pediatrics, Fujita Health University, Toyoake, Aichi, Japan.
Alireza Torabi,1 John S. Pixley,2 Jessica Chase, Esmail D.
Zanjani.1 1Department of Animal Biotechnology and Depart-
ment of Medicine, University of Nevada, Reno, Reno, NV, USA; F1.61 - Characterization and Depletion of Human PBMNC
2
VA Medical Center, University of Nevada, Reno, Reno, NV, Reactive with Murine Stimulator Cells.
USA. L. D. Fast,1 G. DiLeone,1 M. Chuck.1 1Department of Medicine,
Rhode Island Hospital/Brown University, Providence, RI, USA.
F1.56 - Clinical Relevance of Recipient Leukocyte Infusion
(RLI) Therapy
Therapy.. Poster Session 2
T. I. Saito,1 M. Sykes.1 1TBRC/BMT Section, Massachusetts Friday
Friday,, May 13, 2005
General Hospital, Boston, MA, USA. 3:30 pm - 7:30 pm
Reproductive Immunology
F1.57 - Anti-Mouse Thymocyte Globulin Administration Pre-
vents Acute Graft-versus-Host Disease in a Murine Model. F2.01 - Cytokines in the Placenta of Pakistani Newborns with
M. C. Ruzek,1 J. S. Waire,1 A. Vitsky,2 J. Williams,3 S. M. and without Intrauterine Growth Retardation.
Richards,1 R. D. Garman.1 1Immunology and Clinical Labora- M. Hahn-Zoric,1 S. Amu,1,2 A. Malik,2 R. Asraf,3 S. Zaman,4 I.
tory Sciences, Genzyme Corporation, Framingham, MA, USA; Kjellmer,5 H. Hagberg,6 L. Padyukov,1 L. A. Hanson.1 1Depart-
2
Pathology, Genzyme Corporation, Framingham, MA, USA; 3Im- ment of Clinical Immunology, Gothenburg University/Sahlgrenska
mune Mediated Diseases, Genzyme Corporation, Framingham, University Hospital, Gothenburg, Sweden; 2Department of Ob-
MA, USA. stetrics and Gynecology, King Edward Medical College, Lahore,
Pakistan; 3Department of Social and Preventive Pediatrics, King
F1.58 - IFN-Gamma Promotes LLymphohematopoietic
ymphohematopoietic GVH Re- Edward Medical College, Lahore, Pakistan; 4Department of
actions while Attenuating GVHD in Murine Allogeneic He- Social and Preventive Pediatrics, Fatima Jinnah Medical Col-
matopoietic Cell TTransplantation
ransplantation Models. lege/Sir Ganga Ran Hospital, Lahore, Pakistan; 5Perinatal Cen-
Hui Wang,1 Shumei Wang,1 Megan Sykes,1 Yong-Guang ter, Department of Pediatrics, Gothenburg University, Gothenburg,
Yang.1 1Bone Marrow Transplantation Section, Transplantation Sweden; 6Department of Obstetrics and Gynecology,
Biology Research Center, Boston, MA, USA. Gothenburg University, Gothenburg, Sweden.
72
2005
ANNUAL MEETING
F2.02 - Setup of IgG MAR Methods and Determination of the F2.06 - Prolonged Preterm Rupture of Fetal Membranes
Prevalence of Antisperm Antibodies in Semen of (PPROM), Is Associated with an Increased Maternal Anti-Fe-
Immunoinfertile. tal TT-Cell
-Cell Responsiveness.
Abdolreza Esmaeilzadeh, Mehri Ghasemi, Sudabeh A. Steinborn,1 C. Seidl,2 E. Schmitt,3 Y. Stein,1 A. Klee,4 M.
Esmaeilzadeh. 1Immunology, Zanjan Medicall Collage, Zanjan, Gonser,4 E. Seifried,2 C. Sohn.5 1Depart. Obstet. Gynecol.,
Zanjan, Islamic Republic of Iran; 2Zanjan University of MedicalUniversity of Frankfurt, Frankfurt/Main, Germany; 2Institute of
Scienc, Zanjan, Zanjan, Islamic Republic of Iran; 3Azad Uni- Transfusion Medicine and Immunohaematology, Blood Transfu-
versity of Bonab, Bonab, Azerbaijan e Shargi, Islamic Republic sion Center of German Red Cross, Frankfurt/Main, Germany;
of Iran. 3
Institute of Immunology, University of Mainz, Mainz, Germany;
4
Depart. Obstet. Gynecol., Dr. Horst-Schmidt Hospital,
F2.03 - Sildenafil Does Not Influence Natural Killer Cell Ac- Wiesbaden, Germany; 5Depart. Obstet. Gynecol., University
tivity in Women with a Histor
Women y of Recurrent Spontaneous of Heidelberg, Heidelberg, Germany.
History
Abortion.
M. Jerzak,1 M. Kniotek,2 N. Stachowicz,3 A. Gorski,2 W. F2.07 - ST STAAT3 Knock Down Reduces the Invasion of Chorio-
Baranowski. Department of Gynecology, Military Institute of carcinoma Cells.
1 1
Medicine, Warsaw, Poland; 2Department of Clinical Immunol- Tobias G. Poehlmann, Anja Meissner, Tobias Wengenmayer,
1 2 1
ogy, Transplantation Institute, University School of Medicine, Karlheinz Friedrich, Ekkehard Schleussner, Udo R. Markert.
2 1 1
Warsaw, Poland; 1st Department of Gynecology, University Obstetrics, Friedrich Schiller University, Jena, Germany; Bio-
3 1 2
Medical School, Lublin, Poland. chemistry, Friedrich Schiller University, Jena, Germany.
F2.04 - IgE Is Distributed on Macrophages Both in Human F2.08 - Evaluation of Four Different Methods of Sperm Sur-
and Murine TTererm Placentae.
erm face Antigens Extraction Using Biotinilated Sperm Due to Find-
J. Wang,1 X. Cui.2 1Department of Immunology and Cell Biol- ing a Better Method for ELISA TTechnique.
echnique.
ogy, School of Animal Health Science, Hebei Agricultural Uni- Asghar Talebian, Mohammad Reza Sadeghi. 1Reproductive
versity, Baoding, Hebei, China; 2Department of Medicine, Hos- Endocrinology, Avesina Research Center, Tehran, Tehran, Islamic
pital Affiliated to Xuanhua Iron and Steel Company Ltd, Republic of Iran; 2Reproductive Endocrinology, Avesina Research
Xuanhua, Hebei, China. Center, Tehran, Tehran, Islamic Republic of Iran.
F2.05 - Complement Activation as a Mediator of Recurrent F2.09 - The Changes of T LLymphocyte

ymphocyte CD Markers in Patients
Immunologically-T riggered Miscarriages.
Immunologically-Triggered Exposed to Mustard Gas.
G. Girardi,1 E. Chan,1 P. Redecha,1 J. M. Thurman,2 V. M. Minoo K. Adib,1 Fariborz Mokarian,2 Mohammad R. Azizy.1
Holers,2 J. Salmon.1 1Department of Medicine, Hospital for 1
Immunology, Medical School.Isfahan University of Medical Sci-
Special Surgery-Weill Medical College, Cornell University, New ences, Isfahan, Isfahan, Islamic Republic of Iran; 2Oncology,
York, NY, USA; 2Departments of Medicine and Immunology, Omid Hospital.Isfahan University of Medical Sciences, Isfahan,
University of Colorado HSC, Denver, CO, USA. Isfahan, Islamic Republic of Iran; 3Immunology, Medical
School.Isfahan University of Medical Sciences, Isfahan, Isfahan,
Islamic Republic of Iran.
F2.10 - Binding of Phage Displaying Multimeric CD147 on

U937 Cell Conducts Apoptotic Signal.
Nutjeera Intasai,1 Watchara Kasinrerk,1 Sabine Mai,2 Chatchai
Tayapiwatana.1 1Clinical Immunology, Fac of Associated Medi-
cal Sciences, Chiang Mai, Thailand; 2The Genomic Centre for
Cancer Research & Diagnosis, Manitoba Institute of Cell Biol-
ogy, Manitoba, Winnipeg, Canada.
73
2005
ANNUAL MEETING
F2.11 - Sensitivity of Soil Bacteria towards Cadmium Metal F2.17 - Cigarette Smoke Extract Impairs CD40 Ligand-Induced
and Its Effect on Moung Bean Plant. Maturation of Human Dendritic Cells.
Rafia Azmat, Aliya Hayat, Tanveer Khanum. 1Chemistry, Jinnah T. W. Barnes,1 P. R. Kroening,1 H. Kita,2 R. Vassallo.1 1Pulmo-
University for Women, Karachi, Sindh, Pakistan; 2Microbiology, nary and Critical Care Medicine, Mayo Clinic College of Medi-
Jinnah University for Women, Karachi, Sindh, Pakistan; 3Micro- cine, Rochester, MN, USA; 2Division of Allergic Diseases, Mayo
biology, Jinnah University for Women, Karachi, Sindh, Pakistan. Clinic College of Medicine, Rochester, MN, USA.
F2.12 - Surgical TTrauma

rauma and the Mannan-Binding Lectin (MBL) F2.18 - Isolation of Lactobacilli, Bacillus and Psuedomonas
Immunity..
Pathway of Innate Immunity from Y ogur
ogurtt and TTo
Yogur o Deter mine Their Bacteriocin Activity
Determine
H. Ytting,1 I. J. Christensen,1 S. Thiel,2 J. C. Jensenius,2 H. J. Against V arious Clinical Isolates.
Various
Nielsen.1 1Dept. of Surgical Gastroenterology, Hvidovre Uni- Tanveer Khanum, Nadia Noor, Nasra Jalil, Sadaf Hedayat.
versity Hospital, Hvidovre, Denmark; 2Institute of Medical Micro- 1
Microbiology, Jinnah University for Women, Karachi, Sindh,
biology and Immunology, University of Aarhus, Aarhus, Den- Pakistan; 2Microbiology, Jinnah University for Women, Karachi,
mark. Sindh, Pakistan.
F2.13 - The Theor

Theory y of Hemaimmune Reaction Road Map. F2.19 - Dendritic Cells Overexpressing FasL Induce Anti-T u-
Anti-Tu-
Guo Feng. 1Department of Blood Transfusion, Chang Hai Hos- moral TT-Cell -Cell Response In V ivo.
Vivo.
pital Second Military Medical University, Shanghai, China. Sofia Buonocore, Najate Ouled Haddou, Fabrice Moore,
Marianne Laporte, Frederic Paulart, Francoise Flemal, Kris
F2.14 - A Novel CD70+ APC Imprints a Unique Pattern of NK Thielemans, Michel Goldman, Veronique Flamand. 1Labora-
Receptors on Gut Mucosal CD8 T Cells. tory of Experimental Immunology, Institut d’Immunologie
A. Laouar,1 V. Haridas,1 R. A.W. van Lier,2 H. Yagita,3 N. Medicale (IMI), Brussels, Belgium; 2Dermatology Department,
Manjunath.1 1Dept. of Pediatrics, Harvard Medical School, Erasme Hospital, Brussels, Belgium; 3Laboraory of Physiology,
CBR Institute for Biomedical Research, Boston, MA, USA; 2Dept. Vrije Universiteit Brussel, Brussels, Belgium.
of Pediatrics, Harvard Medical School, CBR Institute for Biomedi-
cal Research, Boston, MA, USA; 3Dept. of Laboratory Immunol- F2.20 - CD8aa + TT-Cells -Cells Represent a Long-Lived Memor
Memory y
ogy, Academic Medical Center, Amsterdam, Amsterdam, Neth- T-Cell Subset in Patients with Melanoma Undergoing Epitope-
erlands; 4Dept. of Medicine, Juntendo University, Tokyo, Tokyo,
Based TTumor
umor V accination.
Vaccination.
Japan; 5Dept. of Pediatrics, Harvard Medical School, CBR Insti-
I. Magalhaes,1 N. K. Vudattu,1 K. Freitag,1 J. Karbach,2 A.
tute for Biomedical Research, Boston, MA, USA.
Kumar,3 Z. Zhu,3 K. Kuus-Reichel,3 M. Juelch,4 C. Castelli,5 E.
Jaeger,2 M. Maeurer.1 1Dept. of Medical Microbiology, Univer-
F2.15 - CAUSAL Protein Signaling Networks Derived from sity of Mainz, Mainz, Germany; 2Dept. of Hematology/Oncol-
Multiparameter Single-Cell Data. ogy, Krankenhaus Nordwest, Frankfurt, Germany; 3Immunomics
O. D. Perez, K. Sachs, D. Pe’er, D. Lauffenburger, G. P. Operation, Beckman Coulter Inc., San Diego, CA, USA; 4Thymed
1 2 3 2
Nolan.1 1Department of Microbiology and Immunology, Stanford GmbH, Mainz, Germany; 5Dept. of Immunotherapy of Human
University School of Medicine, Stanford, CA, USA; 2Biological Tumors, Istituto Tumori, Milano, Italy; 6Microbiology and Tumor
Engineering Division, Massachusetts Institute of Technology, Cam- Biology Center, Karolinska Institute, Solna, Sweden.
bridge, MA, USA; 3Department of Genetics, Harvard Medical
School, Boston, MA, USA.
F2.16 - Don’t Judge a Cell by Its Surface Only: Combina-

tion with Functional Assays.
D. T. Montag,1 M. T. Lotze.1,2,3 1Bioengineering, University of
Pittsburgh, Pittsburgh, PA, USA; 2Surgery, University of Pittsburgh,
Pittsburgh, PA, USA; 3Molecular Genetics and Biochemistry,
University of Pittsburgh, Pittsburgh, PA, USA.
74
2005
ANNUAL MEETING
F2.21 - Human Adipocyte and Its Participation in F2.26 - The Role of Mannose-Binding Lectin in Natural IgM
Innate Immunity
Immunity.. Mediated Ischemia/Reper fusion Injur
Ischemia/Reperfusion Injuryy.
Laurence Hoareau,1 Marie-Paule Gonthier,1 Regis Roche,1 Franck M. Zhang,1 K. Takahashi,4 E. M. Alicot,6 T. Vorup-Jensen,1 B.
Festy,1 Christian Lefebvre D Hellencourt,1 Maya Cesari,1 Jean- Kessler,2 J. Christian Jensenius,5 R.A. B. Ezekowitz,4 F. D. Moore,3
Pierre Riviere,2 Marie-Amedee Dijoux,2 Sandrine Bes-Houtmann.1 M. C. Carroll.1 1CBR Institute of Biomedical Research, Harvard
1
University of Reunion, LBGM, Saint Denis, Reunion, France; Medical School, Boston, MA, USA; 2Dept. of Pathology, Harvard
2
Laboratoire d’anapathologie, CHD Felix Guyon, Saint Denis, Medical School, Boston, MA, USA; 3Surgery, Brigham and
Reunion, France. Women’s Hospital, Boston, MA, USA; 4Dept. of Pediatrics, Mas-
sachusetts General Hospital, Boston, MA, USA; 5Dept. of Medi-
F2.22 - HDL-Reverse Cholesterol TTranspor
ranspor rans- cal Microbiology and Immunology, University of Aarhus, Aarhus
ransportt and Signal TTrans-
duction in TT-Cells.
-Cells. C, Denmark; 6DecImmune Therapeutics, Boston, MA, USA.
T. Fulop,1 A. Larbi,1 A. Khalil,1 N. Douziech,1 C. Fortin,1 G.
Dupuis.2 1Research Center on Aging, Universite de Sherbrooke, F2.27 - Effect of Plaferon LB on the Damaged Peripheral Ner Nerveve
Sherbrooke, QC, Canada; 2Deapartment of Biochemistry, Regeneration.
Universite de Sherbrooke, Sherbrooke, QC, Canada. T. Chikovani,1,2 M. Kvezereli,2 G. Burkadze,1 T. Giorgadze,2 V.
Bakhutashvili.2 1Microbilogy, Virology & Immunology, Tbilisi State
reatment Recurrent Herpes Simplex with Medical University, Tbilisi, Georgia; 2Biomedicine, Institute of
F2.23 - The Effect of TTreatment
Larifan. Medical Biotechnology, Tbilisi, Georgia.
Evita Niedrite, Ingmars Mikazans, Guna Feldmane, Arija
1 1 2
Volrate.2 1Dept. of Dermatovenereology, Riga Stradin’s Univer- F2.28 - Activation of the Lectin Pathway of Complement in
sity, Riga, Latvia; 2Institute of Microbiology and Virology, Riga, IgA Nephropathy
Nephropathy..
Latvia. M. R. Daha,1 M. P. Rastaldi,2 M. A. Seelen,1 J. W. Eijgenraam,1
B. D. Oortwijn,1 D. J. Van Gijlswijk - Janssen,1 M. C. Faber -
F2.24 - Multidimensional Liquid Phase Separations of Intact Krol,1 N. Calvaresi,2 M. Matsushita,3 T. Fujita,4 C. Van Kooten,1
Proteins as an Alternative to 2D Gel Electrophoresis for A. Roos. Department of Nephrology, Leiden University Medi-
1 1
cal Center, Leiden, Netherlands; 2Renal Immunopathology Cen-

Proteomics.
ter, Milan, Italy; 3Institute of Glycothechnology and Department
A. Apffel,1 A. Adler,1 T. Sana,1 J. Garcia,1 R. Kincaid,1 S.
of Applied Biochemistry, Tokai University, Hiratsuka, Japan; 4De-
Udiavar.1 1Molecular Technologies Laboratory, Agilent Labora-
partment of Biochemistry, Fukushima Medical University,
tories, Palo Alto, CA, USA.
Fukushima, Japan.
F2.25 - Screening of Immunostimulator
Immunostimulatory y Oligosaccharides
F2.29 - Characterisation of Antibody Titres in an Intravenous
by Using a New HPLC-Chip/MS TTechnology
echnology
echnology..
Immunoglobulin Concentrate (Flebogamma®).
R. Grimm,1 H. Yin,1 M. Ninonuevo,2 K. Killeen,1 C. Lebrilla.2
M. Lopez,1 J. I. Jorquera.1 1R&D Area, Instituto Grifols, S.A.,
1
Integrated Biology Solutions, Agilent Technologies, Palo Alto,
Parets del Valles, Barcelona, Spain.
CA, USA; 2Department of Biomedicine, UC Davis, Davis, CA,
USA.
F2.30 - FLEBOGAMMA® Intravenous Immunoglobulin; Evalu-
ation of Neutralizing Antibodies to Vaccinia V
Vaccinia irus.
Virus.
H. Biescas,1 R. Gajardo,1 A. Vandermeeren,2 M. Esteban,2 J. I.
Jorquera.1 1Research and Development Area, Instituto Grifols,
Barcelona, Spain; 2Centro Nacional de Biotecnologia, CSIC,
Campus Universidad Autonoma, Madrid, Spain.
75
2005
ANNUAL MEETING
F2.31 - Compatibility Study of TTwo wo Intravenous Immunoglo- F2.37 - Use of C1 Inhibitor Concentrate for TTreatment
reatment of An-
bulin Preparations with Plastic Containers. gioedema Attacks in Patients with C1 Inhibitor Deficiency
Deficiency..
M. Lopez,1 M. Costa,1 J. I. Jorquera.1 1R&D Area, Instituto Grifols,
Sur vey of 1102 Infusions in 503 Patients.
Survey
S.A., Parets del Valles, Barcelona, Spain. A. Zanichelli,1 L. C. Zingale,1 B. Cicardi,1 L. Maggioni,1 E.
Pappalardo,1 M. Cicardi.1 1Internal Medicine, University of
F2.32 - Peripheral Blood LLymphocyte
ymphocyte Immunological Profile Milan, Hospital S. Giuseppe, Milan, Milan, Italy.
of Patients with Autoimmune Hepatitis in Different Stages of
Immunosuppressive Therapy
Therapy.. F2.38 - Immunonutritional Assessment of Special Plasma’Plasma’ss
K. Gutkowski, M. Hartleb, A. Pluta, D. Gutkowska. Physio- Donors.
1
therapy Institute, Rzeszow’s University, Rzeszow, Poland; Osmel Gaspar Guerra Segura, Nerys Noa Rdguez. 1Immunol-
2
Gastroenetology Department, Medical University of Silesia, ogy Lab, Teach.and Gen. Hosp. Dr. A.Neto, Guantanamo,
Katowice, Poland; 3Physiotherapy Institute, Rzeszow’s Univer- Guantanamo, Cuba; 2Quality Control, Provincial Blood Bank,
sity, Rzeszow, Poland; 4Epidemiology Department, Center for Guantanamo, Guantanamo, Cuba.
Disease Control and Prevention, Rzeszow, Poland.
F2.39 - Presentation of the Human Hepatitis B Surface Anti-
F2.33 - Identifying Common “Innate Signature” from Gene gen – Loop by the Cpn10 Scaffold Induces a Specific Anti-
Expression Profile in Innate vs. Adaptive LLymphocytes.
ymphocytes. body Response in Mice by Genetic Immunization.
T. Yamagata,1 C. Benoist,1 D. Mathis.1 1Section on Immunology S. Neckermann,1 J. Lohrmann,2 W. Zimmermann.1 1Tumor Im-
and Immunogenetics, Joslin Diabetes Center, Boston, MA, USA. munology Laboratory, Department of Urology, University Clinic
Grosshadern, Ludwig-Maximilians-University, Munich, Germany;
F2.34 - Different O-glycosylated Structures Are Expressed in 2GENOVAC GmbH, Freiburg, Germany.
T Cell Activation.
Marisela Linares,1 Ma.Carmen Jimenez-Martinez,1 Blanca F2.40 - Angioedema without Urticaria in 929 Italian Patients:
Ortiz,2 Edgar Zenteno,2 Ricardo Lascurain.3 1Research Unit, Proposal for a Diagnostic and Therapeutic Approach.
Institute of Ophthalmology, Fundacion Conde de Valenciana, L. C. Zingale,1 L. Beltrami,2 A. Zanichelli,1 M. Cicardi.1 1Dpt of
Mexico, D.F., Mexico, D.F., Mexico; 2Biochemistry, Instituto Internal Medicine, University of Milan, Milan, Italy; 2Dpt of Car-
Nacional Enfermedades Respiratorias, Mexico, D.F., Mexico, diology, University of Milan, Milan, Italy.
D.F., Mexico; 3Biochemistry, Universidad Nacional Autonoma
de Mexico, Mexico, D.F., Mexico, D.F. F2.41 - Dynamic Control of T Cell Homing by Gut and Pe-
ripheral Dendritic Cells.
F2.35 - Shor t-T
Short-T er
t-Term Ator
erm vastatin TTreatment
Atorvastatin reatment Enhances Specific J. R. Mora,1 G. Cheng,1 D. Picarella,2 M. Briskin,2 N. Buchanan,2
Antibody Production Following TTetanus etanus TToxoid
oxoid Vaccination
Vaccination U. H. von Andrian.1 1CBRI, Harvard Medical School, Boston,
in Healthy V olunteers.
Volunteers. MA, USA; 2Millennium Pharmaceuticals, Cambridge, MA, USA.
P. Y. Lee,1 P. O. Scumpia,1 J. A. Byars,1 K. M. Kelly,1 H. Zhuang,1
D. Theriaque,1 J. Shuster,1 P. W. Stacpoole,1 M. S. Segal,1 W.
F2.42 - Isoation and Characterization of W ater Isolates for
Water
H. Reeves,1 M. L. Brantly.1 1General Clinical Research Center,
Bacteriocinogenic Activity
Activity..
University of Florida, Gainesville, FL, USA. Hina Waheed, Nazish Aziz, Tanveer Khanum, Kishwar Jabeen,
Saba Ali Imama, Hina Rahat, Aliya Hayat. 1Microbiology, Jinnah
F2.36 - An Immunology Syllabus to Student’
Student’ss Medicine. University for Women, Karachi, Sindh, Pakistan; 2Microbiology,
Osmel Gaspar Guerra Segura. Immunology Lab, Teach. and Same, Karachi, Sindh, Pakistan; 3Microbiology, Same, Karachi,
1
Gen. Hosp. Dr. A. Neto, Guantanamo, Guantanamo, Cuba. Sindh, Pakistan; 4Microbiology, Same, Karachi, Sindh, Pakistan;
5
Microbiology, Same, Karachi, Sindh, Pakistan.
76
2005
ANNUAL MEETING
F2.43 - Inhibition of Pericardic Adhesions by the Amoebian F2.49 - Protective Effect of Thalidomide in Rats with Granu-
Anti-Inflammator
Anti-Inflammatory y Pentapeptide (MLIF). Preliminar y Results.
Preliminary loma in the Cerebral Amygdala and Pentylenetetrazole-In-
J. A. Gimenez-Scherer,1 C. Riera-Kinkel,2 R. Silva-Garcia,1 M. duced Epilepsy
Epilepsy..
G. Rico Rosillo,1 J. Garcia,3 E. Foyo,3 E. Tena,3 R. Arguero,2 R.
L. Aguirre-Cruz,1 M. Martinez-Moreno,1 G. Palencia,1 N.
R. Kretschmer. 1 1Unidad de Investigacion Medica en Mendez-Mar,1 J. Manjarrez,2 R. Alvarado,2 E. Flores,3 M.
Inmunologia, H. Pediatria, Centro Medico Nacional Siglo XXI, Pacheco,3 P. Salgado,3 L. Rodriguez-Fragoso,4 J. Sotelo.1
IMSS, Mexico, DF, Mexico; 2Hospital de Cardiologia, Centro 1
Neuroimmunology Department, National Institute of Neurology
Medico Nacional Siglo XXI, IMSS, Mexico, DF, Mexico; 3Bioterio,and Neurosurgery (INNN), Mexico City, Mexico; 2Reticular For-
Centro Medico Nacional Siglo XXI, IMSS, Mexico, DF, Mexico. mation Physiology Laboratory, INNN, Mexico City, Mexico;
3
Magnetic Resonance Unity, INNN, Mexico City, Mexico; 4Phar-
F2.44 - Attenuation of the GAA-Specific Immune Response in macy Faculty, Autonomous University of Morelos, Cuernavaca,
6 neo/6neo GAA Knockout Mice, a Model of Pompe Disease. Morelos, Mexico.
K. J. Munroe,1 S. M. Richards,1 R. D. Garman,1 A. M. Joseph.1
1
&, Framingham, MA, USA. F2.50 - Self-Limitation of Th1-Mediated Inflammation by
Ig!õ
F2.45 - The Effect of Electro Active Dental Metal Fillings Re- M. Feuerer, K. Eulenburg, A. Hamann, J. Huehn. 1Exp. Rheu-
ymphocyte Activity in Patients with Oral Dis- matology, Charite Universitaetsmedizin Berlin, Berlin, Germany.
placement on LLymphocyte
comfort.
J. Prochazkova,1 S. Podzimek,1 M. Miksovsky,1 J. Bartova,1 K. F2.51 - Origin and Generation of Distinct CD4+ Regula-
Hana.2 1Clinical Department, The Institute of Dental Research, tor
toryy T Cell Subsets.
1st Medical Faculty and GUH, Charles University, Prague, Czech C. Siewert,1 K. Siegmund,1 M. Feuerer,1 L. Klein,2 A. Hamann,1
Republic; 2Research Department, The Institute of Biomedical Engi- J. Huehn. 1 1
Experimental Rheumatology, Charite
neering, Czech Technical University, Prague, Czech Republic. Universitaetsmedizin Berlin, Berlin, Germany; 2IMP/IMBA,
Vienna, Austria.
F2.46 - A Review of the Allergic /T oxic Adverse Reactions to
/Toxic
Anti-Tuberculous Drugs(A
Anti-Tuberculous TD), A 10 Y
Drugs(ATD), ears Therapeutic Sur
Years vey.. F2.52 - Correlation between Histamine and Mast Cells and
vey
Survey
M. Ishaq, Taj M. , I. M. Sameera. Allergy/Pulmonology, Al- Presence of IgE.
1
Junaid Hospital, Nowshera, Pakistan. Mandana Sattari,1 Shidehmehr Mofakham,1 Saeed Khalili.1
1
Immunology, Shaheed Beheshti University, Medical School,
F2.47 - Defective Intrathymic T Cell Development and Early Tehran, Islamic Republic of Iran.
Onset of IBD in Mice Devoid of W ASP and N-W
WASP ASP
ASP..
N-WASP
V. Cotta-de-Almeida,1,3 D. Onaldi,1 M. Maillard,1,4 F. W. Alt,2 F2.53 - Neutrophil Chemotaxis and Dental Caries.
S. B. Snapper.1 1Dept of Medicine, Massachusetts General Mandana Sattari,1 Saeed Khalili,1 Maryam Basirat.1 1Immu-
Hospital/Harvard Medical School, Boston, MA, USA; 2Dept of nology, Shaheed Beheshti University Medical Science, Tehran,
Genetics, Children’s Hospital/Harvard Medical School, Boston, Islamic Republic of Iran.
MA, USA; 3Dept of Cell Biology, Oswaldo Cruz Foundation, Rio
F2.54 - Correlation between Neuropeptides Concentration
de Janeiro, RJ, Brazil; 4Lausanne University Hospital, Lausanne,
Switzerland. and Different Parts of Human Gingiva and the Effects of Neu-
ropeptides on Neutrophil Death.
F2.48 - FFAS
AS Induced Apoptosis – A Model System for BiFARTM Mandana Sattari,1 Saeed Khalili.1 1Immunology Dept, Shaeed
BiFAR
Implementation. Beheshti University of Medical Science, Tehren, Islamic Republic
H. Kalinski, A. Chajut, A. Khan, R. Skaliter. 1Research and of Iran.
Development, Quark Biotech, Inc., Fremont, CA, USA.
77
2005
ANNUAL MEETING
F2.55 - Human MyD88s Is the Result of MyD88 Splicing like Poster Session 1
That Reported in the Mouse. Saturday,, May 14, 2005
Saturday
A. Dominguez,1 J. L. Ventura,2 A. Zentella,2 R. Kretschmer,1 J. R. 7:30 am - 1:30 pm
Velazquez.1 1Investigation in Medical Immunology, Instituto
Mexicano del Seguro Social CMNSXXI, Mexico City, DF, Mexico; Autoimmune Neurologic Diseases
2
Biochemestry, Instituto Nacional de Nutricion Salvador Zubiran, Sa1.01 - Receptor-Modified T Cells as Novel Therapeutic
Mexico City, DF, Mexico.
Approach for Multiple Sclerosis.
I. Moisini, T. L. Geiger. 1Pathology, St. Jude Children’s Research
F2.56 - Relationship of School Attendance with Quality of
Hospital, Memphis, TN, USA; 2Pathology, University of Tennes-
Life, Physical Function, Disease Activity and Damage in Pe- see Health Science Center, Memphis, TN, USA.
diatric Systemic Lupus Er ythematosus.
Erythematosus.
L. N. Moorthy,1 M. G. Peterson,2 M. J. Harrison,2 K. B. Onel,3 Sa1.02 - The Role of Leukemia Inhibitor Inhibitoryy Factor (LIF) in Ex-
M. J. Baratelli,1 D. R. Mohan,1 Thomas Lehman.2 1Robert Wood perimental Autoimmune Encephalomyelitis (EAE).
Johnson University, New Brunswick, NJ; 2Hospital for Special
R. A. Linker,1 A. Wieczarkowiecz,1 S. Weikard,2 N. Kruse,1 C.
Surgery, New York, NY; 3La Rabida Children’s Hospital, Chi-
Kleinschnitz,2 B. Holtmann,3 M. Sendtner,3 R. Gold.1 1Insitute
cago, IL.
for Multiple Sclerosis Research, University of Goettingen and
Gemeinnuetzige Hertie-Stiftung, Goettingen, Germany; 2Dept.
F2.57 - Improvement of Antimycobacterial Therapy Due to IL- of Neurology, Clinical Research Group for Multiple Sclerosis,
10 Activity Blockage Is Strain Dependent. University of Wurzburg, Wuerzburg, Germany; 3Institute for
S. Roque, C. Nóbrega, R. Appelberg, M. Correia-Neves.
1,2 1 1,3
Neurobiology, University of Wurzburg, Wuerzburg, Germany.
1
Laboratory of Microbiology and Immunology of Infection, Insti-
tute for Molecular and Cell Biology (IBMC), Porto; 2Mestrado Sa1.03 - Novel Immunotoxin: A Fusion Protein Consisting of
de Imunologia Clinica, Universidade da Beira Interior; 3Instituto Gelonin and an Acetylcholine Receptor Fragment as a Poten-
Superior de Saude do Alto Ave (ISAVE), Fontarcada, Portugal.
reatment of Myasthe-
tial Immunotherapeutic Agent for the TTreatment
F2.58 - Quality Control of DNA with the Agilent 2100 nia gravis. 1
M. Hossann, Z. Li,2 Y. Shi,2 U. Kreilinger,1 J. Buettner,1 P. D.
Bioanalyzer for Oligonucleotide Array CGH (aCGH).
Vogel,1 Y. Jingming,2 J. G. Wise,1 W. E. Trommer.1 1Chemistry,
Samar Lightfoot,1 Hans Brunnert,2 Carsten Buhlmann,2 Paige
TU Kaiserslautern, Kaiserslautern, Germany; 2Biotechnology,
Anderson.1 1Agilent Technologies, Palo Alto, USA; 2Agilent Tech-
Shanxi University, Taiyuan, China.
nologies, Waldbronn, Germany.
Sa1.04 - Fumarate Therapy Ameloriates Chronic Experimen-
F2.59 - Improvement of Antimycobacterial Therapy Due to IL-
tal Autoimmune Encephalomyelitis (EAE).
10 Activity Blockage is Strain Dependent
S. Schilling,1 S. Goelz,2 R. A. Linker,1 F. Luhder,1 R. Gold.1 1In-
S. Roque,1,2 C. Nóbrega, R. Appelberg,1 M. Correia-Neves.1,3
stitute for Multiple Sclerosis Research, University of Goettingen
1
Laboratory of Microbiology and Immunology of Infection, Insti-
and Gemeinnuetzige Hertie-Stiftung, Goettingen, Germany;
tute for Melecular and Cell Biology (IBMC), Porto; 2Mestrado 2
Biogen Idec, Cambridge, USA.
de Imunologia Clínica, Universidade da, Beira Interior; 3Instituto
Superior, de Saúde do Alto Ave, Fontarcada, Portugal.
Sa1.05 - Beneficial Autoimmunity Restrains Destructive Immu-
F2.60 - Somatostatins in Clinical Immunology: An Over view nity in a Regulator
Overview Regulatoryy Manner
Manner..
P.M. Van Hagen, V. Dalm, L.J. Hofland Dept. Internal Medicine Nathan Karin,1
Yaniv Zohar,1 Uri Weinberg,1 Rachel Anunu,1
and Immunology, Erasmus MC, Rotterdam, The Netherlands Gizi Wildbaum. Immunology, Rappaport Faculty of Medi-
1 1
cine, Technion, Haifa, Israel.
78
2005
ANNUAL MEETING
Sa1.06 - CD4+CD25+FoxP3+ Regulator

Regulatoryy T Cells Are a Highly Sa1.12 - Antibodies Specific for Myelin Proteolipid Pro-
Apoptosis Sensitive T Cell Population with an Impaired Sup- tein Are of Potential Pathogenic Relevance in Myelin
pressive Function in Multiple Sclerosis. Opsonization in Multiple Sclerosis.
B. Fritzsching,1,2 N. Oberle,1 N. Eberhardt,1 J. Haas,2 M. J. M. Greer,1 M. P. Pender.1 1School of Medicine, University of
Korporal,2 B. Wildemann,2 P. H. Krammer,1 E. Suri-Payer.1 1De- Queensland, Brisbane, Queensland, Australia.
partment of Immunogenetics, German Cancer Research Center,
Heidelberg, Germany; 2Section of Molecular Neuroimmunology, Sa1.13 - Autoantigen Specific T Cells Inhibit Glutamate Up-
Department of Neurology, University of Heidelberg, Heidelberg, take in Astrocytes by Decreasing Expression of Astrocytic
Germany.
Glutamate TTranspor
ranspor ter GLAST – A Mechanism Mediated by
ransporter
Tumor Necrosis Factor -a.
Factor-a.
Sa1.07 - Accumulation of CD4+CD25+ Regulator
Regulatory y T Cells
T. Korn,1 T. Magnus,2 S. Jung.1 1Department of Neurology,
in the CNS during Recover
Recovery y from EAE. Universitaet des Saarlandes, Homburg, Germany; 2Stem Cell
M. J. McGeachy,1 L. A. Stephens,1 S. M. Anderton.1 1Institute Section, Laboratory of Neurosciences, National Institute on Ag-
of Immunology and Infection Research, University of Edinburgh, ing, National Institutes of Health, Baltimore, MD, USA.
Edinburgh, United Kingdom.
Sa1.14 - The MHC Is the Major Determinant for the Require-
Sa1.08 - The Pathology of Progressive Multiple Sclerosis. ment of B7.1/7.2-Costimulation in the Induction of Experi-
A. E. Kutzelnigg,1 C. Lucchinetti,2 W. Brueck,3 M. Schmidbauer,4
H. Lassmann.1 1Department of Neuroimmunology, Brain Re- mental Autoimmune Encephalomyelitis (EAE).
search Center, Medical University Vienna, Vienna, Austria; 2De- B. Greve,1 C. Jabs Mansell,1 R. A. Sobel,2,3 A. H. Sharpe,4 V.
partment of Neurology, Mayo Clinic, Rochester, MN, USA; 3In- K. Kuchroo.1 1Center for Neurologic Diseases, Harvard Insti-
stitute of Neuropathology, University of Goettingen, Goettingen, tutes of Medicine, Brigham and Women’s Hospital, Boston, MA,
Germany; 4Department of Neurology, Municipal Hospital Lainz, USA; 2Laboratory Service, Veterans Affairs Medical Center, Palo
Vienna, Austria. Alto, CA, USA; 3Department of Pathology, Stanford University
School of Medicine, Stanford, CA, USA; 4Department of Pathol-
ogy, Harvard Medical School, Boston, MA, USA.
Sa1.09 - Endoneural CD34+ Fibroblasts: Putative Regulators
of Macrophage Activation in the Peripheral Ner ve?
Nerve?
Sa1.15 - Anti-CTLA4 scFv scFv,, a Single-Chain Antibody
Antibody,, Attenu-
A. Kroner,1 B. D. Kohl,1 I. Kobsar,1 R. Martini,1 M. Maeurer.1
1
Experimental Developmental Neurobiology, Julius Maximilians ated Host Humoral Immune Responses during Repeated DNA
University, Wuerzburg, Bavaria, Germany. Vaccination in Immune Competent Animals.
An-Bang Liu,1 Steve R. Roffler.2 1Neuromuscular Research, Tzu
Sa1.10 - Decreased TT-Cell
-Cell Immunity to Epstein-Barr V irus in Chi Neuro-Medical Scientific Center, Tzu Chi Medical Center,
Virus
Hualien, Taiwan; 2Institute of Biomedical Science, Academia
Multiple Sclerosis.
Sinica, Taipei, Taiwan.
M. P. Pender, A. Lenarczyk, J. M. Burrows, J. Harness, S. R.
Burrows. Medicine, The University of Queensland, Brisbane,
1
QLD, Australia; 2Queensland Institute of Medical Research, Sa1.16 - Memor Memory y CD4+ T Cells and EAE.
Brisbane, QLD, Australia. W. Elyaman, 1
T. Chitnis,1
J. Imitola,1 M. H. Sayegh,2 S. J. Khoury.1
1
Center for Neurologic Diseases, Brigham and Women’s Hospi-
tal, Boston, MA, USA; 2Transplantation Center, Brigham and
Sa1.11 - HLA-DR2 Is Associated with Chronic Inflammator
Inflammatory y
Women’s Hospital and Children’s Hospital, Boston, MA, USA.
Demyelinating Polyradiculoneuropathy (CIDP) in Females, but
Not Males. Sa1.17 - Therapeutic Effects of Glycosylated β Interferon
P. A. McCombe,1 P. A. Csurhes,1 M. A. Alizart,1 J. M. Greer.1
(βIFN) on Childhood Adrenoleukodystrophy (ALDCCER)
1
School of Medicine, University of Queensland, Brisbane,
G. A. Moviglia,1 A. E. Pereyra,1 G. S. Shuster,2 C. Ruggilo.2
Queensland, Australia. 1
Immunotherapy, Regina Mater Foundation, Buenos Aires, Ar-
gentina; 2MRI, Medical Image, Buenos Aires, Argentina.
79
2005
ANNUAL MEETING
Sa1.18 - Anti-Myelin Antibodies as an Immune-Modulator

Immune-Modulatory y Sa1.23 - Individual Statins Differ in Immunomodulator
Immunomodulatory y Po-
Marker for IVIG TTreatment
reatment in Patients with Progressive Mul- tential and Capability TToo TTreat
reat Th1-Mediated CNS Autoim-
tiple Sclerosis. mune Disease.
Sarah B. Kelley, Isaac Melamed, David Barr-Or. 1Immunology, M. J. Goldstein,1 M. S. Weber,2 S. E. Dunn,1 T. Prod’homme,2 L.
1st Immunology and Infusion Center, Englewood, CO, USA; 2Im- Steinman,1 S. S. Zamvil,2 S. Youssef.1 1Neurology, Stanford
munology, 1st Immunology and Infusion Center, Englewood, CO, University, Stanford, CA, USA; 2Neurology, University of Califor-
USA; 3Trauma Research Department, Swedish Medical Center, nia, San Francisco, CA, USA.
Englewood, CO, USA.
Sa1.24 - FMRI Correlates of Strategic Planning in Multiple
Sa1.19 - T Cell TTolerance
olerance Induced by Cross-Reactive TCR Sclerosis.
Ligands Can Be Broken by Superagonist Ligand Resulting in J. J. Randolph,1 H. A. Wishart,1 R. M. Roth,1 B. C. McDonald,1
Anti-Inflammator
Anti-Inflammatory y Cytokine Production. J. W. MacDonald,1 J. D. West,1 N. S. Koven,1 A. C. Mamourian,2
Z. Illes,1,2 H. Waldner,1 J. Reddy,1 E. Bettelli,1 L. B. Nicholson,1,3 L. H. Kasper,3 A. J. Saykin.1 1Department of Psychiatry, Dartmouth
V. K. Kuchroo.1 1Center for Neurologic Diseases, Harvard Medical School, Lebanon, NH, USA; 2Department of Radiol-
Medical School, Brigham and Women’s Hospital, Boston, MA, ogy, Dartmouth Medical School, Lebanon, NH, USA; 3Section
USA; 2Department of Neurology, University of Pecs, Pecs, Hun- of Neurology, Dartmouth Medical School, Lebanon, NH, USA.
gary; 3School of Medical Sciences, Bristol, United Kingdom.
Sa1.25 - A New Clinically Relevant Approach TTo o Expand
Sa1.20 - Agonistic Anti-CTLA4 Antibody Inhibits T Cells Myelin Specific T Cells.
Expansion, Cytokine Production and Development of Autoim- Nathalie Arbour,1 Rejean Lapointe,2 Philippe Saikali,1 Jack P.
munity
munity.. Antel.1 1Neuroimmunology Unit, Montreal Neurological Insti-
K. Miyamoto,1,3 L. Vijayakrishnan,1 E. Greenfield,1 B. Carreno,1 tute McGill University, Montreal, QC, Canada; 2Department of
A. Sharpe,2 V. Kuchroo.1 1Center for Neurolosic Diseases, BWH, Medicine, Faculty of Medicine, University of Montreal (Hospital
Harvard Medical School, Boston, MA, USA; 2Pathology, BWH, Centre Notre-Dame), Montreal, QC, Canada.
Harvard Medical School, Boston, MA, USA; 3Neurology, Kinki
University, Osaka-Sayama, Osaka, Japan. Sa1.26 - IL-15 and IL-2 Fusion Proteins Attenuate Experimen-
tal Autoimmune Encephalomyelitis.
Sa1.21 - TTumor Factor-- α Gene Polymorphism in C. Gutierrez,1 T. Chitnis,1 M. H. Sayegh,2 X. X. Zheng,3 S. J.
umor Necrosis Factor
Iranian Patients with Multiple Sclerosis. Khoury. 1Center for Neurologic Diseases, Brigham and Women’s
M. Izad,1 A. A. Amirzargar,1 D. Fathi,2 M. H. Niknam,1 M. Hospital, Boston, MA, USA; Transplantation Center, Brigham
2
Vodjgani.1 1Dep.of Immunology, Faculty of Medicine, Tehran and Women’s Hospital and Children’s Hospital, Boston, MA,
University of Medical Sciences, Tehran, Islamic Republic of Iran; USA; 3
Immunology, Beth Israel Deaconess Medical Center, Bos-
2
Dep. of Neurology, Shariati Hospital, Tehran University of Medi- ton, MA, USA.
cal Sciences, Tehran, Islamic Republic of Iran.
Sa1.27 - Dendritic Cells from the Mesenteric LLymph
ymph Nodes
Sa1.22 - Corticotropin-Releasing Hormone Contributes to the of OV
OVAA Fed Animals Stimulate Naïve T Cells In V itro TTo
Vitro o Ex-
Peripheral Inflammator
Inflammatory y Response in Experimental Autoim- press Latency-Associated Peptide.
mune Encephalomyelitis. Kaiyong Yang,1 Ana Faria,2 Howard L. Weiner.1 1Center for
Y. Wang,1 C. Benou,1 J. Imitola,1 L. VanVlerken,2 C. Chandras,2 Neurologic Diseases, Brigham and Women’s Hospital, Boston,
K. P. Karalis,2 S. J. Khoury.1 1Center for Neurologic Diseases, MA, USA; 2Departamento de Bioquimica e Imunologia,
Brigham and Women’s Hospital and Harvard Medical School, Universidade Federal de Minas Gerais, Brazil.
Boston, MA, USA; 2Division of Endocrinology, Children’s Hospi-
tal and Harvard Medical School, Boston, MA, USA.
80
2005
ANNUAL MEETING
Sa1.28 - Immature Dendritic Cells Can Reduce Experimental Sa1.34 - Intrathymic Expression of TTorpedo
orpedo Acetylcholine Re-
Autoimmune Encephalomyelitis in the Mouse. ceptor Alpha Subunit.
M. I. Iruretagoyena,1 S. E. Sepulveda,1 A. M. Kalergis.1 D. Song,1 Y. Zheng,1 A. I. Levinson.1 1Allergy/Immunology Sec-
1
Departamento de Genetica Molecular y Microbiologia, tion, University of Pennsylvania School of Medicine, Philadel-
Pontificia Universidad Catolica de Chile, Santiago, Chile. phia, PA, USA.
Sa1.29 - CD4+CD25+ Regulator

Regulatoryy T Cells Mediate Recover y
Recovery Sa1.35 - The Cytokine Pattern of Glatiramer Acetate Reactive
from Experimental Autoimmune Encephalomyelitis in Asso- CD8+ T Cell Lines Derived from MS Patients and Healthy V ol-
Vol-
ciation with LAP+TGF β Secreting Cells. unteers.
H. Ochi,1,2 X. Zhang,1,2 J. Reddy,1 D. Frenkel,1 V. K. Kuchroo,1 A. Dressel,1 A. Vogelgesang,1 S. Peters,1 F. Weber.2 1Depart-
H. L. Weiner.1 1Center for Neurologic Diseases, Department of ment of Neurology, University Greifswald, Greifswald, Germany;
Neurology, Brigham and Women’s Hospital, Harvard Medical 2
Section of Neurology, Max-Planck-Institute of Psychiatry, Munich,
School, Boston, MA, USA; 2Contributed Equally. Germany.
Sa1.30 - Genetic Markers of Disease Risk, Prognosis and Sa1.36 - An Exploration of the Role of TLR2 and TLR4 in CD14+
Treatment Response in Multiple Sclerosis. Cells in Multiple Sclerosis.
A. Foti,1 D. Lichter,1 J. Parekh,1 J. Bryce,3 G. Ginsburg,1 J. Lekstrom- P. L. De Jager, C. S. Wolfish, V. Viglietta, J. Flores, H. L. Weiner,
Himes,1 D. Hafler,2 P. DeJaeger,2 R. Roubenoff,1 S. Khoury,2 H. D. A. Hafler, S. J. Khoury. 1Neurology, Brigham and Women’s
Weiner,2 A. Parker.1 1Department of Molecular Medicine, Mil- Hospital, Center for Neurologic Diseases, Harvard Medical
lennium Pharmaceuticals, Inc., Cambridge, MA, USA; 2Depart- School, Boston, MA, USA;
ment of Neurology, Harvard Medical School, Boston, MA, USA;
3
Department of Clinical Operations, Millennium Pharmaceuti- Sa1.37 - Regulation of Expression of Matrix
cals, Inc., Cambridge, MA, USA. Metalloproteinases in CNS Inflammation V ersus CNS Injur
Versus y.
Injury
H. Toft-Hansen,1 A. A. Babcock,1 R. K. Nuttall,2 D. R. Edwards,2
Sa1.31 - Investigating Anti Human MOG Antibodies in Mul- T. Owens.1,3 1Neuroimmunology, Montreal Neurological Insti-
tiple Sclerosis Using Stably MOG TTransduced
ransduced Cell Lines. tute, McGill University, Montreal, QC, Canada; 2School of Bio-
Rajneesh Srivastava,1 Dun Zhou,1 Stefan Nessler,1 Sabine logical Sciences, University of East Anglia, Norwich, Norfolk,
Cepok,1 Hans-Peter Hartung,1 Bernhard Hemmer.1 1Department United Kingdom; 3Medical Biotechnology Center, University of
of Neurology, Heinrich-Heine-University Dusseldorf, Dusseldorf, Southern Denmark, Odense, Denmark.
NRW, Germany.
Sa1.38 - Searching for Biomarkers in Multiple Sclerosis: The
Sa1.32 - Role of CD46 in Multiple Sclerosis. Need for Natural Histor y Studies.
History
A. L. Astier,1 D. A. Hafler.1 1Center for Neurologic Diseases, Vissia Viglietta,1 Bonnie Glanz,1 Guy Buckle,1 Howard L.
Brigham and Women’s Hospital, Boston, MA, USA. Weiner,1 Samia J. Khoury.1 1Neurology, Brigham and Women’s
Hospital, Boston, MA, USA.
Sa1.33 - Myelin-Specific Cytokine Responses Show a Dra-
matic Gender Bias in Multiple Sclerosis (MS). Sa1.39 - Protection in a Rodent Model of Multiple Sclerosis
I. M. Moldovan,1 A. C. Cotleur,1 N. Zamor,1 J.-C. Lee,3 R. A. by Carbon Monoxide Release.
Rudick,2 C. M. Pelfrey.1 1Neurosciences, NC30, Cleveland Clinic M. V. George,1 S. Iyer,2 L. Gao,3 T. Fong,4 R. Buelow,5 D. J.
Foundation, Cleveland, OH, USA; 2Mellen Center for MS Treat- Matthes.1 1Biological Sciences, San Jose State University, San
ment and Research, Cleveland Clinic Foundation, Cleveland, Jose, CA, USA; 2Development Sciences, Genentech, South San
OH, USA; 3Biostatistics, Cleveland Clinic Foundation, Cleveland, Francisco, CA, USA; 3Research, Genzyme Corporation,
OH, USA. Framingham, MA, USA; 4Research, Cellerant Therapeutics, Palo
Alto, CA, USA; 5Research, Therapeutic Human Polyclonals,
Mountain View, CA, USA.
81
2005
ANNUAL MEETING
Sa1.40 - IFN γ−Dependent Regulation of the Neutrophil- Sa1.45 - Genetic Resistance to Autoimmunity Is Mediated
γ−Dependent
IFNγ−
Activating Cytokines IL-17 and IL18 in EAE. by Autoantigen-Specific CD4+CD25+ Regulator Regulatoryy Cells.
R. D. Wheeler,1 L. M. Kelly,1 S. L. Carter,1 T. Owens.1,2 J. Reddy, Z. Illes, X. Zhang, J. Encinas, J. Pyrdol, L. Nicholson,
1
Neuroimmunology Unit, Montreal Neurological Institute, R. Sobel, K. Wucherpfennig, V. Kuchroo. 1Center for Neuro-
Montreal, QC, Canada; 2Medical Biotechnology Center, Uni- logic Diseases, Brigham and Women’s Hosp/Harvard Medical
versity of Southern Denmark, Odense, Denmark. School, Boston, MA, USA; 2Cancer Immunology and AIDS,
Dana-Farber Cancer Institute, Boston, MA, USA; 3Pathology,
Sa1.41 - Differential Reactivity Against Solid-Phase and Liq- Stanford University School of Medicine, Stanford, CA, USA.
uid-Phase Myelin/Oligodendrocyte Glycoprotein in Multiple
Sclerosis and Experimental Allergic Encephalomyelitis. Autoimmune Rheumatologic Diseases
T. Menge, H.C. von Budingen, P. H. Lalive, S. L. Hauser, C. Sa1.46 - A 20 Y
1 2 1 1
ear Old with Knee Ar
Year thritis Develops Multiple
Arthritis
P. Genain.1 1Department of Neurology, University of California
Organ Dysfunction: Think Zebras, Not Horses.
San Francisco, San Francisco, CA, USA; 2Neurologische Klinik,
P. B. Pinho,1 M. Rodriguez,1 D. Menasha,1 B. Suri,1 M. Youseff-
Universitat Zurich, Zurich, Switzerland.
Bessler,1 B. Suri,1 R. K. Messo,2 L. Bielory.1 1Internal Medicine,
UMDNJ-NJMS, Newark, NJ, USA; 2Internal Medicine, Staten
Sa1.42 - Characterization of B Cell Immunoglobulin V ariable Island University Hospital, Staten Island, NY, USA.
Variable
Region Genes Derived from Muscle Tissue of Subjects with
Inclusion Body Myositis. Sa1.47 - Differential Expression of Co-Stimulator
Co-Stimulatory y Molecules
E. M. Bradshaw,1 L. Bregoli,1 A. A. Amato,2 D. A. Hafler,1 S. A. on PBMCs from Patients with Active Systemic Lupus Er ythe-
Erythe-
Greenberg,2 K. C. O’Connor.1 1Department of Neurology, matosus and Rheumatoid Arthritis.
Center for Neurologic Diseases, Brigham and Women’s Hospi-
E. Rojas-Ramos,1 N. E. Martinez-Jimenez,1 Y. B. Garfias,2 E. G.
tal, Boston, MA, USA; 2Department of Neurology, Division of
Zenteno,2 R. L. Lascurain.2 1Clinical Immunology and Allergy,
Neuromuscular Disease, Brigham and Women’s Hospital, Bos-
ISSSTE, Mexico, Mexico City, Mexico; 2Biochemistry, INER, SSA,
ton, MA, USA.
Mexico, Mexico City, Mexico.
Sa1.43 - Analysis of Genomic DNA from Human Single Cells
Sa1.48 - Effects of TTaxus
axus Y unnanensis for the Pain on Patients
Yunnanensis
Using Multiple Displacement Amplification: Application to B-
with Rheumatoid Arthritis.
and TT-Cell
-Cell Receptor Variable Region Genes.
Variable Testuroh Okano, 1 Koya Kubo, 1 Yutaka Tajima, 2 Osamu
L. Bregoli, K. O’Connor, D. A. Hafler. 1Center for Neurologic Nakajima,3 Takahiro Nobukawa.4 1Immunology/AHS, Kitasato
Diseases, Brigham and Women’s Hospital, Harvard Medical Univ, Sagamihara, Kanagawa, Japan; 2Infectiom Control Sci-
School, Boston, MA, USA. ences, Juntendo Univ, Bunkyo, Tokyo, Japan; 3Rheumatology,
Institute of Chem. Therapy, Chiba, Chiba, Japan; 4Med. Res.
Sa1.44 - Characterization of B Cell Immunoglobulin V ariable Institute, Kanazawa Med. Univ., Kanazawa, Isikawa, Japan.
Variable
Region Genes Derived from Lesions of Patients with MS.
K. C. O’Connor,1 N. H. Moore,1 L. Bregoli,1 E. Bradshaw,1 K. Sa1.49 - Protection from Collagen-Induced Arthritis by
Wucherpfennig,2 D. A. Hafler.1 1Department of Neurology, Complement Receptor CR2/CR1 Deficiency Deficiency..
Harvard Medical School, Brigham and Women’s Hospital, Bos- K. A. Kuhn,1 V. M. Holers.1 1Immunology and Medicine, Uni-
ton, MA, USA; 2Department of Cancer Immunology and AIDS, versity of Colorado Health Sciences Center, Denver, CO, USA.
Dana Farber Cancer Institute, Harvard Medical School, Boston,
MA, USA.
Sa1.50 - Leptin Modulates Autoimmune Reactivity in (NZB x
NZW)F1 Lupus Mice.
A. La Cava, F. M. Ebling, B. H. Hahn. 1Medicine/Rheumatol-
ogy, University of California Los Angeles, Los Angeles, CA, USA.
82
2005
ANNUAL MEETING
Sa1.51 - Hyperhomocysteinemia in Hughes Syndrome. Sa1.56 - Interferon-alpha Pathway Activation Identifies a Sub-
J. Carbone,1 A. Rodriguez-Huertas,2 E. Dulin,3 M. Rabadan,2 group of Systemic Lupus Er ythematosus Patients with Anti-
Erythematosus
E. Sarmiento,1 D. Micheloud,1 R. Mora,1 E. Fernandez-Cruz.1 bodies against RNA-Binding Proteins, Renal Disease, and
1
Clinical Immunology Unit, University Hospital Gregorio Maranon,
Low Complement.
Madrid, Spain; 2Hematology Department, University Hospital
K. A. Kirou,1 C. Lee,1 S. George,1 K. Louca,1 M. G.E. Peterson,1
Gregorio Maranon, Madrid, Spain; 3Biochemistry Department,
M. K. Crow.1 1Mary Kirkland Center for Lupus Research and
University Hospital Gregorio Maranon, Madrid, Spain.
Department of Medicine, Hospital for Special Surgery and Weill
Medical College of Cornell University, New York, NY, USA.
Sa1.52 - Atherosclerosis in Murine SLE.
Zhongjie Ma,1 Marc Monestier,2 Robert Eisenberg.1 1Depart-
Sa1.57 - The Rheumatic Joint Contains Hyperreactive CD28null
ment of Medicine, University of Pennsylvania, Philadelphia, PA;
Department of Microbiology and Immunology, Temple Univer- CD4 T Cells. 1
+
2
sity, Philadelphia, PA. A. E.R. Fasth, A.-K. Ulfgren,1 L. Klareskog,1 C. Trollmo,1 V.

Malmstrom.1 1Rheumatology Unit, Department of Medicine,
Karolinska Institutet, Stockholm, Sweden.
Sa1.53 - Association of a Single Nucleotide Polymorphism
of PTPN22 (1858C/T) with Rheumatoid Factor Positivity in a
Sa1.58 - Absence of B Cells Decreases Both Proliferation
Healthy Population.
and Cytokine Secretion.
K. D. Deane,1 L. A. Parrish,1 D. S. Majka,1 J. H. Buckner,2 V.
T. Wallerskog,1 L. Klareskog,1 V. Malmstrom,1 C. Trollmo.1 1Rheu-
Gersuk,2 P. Concannon,2 J. M. Norris,3 V. M. Holers.1 1Division
matology Unit, Department of Medicine, Karolinska Institutet,
of Rheumatology, University of Colorado Health Sciences Cen-
Stockholm, Sweden.
ter, Denver, CO, USA; 2Benaroya Research Institute at Virginia
Mason, Seattle, WA, USA; 3Deparment of Preventive Medicine
and Biometrics, University of Colorado Health Sciences Center, Sa1.59 - Synovial Fluid NKT Cells Display Different Proper-
Denver, CO, USA. ties Compared to Peripheral Blood NKT Cells in Rheumatoid
Arthritis.
Sa1.54 - Anti C1q, Anti Histone Antibodies and C1q Depos- L. Linsen, V. Somers, M. Thewissen, P. Geusens, J. Raus, P.
its in Silent Lupus Nephritis. Stinissen. 1Biomedisch Onderzoeksinstituut (BIOMED), Limburgs
M. E. Zabaleta-Lanz,1 L. E. Munoz,1 R. E. Vargas-Arenas,1 F. J. Universitair Centrum (LUC)/Transnational University Limburg (tUL),
Tapanes,1 N. E. Bianco.1 1Institute of Immunology, Central Uni- Diepenbeek, Belgium.
versity School of Medicine, Caracas, DF, Venezuela.
Sa1.60 - Regulation of Myeloid Cell Function and MHC Class
Sa1.55 - Modulation of Inflammation in Refractor y II Expression by TNF TNF..
Rheumathoid Arthritis by Granulocyte Apheresis: First Euro- R. B. Mueller,1
A. Skapenko,1 M. Grunke,1 J. Wendler,1 B.
Stuhlmuller, J. R. Kalden,1 H. Schulze-Koops.1 1Department of
2
pean Prospective Multicenter Open Pilot Study Study..
Internal Medicine III, University of Erlangen, Erlangen, Germany;
R. Sanmarti,1 R. Lafuente,2 J. Gratacos,3 J. Valverde,4 S. Marsal,5 2
Department of Rheumatology, Charite University Hospital, Ber-
E. Casado, D. Reina, J. Rodriguez, A. Erra. Rheumatol-
3 4 1 5 1
lin, Germany.
ogy, Hospital Clinic i Provincial, Barcelona, Spain; Intensive
2
Care Unit, Hospital De L´Hospitalet, Barcelona, Spain;

3
Rheumathology, Hospital Parc Tauli, Sabadell, Barcelona, Spain;
4
Rheumathology, Hospital de Bellvitge, Hospitalet de Llobregat,
Barcelona, Spain; 5Rheumathology, Hospital Vall d´Hebron,
Barcelona, Spain.
83
2005
ANNUAL MEETING
Sa1.61 - Isolated TType

ype 5 Antimitochondrial Autoantibodies Sa1.66 - Modulation of Murine Lupus by an Inhibitor
Inhibitoryy
Associated with Histor
Historyy of Thrombocytopaenia and Foetal GpG Oligonucleotide.
Loss. K. L. Graham,1 L. Y. Lee,2 P. Teo,1 L. Steinman,2 P. J. Utz,1 P. P.
Alvarez Silvia, Sanchez-Ramon Silvia, Rodriguez-Mahou Ho.2 1Department of Medicine, Division of Immunology and
Margarita, Carbone Javier, Gil Juana, Micheloud Dariela, Rheumatology, Stanford University School of Medicine, Stanford,
Fernandez-Cruz Eduardo. 1Immunology, University General CA, USA; 2Department of Neurology, Stanford University School
Hospital Gregorio Maranon, Madrid, Spain. of Medicine, Stanford, CA, USA.
Sa1.62 - FOXP3+ Regulator

Regulatory y T Cells in the Rheumatic Joint: Sa1.67 - The Phosphodiesterase Inhibitor Rolipram Facilitates
Contribution of Both CD25+ and CD25- T Cells. the Suppression of Antigen-Induced Arthritis in Mice by Oral
D. Cao,1 A.-K. Ulfgren,1 C. Trollmo,1 V. Malmstrom.1 1Dept of Administration of the Inducing Antigen.
Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Shin Yoshino,1 Kouya Yamaki,1 Yoshiki Harada.1 1Department
Sweden. of Pharmacology, Kobe Pharmaceutical University, Kobe, Hyogo,
Japan.
Sa1.63 - Increased Systemic and Local Expression of TToll- oll-
Like Receptor 2 and 4 in Spondyloarthropathy Is Sa1.68 - Therapeutic Response of Rituximab in a Patient with
umour Necrosis Factor alpha Blockade.
Downmodulated by TTumour Amyopathic Der matomyositis Refractor
Dermatomyositis Refractoryy to Methotrexate and
L. De Rycke,1 B. Vandooren,1 E. Kruithof,1 F. De Keyser,1 E. M. Cyclosporin.
Veys,1 D. Baeten.1 1Rheumatology, Ghent University Hospital, S. M. Fung, R. Herzog, Y. Padeh, A. Rubenstein. 1Division of
Ghent, Belgium. Allergy and Immunology, Albert Einstein College of Medicine,
Bronx, NY, USA.
Sa1.64 - IgM Anti-dsDNA Antibodies Are the Main Anti-
Nuclear Reactivity Induced by Infliximab but Not Etanercept Sa1.69 - Azathioprine Use but Not Hydroxycholorquine or
Treatment: Biological and Clinical Implications. Prednisone Use Is Associated with Lower CoronarCoronary y Ar ter
Arter
teryy
L. De Rycke,1 D. Baeten,1 E. Kruithof,1 E. M. Veys,1 F. De Keyser.1 Calcification Deter mined by Electron Beam Computed TTomog-
Determined omog-
1
Rheumatology, Ghent University Hospital, Ghent, Belgium. raphy (EBCT) in SLE Patients.
E. R. Gehrie,1 A. J. Cucchiara,1 E. Nackos,1 J. M. Von Feldt.1
Sa1.65 - High Serum Levels of Chemokines but Low Expres- 1Department of Rheumatology, University of Pennsylvania, Phila-
sion of Chemokine Receptors of Peripheral Blood Mono- delphia, PA, USA.
nuclear Cells in Juvenile Systemic Lupus Er ythematosus.
Erythematosus.
J.-L. Huang,1 C.-J. Lin,2,3 C.-L. Liu,4 T.-C. Yao,1 H.-Y. Chang,2 G.- Sa1.70 - Proteomic Analysis of Secreted Proteins Defines Sub-
W. Chen,2 C.-R. Shen.2 1Division of Rheumatology, Chang Gung types of Rheumatoid Arthritis.
Children Hospital, Kweishan, Taoyuan, Taiwan; 2Graduate In- W. Hueber,1,2 B. H. Tomooka,1,2 W. J. van Venrooij,3 P. J. Utz,1
stitute of Medical Biotechnology, Chang Gung University, M. C. Genovese,1 W. H. Robinson.1,2 1Division of Immunology
Kweishan, Taoyuan, Taiwan; 3Department of Loaboratory Medi- and Rheumatology, Stanford University School of Medicine,
cine, Mackay Memorial Hospital, Taipei, Taipei, Taiwan; Stanford, CA, USA; 2GRECC, VA Palo Alto Heath Care System,
4
Graduate Institute of Engineering and Department of Biochemi- Palo Alto, CA, USA; 3Department of Biocehmistry, Radboud
cal Engineering, Ming-Chi University of Technology, Taishan, University Nijmegen, Nijmegen, Netherlands.
Taipei, Taiwan.
Sa1.71 - Death Receptor 5 as a Therapeutic TTarget:
arget: Increased
Expression in B and T Cell Subsets in SLE.
R. H. Carter,1 S. Pandey,1 T. Zhou.1 1Dept. of Medicine, Univer-
sity of Alabama at Birmingham, Birmingham, AL, USA.
84
2005
ANNUAL MEETING
Sa1.72 - Immune Response to a Citrullinated Peptide of Fi- Sa1.76 - Characteristics of Patients with Clinical Manifesta-
brinogen in DR4 tg Mice Following Intra-Articular Injection tions of APS with Anti-beta 2 -Glycoprotein-I but Not
of Streptococcal Cell W all Antigen.
Wall Anticardiolipin Antibodies or Any Other Autoimmune Condi-
W. Brintnell,1 J. A. Hill,1 C. Nadasdy,1 D. A. Bell,1 E. Cairns.1 tion.
1
Department of Medicine, Division of Rheumatology and De- D. Micheloud,1 J. Carbone,1 S. Sanchez-Ramon,1 J. Lopez-
partment of Microbiology and Immunology, London Health Sci- Longo,2 A. Velastegui,1 J. Ruiz-Tiscar, 1 E. Sarmiento,1 E.
ences Centre, University of Western Ontario, London, ON, Fernandez-Cruz,1 M. Rodriguez-Mahou.1 1Autoimmunity Sec-
Canada. tion, Immunology Department, University Hospital Gregorio
Maranon, Madrid, Spain; 2Rheumatology Department, Univer-
Sa1.73 - Homozygous TType ype I C2 Deficiency and Immunoglo- sity Hospital Gregorio Maranon, Madrid, Spain.
bulin Deficiencies in a HLA-B27 Positive Y oung Girl Present-
Young
ing with an Antinuclear Antibody-Positive Juvenile Rheuma- Sa1.77 - TTranscriptional
ranscriptional Regulation of Fli1 and Lupus.
toid Arthritis. J. D. Fulton, 1
G. Gilkeson,1 T. Nowling.1 1Medicine, Rheuma-
G. Hauptmann,1 A. Meyer,2 B. Uring-Lambert,1 J. Goetz,2 I. tology Div., Medical University of South Carolina, Charleston,
Jahn,2 S. Finck,3 B. Cribier,4 D. Lipsker.4 1Centre de Recherche SC, USA.
d’Immunologie, Faculte de Medecine, Strasbourg, France;
2
Laboratoire d’Immunologie, Hopitaux Universitaires, Strasbourg, Sa1.78 - Chronic GVH-Like Disease in a Man Exposed to
France; 3Service de Pediatrie, Centre Hospitalier, Haguenau, Organic Solvents: Evidence for a Role of Microchimeric Cells
France; 4Service de Dermatologie, Hopitaux Universitaires, of Maternal Origin.
Strasbourg, France. A. de Lavareille,1 O. Michel,2 P. Heimann,3 E. Cogan,4 M.
Goldman,1 F. Roufosse.1,4 1Clinical Immunology Unit, Institute
Sa1.74 - The Combination of Complement Deficiency and for Medical Immunology, Erasme Hospital, Brussels, Belgium;
Cigarette Smoking as Risk Factor for Cutaneous Lupus Er ythe- 2Department of Internal Medicine, Saint Pierre Hospital, Brus-
Erythe-
matosus (CLE) in Men; a Focus on Combined C2/C4 Defi- sels, Belgium; Department of Medical Genetics, Erasme Hospi-
3
tal, Brussels, Belgium; 4Department of Internal Medicine, Erasme

ciency
ciency..
Hospital, Brussels, Belgium.
G. Hauptmann,1 P. Boeckler,2 M. Milea,2 A. Meyer,3 B. Uring-
Lambert,1 J. Goetz,3 B. Cribier,2 D. Lipsker.2 1Centre de Recher-
che d’Immunologie, Faculte de Medecine, Strasbourg, France; Sa1.79 - IgG Fc Receptor Polymorphisms Influence Suscepti-
2
Service de Dermatologie, Hopitaux Universitaires, Strasbourg, bility to Collagen-Induced Arthritis.
France; 3Laboratoire d’Immunologie, Hopitaux Universitaires, M. Andren, B. Johanneson, M. Alarcon-Riquelme, S. Kleinau.
1 2 2 1
Strasbourg, France.
1
Department of Cell and Molecular Biology, Uppsala Univer-
sity, Uppsala, Sweden; 2Department of Genetics and Pathol-
Sa1.75 - Pregnancy Outcomes in TTen en Japanese W omen with ogy, Uppsala University, Uppsala, Sweden.
Women
Mixed Connective Tissue Disease.
K. Abe, R. Matudaira, Y. Takasaki, H. Hashimoto. 1Internal
Medicine and Rheumatology, Juntendo University School of
Medicine, Tokyo, Japan.
85
2005
ANNUAL MEETING
Sa1.80 - Outcome of a National Israeli Cohort of Pediatric Sa1.84 - Synovial Fluid and Inflammator y Response in Rheu-
Inflammatory
Systemic Lupus Er ythematosus.
Erythematosus. matoid Arthritis.
Natalia Gorodnitsky,1 Pinhas Hashkes,2 Masza Mukamel,3 Shai Lj D. Petrovic-Rackov. 1Clinic for Rheumatology and Clinical
Padeh,4 Riva Brik,5 Judith Barash,6 Dror Mevorach,7 Yakov Immunology, Military Medical Academy, Belgrade, Belgrade,
Berkun,7 Tzvia Tauber,8 Joseph Press,9 Liora Harel,3 Pnina Serbia, Yugoslavia.
Navon,10 Yakov Naparstek,7 Yosef Uziel.1 1Pediatric Medical
Center, Meir Hospital, Kfar-Saba, Israel; 2Rheumatology, Cleve- Sa1.85 - Glycopeptides from TType ype II Collagen Incorporating
land Clinik, Cleveland, USA; 3Pediatric Medical Center, Galactosylated Hydroxylysine Mimetics TTo o Study the Fine
Schneider, Petach-Tikva, Israel; 4Pediatric Medical Center, Tel-
Specificity of Arthritogenic T Cells.
Ha Shomer Hospital, Ramat-Gan, Israel; 5Pediatric Medical
J. Marin,1 M.-A. Blaton,2 J.-P. Briand,1 G. Chiocchia,2 C. Fournier,2
Center, Rambam Hospital, Haifa, Israel; 6Pediatric, Kaplan
G. Guichard.1 1Immunologie et Chimie Therapeutiques (ICT),
Hospital, Rechovot, Israel; 7Rheumatology Center, Hadasa Hos-
UPR 9021 CNRS, Institut de Biologie Moleculaire et Cellulaire
pital, Jerusalem, Israel; 8Pediatric Medical Center, Asaf-Ha-Rofe
(IBMC), Strasbourg, France; 2Departement d’Immunologie,
Hospital, Lood, Israel; 9Pediatric Medical Center, Soroca Hospi-
Institut Cochin, INSERM U567, CNRS UMR8104, Universite Paris
tal, Beer-Sheva, Israel; 10Pediatric, Hadasa, Mt Scopus, Jerusa-
5, Paris, France.
lem, Israel.
Sa1.86 - CD8
CD8αα on Monocytes May Aggravate Immune-Com-
Sa1.81 - Dyslipoproteinemia in the Active Course of SLE: A
plex Mediate Disease by Binding MHC Clacc I and Enhanc-
Contributor
Contributory y Role for Anti-Double Stranded DNA Antibod-
ing TNF Production.
ies.
D. J. Gibbings,1 A. D. Befus.1 1Medicine, University of Alberta,
Sara Kashef,1 Mohammad Mehdi Ghaedian,2 Akbar Rajaee,3
Edmonton, AB, Canada.
Abbas Ghaderi.4 1Allergy Research Center, Pediatric Immunol-
ogy & Allergy, Shiraz University of Medical Sciences, Shiraz,
Sa1.87 - Anti-Cyclic Citrullinated Peptide and Anti-Sa Anti-
Fars, Islamic Republic of Iran; 2Shiraz Medical School, Shiraz
bodies for the Diagnosis of Rheumatoid Arthritis in an Out-
University of Medical Sciences, Shiraz, Fars, Islamic Republic of
Iran; 3Department of Rheumatology, Shiraz University of Medi-Patient Clinic of Chronic Inflammator y Connective TTissue
Inflammatory issue
cal Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Depart-
Diseases (CICTD).
ment of Immunology, Shiraz University of Medical Sciences, J.L. Ruiz-Tiscar,1 S. Sanchez-Ramon,1 D. Micheloud,1 A. Garcia-
Shiraz, Fars, Islamic Republic of Iran. Segovia,1 B. Santamaria,1 R. Urrea,1 M. Escalona,2 A. Estecha,2
J.L. Lopez-Longo,2 E. Fernandez-Cruz,1 M. Rodriguez-Mahou.1
ranscripts of Systemic Lupus 1Immunology, Gregorio Maranon Hospital, Madrid, Madrid,
Sa1.82 - Mutations in Gene TTranscripts
Er ythematosus (SLE) T LLymphocytes.
Erythematosus ymphocytes. Spain; 2Rheumatology, Gregorio Maranon Hospital, Madrid,
Dama Laxminarayana.1 1Section on Rheumatology and Clini- Madrid, Spain.
cal Immunology, Department of Internal Medicine, Wake Forest
University School of Medicine, Winston Salem, NC, USA. Sa1.88 - Evaluation of the Effect of Different Modified Extra-
cellular Matrix Proteins in the Inflammation and Extracellular
Sa1.83 - The Mechanism of Nasal TTolerance
olerance in Lupus Prone Matrix TTur
ur nover in Car
urnover tilage and Synovial TTissue
Cartilage issue Co-Cultures
Mice Is T Cell Anergy Induced by Immature B Cells That Lack from Patients with Osteoarthritis (OA) and Rheumatoid Ar-
B7 Expression. thritis (RA).
Henry Yim Wu, Alon Monsonego, Howard L. Weiner. 1Center O. Munoz-Chable,1 J. Alcocer-Varela,1 E. Diaz-Borjon,2 J. Bar-
for Neurologic Diseases, Brigham and Women’s Hospital & rios, 3 R. Hernandez-Pando, 3 J. Furuzawa-Carballeda. 1
Harvard Medical School, Boston, MA, USA. 1
Inmunologia y Reumatologia, Instituto Nacional de Ciencias
Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico;
2
Ortopedia; 3Patologia Experimental, Instituto Nacional de
Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City,
DF, Mexico.
86
2005
ANNUAL MEETING
Sa1.89 - Anti-alpha-Fodrin Antibodies of IgA Isotype in Pa- Sa1.94 - IL-1 Receptor Expression in Muscle Fibre Membrane
tients with Sjögren’
Sjögren’ss Syndrome (SS). and Muscle Cell Nuclei in Patients with Polymyositis or Der-
J.L. Ruiz-Tiscar, 1 S. Sanchez-Ramon, 1 D. Micheloud, 1 B. matomyositis.
Santamaria,1 R. Urrea,1 M. Escalona,1 A. Estecha,2 F.J. Lopez- I. E. Lundberg,1 C. Grundtman,1 C. Dorph,1 J. Burton,2 U.
Longo,2 E. Fernandez-Cruz,1 M. Rodriguez-Mahou.1 1Immu- Andersson,3 S. Salomonsson.1,2 1Rheumatology Unit, Depart-
nology, Gregorio Maranon Hospital, Madrid, Madrid, Spain; ment of Medicine, Karolinska University Hosptial, Solna,
2
Rheumatology, Gregorio Maranon Hospital, Madrid, Madrid, Karolinska Institutet, Stockholm, Sweden; 2Department fo Physi-
Spain. ology and Pharmacology, Karolinska Institutet, Stockholm, Swe-
den; 3Department of Woman and Child Health, Karolinska
Sa1.90 - TTumor
umor Necrosis Factor Genetic Polymorphism as University Hosptial, Solna, Karolinska Institutet, Stockholm, Swe-
Part of Rheumatoid Arthritis Evolution. den.
A. Cruzat,1 I. Schiattino,2 M. Cuchacovich,3 J. C. Aguillon.1
1
Disciplinary Program of Immunology, Faculty of Medicine. Uni- Sa1.95 - Increased Expression and Production of TTumor umor Ne-
versity of Chile, Santiago, Región Metropolitana, Chile; 2Health crosis Factor-Related Apoptosis Inducing Ligand (TRAIL) by T
Public School, Faculty of Medicine. University of Chile, Santiago, Cells from Lupus Patients Is a Feature of Active Disease.
Región Metropolitana, Chile; 3Rheumatology Section, University V. Rus,1 V. Zernetkina,1 R. Puliaev,3 S. Mathai,1 C. Cudrici,2 C.
of Chile Clinical Hospital. University of Chile, Santiago, Región S. Via.3 1Medicine, University of Maryland School of Medi-
Metropolitana, Chile. cine, Baltimore, MD, USA; 2Neurology, University of Maryland
School of Medicine, Baltimore, MD, USA; 3Pathology, Uniformed
Sa1.91 - Mannan Binding Lectin and Complement C4A in Services of the University Health Sciences, Bethesda, MD, USA.
Icelandic Multicase Families with Systemic Lupus Er ythema-
Erythema-
tosus. Sa1.96 - Intramuscular Administration of Polymerized TTypeype I
S. Saevarsdottir,1 H. Kristjansdottir,2 G. Grondal,2 T. Vikingsdottir,1 Collagen for the TTreatment
reatment of Patients with Rheumatoid Ar thri-
Arthri-
K. Steinsson,2 H. Valdimarsson.1 1Department of Immunology, tis. A Double Blind Placebo-Controlled Clinical TTrial. rial.
Landspitali University Hospital, Reykjavik, Iceland; 2Center for J. Furuzawa-Carballeda,1 J. Alcocer-Varela.1 1Immunology and
Rheumatology Research, Landspitali University Hospital, Rheumatology, Instituto Nacional de Ciencias Medicas y
Reykjavik, Iceland. Nutricion Salvador Zubiran, Mexico City, DF, Mexico.
Sa1.92 - Abnormal Dendritic Cell Activation in SLE. Sa1.97 - Clinical Characteristics of 88 Patients with Juvenile
H. Zhuang,1 D. C. Nacionales,1 S. Narain,1,2 E. Sobel,1,2 P. Y.
or Adult Dermatomyositis.
Lee,1 Jason B. Weinstein,1 K. M. Kelly,1 H. B. Richard,1,2 M.
Tamas Constantin,1 Andrea Ponyi,1,2 Katalin Molnar,3 Judit
Satoh,1,2 W. H. Reeves.1,2 1Division of Rheumatology & Clinical
Muller,1 Zsuzsanna Szalai,3 Gyorgy Fekete,1 Katalin Danko.2
Immunology, University of Florida, Gainesville, FL, USA; 2Center
1
2nd Department of Pediatrics Hungary, Semmelweis Univer-
for Autoimmune Disease, University of Florida, Gainesville, FL,
sity, Budapest, Hungary; 23rd Department of Internal Medicine,
USA.
Division of Clinical Immunology, University of Debrecen,
Debrecen, Hungary; 3Department of Dermatology, Heim Pal
ymphoma with Autoantibodies to Children’s Hospital, Budapest, Hungary.
Sa1.93 - Marginal Zone LLymphoma
RO52 in Sjogren’
Sjogren’ss Syndrome.
R. Lyons,1 M. Rodriguez,1 E.K.L. Chan,1 L. Yang,1 C. Stewart,1 Sa1.98 - Pre-B Cell Colony Enhancing Factor Stimulates Pro-
M. Satoh,1 W. H. Reeves.1 1Division of Rheumatology & Clini-
duction of Proinflammator
Proinflammatory y Mediators by Human Monocytes
cal Immunology, University of Florida, Gainesville, FL, USA.
and Is Overexpressed in Systemic Autoimmune Disease.
S. Liu,1 C. Lee,1 K. A. Kirou,1 M. K. Crow.1 1Mary Kirkland
Center for Lupus Research, Hospital for Special Surgery, New
York, NY, USA.
87
2005
ANNUAL MEETING
Sa1.99 - Mannose-Binding Lectin Polymorphisms in Rheuma- Sa1.105 - Efficacy of Apratastat, a Novel Dual Inhibitor of
toid Arthritis and the Associations with Radiological Progres- TNF-
TNF-aa Converting Enzyme/Metalloproteinase, in Murine
sion Rate and Serological Markers. Collagen-Induced Arthritis Models.
L. De Rycke,1 I. Peene,1 E. Kruithof,1 T. Van De Casteele,2 L. M. Hegen,1 Y. Zhang,1 J. Levin,2 J. Xu,3 T. Cummons,3 K.
Nuytinck,2 E. M. Veys,1 F. De Keyser.1 1Rheumatology, Ghent Harding,4 B. J. Sheppard,5 M. W. Leach,5 L. L. Lin,1 J. Gib-
University Hospital, Ghent, Belgium; 2Innogenetics, Ghent, Bel- bons,3 J. Skotnicki,2 C. L. Nickerson-Nutter.1 1Inflammation, Wyeth
gium. Research, Cambridge, MA, USA; 2Medicinal Chemistry, Wyeth
Research, Pearl River, NY, USA; 3Oncology, Wyeth Research,
Sa1.100 - Interferon Inducible Proteins Are Novel Pearl River, NY, USA; 4Bioresources, Wyeth Research, Cam-
Autoantigens in Systemic Lupus Er ythematosus.
Erythematosus. bridge, MA, USA; 5Exploratory Drug Safety, Wyeth Research,
D. L. Thibault,1 W. Hueber,1 T. Sylvester,1 D. Zeng,1 S. Strober,1 Andover, MA, USA.
P. J. Utz.1 1Department of Medicine, Division of Rheumatology
and Immunology, Stanford University, Stanford, CA, USA. Sa1.106 - Marginal Zone (MZ) B Cells Are Most Susceptible
to Loss of TTolerance
olerance in the Chronic GVH Model of SLE.
Sa1.101 - Estrogen Receptor Effects on the Anti-Inflammator
Anti-Inflammatoryy A. Choudhury, P. L. Cohen, R. A. Eisenberg. 1Medicine, Div of
Action of PP ARs in Lupus Mice.
PPARs Rheumatology, University of Pennsylvania, Philadelphia, PA,
J. L. Svenson, G. S. Gilkeson. Rheumatology, Medical Univ. USA.
1 1 1
of South Carolina, Charleston, SC, USA.

Sa1.107 - Elevated Levels of Anti-Oxidized Low Density Lipo-
Sa1.102 - Pathogenetic V race Ele- protein Autoantibodies Is Correlated with Disease Activity of
alue of the Disbalance TTrace
Value
ments under Systemic Sclerosis. Systemic Lupus Er ythematosus.
Erythematosus.
Andriy I. Mazepa, Mariya A. Mazepa, Ivan V. Mazepa.
1 1 1 Ruihua Wu, Guoqiu Shen, Robert Morris, Galina Lummer, John
1
Biochemistry, Medical Academy, Ivano-Frankivsk, Ivano- Sama, Allan Metzger. 1
R & D, RDL Reference Laboratory, Los
Frankivsk, Ukraine. Angeles, CA, USA.
Sa1.103 - Increased Granulopoiesis in Active SLE Blood: New Sa1.108 - Pediatric Systemic Lupus Er ythematosus (SLE) - Loss
Erythematosus
Insights into SLE Pathogenesis. olerance to Mater
of TTolerance nal Microchimerism?
Maternal
B. Vega, J. Borvak, A. Caldwell, V. Cantrell, J. Banchereau, V. A. M. Stevens,1 N. C. Lambert,2 H. M. Hermes,1 T. E. Erickson,2
J. L. Nelson.2,3 1Pediatrics, University of Washington, Seattle,
Pascual. 1Baylor Institute for Immunology Research, Baylor Insti-
tute for Immunology Research, Dallas, TX, USA. WA, USA; 2Immunogenetics, Fred Hutchinson Cancer Research
Institute, Seattle, WA, USA; 3Medicine, University of Washing-
Sa1.104 - Rheumatoid Factor Seropositivity in a Normal ton, Seattle, WA, USA.
Population Is Associated with the Use of Oral Contracep-
Sa1.109 - Hypogammaglobulinemia in a Pediatric Patient
tives and Cigarette Smoking.
D. S. Majka, S. Pande, K. D. Deane, L. A. Parrish, W. P. with Idiopathic Retroperitoneal Fibrosis TTreated
1 2 3 3 reated with
Arend, V. M. Holers, J. M. Norris. Division of Rheumatol- Tamoxifen.
3 3 2 1
ogy, Northwestern University, Feinberg School of Medicine, R. Tachdjian, R. L. Roberts, D. K. McCurdy. Allergy, Immu-
1 1 1 1
Chicago, IL, USA; Department of Preventive Medicine and Bio- nology and Rheumatology, UCLA School of Medicine, Los An-
2
metrics, University of Colorado Health Sciences Center, Denver, geles, CA, USA.
CO, USA; 3Division of Rheumatology, University of Colorado
Health Sciences Center, Denver, CO, USA.
88
2005
ANNUAL MEETING
Sa1.110 - Dendritic Cells Pulsed with TType

ype II Bovine Collagen Sa1.115 - Four Systemic Lupus Er ythematosus Autoantigens
Erythematosus
Modulate the Murine Collagen Induced Arthritis. Identified by HEp-2 Librar
Libraryy Screening.
L. E. Salazar,1 O. A. Aravena,1 P. Abello,2 A. Aguirre,1 D. A. D. Chang,1 L. Q. Tai,1 J. Nguyen,2 R. A. Gatti,2 D. K.
Catalan,1 C. Llanos,3 F. Sabugo,3 F. Gonzalez,1 C. Gonzalez,2 McCurdy.1 1Pediatric Allergy, Immunology, Rheumatology, Uni-
M. Cuchacovich,3 J. C. Aguillon.1 1Disciplinary Program of Im- versity of California,Los Angeles, Los Angeles, CA, USA; 2Pa-
munology, University of Chile; 2Program of Anatopatologic in thology, University of California,Los Angeles, Los Angeles, CA,
Veterinaria, University of Chile; 3Department of Rheumatologic, USA.
Hospital Clinic of University of Chile, Santiago, Chile.
Sa1.116 - Exploration of a Burn Medication for Potential Anti-
Sa1.111 - IL-12 Regulates Collagen-Induced Arthritis in DQ8 Inflammator
Inflammatory y Agent through Exter nal Application.
External
Mice through STSTAAT4-Dependent Mechanisms. Yuching Wu,1 Rany Ly,1 Wenhsiou Wu,1 Abdulrahman Ibrahim.2
V. Taneja, M. Behrens, H. S. Luthra, M. M. Griffiths, C. S. David. 1
Immunology, MYC, Inc., Irvine, CA, USA; 2Center for Virus Re-
1
Immunology, Mayo Clinic, Rochester, MN, USA; 2Immunology, search, The University of California at Irvine, Irvine, CA, USA..
Mayo Clinic, Rochester, MN, USA; 3Rheumatology, Mayo Clinic, ral usage to treat systemic inflammation.
Rochester, MN, USA; 4Medicine, University of Utah, Salt Lake
City, UT, USA; 5Immunology, Mayo Clinic, Rochester, MN, USA. Sa1.117 - Regulation of Autoimmune Arthritis by the Homolo-
gous Dominant Self and Cr yptic Mycobacterial Hsp65
Cryptic
Sa1.112 - Identification of Genes Participating in Suppres- Epitopes.
sion of Murine SLE by CD8+ Ti Cells. M. Durai,1 H. R. Kim,1 Y. Mia,1 E. Kim,1 K. D. Moudgil.1 1Mi-
R. P. Singh, F. M. Ebling, D. Elashoff, D. V. Sven, C. Zamber, D. crobiology and Immunology, University of Maryland School of
Patel, A. L. Cava, B. H. Hahn. 1Division of Rheumatology/ Medicine, Baltimore, MD, USA.
Medicine, David Geffen School of Medicine at UCLA, Los An-
geles, CA, USA; 2Dept. of Biosatstics, Haematology/Onccology, Sa1.118 - Both Chlordecone and Estrogen Enhance the Ger-
David Geffen School of Medicine at UCLA, Los Angeles, CA,
minal Center B Cell Reaction and Reduce the Splenic B Cell
USA; 3Research Department, Genome Explorations Inc., Mem-
phis, TN, USA. Apoptosis in Ovariectomized (NZB x NZW) F1 Mice.
F. Wang,1,2 S. M. Roberts,1,3 E. S. Sobel.2 1Department of Phar-
macology and Therapeutics, University of Florida College of
Sa1.113 - Impact of Gender on Immune Nephritis.
Medicine, Gainesville, FL, USA; 2Department of Medicine, Uni-
T. Henry, Y. Fu, J. Zhou, C. Mohan. 1Internal Medicine-Rheu-
versity of Florida College of Medicine, Gainesville, FL, USA;
matology, University of Texas Southwestern Medical Center, 3
Department of Physiological Sciences, University of Florida
Dallas, TX, USA.
College of Veterinary Medicine, Gainesville, FL, USA.
Sa1.114 - Use of Gene-Expression Profiling in Labial Sali-
Sa1.119 - IL10 Promoter Polymorphisms in Mexican Patients
var
varyy Glands Using cDNA Microarrays TTo o Identify New Patho-
with Spondyloarthropathies.
genic Pathways in Primar
Primaryy Sjögren’
Sjögren’ss Syndrome. G. Vargas-Alarcon,1 J.M. Rodriguez-Perez,1 G. Hernandez-
Jacques-Eric Gotttenberg,1 Carlo Lucchesi,2 Nicolas Cagnard,2 Pacheco,1 J. Londono,2 C. Pacheco-Tena,3 J. Granados,2 R.
Franck Letourneur,2 Sylvie Mistou, 2 Jean Sibilia, 3 Gilles Burgos-Vargas.3 1Physiology, Instituto Nacional de Cardiologia
Chiocchia,2 Xavier Mariette.1 1Rheumatology, INSERM E 109, Ignacio Chavez, Mexico City, Mexico; 2Immunology and Rheu-
Bicetre Hospital, Le Kremlin Bicetre, France; 2Immunology, Institut matology, Instituto Nacional de Ciencias Medicas y Nutricion
Cochin, Paris, France; 3Rheumatology, Strasbourg Hospital, Salvador Zubiran, Mexico City, Mexico; 3Rheumatology, Hospi-
Strasbourg, France. tal General de Mexico, Mexico City, Mexico.
89
2005
ANNUAL MEETING
Sa1.120 - Genetic Dissection of Congenital Heart Block in a Diabetes & Other Autoimmune
Rat Model. Endocrine Diseases
L. S. Horvath,1 S. Salomonsson,1 M. Jagodic,2 K. Becanovic,2
Sa1.125 - A Fractal Analysis of Binding and Dissociation
S.-E. Sonesson,3 T. Olsson,2 M. Wahren-Herlenius.1 1Depart-
ment of Medicine, Karolinska Institutet, Stockholm, Sweden; Kinetics of Connective Tissue Interstitial Glucose, Adipose
2
Department of Neuroimmunology, Karolinska Institutet, Tissue Interstitial Glucose and Related Analytes on Biosensor
Stockholm, Sweden; 3Department of Women and Child Health, Surfaces.
Karolinska Institutet, Stockholm, Sweden. A. M. Doke, A. Sadana. 1Chemical Enginnering, University of
Mississippi, University, MS, USA; 2Chemical Enginnering, Uni-
Sa1.121 - Identification of Disease Profiles for Rheumatoid versity of Mississippi, University, MS, USA.
Arthritis Using Antibody and Antigen Arrays.
David L. Hirschberg,1 Anya Tsalenko,1 Mark Westall,1 Bill Fisher,1 Sa1.126 - Serum Levels of Interleukin-16 in Patients with Newly
Bo Curry,1 Wolfgang Hueber, Orr Sharpe,2 Beren Toomoka,2 Diagnosed TType ype 1 Diabetes Mellitus.
Dorothy Yang,1 Artie Schleifer,1 Willy McAllister,1 William H. V. V. Popova,1 S. V. Melnichenko,1 T. N. Malinovskaya,1 K. P.
Robinson,2 Viorica Lopez-Avila.1 1Agilent Technologies Inc., Palo Zak,1 B. N. Mankovsky.1 1Diabetes, Institute of Endocrinology,
Alto, USA; 2. Stanford University School of Medicine, Division of Kiev, Ukraine.
Immunology and Rheunatology, Stanford, CA, USA.
Sa1.127 - Antigen-Based Therapies Utilizing Ignored De-
Sa1.122 - Development and V alidation of the Simple Mea- terminants of ß-Cell Antigens Can More Effectively Slow Late-
Validation
sures of Impact of Lupus Er ythematosus in Y
Erythematosus oungsters Stage Autoimmune Disease in Diabetes-Prone Mice.
Youngsters
(SMILEY ) Questionnaire.
(c)
Angelica P. Olcott,1 Jide Tian,1 Valerie Walker,1 Hoa Dang,1
L. N. Moorthy, M. G. Peterson, M. J. Harrison, K. B. Onel, Blake Middleton,1 Luciano Adorini,2 Lorraine Washburn,1 Daniel
1 2 2 3
M. J. Baratelli,1 D. R. Mohan,1 T. Lehman.2 1Robert Wood L. Kaufman.1 1Molecular and Medical Pharmacology, David
Johnson University, New Brunswick, NJ; 2Hospital for Special Geffen School of Medicine, UCLA, Los Angeles, CA, USA;
Surgery, New York, NY; 3La Rabida Children’s Hospital, Chi- 2BioXell, Milano, Italy.
cago, IL.
Sa1.128 - NKT Cells May Contribute to the
Sa1.123 - Relationship of School Attendance with Quality of Immunopathogenesis of Non-Alcoholic Steatohepatis.
Life, Physical Function, Disease Activity and Damage in Pe- Kazuto Tajiri,1 Yukihiro Shimizu,1 Yoshiharu Tokimitsu,1 Yasuhiro
diatric Systemic Lupus Er ythematosus.
Erythematosus. Nakayama,1 Katsuharu Hirano,1 Masami Minemura,1 Kazumi
L N Moorthy, M G Peterson, M J Harrison, K B Onel, D R Ebata,1 Toshiro Sugiyama,1 Koichi Tsuneyama.2 1Third Depart-
1 2 2 3
Mohan,1 Thomas Lehman.2 1Robert Wood Johnson University, ment of Internal Medicine, Toyama Medical and Pharmaceuti-
New Brunswick, NJ, USA; 2Hospital for Special Surgery, New cal University, Toyama, Japan; 2First Department of Pathology,
York, NY, USA; 3La Rabida Children’s Hospital, Chicago, IL, Toyama Medical and Pharmaceutical University, Toyama, Ja-
USA. pan.
Sa1.124 - Development and V alidation of the Simple Mea- Sa1.129 - Pro-Apoptotic DNA V
Validation accination as a Therapy
Vaccination
sures of Impact of Lupus Er ythematosus in Y
Erythematosus oungsters for TType
Youngsters ype 1 Diabetes.
(SMILEY©) Questionnaire. A. Li, O. Ojogho, E. Franco, P. Baron, W. Concepcion, A. Escher.
L N Moorthy, M G Peterson, M J Harrison, K B Onel, M J
1 2 2 3 1
Transplantation Institute for Molecular and Translational Medi-
Baratelli, D R Mohan, T Lehman.
1 1 2 1
Robert Wood Johnson cine, Loma Linda University, Loma Linda, CA, USA.
University, New Brunswick, NJ, USA; Hospital for Special Sur-
2
gery, New York, NY, USA; 3La Rabida Children’s Hospital, Chi-
cago, IL, USA.
90
2005
ANNUAL MEETING
Sa1.130 - Increased β Cell Replication with Onset of Dia- Sa1.135 - The Role of Cytomegalovirus Infection in the
betes and after Induction of Immune TTolerance
olerance in the NOD Development of TTypeype 1 Diabetes-Associated Autoimmunity in
Mouse. HLA-Susceptible Children.
N. A. Sherry,1 M. Glandt,2 Y. Liu,1 A. M. Brillantes,2 K. Herold.2
J. Aarnisalo,1,2 O. Simell,1,3 M. Knip,1,4 J. Ilonen.1,2 1JDRF Cen-
1
Pediatrics, Columbia University, New York, NY, USA; 2Medi- ter for Prevention of Type 1 Diabetes in Finland, Finland; 2De-
cine, Columbia University, New York, NY, USA. partment of Virology, University of Turku, Turku, Finland; 3De-
partment of Pediatrics, University of Turku, Turku, Finland; 4Hos-
Sa1.131 - A Subset of Insulin and Glucagon Positive Cells pital for Children and Adolescents, University of Helsinki, Helsinki,
Sur vives Destruction in “Older” Female NOD Mice.
Survives Finland.
M. Nakayama, N. Babaya, T. Still, E. Liu, R. Gianani.
1 1 1 1 1
1
Barbara Davis Center for Childhood Diabetes, University of Sa1.136 - Rotavirus-Specific TT-Cell -Cell Responses and TType ype 1
Colorado Health Science Center, Denver, CO, USA. Diabetes (T1D): No Evidence for Interrelationship.
M. Makela,1,2 J. Marttila,1,2 M. Knip,1,3,4 O. Simell,1,5 J. Ilonen.1,2
Sa1.132 - PDL1 Regulates Autoimmunity by Limiting Ex- JDRF Center for Prevention of Type 1 Diabetes in Finland, Fin-
1
pansion of Autoreactive Th1 Cells and Mediates Resistance land; Department of Virology, University of Turku, Turku, Fin-
2
land; 3Hospital for Children and Adolescents, University of

to Diabetes in NOD Mice.
Helsinki, Helsinki, Finland; 4Department of Pediatrics, Tampere
I. Guleria,1 S. Eckenrode,2 M. J. Ansari,1 M. Azuma,3 M.
University Hospital, Tampere, Finland; 5Department of Pediat-
Atkinson,4 J. She,2 M. H. Sayegh.1 1Transplantation Research
rics, University of Turku, Turku, Finland.
Center, Brigham and Women’s Hospital and Children’s Hospi-
tal Boston, Harvard Medical School, Boston, MA, USA; Medi-
2
cal College of Georgia, Augusta, GA, USA; 3Tokyo Medical Sa1.137 - The Possible Biochemical TTargets argets of Altered
and Dental University, Tokyo, Japan; University of Florida, Col- Opioid Mediated Nocicpetion at Diabetes Conditions.
4
lege of Medicine, Gainesville, FL. Gayane S. Vardanyan,1 Aghadjanov I. Michael,1 Aghadjanova

M. Elena,1 Alla L. Shaljyan.1 1Biochemistry, Yerevan State Medi-
Sa1.133 - Human HLA-A2 MHC Class 1 Molecule Is Per- cal University, Yerevan, Yerevan, Armenia.
missive for the Development of Diabetes in Experimental Au-
toimmune Diabetes.
Sa1.138 - Combinatorial TTreatment
reatment of Recent-Onset TType
ype
A. Ide,1 E. Melanitou,1,2 E. Liu,1 H. Moriyama,1 D. Miao,1 G. S. 1 Diabetes by Induction of Islet-Antigen Specific TTregs
regs and
Eisenbarth.1 1Barbara Davis Center for Childhood Diabetes, Anti-CD3.
University of Colorado Health Sciences Center, Denver, CO, USA; Damien Bresson,1 Lisa Togher,1 Kevan Herold,2 Matthias von
2
Institut Pasteur, Paris, France. Herrath.1 1La Jolla Institute for Allergy and Immunology, San
Diego, CA, USA; 2Columbia University, New York, NY, USA.
Sa1.134 - Similarities and Differences in Autoimmune Re-
sponses between TType
ype 1 and TType
ype 1.5 Diabetes Patients. Sa1.139 - De Novo Generation of Antigen-Specific
B. Brooks-Worrell,1,2 H. Chiu,1,2 A. Goel,1,2 J. P. Palmer.1,2 1De- CD4+CD25+ Regulator
Regulatory y T Cells from Human CD4+CD25-
partment of Medicine, University of Washington, Seattle, WA, Cells.
USA; 2Metabolism and Endocrinology, Puget Sound Health Care M. R. Walker,1,3 B. D. Carson,2,3 S. F. Ziegler,2,3 G. T. Nepom,1,3
System, Seattle, WA, USA. J. H. Buckner.1 1Diabetes, Benaroya Research Institute at Vir-
ginia Mason, Seattle, WA, USA; 2Immunology, Benaroya Re-
search Institute at Virginia Mason, Seattle, WA, USA; 3Immunol-
ogy, University of Washington, Seattle, WA, USA.
91
2005
ANNUAL MEETING
Sa1.140 - TGF-
TGF-β β Enhances Autoimmune Diabetes by Sa1.144 - The (Relatively) Simple Genetics of a Polygenic
Increasing Sur vival of Memor
Survival Memoryy Effector CD8 LLymphocytes.
ymphocytes. Disease: TType
ype 1 Diabetes (TID).
Amy E. Juedes,1 Chrystelle Asseman,1 Lisa Togher,1 Yufeng Chester A. Alper,1,2 Charles E. Larsen,1,2 Edmond J. Yunis,2,3
Peng,2 Allison Green,2 Richard A. Flavell,2 Matthias G. von Zaheed Husain,1,2 Zuheir L. Awdeh.1 1Immunogenetics Divi-
Herrath.1 1Developmental Immunology, La Jolla Institute for Al-
sion, The CBR Institute for Biomedical Research, Boston, MA,
lergy and Immunology, San Diego, CA, USA; 2Immunobiology, USA; 2Departments of Pediatrics, Medicine and Pathology,
Yale University, New Haven, CT, USA. Harvard Medical School, Boston, MA, USA; 3Department of
Cancer Immunology and AIDS, The Dana-Farber Cancer Insti-
ype 1 Diabetes by iNKT Cells tute, Boston, MA, USA.
Sa1.141 - Protection from TType
May Require Interactions with CD4+CD25+ Regulator y T
Regulatory
Cells. Sa1.145 - An Atypical Case of IPEX Syndrome with Multiple
D. Ly, Q. S. Mi, T. L. Delovitch.
1,2 3 1,2 1
Autoimmune/Diabetes FOXP3 Mutations.
Group, Robarts Research Institute, London, ON, Canada; De-
2 E. Gambineri, 1
C. Azzari,1 M. Moriondo,1 L. Bianchi,1 A. M.G.
partment of Microbiology and Immunology, University of West- Gelli, A. Vierucci, M. de Martino. Department of Pediatrics,
1 1 1 1
ern Ontario, London, ON, Canada; 3Center for Biotechnology “Anna Meyer” Childrens’ Hospital, University of Florence, Flo-
and Genomic Medicine, Medical College of Georgia, Dept of rence, Italy.
Pathology - Section of Dermatology, Augusta, GA, USA.
Immunology of the Eye
Sa1.142 - Immunomodulation in TType
ype 1 Diabetes by NBI-
Sa1.146 - Increase of Serum KL-6 Levels In Sera of Uveitis
6024, An Altered Peptide Ligand of the Insulin B(9-23) Epitope.
Patients with Sarcoidosis.
D. G. Alleva,1 R. A. Maki,1 A. L. Putnam,2 M. S. Kipnes,3 P.
N. Kitaichi,1 S. Ohno.1 1Ophthalmology & Visual Sciences,
Dandona,4 J. B. Marks,5 D. L. Simmons,6 C. J. Greenbaum,7 R.
Hokkaido University Graduate School of Medicine, Sapporo,
J. Jimenez,1 P. J. Conlon,1 P. A. Gottlieb.2 1Molecular Medicine,
Hokkaido, Japan.
Neurocrine Biosciences, Inc., San Diego, CA, USA; 2Barbara
Davis Center for Childhood Diabetes, University of Colorado
S a 1 . 1 4 7 - C y t o t o x i c C D 8 b r i g h tC D 5 6 + T C e l l s A r e
Health Sciences Center, Denver, CO, USA; 3Diabetes and Glan-
dular Disease Clinic, San Antonia, TX, USA; 4Diabetes-Endocri- Immunopathogenic Effectors in Patients with Active Behcet’ Behcet’ss
nology Center of WNY Kaleida Health, Buffalo, NY, USA; 5De- Uveitis.
partment of Diabetes, Endocrinology, and Metabolism, Univer- Jae Kyoun Ahn,1 Hyeong Gon Yu,1 Hum Chung,1 Sung-pyo
sity of Miami, Miami, FL, USA; 6Division of Endocrinology and Park,1 Young Joo Kim.1 1Ophthalmology, Seoul National Uni-
Metabolism, University of Arkansas for Med Sciences, Little Rock, versity College of Medicine, Seoul, Seoul, Republic of Korea.
AR, USA; 7Diabetes Clinical Research Unit,, Virginia Mason
Research Center, Seattle, WA, USA. Sa1.148 - Flt3L-Elicited, In Vitro-Matured Splenic Dendritic
Cells (DC) Induce Autoimmune Disease in the Retina.
Sa1.143 - A Single Explanation for Three Puzzles in TTypeype 1 J. Tang,1 W. Zhu,1 P. B. Sliver,1 S.B. Shu,1 C.C. Chan,2 R. R.
Diabetes (T1D). Caspi.1 1Section of Immunoregulation, Lab of Immunology,
Zuheir L. Awdeh,1 Edmond J. Yunis,1,2,3 Mark J. Audeh,4 Dolores National Eye Institute, NIH, Bethesda, MD, USA; 2Section of
A. Fici,1 Alberto Pugliese,5 Charles E. Larsen,1,3 Chester A. Immunopathology, Lab of Immunology, National Eye Institute,
Alper.1,3 1Immunogenetics Division, The CBR Institute for Bio- NIH, Bethesda, MD, USA.
medical Research, Boston, MA, USA; 2Department of Cancer
Immunology and AIDS, The Dana-Farber Cancer Institute, Bos-
ton, MA, USA; 3Departments of Pathology, Medicine and Pedi-
atrics, Harvard Medical School, Boston, MA, USA; 4Boston Col-
lege, Chestnut Hill, MA, USA; 5Diabetes Research Institute, Uni-
versity of Miami School of Medicine, Miami, FL, USA.
92
2005
ANNUAL MEETING
Sa1.149 - Thrombospondin 1 Mediates a Contact Depen- Sa1.154 - Increased Ratio of Activating:Inhibitor

Activating:Inhibitoryy Killer Im-
dent Mechanism by Which Retinal Pigment Epithelial (RPE) munoglobulin-Like Receptor Genes in Uveitis.
Cells Regulate T Cell Function. R. D. Levinson,1 Z. Du,2 G. N. Holland,1 E. F. Reed,2 R.
J. L. Vega,1,2 S. Masli,2 A. W. Taylor,2 H. L. Weiner,1 J. W. Rajalingam.1 1Ophthalmology, David Geffen School of Medi-
Streilein.2 1Neurology, Brigham and Women’s Hospital, Harvard cine, UCLA, LA, CA, USA; 2Immunogenetics, UCLA, LA, CA,
Medical School, Boston, MA, USA; 2Ophthalmology, Schepens USA.
Eye Research Institute, Harvard Medical School, Boston, MA,
USA. Poster Session 2
Saturday,, May 14, 2005
Saturday
Sa1.150 - Altered Peptide Ligands of a Retinal Antigen 3:30 pm - 7:30 pm
Protect from Anti-Retinal Autoimmunity by Eliciting Active Regu-
Immunity and Infection
latory
lator y Mechanisms.
L. M. Cortes,1 D. Avichezer,1 P. B. Silver,1 C. C. Chan,1 R. R. Sa2.01 - Quality Assurance Sur vey (QAS) in the Detection of
Survey
Caspi.1 1Lab.of Immunology. National Eye Institute, National Infectious Diseases with Outbreak Potential.
Institutes of Health, Bethesda, MD, USA. M. B. Dela Cruz. 1Office of the Secretary-Department of Health
Philippines (on Leave), Department of Health, Manila, Manila,
Sa1.151 - Modulation of Innate Immune Response with Philippines.
Granulocyteapheresis in Behçet’
Behçet’ss Disease: 1 Y ear Experience.
Year
O. Garcia, R. Lafuente, J. Munoz, A. Vidaller, J. Arruga. 1Oph- Sa2.02 - Lack of Association between Interferon-Gamma Re-
thalmology, Hospital Universitari de Bellvitge, Hospitalet, ceptorceptor-1 -1 Polymorphism and Pulmonar
Pulmonaryy TTuberculosis
uberculosis in Ira-
Barcelona, Spain; 2Intensive Care Unit, Hospital General, nian Population Sample.
Hospitalet, Barcelona, Spain; 3Blood Bank, Hospital Universitari
Mehdi Mirsaeidi,1 Masoud Houshmand,2 Payam Tabarsi,1
de Bellvitge, Hospitalet, Barcelona, Spain; 4Internal Medicine,
Mohammad Mehdi Banoei,2 Sonia Zargari,1 Majid Amiri,1
Hospital Universitari de Bellvitge, Hospitalet, Barcelona, Spain;
Davood Seyed Mansouri,1 Mohammad Sanati,2 Mohammad
5
Ophthalmology, Hospital Universitari de Bellvitge, Hospitalet,
Reza Masjedi,1 Ali Akbar Velayati.1 1Tuberculosis & Respira-
Barcelona, Spain.
tory Infections, National Research Institute of Tuberculosis and
Lung Disease, Tehran, Tehran, Islamic Republic of Iran; 2Mo-
Sa1.152 - Systemic Autoimmune Disease in Patients with Uvei- lecular Genetics, The National Research Center for Genetic
tis. Engineering and Biotechnology, Tehran, Tehran, Islamic Repub-
J. Carbone,1 E. Sarmiento,1 D. Micheloud,1 R. Mora,1 M. lic of Iran.
Rodriguez-Mahou,1 R. Cobo,2 J.L. Vicario,3 J.J. Rodriguez-
Molina,1 E. Fernandez-Cruz.1 1Clinical Immunology Unit, Im- Sa2.03 - The Functional Activity of Specific Antibodies in
munology Department, University Hospital Gregorio Maranon, Progression of HIV -Infection.
HIV-Infection.
Madrid, Spain; 2Ophthalmology Department, University Hospi-
Irina I. Andreeva. Clinical of Immunology, Rostov State Medi-
1 1
tal Gregorio Maranon, Madrid, Spain; 3Transfusion Center,
cal University, Rostov-on Don, Russian Federation.
Community of Madrid.
Sa2.04 - Impairment of Recent Thymic Emigrants in HCV In-
Sa1.153 - In Silico Prediciton of Binding of Auto-Antigenic
fection.
Peptides to HLA-DRB1 in V ogt-Koyanagi-Harada Disease.
Vogt-Koyanagi-Harada
R. Cianci,1 M. Nasi,2 M. Pinti,2 S. Starnino,1 A. Florio,1 G.
P. S. Prasad,1 R. D. Levinson.1 1Ophthalmology, David Geffen
Cammarota,1 A. De Luca,3 R. Cauda,3 A. Grieco,1 G. Rapaccini,1
School of Medicine, UCLA, LA, CA, USA.
G. Gasbarrini,1 A. Cossarizza,2 F. Pandolfi.1 1Internal Medi-
cine, Catholic University, Rome, Italy; 2Biochemical Sciences,
University of Modena, Italy; 3Infectious Diseases, Catholic Uni-
versity, Rome, Italy.
93
2005
ANNUAL MEETING
Sa2.05 - The Persistence of Allergen-Specific IgE and Long- Sa2.10 - Discover

Discoveryy of Neutralizing CpG ODN from Sero-
Lived Plasma Cells. type 2 and 5 Adenoviruse Based on the Relationship between
Elke O. Luger,1 Verena Fokuhl,1 Michael Wegmann,2 Harald Free Energy and Bioactivity
Bioactivity..
Renz,2 Andreas Radbruch.1 1DRFZ, German Rheumatism Re- Zhou Hong,1 Wang Liangxi,1 Zheng Jiang,2 Ding Guofu,1 Liu
search Center, Berlin, Germany; 2Department of Clinical Chem- Wei.1 1Department of Pharmacology, Department of Pharma-
istry and Molecular Diagnostics, Philipps-University Marburg, cology, Chongqing, China; 2Medical Research Center, South-
Marburg, Germany. western Hospital, Chongqing, China.
ransmission Hepatic Electron Microscopic Find-

Sa2.06 - TTransmission Sa2.11 - Evaluation of IL-10 Serum Level in Visceral Leishma-
ings in Chronic Experimental Schistosomiasis Mansoni after niasis.
Praziquantel and an Antifibrotic. Abdolvahab Alborzi, Manoochehr Rasouli, Abolfazl Khoshdel,
A. M. Ahour,1 M. A. El khafif,2 S. I. Hassan,3 N. G. Nessim,3 Simin Kiany. 1Clinical Microbiology Research Center, Shiraz
N. M. Amer,3 I. M. Ali.3 1Biochemistry Department, Ein Shams University of Medical Sciences, Shiraz, Fars, Islamic Republic of
Univeristy, Cairo, Egypt; 2Parasitology Department, Ein Shams Iran; 2Clinical Microbiology Research Center, Shiraz University
University, Cairo, Egypt; 3Parasitology Department, Theodore of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 3Clini-
Bilharz Research Institute, Guiza, Cairo, Egypt. cal Microbiology Research Center, Shiraz University of Medical
Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Clinical Micro-
ransmission Hepatic Electron Microscopic Find- biology Research Center, Shiraz University of Medical Sciences,
Sa2.07 - TTransmission
ings in Acute Experimental Schistosomiasis Mansoni after Shiraz, Fars, Islamic Republic of Iran.
Praziquantel and an Antifibrotic.
S. I. Hassan,1 I. M. Ali,1 N. G. Nessim,1 N. M. Amer,1 M. A. El Sa2.12 - IL-10 Gene Polymorphisms and Susceptibility to Bru-
Khafif,2 Amin M. Ahour,3 M. M. Mohandes.4 1Parasitology cellosis.
Department, Theodore Bilharz Research Institute, Guiza, Cairo, Simin Kiany, Manoochehr Rasouli, Mohammad Ali Dehyadegari,
Egypt; 2Biochemistry Department, Ein Shams University, Cairo, Noredin Rafatpour, Abdolvahab Alborzi. Immunology of In-
1
Egypt; Parasitology Department, Ein Shams University, Cairo, fectious Diseases Department- Clinical Microbiology Research
3
Egypt. Center, Shiraz University of Medical Sciences, Shiraz, Fars, Is-

lamic Republic of Iran; 2Immunology of Infectious Diseases De-
ransaminase Levels in Murine Schistoso- partment- Clinical Microbiology Research Center, Shiraz Univer-
Sa2.08 - Serum TTransaminase
sity of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran;
miasis Mansoni after Giving Praziquantel and an Antifibrotic 3
Clinical Microbiology Research Center, Shiraz University of
Agent. Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Clini-
A. M. Ashour,1 M. A. El Khafif,2 Soad I. Hassan,3 N. G. Nessim,3 cal Microbiology Research Center, Shiraz University of Medical
I. M. Ali,3 N. M. Amer.3 1Parasitology Department, Ein Shams Sciences, Shiraz, Fars, Islamic Republic of Iran; 5Clinical Micro-
University, Cairo, Egypt; 2Biochemistry Departemnt, Ein Shams biology Research Center, Shiraz University of Medical Sciences,
University, Cairo, Egypt; 3Parasitology Department, Theodore Shiraz, Fars, Islamic Republic of Iran.
Bilharz Research Institute, Cairo, Egypt.
Sa2.09 - Effect of a Novel Muramyl Dipeptide Derivative TTo-o-

gether with Praziquantel in Experimental Schistosoma
Mansoni Infection.
S. S. Boutros,1 F. A. Ebeid,1 H. A. Ismail,2 N. G. Nessim.3
1
Parmacology Department, Theodore Bilharz Research Institute,
Guiza, Cairo, Egypt; 2Immunology Department, Theodore Bilharz
Research Institute, Guiza, Cairo, Egypt; 3Parasitology Depart-
ment, Theodore Bilharz Research Institute, Guiza, Cairo, Egypt.
94
2005
ANNUAL MEETING
Sa2.13 -Investigation of IFN- γ Gene Polymorphism in Sa2.16 - Dendritic Cell Mediated Immune Response Is Im-
Visceral Leishmaniasis. paired by the Mycobacterium tuberculosis Mannosylated-
Simin Kiany, Manoochehr Rasouli, Abolfazl Khoshdel, LipoArabinoMannan.
Abdolvahab Alborzi. 1Immunology of Infectious Diseases De- N. Dulphy,1 J.-L. Herrmann,2 J. Nigoux,3 G. Puzo,3 D. Charron,1
partment- Clinical Microbiology Research Center, Shiraz Univer- P. H. Lagrange, 2 A. Toubert. 1 1INSERM U662, Institut
sity of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; Universitaire d’Hematologie; Hopital Saint Louis, Paris, France;
2
Immunology of Infectious Diseases Department- Clinical Micro- 2
Equipe d’Accueil EA3510, Faculte Lariboisiere-Saint Louis;
biology Research Center, Shiraz University of Medical Sciences, Universite Paris VII, Paris, France; 3Departement “Mecanismes
Shiraz, Fars, Islamic Republic of Iran; 3Pediatric Infectious Dis- Moleculaires des Infections Mycobacteriennes”, Institut de
eases Department, Shiraz University of Medical Sciences, Shiraz, Pharmacologie et de Biologie Structurale, Toulouse, France.
Fars, Islamic Republic of Iran; 4Clinical Microbiology Research
Center, Shiraz University of Medical Sciences, Shiraz, Fars, Is- Sa2.17 - Inflammator
Inflammatory y Response and Apoptosis of Polymor
Polymor--
lamic Republic of Iran.
phonuclear Neutrophils by Prevalent Strains of Mycobacte-
rium tuberculosis.
Sa2.14 - Polymorphisms of IL-10 Gene Promoter in Patients
Pokkali Supriya,1 Rajavelu Priya,1 Das Sulochana.1 1Dept of
with Kala-azar
Kala-azar.. Immunology, Tuberculosis Research Centre, Chennai, Tamil
Manoochehr Rasouli, Simin Kiany, Abdolvahab Alborzi, Nadu, India.
Abolfazl Khoshdel. 1Immunology of Infectious Diseases Depart-
ment-Clinical Microbiology Research Center, Shiraz University
Sa2.18 - Comparison of Regional and Systemic Humoral Im-
of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Im-
munology of Infectious Diseases Department-Clinical Microbiol- mune Response to a Parasitic Infection.
ogy Research Center, Shiraz University of Medical Sciences, C. H. Wang, 1
S. D. Wagner,1 H. Montalvo, Jr.,1 C. L. Hauschild,1
Shiraz, Fars, Islamic Republic of Iran; 3Clinical Microbiology A. M. Vanhoose. Biology, California State University Channel
1 1
Research Center, Shiraz University of Medical Sciences, Shiraz, Islands, Camarillo, CA, USA.
Fars, Islamic Republic of Iran; 4Pediatric Infectious Diseases,
Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Re- Sa2.19 - Co-Administration of Corticosteroids (CS) with Anti-
public of Iran. Tuberculous Drugs (A TD) in TTuberculous
(ATD) uberculous Menangitis Had Not
Only Reduced the Intra- Cranial Pressure Symptoms, Also Had
Sa2.15 - Role of Regulator
Regulatoryy CD25+CD4+ Cells during Infec- Increased Patient’Patient’ss Compliance.
tion with Tr ypanosoma cruzi. M. Ishaq, I. M. Sameera. 1Allergy/Pulmonology, Al-Junaid
D. Golgher, R. Vasconcelos, R. Arantes, R. T. Gazzinelli. Hospital, Nowshera, Pakistan.
1
Departament of Biochemistry and Immunology, Universidade
Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Bra- Sa2.20 - Relationship Study between the Status of Innate Im-
zil; 2Departament of Biochemistry and Immunology, Universidade munology and the Infection of SARS.
Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Bra- Wang Haibin.1 1Dept. of Clinic Immunology, 302 Hospital,
zil; 3Departament of Pathology, Universidade Federal de Minas Beijing, Beijing, China.
Gerais, Belo Horizonte, Minas Gerais, Brazil; 4Departament of
Biochemistry and Immunology, Universidade Federal de Minas
Sa2.21 - A Safe Nanoemulsion Adjuvant Produces a Killed-
Gerais, Belo Horizonte, Minas Gerais, Brazil.
Virus Nasal V accine for Smallpox.
Vaccine
A. U. Bielinska, K. W. Janczak, J. J. Landers, J. R. Baker, Jr..
1
Internal Medicine and Center for Biologic Nanotechnology,
University of Michigan, Ann Arbor, MI, USA.
95
2005
ANNUAL MEETING
Sa2.22 - Novel Pan-DR Binding TT-Cell

-Cell Epitopes of Aden- Sa2.28 - Circulating V δ1 and V
Vδ δ2 T Cells in HIV
Vδ -1-Infected
HIV-1-Infected
ovirus Induce a Mixed Profile in Healthy Donors. Patients: Response to CXCR3 and CXCR4 Ligands and to HIV HIV--
L. M. Haveman,1,2 M. Bierings,1 M. R. Klein,1,2 S. Albani,2,3 B. J.
1 TTat.
at.
Prakken.1,2 1Department of Pediatric Immunology, Wilhelmina A. Poggi,1 D. Fenoglio,2 G. Murdaca,2 M. Setti,2 F. Indiveri,2
Children’s Hospital / University Medical Center, Utrecht, Neth- M. R. Zocchi.3 1Oncogenesis, Laboratory of Immunology, Na-
erlands; 2IACOPO Institute, University of California, San Diego,tional Institute for Cancer Research, Genoa, Italy; 2Department
USA; 3Department of Pediatrics, University of California, San of Internal Medicine, Laboratory of Clinical Immunology, Uni-
Diego, USA. versity of Genoa, Genoa, Italy; 3Department of Internal Medi-
cine, Laboratory of Tumor Immunology, San Raffaele Scientific
Sa2.23 - Naturally Occurring Breakdown Products of Inflam- Institute, Milan, Italy.
mation, Generated in Inflammator
Inflammatory y Sites, Functioned as Down-
Regulator of Inflammation. Sa2.29 - Adenovirus Capsid Hexon Is the Main TTarget arget Pro-
Liora Cahalon, Zvi Landau, Raanan Margalit, Arie Admon, tein of Adenovirus-Specific CD4 TT-Cells
1 2 1 3 +
-Cells That Display a Th1
Tamar Ziv,3 Alexandra Zanin-Zhorov,1 Ofer Lider.1 1Immunol- like Cytokine Profile in Healthy Adults.
ogy, Weizmann, Rehovot, Israel; 2Internal Medicine “D”, Kaplan O. Arbach,1 M. Frentsch,1 B. Chmielewicz,2 M. Kaiser,3 H.
Medical Center, Rehovot, Israel; 3Biology, the Smoler Proteomic Ellerbrok,2 R. Lauster,4 A. Radbruch,1 A. Scheffold,5 A. Thiel.1
Center, Technion, Haifa, Israel. 1
Clinical Immunology Group, German Rheumatism Research
Center, Berlin, Germany; 2Robert-Koch-Institute, Berlin, Germany;
Sa2.24 - The Inflammator
Inflammatory y & Immunological Complex Clini- 3GenExpress, Berlin, Germany; 4Molecular Biology, German
cal Presentation of Mycoplasmal Infection in School Children. Rheumatism Research Center, Berlin, Germany;
M. Ishaq, I. M. Sameera. 1Allergy/Pulmonology, Al-Junaid Immunomodulation Group, German Rheumatism Research
5
Hospital, Nowshera, Pakistan. Center, Berlin, Germany.
Sa2.25 - Y east Cells Activation Method of Hemaimmune Re-

Yeast Sa2.30 - Identification of SARS T Cell Epitopes Using the
action Road Map Experimental System. iTopia™Epitope Discover
iTopia™Epitope Discovery y System.
Guo Feng. 1Department of Blood Tansfusion, Changhai Hospi- C. A. Johnson,1 J. Chang,1 C. M. Cameron,2 D. J. Kelvin,2 L. R.
tal Second Military Medical University, Shanghai, China. Lofaro,1 K. R. Bray.1 1Clinical Research and Development,
Beckman Coulter, San Diego, CA, USA; 2Division of Experimen-
Sa2.26 - Phage Display Epitope Study of TTwo oxins Pro- tal Therapeutics, University Health Network, Toronto, Canada.
wo TToxins
duced by Enteroaggregative Esherichia coli That Cause Pe-
Sa2.31 - Leishmania Infection in TTwowo TTwins,
wins, Association to
diatric Diarrhea: Identification and Characterization of Anti-
Perforin Defect.
genic and Immunogenic Mimotopes.
M.E. Seoane,1 M.S. Lovillo,2 J.L. Jimenez,1 J.A. Leon,2 M.A.
T. G. Gazarian,1 U. Hernandez,1 J. Villaseca,1 K. G. Gazarian,2
Munoz.1 1Division of Molecular Immuno-Biology, University
C. Eslava. 1 1Department of Public Health, Faculty of
General Hospital Gregorio Maranon, Madrid, Madrid, Spain;
Medicine,UNAM, Mexico City, DF, Mexico; 2Department of 2
Department of Paediatrics, University General Hospital Virgen
Molecular Biology and Biotechnology, Institute of Biomedical Re-
del Rocio, Sevilla, Sevilla, Spain.
search, Mexican National University, Mexico City, DF, Mexico.
Sa2.32 - The Calcium-Promoted Ras Inactivator (CAPRI) Links
Sa2.27 - The Combined Modulation of Nicotine and Chlamy-
Fcg Receptor to Cdc42 and Rac1 and Is Essential for Host
dia Heat Shock Protein on Cell Proliferation and Apoptosis
Innate Defense.
in HEp-2 Cells.
J. Zhang, I. Dzhagalov, J. Guo, W. Y. He. 1Immunology, Duke
A. I. Hakki, A. Radwan, H. Friedman, S. H. Pross. 1Medical
University, Durham, NC, USA.
Microbiology & Immunology, MDC-10, Collge of Medicine-Uni-
versity of South Florida, Tampa, FL, USA.
96
2005
ANNUAL MEETING
Sa2.33 - An 8 Y ear Old Girl with Recurrent Der

Year matomal Her
Dermatomal Her--
Sa2.38 - Evalution CD64 Marker in Neonatal Spesis for Rapid
pes Outbreaks. Diagnosis.
Cecilia P. Mikita,1 Steven M. Holland,2 Michael R. Nelson.1 Mino Adib, Farzad Oreizi, Fereshteh Sahebfosul, Vajiheh
1
Department of Allergy-Immunology, Walter Reed Army Medi- Ostadi. 1Immunology, Medical School of Science, Isfahan,
cal Center, Washington, DC, USA; 2Laboratory of Clinical Infec-
Isfahan, Islamic Republic of Iran; 2Immunology, Medical School
tious Diseases, National Institute of Allergy and Infectious Dis-
of Science, Isfahan, Isfahan, Islamic Republic of Iran; 3Immunol-
eases, Bethesda, MD, USA. ogy, Medical School of Science, Isfahan, Isfahan, Islamic Re-
public of Iran; 4Immunology, Medical School of Science, Isfahan,
Sa2.34 - Reconstitution of Genetically Determined Deficiency Isfahan, Islamic Republic of Iran.
of the Innate Immune Defence with Recombinant Mannan-Bind-
ing Lectin (MBL). Sa2.39 - TT.. Whipplei Specific Immune Reactions Are Signifi-
J. C. Jensenius, M. Axelsen, L. Kongerslev, S. Thiel. Depart- cantly Reduced in Patients with Whipple’
1 2 2 1 1 Whipple’ss Disease.
ment of Medical Microbiology and Immunology, University of V. Moos, 1
D. Kunkel,1
T. Marth, 2
B. LaScola,3 M. Zeitz,1 T.
Aarhus, Aarhus, Denmark; 2NatImmune A/S, Copenhagen, Schneider. Medical Clinic I, Charite, Campus Benjamin
1 1
Denmark. Franklin, Berlin, Germany; 2Internal Medicine, St Josef Hospital,

Zell/ Mosel, Germany; 3Unite de Rickettsies, Faculty of Medi-
Sa2.35 - An Active Role for Complement Regulator CD46 in cine, Marseille, France.
Signal TTransduction
ransduction upon Infection.
P. S. Tsang, S. H. Sacks, N. S. Sheerin. 1Department of Neph- Sa2.40 - Adoptive TTransfer
ransfer of CFSE-Labeled Autologous PBMC
rology and Transplantation, King’s College London, London, for the Visualization of T Cell Migration in a Non-Human
United Kingdom. Primate Model.
D. Kunkel,1 V. Moos,1 C. Stahl-Hennig,2 F. J. Kaup,2 M. Zeitz,1
Sa2.36 - Access to the Entire Human Antigen-Specific CD4+ T. Schneider.1 1Medical Clinic I, Charite - Campus Benjamin
T-Cell Response According to Antigen-Reactive CD154 Ex- Franklin, Berlin, Germany; German Primate Center, Gottingen,
2
Germany.
pression.
Marco Frentsch, Olga Arbach, Dennis Kirchhoff, Thomas
1 1 2
Schneider,3 Alexander Scheffold,2 Andreas Thiel.1 1Clinical Im- Sa2.41 - The Effect of Post-T raumatic Stress Syndrome on the
Post-Traumatic
munology, German Arthritis Research Centre, Berlin, Berlin, Outcome of Influenza V accination.
Vaccination.
Germany; 2Immunmodulation, German Arthritis Research Cen- E. Kosor, A. Gagro, V. Folnegovic-Smalc, M. Vilibic, D.
1 1 4 4
tre, Berlin, Berlin, Germany; Gastroenterology and Infectious Kozaric-Kovacic, M. Grubisic-Ilic, V. Drazenovic, K. Gotovac,
3 5 5 2 1
Diseases, Charite - Campus Benjamin Franklin, Berlin, Berlin, A. Sabioncello, E. Cecuk, V. Kerhin-Brkljacic, I. Gjenero-
1 3 3
Germany. Margan,2 B. Kaic,2 S. Rabatic,1 G. Mlinaric-Galinovic,2 D.

Dekaris.1 1Research and Development, Institute of Immunology,
Sa2.37 - Excessive Innate Immune Responses Could Prime Zagreb, Croatia; Virology, Croatian Institute of Public Health,
2
Zagreb, Croatia; 3National Referal Organ Transplant and Tis-

Massive Hepatocyte Apoptosis Induced by Lipopolysaccha-
sue Centre, University Hospital Centre Zagreb, Zagreb, Croatia;
ride. 4
University Department of Psychiatry, Psychiatric Hospital Vrapce,
Katsuharu Hirano,1 Yukihiro Shimizu,1 Yasuhiro Nakayama,1 Zagreb, Croatia; 5Department of Psychiatry, National Center
Masami Minemura,1 Yoshinari Atarashi,1 Satoshi Yasumura,1 for Psychotrauma Dubrava, Zagreb, Croatia.
Toshiro Sugiyama.1 1The Third Department of Internal Medi-
cine, Toyama Medical and Pharmaceutical University, Toyama,
Japan.
97
2005
ANNUAL MEETING
Sa2.42 - Cholesterol Loading of T Cells as a Model of T Cell Sa2.47 - Class I Restricted Epitopes Highly Represented in
Aging. the Tr ypanosoma cruzi Genome Are Recognized by CD8+ T
A. Larbi,1,2 G. Dupuis,2 C. Fortin,1,2 H. Berrougui,1 A. Khalil,1 T. Cells from Individuals with Chronic T. cruzi Infection.
Fulop.1,2 1Laboratory of Immunology, Research Center on Ag- S. A. Laucella,1 B. Weatherly,2 D. Martin,2 M. C. Albareda,1
ing, Sherbrooke, QC, Canada; 2Immunology Program, Faculty M. G. Alvarez,3 G. Bertochi,3 A. H. Armenti,3 J. Sidney,4 A.
of Medicine, Clinical Research Center, Sherbrooke, QC, Sette,4 M. Postan,1 R. L. Tarleton.2 1Research Department, Instituto
Canada. Nacional de Parasitologia, Buenos Aires, Argentina; 2Center
for Tropical and Emerging Global Diseases, UGA, Athens, GA,
Sa2.43 - The Role of Programmed Death-1 Pathway in a Neu- USA; 3Hospital Interzonal Eva Peron, Buenos Aires, Argentina;
trophil Mediated Shock Syndrome. 4
La Jolla Institute for Allergy and Immunology, San Diego, CA,
B. Zhu, K. Raddassi, M. H. Sayegh, S. J. Khoury. Center USA.
1 1 2 1 1
for Neurologic Diseases, Brigham and Women’s Hospital, Bos-

ton, MA, USA; 2Transplantation Research Center, Brigham and Sa2.48 - Sustained Expansion, Activation and Maturation of
Women’s Hospital and Children’s Hospital Boston, Boston, MA, Virus-Specific CD8+ T Cells after Acute Par vovirus B19 In-
Parvovirus
USA. fection.
V. O. Kasprowicz,1 A. Isa,2 O. Norbeck,2 T. Tolfvenstam,2 P.
Sa2.44 - Immune Response Balance on Human Cutaneous Klenerman,3 P. Bowness.1 1Human Immunology Unit, Weatherall
Leishmaniasis. Institute of Molecular Medicine, University of Oxford, Oxford,
L. Castellano,1 D. Correia Filho,1 L. Argiro,2 H. Dessein,2 A. Prata,1 United Kingdom; 2Department of Virology, Karolinska Institute,
A. Dessein,2 V. Rodrigues.1 1Lab of Immunology, Faculdade de Stockholm, Sweden; 3Peter Medawar Building for Pathogen
Medicina do Triangulo Mineiro, Uberaba, Minas Gerais, Bra- Research, University of Oxford, Oxford, United Kingdom.
zil; 2Fac Medecine, INSERM U399, Marseille, France.
Sa2.49 - Defining Putative T Cell Epitopes from PE and PPE
Sa2.45 - Investigatin of IL-4 Gene Polymorphism in Patients Families of Proteins of Mycobacterium tuberculosis with V ac-
Vac-
with Brucellosis. cine Potential.
Manoochehr Rasouli, Amin Abbasian, Simin Kiany. 1Immunol- G. M. Chaitra,1 Sridhar Hariharaputran,2 Nagasuma R.
ogy of Infectious Diseae Departrment, Clinical Microbiology Re- Chandra,2 S. M. Shaila,1 Rabindranath Nayak.1 1Department
search Center- Shiraz University of Medical Sciences, Shiraz, of Microbiology & Cell Biology, Indian Institute of Science, Ban-
Fars, Islamic Republic of Iran; 2Immunology of Infectious Diseae galore, Karnataka, India; 2Bioinformatics Center, Indian Insti-
Departrment, Clinical Microbiology Research Center- Shiraz tute of Science, Bangalore, Karnataka, India.
University of Medical Sciences, Shiraz, Fars, Islamic Republic of
Iran; 3Immunology of Infectious Diseae Departrment, Clinical Sa2.50 - The Study between the Changes of CD35 Expressed
Microbiology Research Center- Shiraz University of Medical Sci-
on Er ythrocyte in Patients with Hepatocirrhosis and the Se-
Erythrocyte
ences, Shiraz, Fars, Islamic Republic of Iran.
verity of Liver Function Destroying.
Ma Chi,1 Wang Haibin.2 1Dept. Immunology, Peking Union
Sa2.46 - Immunophenotype Characterization of Peripheral
Medical College, Beijing, China; 2Dept. Lab of Clinical Immu-
Blood T LLymphocytes
ymphocytes before and after TTreatment
reatment in TTubercu-
ubercu- nology, Beijing 302 Hospital, Beijing, China.
losis Patients.
Fereshteh Sahebfosul, Farzad Oreizi, Zohre Pessaran, Ahmad Sa2.51 - Deficient IgM to IgG Antibody Switch in Patients
Ghavaminejad. 1Immunology, Medical School, Isfahan,
Unresponsive TTo o Conjugate Pneumococcal Polysaccharides.
Isfahan/Isfahn, Islamic Republic of Iran; 2Immunology, Medical
L. E. Leiva, E. J. Saturno, H. Monjure, E. Barr, K. Mason, R. U.
School, Isfahan, Isfahan/Isfahan, Islamic Republic of Iran; 3Im-
Sorensen. 1Pediatrics, LSU Health Sciences Center and Children’s
munology, Medical School, Isfahan, Isfahan/Isfahan, Islamic
Hospital, New Orleans, LA, USA.
Republic of Iran; 4Immunology, Medical School, Isfahan,
Isfahan/Isfahan, Islamic Republic of Iran.
98
2005
ANNUAL MEETING
Sa2.52 - A Delayed Diagnosis of Cystic Fibrosis in a Patient Sa2.57 - Human ‘Memor

‘Memory’ y’ CD4+ T Cells Are Distributed be-
with Asthma and Allergic Bronchopulmonar
Bronchopulmonary y Aspergillosis. tween Five Phenotypically and Functionally Distinct Subsets.
K. R. Lowe,1 C. P. Mikita.1 1Allergy/Immunology, Walter Reed E. Amyes, A. J. McMichael, M. F.C. Callan. 1Division of Medi-
Army Medical Center, Washington, DC, USA. cine, Chelsea and Westminster Hospital Campus, Imperial Col-
lege, London, United Kingdom; 2MRC Human Immunology Unit,
Sa2.53 - Determination of Borrelia burgdorferi Outer-Sur- Weatherall Institute of Molecular Medicine, Oxford, Oxfordshire,
face Protein A161-175 Peptide Binding to HLA-DR Molecules United Kingdom.
Associated with Antibiotic-Refractor
Antibiotic-Refractoryy or Antibiotic-Respon-
Sa2.58 - Characterization of the Th Cellular Immune Response
sive LLyme
yme Ar thritis.
Arthritis.
E. E. Drouin, B. Falk, L. J. Glickstein, W. Klitz, W. W. Kwok, Induced by the Diphtheria TToxin
1 2 1 3 2 oxin Cr y1A Mutants in Spleen
Cry1A
G. T. Nepom, L.A. Baxter-Lowe, A. C. Steere. CIID/Rheu- Cells from Intranasally Primed BALB/c Mice.
2 4 1 1
matology Division, Massachusetts General Hospital / Harvard Fernando T. Hernandez, Gloria G. Guerrero. Escuela de
1 1 1
Medical School, Boston, MA; Benaroya Res Inst, Seattle, WA; Ciencias Biologicas. Unidad Torreon, Universidad Autonoma de
2
3
UC Berkeley, Oakland, CA; 4Immunogenetics and Transplan- Coahuila, Torreon, Coahuila, Mexico.
tation Lab, UCSF, San Francisco, CA.
Sa2.59 - Intranasal V accination with Chlamydial Protease-
Vaccination
Sa2.54 - Mycobacteria Directly Induces Cytoskeletal Rear- Like Activity Factor and Interleukin-12 Promotes the Clearance
rangements for Macrophage Motility through TLR2-Dependent of Pulmonar Pulmonary y C. trachomatis Infection.
PI3-K Signaling. Ashlesh K. Murthy, 1
Yu Cong,1 Guangming Zhong,2 Bernard P.
E. B. Lasunskaia,1 M. N. Campos,1 R. da Matta,2 T. L. Kipnis,1 Arulanandam. Biology, University of Texas at San Antonio,
1 1
W. D. da Silva.1 1Laboratory of Biology of Recognition, San Antonio, TX, USA; Microbiology and Immunology, Univer-
2
Universidade Estadual do Norte Fluminense, Campos, Rio de sity of Texas Health Science Center, San Antonio, TX, USA.
Janeiro, Brazil; 2Laboratory of Cell and Tissue Biology,
Universidade Estadual do Norte Fluminense, Campos, Rio de Sa2.60 - Identification of ssRNA Sequences That Stimulate
Janeiro, Brazil. Innate Immunity through TLRs.
Alexandra Forsbach,1 Carmen Montino,1 Christian Muller,1 Jorg
Sa2.55 - Chlamydia pneumoniae Infection of Human Immune Vollmer,1 Stefan Bauer,3 Grayson B. Lipford.2 1&ÿÿ2&ÿÿ3Inst. for
Cells Modulates Cytokine Production. Medical Microbiology & Immunology, Technical University of
Y. Mamata, C. Newton, T. W. Klein, Y. Yamamoto, H. Fried- Munich, Munich, Germany.
1 1 1 1,2
man.1 1Medical Microbiology and Immunology, University of

South Florida College of Medicine, Tampa, FL, USA; 2Basic Sa2.61 - Mechanism of In Vivo Cytotoxicity Mediated by
Labolatory Science, Osaka University, Suita, Osaka, Japan. CFP10-Specific CD8+ T Cells.
S. M. Behar,1 J. Woodworth,1 A. B. Kamath.1 1Division of Rheu-
Sa2.56 - Homeostatic Chemokines: Organizers of Cellular matology, Immunology, and Allergy, Brigham and Women’s
Interactions Required for T Cell Priming in the Pulmonar
Pulmonary y En- Hospital, Boston, MA, USA.
vironment during the Influenza Infection.
J. Rangel-Moreno,1 J. E. Moyron-Quiroz,1 K. Kusser, 1 S.
Goodrich,1 L. Hartson,1 M. Tighe,1 T. D. Randall.1 1Immunol-
ogy, Trudeau Institute, Saranac Lake, NY, USA.
99
2005
ANNUAL MEETING
Sa2.62 - Characterization of an Lck-Independent Pathway of Sa2.67 - An Automated Methodology for Evaluation of Den-
T-Cell Activation Used by Bacterial Superantigens: Mecha- dritic Cells in Whole Blood.
nistic and Therapeutic Implications on Autoimmunity
Autoimmunity.. C. Smith,1 E. Rabellino,1 J. Wilkinson,1 S. D’Costa.1 1Biomedi-
C. Bueno,1,2 G. Criado,1,2 M. L. Baroja,1,2 S. S. Ferguson,2,3 C. cal Research Division, Beckman Coulter Inc., Miami, FL, USA.
Tsoukas,5 J. Madrenas.1,2,4 1Immunology, FOCIS Centre for Clini-
cal Immunology and Immunotherapeutics; 2Immunology, Robarts Sa2.68 - Ozonetherapy and Quality of Life in HIV Positive
Research Institute; 3Department of Physiology and Pharmacol- Patients.
ogy; 4Department of Microbiology and Immunology, The Uni- Osmel Gaspar Guerra Segura, Barbara Elias-Calles Fernadez.
versity of Western Ontario, London, ON, Canada; 5Department 1
Immunology Lab., Teach.and Gen Hosp. Dr.A. Neto,
of Biology, San Diego State University, San Diego, CA, USA. Guantanamo, Guantanamo, Cuba; 2Ozonetherapy Dept.,
Teach.and Gen Hosp. Dr.A. Neto, Guantanamo, Guantanamo,
Sa2.63 - HLA Phenotype and the Production of IFN- IFN-γγ and Cuba.
Interleukin-10 in Patients with Chronic Urogenital
Chlamydiosis. Sa2.69 - Characteristics of Fas Ligand Expression by Hu-
G. N. Drannik,1 V. E. Driyanskaya,1 S. N. Vashchenko,1 A. G. man Cytomegalovirus Infection.
Drannik,2 L. M. DuBuske.3 1Institute of Urology, Academy of Eung-Soo Hwnag,1 Jung Heon Kim,1 Ye Jin Kwon,1 Hye Jin Jung,1
Medical Sciences, Kiev, Ukraine; 2McMaster University, Hamilton, Su-Yeon Kim,1 Chung-Gyu Park,1 Chang-Yong Cha.1 1Depart-
ON, Canada; 3Immunology Research Institute of New England, ment of Microbiology and Immunology, Seoul National Univer-
Gardner, MA, USA. sity College of Medicine, Seoul, Republic of Korea.
Sa2.64 - Are Probiotics Essential Adjunctive Therapies for C Sa2.70 - Characterization of a Th1/T c1 TType
Th1/Tc1 ype Immune Response
difficile Enteritis? to the Novel Therapeutic Hepatitis C Peptide V accine IC41 in
Vaccine
K. D. Karpa,1 N. Trenev,1 M. L. McCann.1 1College of Medi- Humans.
cine, PSU, Hershey, PA, USA. S. Jelovcan,1 H. Wedemeyer,2 V. Buerger,1 E. Tauber,1 C. Klade.1
1
Intercell AG, Campus Vienna, Vienna, Austria; 2Medizinische
Sa2.65 - Alterations in Th1 Subpopulations Correspond to Hochschule Hannover, Abt. Gastroenterologie, Hepatologie und
Clinical Pathology in Severe TTrauma
rauma Patients. Endokrinologie, Hannover, Germany.
A. K. De,1 K. Laudanski,1 R. V. Maier,2 P. E. Bankey,1 J. P. Minei,3
C. Elson,4 D. Hayden,4 D. A. Schoenfeld,4 L. L. Moldawer,5 R. Sa2.71 - Hepatitis B V irus X and C Protein Induce TTranscrip-
Virus ranscrip-
G. Tompkins,4 C. L. Miller-Graziano.1 1Surgery, University of tion of hfgl2 Prothrombinase Gene.
Rochester Medical Center, Rochester, NY, USA; 2Surgery, Uni- Meifang Han,1 Dong Xi,1 Gary Levy,2 Xiaoping Luo,1 Qin Ning.1
versity of Washington, Seattle, WA, USA; 3Surgery, University 1Department of Infectious Disease, Tongji Hospital of Tongji
of Texas Southwestern, Dallas, TX, USA; 4Surgery and Biostatis- Medical University, Huazhong University of Science and Tech-
tics, Massachusetts General Hospital, Harvard, Boston, MA, nology, Wuhan, Hubei, China; 2Department of Medicine and
USA; 5Surgery, University of Florida, Gainsville, FL, USA. Surgery and Multiorgan Transplant Program, The Toronto Hos-
pital of the University of Toronto, Toronto, Canada.
Sa2.66 - The Effect of Immunotherapies on In Vivo Antiviral
Responses to HIV
HIV.. Sa2.72 - BCG V accination of the Human Newbor
Vaccination Newborn n Induces
S. Andjelic,1 Z. Popmihajlov,1 L. Kelly-Rossini,1 P. Bellman,1 B. Specific Regulator y CD4+ T Cells.
Regulatory
Boyle,1 M. Lesser,1 J. Ruitenberg,2 C. Waters,2 R. El Habib,3 K. J. Riley,1 A. Keyser,1 A. Soares,1 H. Fletcher,3 W. Hanekom.1
A. Smith.1 1Medicine, Weill Medical College of Cornell Univer- 1Institute of Infectious Diseases, University of Cape Town, Cape
sity, New York, NY, USA; 2Becton Dickinson, San Jose, CA, USA; Town, South Africa; 2University of Oxford, Oxford, United King-
3
Aventis Pasteur, Marcy l’Etoile, France. dom.
100
2005
ANNUAL MEETING
Sa2.73 - Effect of an Anti-Inflammator

Anti-Inflammatoryy Pentapeptide Produced Sa2.79 - Clonal Organization of T Cell Memor
Memory: y: Paradigm
by Entamoeba histolytica upon Gene Expression Related to of “Focused Diversity” Contributes to Reper toire Flexibility
Repertoire Flexibility..
Inflammation/W oundhealing.
Inflammation/Woundhealing. Yuri N. Naumov,1 Shalyn C. Clute,1 Elena N. Naumova,2 Jack
R. Silva,1 G. Rico,1 I. Estrada,2 R. Ramos,2 D. Arenas,3 J. Gorski,3 Liisa K. Selin.1 1Department of Pathology, University of
Gimenez,1 A. Torres,4 M. Morales,1 R. Kretschmer.1 1UIM Massachusetts Medical School, Worcester, MA, USA; 2Depart-
Inmunologia, IMSS, Mexico, DF, Mexico; 2Inmunologia Molecu- ment of Family Medicine and Community Health, Tufts Univer-
lar, IPN, Mexico, DF, Mexico; 3UIM en Genetica, IMSS, Mexico, sity School of Medicine, Boston, MA, USA; 3Blood Research In-
DF, Mexico; 4Genetica de Poblaciones, IMSS, Mexico, DF, stitute, The Blood Center of S.-E. Wisconsin, Milwaukee, WI,
Mexico. USA.
Sa2.74 - Spectrum of CD1d-Restricted T Cells: Control of Sa2.80 - Capture and Specific Deliver
Deliveryy of Exogenous Lipid
Anti-V iral and Anti-T
Anti-Viral umor Responses.
Anti-Tumor Antigens by Apolipoprotein E.
P. van den Elzen,1 S. Garg,2 M. Brigl,2 J. E. Gumperz,2 F. M.
R. Wang,1 S. C. Yue,1 P. Ilyinskii,1 J. J. Van der Vliet,1 Kazuhiko
Yanagisawa,1 A. Shaulov,1 Q. He,2 M. J. Koziel,2 S. P. Balk,1 Sacks,3 G. S. Besra,4 D. B. Moody,2 M. B. Brenner.2 1Pathol-
M. A. Exley.1 1Cancer Biology, Hematology / Oncology, Beth ogy, Brigham and Women’s Hospital, Harvard Medical School,
Israel Deaconess Medical Center, Boston, MA, USA; 2Infectious Boston, MA, United Kingdom; 2Medicine, Division of Rheuma-
Diseases, Beth Israel Deaconess Medical Center, Boston, MA, tology, Immunology and Allergy, Brigham and Women’s Hospi-
USA. tal, Harvard Medical School, Boston, MA, USA; 3Nutrition,
Harvard School of Public Health, Boston, MA, USA; 4School of
Sa2.75 - Establishment of a Substitutive SARS Murine Model Biosciences, University of Birmingham, Edgbaston, Birmingham,
United Kingdom.
and Its Application in SARS Study
Study..
Weiming Yan,1 Chuanglong Zhu,1 Xiaoping Luo,1 Qin Ning.1
1
Department of Infectious Disease, Tongji Hospital of Tongji Sa2.81 - Supertype Analysis: Definition of Overlapping Pep-
Medical College, Wuhan, Hubei, China. tide-Binding Capacities for MHC Class I Molecules.
R. Buchli,1 R. S. VanGundy,1 C. F. Giberson,1 W. H. Hildebrand.2
Sa2.76 - Direct Innate Immune Activation by Human Naive B Research Department, Pure Protein L.L.C., Oklahoma City, OK,
1
USA; 2Department of Microbiology and Immunology, University

Cells Via Combined TLR9 and RP105.
of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Kazuko Yamazaki,1 Takashi Yamazaki,2 Takuma Hayashi,1
Kazuo Sugane,1 Kazunaga Agematsu.1 1Department of Infec-
tious Immunology, Graduate School of Medicine,Shinshu Uni- Sa2.82 - Development and V alidation of Fluorescence Polar
Validation Polar--
versity, Matsumoto, Nagano, Japan; Department of Pediatrics,
2 ization-Based Competitive Peptide Binding Assays - New
Shinshu University, Matumoto, Nagano, Japan. Screening TTools
ools for Epitope Discover
Discovery y.
R. S. VanGundy,1 R. Buchli,1 C. F. Giberson,1 W. H. Hildebrand.2
Sa2.77 - Evaluacion del Numero de Linfocitos T Reguladores 1Research Department, Pure Protein L.L.C., Oklahoma City, OK,
en Pacientes Con TTuberculosis.
uberculosis. USA; 2Department of Microbiology and Immunology, University
L. R. Gamez,1,2 M. Rocha,1 R. Gonzalez,2 S. Romano,1 D. P. of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Portales.1,2 1Inmunologia, Facultad de Ciencias Quimicas de
la Universidad Autonoma de San Luis Potosi, San Luis Potosi, Sa2.83 - Anthrax TToxins
oxins Impair Pulmonar
Pulmonaryy Dendritic Cell Func-
San Luis Potosi, Mexico; 2Inmunologia, Facultad de Medicina tions: Implications in Pathogenesis.
de la Universidad Autonoma de San Luis Potosi, San Luis Potosi, A. Cleret,1 A. Quesnel-Hellmann,1 J. Mathieu,1 D. Vidal,1 J.-N.
San Luis Potosi, Mexico. Tournier.1 1Immunology Unit, CRSSA, La Tronche, France.
Sa2.78 - Direct Epitope Discovery for Y

Discovery ellow Fever V
Yellow irus Asibi-17D.
Virus
A. Collymore-Slovak,1 A. Gilb,1 C. Roberts,1 M. Jones,1 W. H.
Hildebrand.1 1Microbiology and Immunology, University of
Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
101
2005
ANNUAL MEETING
Sa2.84 - Rheumatic Fever: Development of an Animal Model Sa2.89 - Is There Any Relation between LLymphocyte
ymphocyte Subsets,
Using Streptococcal M1 Recombinant Protein. NK Activity and Infection in Beta Thalassemia Patients.
F. F. Alcantara,1,2,3 E. Postol,1,3 E.R. Alencar,1,3 V. R. Assis,1 L.
Arezoo Jamali,1 Hossein Hadi nadoushan,2 Mina Izadyar,3
Demarchi,1 J. Kalil,1,2,3 L. Guilherme.1,3 1Immunology Labora- Farhad Vaezzadeh,1 Mahroo Mirahmadian,2 Bita Ansaripour.2
tory, Heart Institute (InCor), Sao Paulo, Sao Paulo, Brazil; 2Al- 1
Medical Laboratory Scienses, Allied Medical School,Tehran
lergy and Clinical Immunology, University of Sao Paulo, Sao University of Medical Scienses, Tehran, Tehran, Islamic Repub-
Paulo, Sao Paulo, Brazil; 3Institute for Immunological Investiga- lic of Iran; 2Immunology, Tehran University of Medical Scienses,
tions, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil. Tehran, Tehran, Islamic Republic of Iran; 3Medical Center of
Peditrics, Tehran University of Medical Scienses, Tehran, Tehran,
Sa2.85 - Effect of the Zinc in the Viability and Differentiation Islamic Republic of Iran.
in Human and Murine Cells.
G. B. Vega,1 A. Polo,1 M. E. Morales,2 G. Rico.2 1Coordinacion Immuno-Oncology
de Educacion Medica Continua Facultad de Medicina, UNAM,
Sa2.90 - Dysregulation of Histone Modification and DNA
Mexico, DF, Mexico; 2UIM en Inmunologia. Hospital de Pediatria
CMN-SXXI, IMSS, Mexico, DF, Mexico. Methylation in Acute Myeloid Leukemia.
M. Ogawa, K. Sakashita, K. Koike. 1Pediatrics, Shinshu Uni-
versity School of Medicine, Matsumoto, Nagano, Japan.
Sa2.86 - IL-27/WSX-1 Signalling: An Important Role in the
Pathogenesis of Experimental Septic Peritonitis.
Sa2.91 - Immunological and Comparitive Study of Ras Fam-
Stefan Wirtz,1 Ingrid Tubbe,1 Mark Birkenbach,2 Richard S.
ily Oncogene Product in V arious Human TTissues.
Various issues.
Blumberg,3 Neurath F. Neurath.1 1I. Medical Department,
Univesity of Mainz, Mainz, Germany; Department of Pathol-
2 V. Mehrotra, V. L. Lahiri. 1
Biochemistry, Himalayan Institute of
ogy and Anatomy, Eastern Virginia Medical School, Norfolk, Medical Sciences, Dehradun, Uttranchal, India; 2
Pathology, S
VA, USA; Gastroenterology Division, Brigham and Women’s
3 N Medical College, Agra, Uttar Pradesh, India.
Hospital, Harvard Medical, Boston, MA, USA.
Sa2.92 - Defects in TCR Associated Proteins in Relation to
ransendothelial Migration of Immune Impairment in Oral Cancer Patients.
Sa2.87 - Morphine Facilitates TTransendothelial
-1 Infected Monocytes across the Blood Brain Barrier by V. T. Cheriyan, S. C. Dutt, S. M. Krishna, P. Balaram. Divi-
1 2 1 1 1
HIV
HIV-1
sion of Cancer Research, Regional Cancer Centre, Trivandrum,
Modulating P-Glycoprotein Expression in Brain Microvascu-
Kerala, India; 2Division of Radiotherapy, Regional Cacner Cen-
lar Endothelial Cells. tre, Trivandrum, Kerala, India.
S. D. Mahajan, 1 S. A. Schwartz, 1 R. C. Chawda, 1 N.
McCulloch, 1 M. P. Nair. 1 1 Medicine, Division of
Sa2.93 - Is the Oncogenesis Epigenetic Induced Alternative
Allergy,Immunology and Rheumatology, State University of New
Way for Cell Sur vival?
Survival?
York at Buffalo, Buffalo, NY, USA.
I. Bubanovic, S. Najman. 1Ob/Gyn, Medica Centre, Nis,
Serbia, Yugoslavia; 2Department for Byology, Medical Univer-
Sa2.88 - Intralesional T Cell Lines Obtained from Rheumatic
sity School, Nis, Serbia, Yugoslavia.
Hear
Heartt Disease Lesions Can Be Used as a TTool ool for Searching
for Non-Autoimmune M Protein Epitopes for Developing a Sa2.94 - Anti-Interleukin-10 Strategies in TTreatment reatment of Malig-
Safe V accine Against Group A Streptococci.
Vaccine nant Diseases.
L. Guilherme,1,3 S. E. Oshiro,1,3 C. Puschel,1,3 W. R. Silva,1,3 F. I. Bubanovic, S. Najman. 1Ob/Gyn, Medica Centre, Nis,
Higa,1,3 L. Chaves,1,3 A. C. Tanaka,1 G. Spina,1 P. M.A. Serbia, Yugoslavia; 2Institute for Biology, Medical University
Pomerantzeff,1 J. Kalil.1,2,3 1Heart Institute, University of Sao School, Nis, Serbia, Yugoslavia.
Paulo, Sao Paulo, São Paulo, Brazil; 2Clinical Immunology and
Allergy, School of Medicine, University of Sao Paulo, Sao Paulo,
São Paulo, Brazil; 3Institute for Immunology Investigation, Uni-
versity of Sao Paulo, Sao Paulo, São Paulo, Brazil.
102
2005
ANNUAL MEETING
Sa2.95 - Modulation of TNF alpha Effects on Apoptosis In- Sa2.99 - Innate Immune Adherence Activity to TTumor
umor Cells
duction in PC Cell Line. Proper ties of Methotrexate-Loaded Adult and Cord Blood Er
Properties yth-
Eryth-
V. Jurisic,1 G. Bogdanovic,2 T. Srdic,2 V. Kojic,2 J. Dimitar,2 N. rocytes.
Kraguljac.3 1Pathophysiology, University of Kragujevac, School Wang Xuan. 1Department of Transfusion, Changhai Hospital
of Medicine, Kragujevac, Serbia, Yugoslavia; 2Experimental Second Military Medical University, Shanghai, China.
Oncology, Institute of Oncology, Novi Sad, Serbia, Yugoslavia;
3
Institute of Hematology, Belgrade, Serbia, Yugoslavia. Sa2.100 - Er ythrocytes Promote the Expression of CXCR4 on
Erythrocytes
Leucocyte Membrane Actived by TTumor
umor Cell.
Sa2.96 - Priming of T Cells to Intracranial TTumor
umor Antigens Cha Zhanshan. 1Department of Blood Transfusion, Changhai
Does Not Confer a Sur vival Advantage.
Survival Hospital Second Military Medical University, Shanghai, China.
S. Velicu,1 Y. Han,1 I. Ulasov,1 T. Gajewski,1 M. S. Lesniak.1
1
Neurosurgery, The University of Chicago, Chicago, IL, USA. Sa2.101 - Cancer Cell Activation Study of Hemaimmune Re-
action Road Map Experimental System.
Sa2.97 - An In V ivo Role for Tr ypanosoma cruzi Calreticulin
Vivo Guo Feng. 1Department of Blood Tansfusion, Changhai Hospi-
in Antiangiogenesis. tal Second Military Medical University, Shanghai, China.
M. C. Molina,1 V. Ferreira,1 W. Schwaeble,2 D. Lemus,3 A.
Ferreira.1 1Immunology Disciplinary Program, ICBM, Faculty of Sa2.102 - Apoptosis-Based Therapies for Hematological Ma-
Medicine, University of Chile, Santiago, Santiago, Chile; 2Mor-
lignancies.
phology Disciplinary Program, ICBM, Faculty of Medicine, Uni-
F. Q.B. Alenzi.1 1Department of Medical Laboratory Sciences,
versity of Chile, Santiago, Santiago, Chile; 3Department of Mi-
King Faisal University, Dammam, Saudi Arabia.
crobiology and Immunology, University of Leicester, Leicester,
United Kingdom.
Sa2.103 - The Role of CD4+CD25+ T Cells in Leukemia Re-
Sa2.98 - Post-T ranscriptional Control of MICA Expression lapse after BMT
Post-Transcriptional BMT..
F. Q.B. Alenzi.1 1Department of Medical Laboratory Sciences,
by BCR/ABL Oncogene through PI3K/mTOR Pathway Pathway..
King Faisal University, Dammam, Saudi Arabia.
N. Boissel,1 D. Rea,3 V. Tieng,1 N. Dulphy,1 M. Brun,1 J.M.
Cayuela, P. Rousselot, R. Tamouza, P. Le Bouteiller, F.X.
4 5 1 6
Mahon,7 A. Steinle,8 D. Charron,1 H. Dombret,2 A. Toubert.1 Sa2.104 - The Immunoreactivity of Serum IgA with Gliadin in
1
Unite INSERM U396, Laboratoire d’Immunologie et Patients with Myeloma Multiplex.
d’Histocompatibilite, Institut Universitaire d’Hematologie, Paris, Zorica D. Juranic, Aleksandra I. Konic-Ristic, Svetislav Jelic,
1 2 1
France; Service d’Hematologie Adulte, Hopital Saint-Louis, Nenad Milanovic, Milica Marinkovic, Dusanka Milosevic,
2 1 1 1
Paris, France; Unite de Therapie Cellulaire et Clinique Jelena Radic, Nevenka Stanojevic-Bakic. Experimental On-
3 1 1 1
Transfusionnelle, Hopital Saint-Louis, Paris, France; 4Laboratoire cology, Institute of Oncology and Radiology of Serbia, Belgrade,
Central d’Hematologie, Hopital Saint-Louis, Paris, France; 5Ser- Serbia, Yugoslavia; Institute of Bromatology, Faculty of Phar-
2
vice d’Onco-Hematologie, Centre Hospitalier de Versailles, Le macy, Belgrade, Serbia, Yugoslavia.

Chesnay, France; 6Unite INSERM U563, Hopital Purpan,
Toulouse, France; 7Laboratoire d’Hematologie, CHU de Bor- Sa2.105 - TTranscriptionranscription Factors Abnor malities Associated
Abnormalities
deaux, Bordeaux, France; 8Institute for Cell Biology, Eberhard- with LLymphoid
ymphoid Malignancies.
Karls-University, Tuebingen, Germany. R. Beluzic,1 A. Tomljenovic,1 S. Dzebro,2 M. Dominis,2 M. Antica.1
1
Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia;
2
Merkur Clinical Hospital, Department of Pathology, Zagreb,
Croatia.
103
2005
ANNUAL MEETING
Sa2.106 - Generation of Linear and Cyclic Peptides Re- Sa2.110 - The Application of an In Vitro Viability Assay Fol-
vealed a Unique Fine Specificity of Rituximab and Its Pos- lowed by Subtractive Hybridization for Identification of Prog-
sible Cross-Reactivity with an Acid Sphingomyelinase-Like nostic Markers in Acute Myeloid Leukemia.
Precursor..
Phosphodiesterase 3B Precursor A. Maha,1 H. F. Seow,1 S. K. Cheong,2 C. F. Leong.2 1Clinical
Federico Perosa,1 Elvira Favoino,1 Maria Antonietta Caragnano,1 Laboratory Sciences, Universiti Putra Malaysia, Serdang,
Marcella Prete,1 Franco Dammacco.1 1Department of Internal Selangor, Malaysia; 2Clinical Haematology & Stem Cell Trans-
Medicine and Clinical Oncology (DIMO), University of Bari plantation Services, Hospital University Kebangsaan Malaysia,
Medical School, Bari, Italy. Bandar Tun Razak, Kuala Lumpur, Malaysia.
Sa2.107 - Functional Analysis of Peripheral Blood LLympho-

ympho- Sa2.111 - Expression of Granzyme B and CD86 Is Associ-
cytes Subsets in Patients with Cancer-Associated Dermato- ated with Persistence of Cer vical Cancer
Cervical Cancer..
myositis. Valeska B. Guzman,1 Andrey Morgun,1 Ismael D.C.G. Silva,2
A. Ponyi,1,2 M. Aleksza,1 L. Gergely,1 M. Garami,2 T. Constantin,2 Sylvia M.F. Brenna,2 Carmen R.N. Carvalho,2 Julisa C.L.
K. Danko.1 1Division of Clinical Immunology, 3rd Department Ribalta,2 Natalia Shulzhenko,1 Maria Gerbase-de-Lima.1 1Im-
of Internal Medicine, Medical and Health Science Center, Uni- munogenetics Division - Pediatrics Department, Federal Univer-
versity of Debrecen, Debrecen, Hungary; 22nd Department of sity of Sao Paulo, Sao Paulo, SP, Brazil; 2Gynecology Depart-
Pediatrics, Faculty of Medicine, Semmelweis University, Budapest, ment, Federal University of Sao Paulo, Sao Paulo, SP, Brazil.
Hungary.
Sa2.112 - Potent TTumoricidal
umoricidal Capacity of Macrophages Ac-
Sa2.108 - Bacteriophage HAP1: Molecular Basis of Its tivated by GcMAF and Therapeutic Use of GcMAF for a V a-
Va-
Antitumour Activity
Activity.. riety of Cancers.
K. Dabrowska,1 M. Zembala,2 J. Boratynski,1 M. Kujawa,3 K. N. Yamamoto,1 M. Urade,2 Y. Koga,1 M. Ueda.1 1Molecular
Switala-Jelen,1 J. Wietrzyk,1 A. Opolski,1 A. Gorski.1,4 1Institute Immunology, Socrates Institute for Therapeutic Immunology, Phila-
of Immunology and Experimental Therapy, Polish Academy of delphia, PA, USA; 2Oral Surgery, Hyogo College of Medicine,
Sciences, Wroclaw, Poland; 2Institute of Catalysis and Surface Hyogo, Japan.
Chemistry, Polish Academy of Sciences, Cracow, Poland; 3Cen-
ter for Biostructure, Medical University of Warsaw, Warsaw, Sa2.113 - Clonal B Cells in Blood and Bone Marrow of Pa-
Poland; 4Transplantation Institute, Medical University of War- tients with a Plasma Cell Dyscrasia- Light Chain Amyloidosis.
saw, Warsaw, Poland. Michelle K. Manske,1 Stephanie Maiden,2 Roshini S. Abraham.1
1
Hematology / Internal Medicine, Mayo Clinic College of Medi-
Sa2.109 - Thy-1 Immature Natural Killer Cells Suppress Den- cine, Rochester, MN, USA; 2Department of Biochemistry, Univer-
+
dritic Cell Functions during the Development of Leukemia in a sity of Missouri at Rolla, Rolla, MO, USA.
Mouse Model.
Kazumi Ebata,1 Yukihiro Shimizu,1 Yasuhiro Nakayama,1 Sa2.114 - Immunomodulation by Different Forms of a Chi-
Masami Minemura,1 Jun Murakami,1 Tsutomu Kato,1 Toshiro meric Costimulator Costimulatory y Molecule That Selectively Binds to CD28.
Sugiyama,1 Shigeru Saito.2 1Third Department of Internal Medi- M. Neighbors,1 J. C.-C. Chang,1 S. Leong,1 R. Ong,1 I. Sipos,1
cine, Toyama Medical and Pharmaceutical University, Toyama, D. Apt,1 J. Punnonen.1 1Human Therapeutics, Maxygen, Red-
Toyama, Japan; 2Department of Obstetrics and Gynecology, wood City, CA, USA.
Toyama Medical and Pharmaceutical University, Toyama,
Toyama, Japan. Sa2.115 - Enhanced Melanoma TTumor umor Growth in CD28 Defi-
cient Mice.
F. Luhder,1 H. Voigt,2 D. Schrama,2 A. O. Eggert,2 J. C. Becker.2
1
Institute for Multiple Sclerosis Research, Georg-August Univer-
sity, Gottingen, Germany; 2Department of Dermatology, Julius-
Maximilians-University, Wurzburg, Germany.
104
2005
ANNUAL MEETING
Sa2.116 - ALL and CLL Cells Express Elevated TNF-alpha upon Sa2.123 - Regulator
Regulatory y Cells and Human Malignant Gliomas.
Stimulation When Compared with Normal B Cells. A. Waziri,1 A. T. Ogden,1 R. C.E. Anderson,1 J. N. Bruce,1 D. E.
T. Selvaggi,1 S. Liau,1 M. Michelis,1 G. Mantile-Selvaggi.1 1Spe- Anderson.2 1Department of Neurological Surgery, Columbia
cial Diagnostic Immunology Laboratory, Hackensack University University College of Physicians & Surgeons, the Gabriele Bartoli
Medical Center, Hackensack, NJ, USA. Brain Tumor Research Laboratory, the Neurological Institute, New
York, NY, USA; 2Center for Neurologic Diseases, Harvard Medi-
Sa2.117 - Role of the MAP Kinase Signaling Pathway in the cal School, Boston, MA, USA.
Regulation of Antigen Expression by Human Melanomas.
M. Kono,1 I. S. Dunn,1,2 L. B. Rose,1,2 P. J. Durda,2 J. T. Kurnick.1,2 Sa2.124 - TTransfection
ransfection of Breast and Lung Cancer Cell Lines
1
Pathology, Massachusetts General Hospital, Boston, MA, USA; with sHLA-A*0201 and sHLA-B*0702.
2
CytoCure, LLC, Beverly, MA, USA. M. L. Gonzalez,1 C. M. Roberts,1 A. R. Gilb,1 W. H. Hildebrand.1
1
Microbiology and Immunology, University of Oklahoma Health
Sa2.118 - Optimization of a Manufacturing Process of Den- Sciences Center, Oklahoma City, OK, USA.
dritic Cell Vaccine TTo
Vaccine o TTreat
reat Colorectal Cancer
Cancer..
O. Faure,1 R. Guillermo,1 M. Loudovaris,1 S. M. Lee,1 F. Aono,1 Sa2.125 - Serologic Study Using a GST -Capture ELISA for
GST-Capture
T. Vo, L. Ho, M. Schilling, J. Bender. Product Development Deter
1 1 1 1 1 mination of Anti-HPV16 Antibodies in TTunisian
Determination unisian W omen.
Women.
/ Manufacturing Departments, IDM, Irvine, CA. M. Achour, P. Sehr, D. Zeghal, L. Kochbati, F. Zouari, M. Pawlita,
R. Oueslati. 1Biology, Faculty of Sciences, Bizerte, Zarzouna,
Sa2.119 - Hfgl2 Prothrombinase/Fibroleukin Expression in Tunisia; DKFZ, Heidelberg, Germany; Hospital la Rabta, Tunis,
2 3
Tunisia; Institute Salah Azaiz, Tunis, Tunisia; 5Hospital la Rabta,

4
Cancer and Its Potential Clinical Significance.
Tunis, Tunisia; 6DKFZ, Heidelberg, Germany; 7Biology, Faculty
Qin Ning,1 Fang Chen,1 Hanying Sun,1 Weiming Yan,1 Wenli
of Sciences, Bizerte, Zarzouna, Tunisia.
Liu.1 1Department of Infectious Disease, Tongji Hospital of Tongji
Medical College, Wuhan, Hubei, China.
Immunology of the Eye
Sa2.120 - Expression of Stromal Cell-Derived Factor-1 in Brain Sa2.126 - The Involvement of Autoimmunity Against Retinal
Biopsies from Patients with Primar
Primaryy Central Ner vous System
Nervous Antigens in Deter mining Disease Severity in TToxoplasmosis.
Determining oxoplasmosis.
Lymphoma. A. L. Vallochi, C. Silveira, R. Belfort, Jr., L. V. Rizzo.1 1Immu-
1 2 2
J. R. Smith,1 K. M. Falkenhagen,1 R. M. Braziel,2 S. E. Coupland,3 nology, University of Sao Paulo, Sao Paulo, São Paulo, Brazil;
J. T. Rosenbaum.1 1Casey Eye Institute, Oregon Health & Sci- 2
Ophthalmology, Federal University of Sao Paulo, Sao Paulo,
ence University, Portland, OR, USA; 2Department of Surgical São Paulo, Brazil.
Pathology, Oregon Health & Science University, Portland, OR,
USA; 3Department of Pathology, University Hospital Benjamin Sa2.127 - Ipsilateral LLymphadenectomy
ymphadenectomy TToo Inhibit Cor neal
Corneal
Franklin, Berlin, Germany. Allograft Rejection in Rats.
Sa2.121 - Phase 1-2 Evaluation of Different Immunotherapy Ling Shiqi, Hu Yanhua. 1Ocular Surface Center, Sun Yat-sen
Protocols for GBM. University, Guangzhou, Guangdong, China; 2Ophthalmology
G. A. Moviglia,1 A. Carrizo,1 G. Varela,1 A. Kreutel,1 C. A. of Tongji Medical College, Huazhong University of Science and
Gaeta,1 R. Moya,1 P. Farina,1 H. Costanzo,1 S. Merino,1 M. J. Technology.
Veloso,1 A. Paes de Lima,1 H. Molina.1 1Immunotherapy, Regina
Mater Foundation, Buenos Aires, Argentina. Sa2.128 - Different Circulating Levels of Endothelin-1 in
Plasma from Glaucoma Patients.
Sa2.122 - Suppression of Lck Sensitizes Acute LLymphoblas-
ymphoblas- Aida Jimenez-Martinez,1 MaCarmen Jimenez-Martinez,1 Vincent
tic T Cells to the Antiproliferative Action of Interferon Alpha. Korder.1 1Research Unit, Institute of Opthalmology, Conde de
S. M. Chan,1 P. J. Utz.1 1Medicine, Stanford University, Stanford, Valenciana, Mexico, D.F., Mexico, D.F., Mexico.
CA, USA.
105
2005
ANNUAL MEETING
Sa2.129 - LPS Stimulation Induce an up Regulation of TLR-4 Poster Session 1

on Limbal Epithelial Cells without Secretion of TNF-Alpha. Sunday,, May 15, 2005
Sunday
Yonathan Garfias,1 Marisela Linares,1 Raul Suarez,1 Alejandra 7:30 am - 1:30 pm
Sanchez-Navarro,1 MaCarmen Jimenez-Martinez.1 1Research
Unit, Institute of Ophthalmology, Conde de Valenciana, Mexico, Cytokines/Chemokines
D.F., Mexico, D.F., Mexico.
Su1.01 - ST AT-1 Mediates the Stimulator
STA Stimulatoryy Effect of IL-10 on
Sa2.130 - CD80 and CD86 Expression on Corneal Epithe- CD14 Expression in Human Monocytic Cells.
lial Cells Infected with Adenovirus. A. A. Rahim Rahimi,1 K. Gee,3 S. Mishra,1 W. Lim,1 A. Kumar.1,2,3
MaCarmen Jimenez, Herlinda Mejia, Marisela Linares,
1 1 1 1
Departments of Biochemistry, Microbiology and Immunology,
Alejandra Sanchez-Navarro, Raul Suarez, Yonathan Garfias. University of Ottawa; Pathology and Laboratory Medicine,
1 1 1 2
Research Unit, Institute of Ophthalmology, Fundacion Conde University of Ottawa; Division of Virology and Molecular Immu-
1 3
de Valenciana, Mexico, D.F., Mexico, D.F., Mexico. nology, Research Institute, Children’s Hospital of Eastern Ontario,
Ottawa, ON, Canada.
Sa2.131 - Adamantiades-Behcet’
Adamantiades-Behcet’ss Disease: A TTrendrend in TTime.
ime.
L. I. Kump,1 K. L. Moeller,1 S. Kurup,1 G. F. Reed,1 R. B. Su1.02 - Altered Cytokine Production and Reduced Membrane
Nussenblatt.1 1Laboratory of Immunology, National Eye Insti- Signaling through the Antigen Receptor in CD4+ T Cells
tute, NIH, Bethesda, MD, USA. y-6A.2 Molecule.
Overexpressing LLy-6A.2
Anil Bamezai, Jennifer Reed, Abraham Chacko. 1Biology De-
Sa2.132 - Visual Outcomes in Children with Juvenile Idio- partment, Villanova University, Villanova, PA, USA.
pathic Arthritis-Associated Uveitis.
L. I. Kump,1,2 R. A. Cervantes Castaneda,1 S. N. Androudi,1 G. Su1.03 - LLymphocytes
ymphocytes Demonstrate Different Functioning
F. Reed, C. S. Foster. Ocular Immunology and Uveitis Ser- Changes Induced by Exogenous PDGF-AB and TGF-b In Vitro
2 1 1
vice, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; at Cerebral and Coronar Coronary y Atherosclerosis: What Is Estab-
2
Laboratory of Immunology, National Eye Institute, NIH, Bethesda,
lished?
MD, USA.
Andrei I. Teplyakov.1 1Resrarch Institute for Ecopathology and
Sa2.133 - Increased Expression of IIκ κB α Per mits TTolerance
Permits olerance Occupational Diseases, Mogilev, Belarus.
Induction by TGF
TGFβ β-Treated Antigen Presenting Cells.
-Treated
A. P. Ghafoori,1 B. Turpie,2 J. W. Streilein,2 S. Masli.2 1HMS, Su1.04 - Live Measurement of Chemokine TTriggered riggered Integrin
Harvard Medical School, Boston, MA, USA; 2Department of
Activation on a Single-Molecule Level.
Ophthalmology, Schepen Eye Research Institute,Harvard Medi-
R. H. Eibl.1 1Institute of Pathology, Technical University of Munich,
cal School, Boston, MA, USA.
Munich, Germany.
Sa2.134 - CD36 and Thrombospondin Interaction Is Essen-
Su1.05 - Sp1 Binding Site of TGF-beta1 Promoter Is the TTar ar
ar--
tial for the TTolerance
olerance Inducing Proper ties of TGF
Properties TGFββ-Treated
-Treated
get for TTrans-Activation
rans-Activation by HPV -16 E6 and E7 Oncoproteins.
HPV-16
Antigen Presenting Cells. O. Peralta-Zaragoza,1 V. Bermudez-Morales,1 M. Bahena-Ro-
S. Masli,1 B. Turpie,1 J. W. Streilein.1 1Department of Ophthal-
man,1 J. Alcocer-Gonzalez,2 F. Recillas-Targa,3 V. Madrid-Ma-
mology, Schepens Eye Research Institute, Harvard Medical rina.1 1Division of Pathogens Molecular Biology, National Insti-
School, Boston, MA, USA. tute of Public Health from Mexico, Cuernavaca, Morelos, Mexico;
2
School of Biological Sciences, Autonomous University of Nuevo
Sa2.135 - α Blocking Therapy in Patients with Endogeneous Leon, Monterrey, Nuevo Leon, Mexico; 3Department of Molecu-
Uveitis. lar Genetics, Institute of Cellular Physiology, National Autono-
P.M. Van Hagen for the RESCU study group. Erasmus MC mous University of Mexico, Mexico, DF, Mexico.
Rotterdam and, Eye Hospital Rotterdam, The Netherlands
106
2005
ANNUAL MEETING
Su1.06 - Orexin-A Has Delayed Reponse to Intestinal Ischemia- Su1.12 - Quantification of mRNA Expression of TNF-
TNF-αα and
Reper fusion Injur
Reperfusion Injuryy. β−
β−,, Fas, TNFR1 and 2 Using Real-T
TGFβ−
TGF ime Quantitative R
Real-Time RTT-
Ji Lin,1 Guang-Tao Yan,1 Xiu-Hua Hao,1 Lu-Huan Wang,1 Kai PCR.
Zhang.1 1Research Laboratory of Biochemistry, Basic Medical F. Q.B. Alenzi. 1Department of Medical Laboratory Sciences,
Institute,General Hospital of P.L.A, Beijing, Beijing, China. King Faisal University, Dammam, Saudi Arabia.
Su1.07 - Increased Interleukin-6 Serum Levels in Subjects with Su1.13 - Role of TWEAK, a Member of the TNFa Family of
Metabolic Syndrome. Cytokines, in Arthritis.
I. N. Kondratska,1 B. N. Mankovsky.1 1Diabetes, Institute of S. Perper,1 B. Browning,2 C. Gao,1 K. Giza,1 L. Rajman,3 L.
Endocrinology, Kiev, Ukraine. Runkel, 3 M. Scott, 3 L. C. Burkly, 2 T. Zheng, 2 H. Hess. 1
1
Immunopharmacology, Biogen Idec, Cambridge, MA, USA;
Su1.08 - LIGHT Regulates CD86 Expression on Dendritic Cells Exploratory Science, Biogen Idec, Inc, Cambridge, MA, USA;
2
through NF-kB, but Neither p44/42 MAPK nor JNK/AP-1 Sig- 3Validation Genetics, Biogen Idec, Inc, Cambridge, MA, USA.
ransduction Pathway
nal TTransduction Pathway..
G. M. Zou,1 W. Y. Hu.2 1Bone Marrow Transplantation, Rush Su1.14 - The Anti-Proliferative Effect of Infliximab on TT-Cells -Cells Is
University Medical Center, Chicago, IL, USA; Physiology and Prevented by CD28 Induced Co-Stimulation.
2
Biophysics, University of Illinois at Chicago, Chicago, IL, USA. B. Gunnlaugsdottir,1,2 S. M. Maggadottir,1,2,3 B. R. Ludviksson.1,2,3
1
Center for Rheumatology Research, Landspitali - University Hos-
Su1.09 - An Impor .acnes- pital, Reykjavik, Iceland; 2Institute of Laboratory Medicine, De-
tant Role of Inducible Histamine in PP.acnes-
Important
Primed and LPS-Induced Hepatitis in Mice. partment of Immunology, Landspitali - University Hospital,
M. Nishibori, H. K. Takahashi, M. Yokoyama, A. Yokoyama, Reykjavik, Iceland; Department of Medicine, University of Ice-
3
1 1 1 1
T. Yoshino,2 T. Watanabe,3 T. Watanabe,4 H. Ohtsu,5 H. Wake,1 land, Reykjavik, Iceland.

S. Mori.1 1Department of Pharmacology, Okayama Univ Grad
Schl of Med & Dent, Okayama, Okayama, Japan; 2Depart- Su1.15 - Lack of Linkage between DNA Methylation and
ment of Pathology, Okayama Univ Grad Schl of Med & Dent, Interleukine-10 Gene Expression.
Okayama, Okayama, Japan; 3Department of Mol Immunology, Jun Dong,1 Claudia Ivascu,2 Florian Eckhardt,2 Hyun-Dong
Kyushu Univ, Fukuoka, Fukuoka, Japan; 4Department of Phar- Chang,3 Carolina Haefliger,2 Lars Tykocinski,3 Martin Rudwaleit,4
macology, Tohoku Univ Gad Schl Med, Sendai, Miyagi, Ja- Jochiem Sieper,4 Andreas Radbruch,3 Andreas Thiel.1 1Clinical
pan; 5Department of Appl Quant Med Eng, Tohoku Univ Grad Immunology, German Rheumatism Research Center, Berlin, Ger-
Schl Eng, Sendai, Miyagi, Japan. many; 2Epigenomics, Berlin, Germany; 3Cell Biology, German
Su1.10 - Receptors for V ascular Endothelial Growth Factor
Vascular Rheumatism Research Center, Berlin, Germany; 4Rheumatology,
(VEGF) on Murine LLymphocytes
ymphocytes and Macrophages. Charite Campus Benjamin Franklin, Berlin, Germany.
Ekaterina P. Kisseleva,1 Andrei V. Krylov,1 Victoria I. Lioudyno.1
1 Su1.16 - Epigenetic Regulation of TNF alpha in Monocytes/
Immunology, Institute for Experimental Medicine, St.Petersburg,
Russian Federation. Macrophages.
K. E. Sullivan,1 K. Dietzmann,1 A. R. Suriano,1 A. N. Sanford,1
Su1.11 - Modulation of Suppressor of Cytokine Signalling 3 M. A. Petri, M. Bhatia,2 B. Aramati.1 1Allergy Immunology,
(SOCS3) Expression and Stability in Human Neutrophils and Children’s Hospital of Philadelphia, Philadelphia, PA, USA;
2
Stem Cell Biology, Robarts Research Institute, London, ON,
in Differentiated PLB-985 Cells by G-CSF
G-CSF,, GM-CSF and IL-4.
Canada; 3Rheumatology, Johns Hopkins University School of
C. Ratthe, D. Girard. INRS, Institut Armand-Frappier, Pointe-
1 1 1
Medicine, Baltimore, MD, USA.
Claire, QC, Canada.
107
2005
ANNUAL MEETING
Su1.17 - A Fast and Robust Multiplexed Immunoassay Panel Su1.22 - Phosphodiesterase Regulation of TNF- α Expression
TNF-α
for Simultaneously Quantifying 24 Cytokines/Chemokines after Spinal Cord Injur y.
Injury
in Rat Serum or Plasma Using Luminex xMAP TTechnology
echnology
echnology.. S. M. Schaal, M. Perez, A. E. Marcillo, W. D. Dietrich, D. D.
S. Ji,1 T. Whitehead,1 H. Hwang,1 R. Rick,1 J. Mistry.1 1. R&D, Pearse. 1Miami Project To Cure Paralysis, Departments of Neu-
LINCO Research, St. Charles, MO, USA. rological Surgery, Neurology, and Cell Biology and Anatomy,
Miller School of Medicine, Miami, FL, USA.
Su1.18 - Markers of Inflammation, Vitamin E and Peripheral
Ner vous System Function. The InCHIANTI Study
Nervous Study.. Su1.23 - Analysis of IL-27 (EBI3/p28) Expression in EBVEBV-- and
HTL
HTLVV-1-Associated LLymphomas:
R. Paganelli,1 A. Di Iorio,1 L. Ferrucci,2 E. Sparvieri,1 A. Michetti,1 ymphomas: Heterogeneous Expression of
C. Franceschi,4 A. Cherubini,3 U. Senin,3 G. Abate.1 1Depart-EBI3 Subunit by TTumoral
umoral Cells.
ment of Medicine and Sciences of Aging, University G. F. Larousserie,1,2 E. Bardel,1 S. Pflanz,3 B. Arnulf,4 C. Lome-
d’Annunzio, Chieti, Italy; 2Longitudinal Studies Section, Clinical
Maldonado,5 O. Hermine,1 L. Bregeaud,2 M. Perennec,2 N.
Research Branch, NIH, Baltimore, MD, USA; 3Institute of Geron-
Brousse,2 R. Kastelein,3 O. Devergne.1 1CNRS UMR 8147,
tology and Geriatrics, University of Perugia, Perugia, Italy; 4De-
Universite Paris V, IFR Necker, Paris, France; 2UPRES EA 219,
partment of Biomedical Sciences, University of Bologna, Bolo-Hopital Necker, Paris, France; 3DNAX Research Institute, Palo
gna, Italy. Alto, CA, USA; 4Service d’Immuno-Hematologie, Hopital Saint-
Louis, Paris, France; 5Department of Pathology, Instituto Salva-
Su1.19 - Protective Effect of Galectins Against the General- dor Zubiran, Mexico City, Mexico.
ized Shwartzman Reaction of Mice.
Ryusuke Nakagawa,1 Hiroko Abe,1 Mitsuomi Hirashima,2 Akira Su1.24 - Pin1 Regulates Cytokine Expression in Human Pe-
Yamauchi.1 1Cell Regulation, Kagawa University, School of ripheral Blood Mononuclear Cells.
Medicine, Kita-gun, Miki-cho, Kagawa, Japan; 2Immunology S. J. Esnault,1 Z. J. Shen,1 J. S. Malter.1 1Pathology and Labora-
and Immunopathplogy, Kagawa University, School of Medicine, tory Medicine, Waisman Center, University of Wisconsin, Madi-
Kita-gun, Miki-cho, Kita-gun, Miki-cho, Japan. son, WI, USA.
Su1.20 - Analysis of Cytokine Network for Initiation of Im- racheobronchial

Su1.25 - Cytokine and Enzyme Spectrum in TTracheobronchial
mune Responses in the Hyperplastic Thymus Associated with Aspirate of Newbor
Newborns ns with Pneumonia TTreated
reated with Recom-
Myasthenia Gravis. binant IL2.
I. Kamo,1 A. Kikuchi,2 H. Tomoyasu,3 N. Sakuragawa.1 1Re- Dilbar Kajumova,1 Leonid Nikulin,1 Oleg Borovikov.2 1Pediatric
generative Medicine, School of Medicine, Toho University, Department, Kuban State Medical Academy, Krasnodar, Rus-
Sagamihara, Kanagawa, Japan; 2Ultrastracuture, National In- sian Federation; 2Clinical Immunology and Allergy, Kuban State
stitute of Neuroscience, Kodaira, Tokyo, Japan; 3Respiratoy, Ja- Medical Academy, Krasnodar, Russian Federation.
pan Red Cross, Ohmori, Tokyo, Japan.
Su1.21 - Age-Related Changes in Cytokine Production in Su1.26 - Cytokines and Anticytokines Therapy in Severe Acute
Cher nobyl Clean-up W
Chernobyl orkers from Latvia.
Workers Pancreatitis.
Natalja Kurjane,1 Natalija Gabrusheva,2 Ruta Bruvere,2 Elvira S. Chooklin,1 A. Perejaslov.1 1Department of Surgery, Medical
Hagina,3 Tija Zvagule,1 Arija Volrate,4 Guna Feldmane.4 1Cen- University, Lviv, Ukraine.
tre of Occupational and Radiological Medicine, P.Stradins Uni-
versity Hospital, Riga, Latvia; 2Biomedical Research and Study
Centre, University of Latvia, Riga, Latvia; 3Institute of Immunol-
ogy, Riga, Latvia; 4Institute of Virology and Microbiology, Riga,
Latvia.
108
2005
ANNUAL MEETING
Su1.27 - Cytokine Production by Dendritic Cells Stimulated Su1.33 - Regulation of Inducible Heparanase Gene Expres-
with Microbial Products Modulated by Epigallocatechin sion in Human TT-Cells
-Cells by Soluble and Immobilize TNF α.
TNFα.
Gallate (EGCG). Ilya Sotnikov, Liora Cahalon, Oded Vainas, Rinat Eshel, Ben-
Zion Katz, Neta Ilan, Israel Vlodavsky, Irun Cohen, Ofer Lider.
J. Rogers,1 I. Perkins,1 A. van Olphen,1 N. Burdash,1 T. W. Klein,1
H. Friedman.1 1Medical Microbiology and Immunology, Uni-
1
Immunology, The Weizmann Institute of Science, Rehovot, Is-
versity of South Florida College of Medicine, Tampa, FL, USA. rael; 2Bone Marrow Transplantation, The Hematology Institute,
Sourasky Medical Center, Tel-Aviv, Israel; 3Oncology, Hadassah-
Su1.28 - TSG-6 Protein Up-Regulates Cyclooxygenase-2 Ex- Hebrew University Hospital, Jerusalem, Israel.
pression and Prostaglandin Biosynthesis in Macrophage Cell
Su1.34 - Serum Free PBMC Freezing and TTesting esting Conditions
Line.
C. Mindrescu, J. Le, H.-G. Wisniewski, J. Vilcek. Depart-
1 1 1 1 1 Afford Enhanced Detection of Antigen-Specific T Cells and
ment of Microbiology, New York University, School of Medicine, Standardization of Immune Monitoring.
New York, NY, USA. W.J. Zhang,1 S. Gregory,2 M. Ewell,2 W. Lopaczynski,2 T. Watts,2
C. Shive,1 N. Sigmund,1 S. Berry,1 O. Targoni,1 J. Lathey,2 P. V.
Su1.29 - The Experimental Study on the Antitumor Effect of 4- Lehmann. &1ÀŒ-õŒ-õ BBI Biotech Research Laboratories,
1 1 2
A Division of SeraCare Life Sciences, Gaithersburg, MD, USA.

1BBL In Vivo.
Li Qiaoxia, Shan Baoen. Research Center, The Fourth Hospital
1
of Hebei Medical University, Shijiazhuang, Hebei, China; 2Re- Su1.35 - Serum High Mobility Group B1 [HMGB1] Is a Dam-
search Center, The Fourth Hospital of Hebei Medical University, age Associated Molecular Pattern [DAMP] Cytokine Elevated
Shijiazhuang, Hebei, China. in Chronic Hepatitis C Patients and Diminishing Following
Or thotopic Liver TTransplantation.
Orthotopic ransplantation.
Su1.30 - Enhanced Immunol Efficacy of mIL-23 Gene Modi- M. T. Lotze,1 R. Day,2 M. E. DeVera,3 A. J. Demetris,3 R. A.
fied TTumor
umor V accine.
Vaccine. DeMarco,1 O. Shakil.3 1Surgery, Bioengineering, and Molecu-
Shan Banen, H.A.O. Jingsheng. Research Center, The Fourth lar Genetics and Biochemistry, University of Pittsburgh Molecu-
1
Hospital of Hebei Medical University, Shijiazhuang, Hebei, lar Medicine Institute, Pittsburgh, PA, USA; Department of Bio-
2
China; Research Center, The Fourth Hospital of Hebei Medical statistics, University of Pittsburgh, Pittsburgh, PA, USA; Surgery,
2 3
University, Shijiazhuang, Hebei, China. Medicine, and Pathology, Starzl Transplant Institute, Pittsburgh,
PA, USA.
Su1.31 - Expressions of mIL-23 Gene in Murine Colon Carci-
noma Cells Induces Production of NO and TNF- α in Murine
TNF-α Su1.36 - Ex V ivo Pro-Inflammator
Vivo Pro-Inflammatoryy Cytokines Expression in
Macrophages. Patients with Aggressive Periodontitis.
H.A.O. Jingsheng, Shan Baoen. 1Research Center, The Fourth F. E. Gonzalez,1,2 D. Catalan,1 J. C. Aguillon.1 1Disciplinary
Hospital of Hebei Medical University, China, Hebei, China; 2Re- Program of Immunology, Faculty of Medicine, University of Chile,
search Center, The Fourth Hospital of Hebei Medical University, Santiago, Región Metropolitana, Chile; 2Dentomaxilofacial Ser-
Shijiazhuang, Hebei, China. vice, University of Chile Clinical Hospital. University of Chile,
Santiago, Región Metropolitana, Chile.
Su1.32 - Control of Apoptosis of Primar
Primary y Human Peripheral
CD4+ T Cells.
M. Pajusto, J. Tarkkanen, P. S. Mattila. 1Department of Otorhi-
nolaryngology, Helsinki University Central Hospital, Helsinki, Fin-
land; 2Department of Pathology, Helsinki University Central Hos-
pital, Helsinki, Finland; 3Department of Otorhinolaryngology,
Helsinki University Central Hospital, Helsinki, Finland.
109
2005
ANNUAL MEETING
Su1.37 - IL-22 Increases the Innate Immunity of the Skin. Su1.42 - Local TT-L
-Lymphocytes from Subacute and Chronic
-Lymphocytes
K. Wolk, S. Kunz, E. Witte, M. Friedrich, K. Asadullah, R. Sabat. Hypersensitivity Pneumonitis Show Phenotypic and Functional
1
Interdisciplinary Group Molecular Immunopathology, Derma- Differences.
tology/Medical Immunology, University Hospital Charite, Berlin, Felipe Mendoza,1 Lourdes Barrera,1 Emma Melendro,2 Annie
Germany; 2Interdisciplinary Group Molecular Immunopathology, Pardo,3 Moises Selman.1 1Inmunoquimica, National Institute of
Dermatology/Medical Immunology, University Hospital Charite, Respiratory Diseases, Mexico City, Mexico; 2Medicina Experi-
Berlin, Germany; 3Interdisciplinary Group Molecular Immuno- mental, Universidad Nacional Autonoma de Mexico, Mexico
pathology, Dermatology/Medical Immunology, University Hos- City, Mexico; 3Facultad de Ciencias, Universidad Nacional
pital Charite, Berlin, Germany; 4Interdisciplinary Group Molecu- Autonoma de Mexico, Mexico City, Mexico.
lar Immunopathology, Dermatology/Medical Immunology, Uni-
versity Hospital Charite, Berlin, Germany; 5CRBA Dermatology,
Su1.43 - Phenotypic and Functional Analysis of Memor
Memory y CD4
Schering Inc., Berlin, Germany; 6Interdisciplinary Group Mo-
lecular Immunopathology, Dermatology/Medical Immunology, ymphocytes in Subacute and Chronic Hypersen-
and CD8 T LLymphocytes
University Hospital Charite, Berlin, Germany. sitivity Pneumonitis.
L. Barrera,1 F. Mendoza,2 M. Selman.1 1Immunochemistry,
Su1.38 - IL-7 in Human B Cell Development. National Institute of Respiratory Diseases, Mexico City, Mexico
Y. K. Parrish, E. Sahakian, G. M. Crooks, E. Zielinska, L. W. City, Mexico; Sistemas Biologicos, Universidad Autonoma
2
1 1 1 1
Barsky,1 K. J. Payne.1 1Research Immunolgy/BMT, Childrens Metropolitana, Mexico, D.F., Mexico.

Hospital Los Angeles, Los Angeles, CA, USA.
Su1.44 - Pro-Inflammator
Pro-Inflammatory y and Anti-Inflammator
Anti-Inflammatoryy Cytokines
Su1.39 - An Impor tant Role for CX3CR1 in V
Important ascular Remodeling.
Vascular T rack with KIR Haplotypes A and B in Octo/Nonagenarian
P. Liu,1 S. Patil,2 M. Rojas,3 A. Fong,1 S.S. Smyth,3 D.D. Patel.1 Subjects.
1
Thurston Arthritis Research Center and Department of Medi- I. M. Rea,1 L. D. Maxwell,2 O. A. Ross,2 C. A. Rea-Lyon,1 H. D.
cine, University of North Carolina at Chapel Hill, Chapel Hill, Alexander,3 D. Middleton.2 1Geriatric Medicine, Queens Uni-
NC; 2School of Medicine, Duke University, Durham, NC; 3Divi- versity Belfast, Belfast, Northern Ireland, United Kingdom; 2NI
sion of Cardiology and Carolina Cardiovascular Biology Cen- Regional Histocompatability and Immunogenetics Laboratory,
ter, University of North Carolina at Chapel Hill, Chapel Hill, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom;
NC, USA. 3
Haematology Laboratory, Belfast City Hospital, Belfast, North-
ern Ireland, United Kingdom.
Su1.40 - Chromatin Regulation of Interleukin 10 Gene Ex-
pression at the Allele Level. Su1.45 - Evaluation of TH1/TH2 Cytokine Modulations in
D. Calado, D. Holmberg, H. Matthias. Cellular Differentia- Chronically HIV
1 2 1 1 -Infected Adults Who Received Therapeutic
HIV-Infected
tion, Gulbenkian Institute for Science, Oeiras, Portugal; 2Umea Vaccination and Inter mittent HAAR
Intermittent HAARTT Following an Initial HAART
HAART
Center for Genome Research, Umea University, Umea, Sweden. Intensification (CTN-140 Pilot TTrial). rial).
Sardar Sindhu,1,2,3 Maude Loignon,1 Jose Menezes,2,3 Emil
Su1.41 - Local Interleukin-1 Immunotherapy Effectiveness De- Toma.1,3 1Microbiology & Infectious Diseases, CHUM-Hotel Dieu
pends on Cytokine Genetic Background. Hospital, Montreal, QC, Canada; 2Immunovirology Lab and
A. S. Simbirtsev, A. J. Gromova, L. E. Timchuk, E. A. Viral & Immune Diseases Program, CHUM-Ste Justine Hospital,
1 1 1
Variouchina.1 1Immunopharmacology, Institute of Highly Pure Montreal, QC, Canada; 3Microbiology & Immunology, Univer-
Biopreparations, St.Petersburg, Russian Federation. sity of Montreal, Montreal, QC, Canada.
110
2005
ANNUAL MEETING
Su1.46 - Cytokine Expression in CD4+ Cells Exposed to the Su1.53 - TGF-

TGF-αα in Foxp3 Expression and Development of
y Factor Produced by E.
Inhibitory
Monocyte Locomotion Inhibitor Peripheral CD4+CD25+ TTreg.
reg.
histolytica. W.J. Chen, Y. Liu. 1Mucosal Immunology Unit, OIIB, NIDCR,
S. Rojas,1 G. Rico,1 J. Perez,2 J. Velazquez,1 R. Kretschmer.1 NIH, Bethesda, MD, USA.
1
UIM en Inmunologia, Hospital de Pediatria CMN S-XXI, IMSS,
Mexico, DF, Mexico; 2Division de Ciencias Biologicas y de la Su1.54 - Osteoprotegerin Synthesis by Circulating T Cells Is
Salud, Universidad Autonoma Metropolitana, Mexico, DF, Related to Osteoporosis in HIV -Infected Patients.
HIV-Infected
Mexico. A. Chakravarti,1 L. Flamand,1 R. Lalonde,2 P. E. Poubelle.1 1De-
partment of Medicine, Centre de Recherche en Rhumatologie et
Su1.47 - Interleukin 21 Modulates Cytokine Pathways That Immunologie,Universite Laval, Quebec, QC, Canada; 2Division
Contribute to the Pathology of Arthritis. of Infectious Diseases, Royal Victoria Hospital, McGill Univer-
L. Lowe, M. Senices, M. Hegen, J. C. Keith, Jr., J. Lamothe, sity, Montreal, QC, Canada.
1 1 1 1 1
P. Wu,1 M. Whitters,1 C. Nickerson-Nutter,1 D. Young,1 M.

Collins.1 1Inflammation, Wyeth Research, Cambridge, MA, USA. Su1.55 - Detection of Cytokines in Patients with Hypersensi-
tivity to Metals.
Su1.48 - Critical Role of ST AT1 on Self-Renewal Capacity of Z. Venclikova,1 J. Bartova,1 L. Mrklas.1 1Clinical Department,
STA
CNS Stem Cells by an Inducible Interferon-g The Institute of Dental Research, 1st Medical Faculty and GUH,
J. Imitola, R. Fryer, Y. Wang, S. Rasmussen, R. V. Jensen, S. J. Charles University, Prague 2, Prague, Czech Republic.
Khoury. 1Neurology, Brigham and Women’s Hospital, Boston,
MA, USA. Su1.56 - SCY A4L Polymorphism Genotyping by Fluorescent
SCYA4L
Resonance Emission (FRET) Probes in Real-Time PCR.
Su1.49 - Role of CXCL1/CXCR2 in Promotion of Glial Sur- Roger Colobran,1 Rosa Faner,1 Carles Llop,1 Ricardo Pujol,1
vival during Experimental Demyelination. Manel Juan.1 1LIRAD (Laboratori d’Immunobiologia per a la
L. T. Remington,1 S. P. Zehntner,1 C. A. Hollmann,1 T. Owens.1 Recerca i Aplicacions Diagnostiques) / IICSGTIP (Institut
1
Neuroimmunology, Montreal Neurological Institute, Montreal, d’Investigacio en Ciencies de la Salut Germans Trias i Pujol),
QC, Canada. CTBT (Centre de Transfusio i Banc de Teixits) / UAB (Universitat
Aut.
Su1.50 - Standardizing Multiparameter Flow Cytometr
Cytometryy for
Evaluation of Cytokine-Secreting Activity in T Cells Via Auto- Su1.57 - Correlation of Interleukin-4 and Chronic Periodonti-
mation of Sample Preparation and Analysis. tis.
J. Wilkinson,1 C. Smith,1 S. D’Costa,1 E. Rabellino.1 1Biomedi- Mandana Sattari,1 Saeed Khalili,1 Leili Mehrdad.1 1Immunol-
cal Research Division, Beckman Coulter Inc., Miami, FL, USA. ogy, Shaheed Beheshti University Medical School, Tehran, Is-
lamic Republic of Iran.
TβR Expressed, Functional, and Regulated on En-
Su1.51 - LLT
Su1.58 - Interleukin-21 Maintains T Cells in a Naive Pheno-
dothelial Cells during Contact Sensitization.
S. Liao, N. H. Ruddle.
1 1 1
Epidemiology and Public Health, type.
Yale University School of Medicine, New Haven, CT, USA. S. Ferrari-Lacraz,1 D. C. Foster,2 R. Chicheportiche.1 1Immunol-
ogy and Allergy, University Hospital, Geneva, Geneva, Swit-
zerland; 2Cytokine Biology, Zymogenetics, Seattle, WA, USA.
Su1.52 - Interferon-að Inducing TLR9 Agonists.
E. R. Kandimalla, D. Yu, T. Sullivan, S. Agrawal. 1Discovery,
Hybridon, Inc., Cambridge, MA, USA.
111
2005
ANNUAL MEETING
Su1.59 - Osteopontin, a Th1 Cytokine, Promotes Cell Sur- Su1.64 - Gene Identification of Single Chain Format
vival and Inhibits Programmed Cell Death of Activated T Cells. Variable(scFv) Anti-ß2-Glycoprotein-I (aß2GP-I) and Anti-Pro-
E. M. Hur,1 L. Steinman.2 1Program in Immunology, Stanford thrombin (aPt) Antibodies Obtained from a PrimarPrimaryy Anti-Phos-
University, School of Medicine, Stanford, CA, USA; 2Neurology pholipid Syndrome (P APS) Patient by Phage Display
(PAPS) Display..
and Neurological Sciences, Stanford University, Medical School, J. Cabiedes,1 M. Languren,1 B. Becerril,2 L. E. Fernandez-Altuna,2
Stanford, CA, USA. D. F. Hernandez-Ramirez,1 V. Pascual,1 A. R. Cabral.1 1Immu-
nology and Reumathology, Instituto Nacional de Ciencias
Su1.60 - Comparison of RNA Preparation Methods and Their Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico;
Effect on Cytokine/Chemokine Gene Expression. 2
Biotecnologia y Bioprocesos, Instituto de Biotecnologia. UNAM.,
A. L. Asare, S. A. Kolchinsky, P. Wood, V. L. Seyfert-Margolis. Cuernavaca, Morelos, Mexico, Malta.
1 1 2 1
1
Immune Tolerance Network, University of California, San Fran-
cisco, San Francisco, CA, USA; 2Center for Human Genetics Su1.65 - A Novel Network of Human B Cell Effector Cytokines
and Integrated Biology, University of Pittsburgh, Pittsburgh, PA, Is Implicated in Autoimmunity: Dysregulation in Patients with
USA.
arget.
Multiple Sclerosis and Potential as Therapeutic TTarget.
A. Bar-Or,1 M. Niino,1 M. Duddy,1 F. Adatia,1 S. Hebert,1 H.J.
Su1.61 - Regulation of Inter feron Gamma Expression by TTu-
Interferon u- Kim.1 1Neuroimmunology Unit, Montreal Neurological Institute,
mor Necrosis Factor Receptor TTypeype 1 Signaling. McGill University, Montreal, QC, Canada.
L. M. Kelly,1 R. D. Wheeler,1 T. Owens.1,2 1Neuroimmunology
Unit, Montreal Neurological Institute, Montreal, QC, Canada; Su1.66 - Class Switch Recombination in B-L ymphopoiesis Is
B-Lymphopoiesis
2
Medical Biotechnology Center, University of Southern Denmark,
a Novel Pathway for Development of Autoimmune B Cells.
Odense, Denmark.
Doron Melamed.1 1Immunology, Technion, Faculty of Medicine,
Haifa, Israel.
General Autoimmunity
Su1.62 - Bacterial HSP70 Immunization Inhibits Proteoglycan- Su1.67 - The Role of VCAM-1 in Self-Reactive T Cell Fate.
Induced Arthritis. Jonathan A. Abbas,1 Pandelakis A. Koni.1 1Program in Mo-
S. E. Berlo,1 C. B. ten Brink,1 P. J. van Kooten,1 R. van der Zee,1 lecular Immunology, Institute of Molecular Medicine and Genet-
M. Singh,2 B. J. Prakken,3 T. T. Glant,4 W. van Eden,1 C. P. ics, Medical College of Georgia, Augusta, GA, USA.
Broeren.1 1Department of Infectious Diseases and Immunology,
University of Utrecht, Utrecht, Netherlands; 2German NationalSu1.68 - The Autoimmune Response to Modified Human Low-
Research Institute for Biotechnology, Braunscheig, Germany; Density Lipoprotein.
3
Department of Pediatric Immunology, UMCU, Utrecht, Nether- G. Virella,1 M. B. Derrick,1 C. Chassereau,1 S. R. Thorpe,3 M. F.
lands; 4Department of Orthopedic Surgery, Rush University, Lopes-Virella.1,2 1Depts. of Microbiology & Immunology and
Chicago, Netherlands. Medicine, Medical University of South Carolina, Charleston, SC;
2
Ralph H. Johnson VAMC, Charleston, Charleston, SC; 3Depart-
Su1.63 - Characterization of Functionally Important Regions ment of Chemistry and Biochemistry, University of South Caro-
of CD200:CD200R for Immunoregulation Using Blocking Syn- lina, Columbia, SC.
thetic Peptides and/or mAbs.
R. M. Gorczynski, D. X. Chen. 1Transplant Research Division, Su1.69 - Studies on Signal TTransduction
ransduction Pathways Downstream
University Health Network (UHN), Toronto, ON, Canada. of CD28/IL-2 That Regulate the E3 Ligase, GRAIL.
L. X. Wu,1 L. Soares,1 C. G. Fathman.1 1Department of Medi-
cine, Division of Immunology and Rheumatology, Stanford Uni-
versity, Stanford, CA, USA.
112
2005
ANNUAL MEETING
Su1.70 - Immune Monitoring the Effects of hOKT3 hOKT3γγ1 Ala-Ala Su1.75 - Premature Senescence of the Immune System in Rheu-
in a patient with New Onset TType ype 1 Diabetes Mellitus. matoid Arthritis and Multiple Sclerosis Patients.
W. H. Liu,1 G. Szot,1 K. E. Earle,1,2 K. C. Herold,3 U. Masharani,1,2 M. M. Thewissen, L. Linsen, P. Geusens, J. Raus, P. Stinissen.
S. E. Gitelman,4 J. A. Bluestone.1,2 1Diabetes Center, University 1
Biomedisch Onderzoeksinstituut (BIOMED), Limburgs Universitair
of California at San Francisco, San Francisco, CA; 2Department Centrum (LUC)/Transnational University Limburg (tUL),
of Medicine, University of California at San Francisco, San Fran- Diepenbeek, Belgium.
cisco, CA; 3Department of Medicine, Division of Endocrinology,
and the Naomi Berrie Diabetes, Columbia University, New York, Su1.76 - Histamine Release and Autoantbodies in Chronic
NY; 4Department of Pediatrics, University of California at San Idiopathic Urticaria and Cough.
Francisco, San Francisco, CA. Francesca Gibellino,1 Stefania Stella,2 Michele Massimino,2
Manuela Di Stefano,3 Anna M. Longo,1 Costantino Sipione,4
Su1.71 - Essential Role of the Co-Receptor CD72 in B Cell Angelo Messina.1 1Respiratory Pathophisiology Service,
Peripheral TTolerance.
olerance. Cannizzaro Hospital, Catania, Italy; 2Biomedical Sciences, Uni-
Daniel H. Li,1 Albert Chen,1 James Tung,2 Paulo Fontoura,3 Larry versity of Catania, Catania, Italy; 3Endoscopic Service,
Steinman,3 Jane R. Parnes.1 1Department of Medicine, Stanford Cannizzaro Hospital, Catania, Italy; 4Endocrinology and Dia-
University, Stanford, CA, USA; 2Department of Genetics, Stanford betes Unit, Cannizzaro Hospital, Catania, Italy.
University, Stanford, CA, USA; 3Department of Neurology &
Neurological Sciences, Stanford University, Stanford, CA, USA. Su1.77 - A Polymorphism of the Inhibitor y Receptor
Inhibitory FcγγRIIb,
Receptor,, Fc
It’ss Access to Lipid Rafts and Alters Macrophage
Prevents It’
Su1.72 - Identification of the TTarget
arget Self-Antigens in Ischemia/ Responses to Immune Complexes and Opsonized Bateria.
Reper fusion Injur
Reperfusion y.
Injury R. A. Floto,1 M. R. Clatworthy,1 P. A. McAry,1 E. U. Walker,1 K.
M. Zhang, E. M. Alicot, I. Chiu, N. Verna, T. Vorup-Jensen, R. Heilbronn,1 A. Rankin,2 J. M. Allen,3 N. A. Watkins,2 K. G.C.
1 5 1 2 1
B. Kessler,3 M. Shimaoka,1 R. Chan,2 D. Friend,2 L. H. Michael,4 Smith.1 1Cambridge Institute for Medical Research and Depart-
M. L. Entman,4 F. D. Moore,2 M. C. Carroll.1 1CBR Institute of ment of Medicine, University of Cambridge School of Clinical
Biomedical Research, Harvard Medical School, Boston, MA, Medicine, Cambridge, Cambs, United Kingdom; 2Division of
USA; 2Surgery-Brigham & Women’s Hospital, Harvard Medical Transfusion Medicine, University of Cambridge School of Clini-
School, Boston, MA, USA; 3Pathology, Harvard Medical School, cal Medicine, Cambridge, Cambs, United Kingdom; 3Discov-
Boston, MA, USA; 4DeBakey Heart Center and Department of ery Biology, Inpharmatica, London, United Kingdom.
Medicine, Baylor College of Medicine and the Methodist Hos-
pital, Houston, MA, USA; 5DecImmune Therapeutics, Boston, Su1.78 - On the Role of Th1 Cytokines (gIFN, IL18) and Growth
MA, USA.
Factor TGFb1 in Autoimmune Thyroid Disease.
Roman Khanferyan,1 Ljudmila Ravovaya.1 1Clinical Immunol-
Su1.73 - Shared Epitopes among HLA Class II Molecules in ogy and Allergy, Kuban State Medical Academy, Krasnodar,
Common Autoimmune Diseases. Russian Federation.
Elissaveta J. Naumova,1 Milena I. Ivanova,1 Snejina M.
Mihaylova, 1 Antoaneta P. Nedialkova, 1 Anastassia P. Su1.79 - Autoimmunity: Common Origin for Diverse Diseases.
Mihaylova.1 1Central Laboratory for Clinical Immunology, Uni- G. J. Tobon,1,2 P. Vega,1,2 R. Pineda-Tamayo,1,2 J. M. Anaya.1,2
versity Hospital Alexandrovska, Sofia, Bulgaria. 1
Rheumatology, Clinica Universitaria Bolivariana, Medellin,
Colombia; 2Cellular Biology and Immunogenetics Unit,
Su1.74 - In Vivo Blockade of Human IL-2 Receptor (IL-2R) In- Corporacion para Investigaciones Biologicas, Medellin, Colom-
duces Expansion of CD56bright Regulator
Regulatoryy NK Cells in Pa- bia.
tients with Active Uveitis.
Zhuqing Li,1 Wee Kiak Lim,1,2 Sankaranarayana P. Mahesh,1
Robert B. Nussenblatt.1 1Laboratory of Immunology, National
Eye Institute, NIH, Bethesda, MD, USA; 2Singapore National
Eye Center, Singapore, Singapore.
113
2005
ANNUAL MEETING
Su1.80 - Selective Unresponsiveness of TNFR1-/- Macroph- Su1.86 - Pinocytosis by Human Dendritic Cells TTargets
argets Exog-
ages to IFN-g enous Material Selectively to Intracellular Cathepsin S.
C. J. Calder,1 A. D. Dick,2 L. B. Nicholson.1,2 1Pathology & Michael Reich,1 Stella Erfurth,2 Marianne Kraus,1 Herman
Microbiology, University of Bristol; 2Clinical Sciences, University Overkleeft,3 Christoph Driessen.1 1Medicine II, University of
of Bristol, Bristol, United Kingdom. Tubingen, Germany; 2Microbiology, University of Tubingen,
Germany; 3Organic Chemistry, University of Leiden, Netherlands.
Su1.81 - Suppressor Potency among Regulator
Regulatory y T Cells Is
Discriminated by Functionally Active CD44. Su1.87 - Induction of CD4+CD25+ TTreg
reg Suppressive Activity
M. Firan, P. Estess, M. Siegelman. Pathology, University of and IL-10 Production by IL-2.
1 1 1 1
Texas Southwestern Medical Center, Dallas, TX, USA. Susan Brandenburg,1 Maurus De La Rosa,1 Gabriela Karsten,1
Heike Dorninger, 1 Sascha Rutz, 1 Alexander Scheffold. 1
Su1.82 - Characterization of Immune Response in β− β−TTubulin 1Immunomodulation, German Rheumatism Research Center,
Indiced Murine Autoimmune Hearing Loss. Berlin, Germany.
B. Zhou, J. Glickstein, J. Lee, M. H. Kermany, T. J. Yoo. 1Depart-
ment of Medicine, University of Tennessee, Memphis, TN, USA. Su1.88 - Comparison of Anti- DNA Antibodies for Their Abil-
ity TTo
o Restore Mesenteric Ischemia/Reper fusion-Induced In-
Ischemia/Reperfusion-Induced
Su1.83 - Endogenous Expression of IRBP Is Dispensable for jur jury issue Damage in Rag 1 Deficient Mice.
y and Remote TTissue
Generation of CD4+CD25+ RegulatorRegulatoryy T Cells That Protect C. Moratz,1/4 S. Fleming,2 M. Monestier,3 G. Tsokos.1/4 1De-
Against IRBP-Induced Retinal Autoimmunity
Autoimmunity.. partment of Medicine, Uniformed Services University of the Health
R. S. Grajewski,1 P. B. Silver,1 R. K. Agarwal,1 S. B. Su,1 C. C. Sciences, Bethesda, MD, USA; Department of Biology, Kansas
2
Chan,1 G. I. Liou,2 R. R. Caspi.1 1Laboratory of Immunology, State Universtiy, Manhattan, KS, USA; 3
Department of Microbi-
NEI, NIH, Bethesda, MD, USA; 2Department of Ophthalmol- ology and Immunology, School of Medicine, Temple Universtiy,
ogy, Medical College of Georgia, Augusta, GA, USA; Philladelphia, PA, USA; 4
Department of Cellular Injury, Walter
3
Bethesda, MD, USA. Reed Army Institute of Research, Silver Spring, MD, USA.
Su1.84 - Prevention and TTreatment

reatment of Experimental Autoim- Su1.89 - The Functional Role of CD48-Related Pathways in
mune Myocarditis with Altered Peptide Ligand (APL). Autoimmunity
Autoimmunity..
D. Cihakova,1 M. Kimura,1 M. Talor,1 J. Barin,1 E. Talor,2 D. A. Tamir,1 C. Arancibia,2 M. Ali,1 A. Sharpe,2 Y. Latchman.1
Zimmerman,2 N. Rose.1 1Pathology, Johns Hopkins Medical
1
Department of Immunology, Puget Sound Blood Center and
Institutions, Baltimore, MD, USA; 2Research and Development, Program, Seattle, WA, USA; 2Department of Pathology, Harvard
CEL-SCI Corporation, Baltimore, MD, USA. Medical School, Boston, MA, USA.
Su1.85 - T Cell Responses Induced by Myelin Oligodendro- Su1.90 - The Lifecycle of In Vitro Generated
cyte Glycoprotein Are Suppressed by CD4+CD25+ FOXP3+ CD4+CD25+FoxP3+ Human TR: Generation, Expansion, and
Regulator
Regulatory y T Cells from Thymus and Cord Blood. Persistence.
K. Wing,1 P. Larsson,1 K. Sandstrom,2 S. Lundin,3 E. Suri-Payer,4 M. R. Walker,1,3 B. D. Carson,2,3 S. F. Ziegler,2,3 J. H. Buckner.1
A. Rudin. 1 1Rheumatology and Inflammation Research,
1
Diabetes, Benaroya Research Institute at Virginia Mason, Se-
Gothenburg University, Gothenburg, Sweden; 2Paediatric Ana- attle, WA, USA; 2Immunology, Benaroya Research Institute at
esthesia and Intensive Care at, The Queen Silvia Children’s Virginia Mason, Seattle, WA, USA; 3Immunology, University of
Hospital, Gothenburg, Sweden; 3Medical Microbiology and Washington, Seattle, WA, USA.
Immunology, Gothenburg University, Gothenburg, Sweden; 4Di-
vision of Immunogenetics, German Cancer Research Center,
Heidelberg, Germany.
114
2005
ANNUAL MEETING
Su1.91 - siRNA TTargeted

argeted Reduction of IL-23 Production by Su1.97 - Small Molecules TTrigger
rigger Peptide Loading of HLA-DR
Human Dendritic Cells Increases IL-10 Production and De- by Allele-Specific Induction of a Peptide-Receptive State.
creases Antigen Presentation Capacity
Capacity.. Heiko Kramer,1 Katharina Dickhaut,1 Maria Hofstaatter,1 Sabine
A. Vaknin-Dembinsky, H. L. Weiner. 1Neurology, Center for Hopner,1 Dominik Ruckerl,1 Arvid Soderhall,2 Viviana Marin-
Neurological Diseases, Boston, MA, USA. Esteban,1 Ronald Kuhne,2 Christian Freund,2 Gunther Jung,3
Kirsten Falk,1 Olaf Rotzschke.1 1Celluar Immunology of Autoim-
Su1.92 - Opposite Effect of IL-4 and IL-13 in Experimental mune Reactions, Max-Delbruck-Center for Molecular Medicine
(MDC), Berlin, Berlin, Germany; 2NMR Supported Structural Bi-
Autoimmune Myocarditis (EAM).
ology, Forschungsinstitut for Molecular Pharmacy (FMP), Berlin,
Daniela Cihakova,1 Marina Afanasyeva,1,2 Miho Kimura,1
Berlin, Germany; 3Organic Chemistry, Eberhard Karls Universitat,
Monica Talor,1 Jobert Barin,1 Noel R. Rose.1 1Department of
Tubingen, Tubingen, Baden Wurtenberg, Germany.
Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD,
USA; 2Department of Medicine, University of Calgary, Calgary,
AB, Canada. Su1.98 - B Cell Receptor Editing Begins in the Bone Marrow
Marrow..
Elahna Paul,1 Thomas J. Schneider,2 Michael C. Carroll.2 1Pe-
diatric Nephrology, Massachusetts General Hospital, Boston,
Su1.93 - CTLA4-Ig Inhibts IL-2 Production and In-Vivo Expan-
MA, USA; 2CBR Institute for Biomedical Research, Harvard
sion of Antigen-Stimulated Memor
Memory y CD4 T Cells. Medical School, Boston, MA, USA.
M. P. Ndejembi, D. S. Patke, A. W. Bingaman, D. L. Farber.
1
Surgery, University of Maryland, Baltimore, MD.
Su1.99 - The Macrophage C5a:C5aR-Gai2-FcgRIIB/FcgRIII-Axis
Defines the Inflammator
Inflammatoryy Response in the Ar thus Reaction.
Arthus
Su1.94 - Both FcFcγγR and C5a Are Indispensable in Antibody
S. R. Ali,1 J. Skokowa,1 O. Felda,2 V. Kumar,1 S. Konrad,1 R. E.
Dependent Autoimmune Disease. Schmidt, 1 R. P. Pierkorz, 2 B. Nunberg, 2 K. Spicher, 3 L.
Varsha Kumar,1 Syed R. Ali,1 Olga Felda,1 Jorg Zwirner,2 Josef Birnbaumer,4 J. Zwirner,5 N. Rooijen,6 J. E. Gessner.1 1Clinical
S. Verbeek,3 Reinhold E. Schmidt,1 Johannes E. Gessner.1 1De- Immunology, Hannover Medical School, Hannover, Germany;
partment of Clinical Immunology, Hannover Medical School, 2Biochemistry and Molecular Biology, Heinrich-Heine-University,
Hannover, Lower Saxony, Germany; 2Department of Immunol- Dusseldorf, Germany; 3Institute of Pharmacology, Berlin Free
ogy, Georg-August-University Gottingen, Gottingen, Germany; University, Berlin, Germany; 4Laboratory of Signal Transduction,
3
Department of Human Genetics, Leiden University Medical NIEHS, NIH, USA; 5Department of Immunology, Georg August
Center, Al Leiden, Netherlands. University, Gottingen, Germany; 6Department of Molecular Cell
Biology, Vrije University, Amsterdam, Netherlands.
Su1.95 - Regulator
Regulatory y T Cells: Differential Requirement for In-
nate and Adaptive Immune Cells Inhibition In Vitro. Su1.100 - T Cells and Autoimmunity: Immunoregulation by
S. Zelenay,1 I. Caramalho,1 J. Demengeot.1 1Lymphocyte Physi- CD40 Expressed on CD4+ T LLymphocytes.
ymphocytes.
ology Unit, Instituto Gulbenkian de Ciencia, Oeiras, Portugal. M. E. Munroe,1 G. A. Bishop.1,2 1Departments of Microbiology
and Internal Medicine, University of Iowa, Iowa City, IA, USA;
Su1.96 - CCR6 Expression Defines Regulator Regulatoryy Effector/ 2
VAMC.
Memor y-Like Cells within the CD25+CD4+ T Cell Subset.
Memory-Like
Markus Kleinewietfeld,1 Fabiola Puentes,1 Giovanna Borsellino,2 Su1.101 - Induction of TTolerance
olerance by Gene Therapy with B-
Luca Battistini,2 Olaf Rotzschke,1 Kirsten Falk.1 1Cellular Immu- Cells Expressing Ig Fusion Proteins: Mechanisms and Pre-
nology of Autoimmune Reactions, Max-Delbruck-Center for Mo-
Clinical Success in Naïve and Immune Hemophilia A Mice.
lecular Medicine (MDC), Berlin, Berlin, Germany; 2Laboratory
D. W. Scott,1 T. C. Lei,1 Y. Su,1 N. Soukhareva.1 1Surgery, Uni-
of Neuroimmunology, IRCCS Santa Lucia, Rome, Rome, Italy.
versity of Maryland School of Medicine, Rockville, MD, USA.
115
2005
ANNUAL MEETING
Su1.102 - Increase in Pancreatic NK Cells at Early Onset of Su1.108 - Study of the Thymic Function in Patients with Au-
Autoimmune Diabetes in IFN IFNβ β Transgenic NOD Mice. toimmune Thyroiditis.
A. Alba,1 R. Planas,1 J. Carrillo,1 M. C. Puertas,1 R. Ampudia,1 M. P. Armengol,1 M. A. Fernandez,2 L. Sabater,1 M. Juan,1 R.
X. Pastor,1 M. A. Fernandez,1 R. Pujol-Borrell,1 J. Verdaguer,1 Pujol-Borrell.1 1Laboratory of Immunobiology for Research and
M. Vives-Pi.1 1Immunobiology for Research and Diagnostic Diagnosis (LIRAD). Centre for Transfusion and Tissue Bank (CTBT),
Applications, Transfusion Centre and Tissue Bank, Fundacio Institut Institut per a la Recerca Biomedica Germans Trias i Pujol.,
d’Investigacio en Ciencies de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain; 2Cytometry Unit, Institut per a la
Badalona, Barcelona, Spain. Recerca Biomedica Germans Trias i Pujol., Badalona, Barcelona,
Spain.
Su1.103 - Rapid Protocol TToo Generate TTolerogenic
olerogenic Dendritic
Cells Using Microbial Lipopeptide (BLP). Su1.109 - A Novel Low-Calcemic Vitamin D Analog as a Po-
tential Therapeutic TTreatment
O. A. Aravena,1 L. Salazar,1 C. Mass,1 A. Aguirre,1 D. Catalan,1 reatment for Autoimmune Diseases.
M. Hermoso,1 J. C. Aguillon.1 1Disciplinary Program of Immu-N. Chouinard,1 A. H. Collop,1 K. A. Ryder,1 S. P. Tabash,1 G.
nology, ICBM, University of Chile, Santiago, Chile. H. Posner,2 B. Korczak,1 S. S. Chuang.1 1Research and Devel-
opment, Cytochroma Inc., Markham, ON, Canada; 2Depart-
Su1.104 - Mucosal Administration of Anti-CD3 Antibody Sup- ment of Chemistry, The Johns Hopkins University, Baltimore, MD,
presses EAE, Collagen Arthritis, Diabetes and Prolongs Car- USA.
diac Allograft Sur vival.
Survival.
H. L. Weiner,1 H. Ochi,1 M. Abraham,1 H. Ishikawa,1 H. Wu,1 Su1.110 - SP-A May Be a Candidate of “Qi” Molecule TTrig- rig-
R. Maron, D. Frenkel, R. Gandi, M. L. Chen, A. Izawa, I.
1 1 1 1 1 gers Some Autoimmune Diseases.
Guleria,1 M. H. Sayegh.1 1Brigham and Women’s Hospital, J. Luo, Y. Wan. Orthopaedics, Rhode Island Hospital/Brown
1 2 1
Harvard Medical School, Boston, MA, USA. Medical School, Providence, RI, USA; 2Biology, Providence Col-
lege, Providence, RI, USA.
Su1.105 - The Role of Ultralarge Complexes (ULC) in Hep-
arin Induced Thrombocytopenia (HIT). Su1.111 - The Inhibitions of Autoreactive TT-Cell
-Cell Functions by
a Peptide Based on the Complementarity Determining Region-
L. Rauova,1 D. B. Cines,2 B. B. Sachais,2 M. Poncz.1 1Division
of Hematology, Children’s Hospital of Philadelphia, Philadel-1 of an Anti-DNA Autoantibody Is Via TGF TGFββ Mediated Sup-
phia, PA, USA; 2Department of Pathology and Laboratory Medi- pression of LFA-1 and CD44 Expression and Function.
LFA-1
cine, University of Pennsylvania, Philadelphia, PA, USA. Uri Sela,1 Nora Mauermann,1 Rami Hershkoviz,2 Edna Mozes,1
Liora Cahalon,1 Ofer Lider.1 1Immunology Department, The
Su1.106 - Effect of Freezing/Thawing Conditions and Their Weizmann Institute of Science, Rehovot, Israel; 2Internal Depart-
Optimization for Quality Control of PBMC Viability and Func- ment D, Assaf-Harofeh Medical Center and the Sakler Faculty
tional Assays. of Medicine, Tel-Aviv University, Zerifin, Israel.
Khadir Raddassi,1,2 Kasia Bourcier,2 Jose Estevam,1,2 David A.
Hafler,1 Vicki Seyfert-Margolis.2 1Neurology, Harvard Medical Su1.112 - Fas Ligand (CD95L)-T ransduced Monocyte-Derived
(CD95L)-Transduced
School, Boston, MA, USA; 2Immune Tolerance Network, Univ. Killer-DC Are Protected from CTL-Induced Cytotoxicity and
California San Francisco, San Francisco, CA, USA. Delete Antigen-Specific CD8+ T Cells.
Ch. Schuetz,1 A. Mackensen,2 H. Herfarth,1 D. Halbritter,1 M.
Su1.107 - MBLA/C Deficienct Mice Display Defective Fleck.1 1Department of Internal Medicine I, University of
Apoptotic Cell Clearance but No Autoimmune Phenotype. Regensburg, Regensburg, Bavaria, Germany; 2Division of He-
L. M. Stuart, K. Takahshi, L. Shi, J. Savill, R. A. Ezekowitz. matology, University of Regensburg, Regensburg, Bavaria, Ger-
1,2 1 1 2 1
1
Laboratory of Developmental Immunology, Massachusetts Gen- many.
eral Hospital, Boston, MA, USA; 2MRC Center for Inflammation
Research, University of Edinburgh, Edinburgh, United Kingdom.
116
2005
ANNUAL MEETING
Inflammator
Inflammatoryy Bowel Diseases Su1.117 - Cytokine and Chemokine TTranscript ranscript Profiles in
Acute Pouchitis.
Su1.113 - The Peripheral Cannabinoid Receptor CB2 Is Re-
A. Stallmach,1 T. Giese,2 C. Schmidt,3 B. Ludwig,3 S. Meuer.2
quired for the Normal Formation of B and T Cell Subsets. 1
Gastroenterology, Catholic Clinics Essen-Nord, Essen, Germany;
D. A. Ziring,1 B. Wei,2 P. Velazquez,2 M. Schrage,2 N. Buckley,3 2Immunology, University of Heidelberg, Heidelberg, Germany;
J. Braun.2 1Division of Pediatric Gastroenterology, UCLA David 3Internal Medicine II, Saarland University, Homburg, Germany.
Geffen School of Medicine, Los Angeles, CA, USA; 2Depart-
ment of Pathology and Laboratory Medicine, UCLA David
Su1.118 - Inflammator
Inflammatory y TTranscript
ranscript Profiles Reflect Onset of
Geffen School of Medicine, Los Angeles, CA, USA; 3Depart-
ment of Biological Sciences, California State Polytechnic Univer- Clinical Remission in Patients with Steroid Refractor
Refractoryy Crohn’
Crohn’ss
sity, Pomona, CA, USA. Disease after TTreatment
reatment with Cyclophosphamide or Infliximab.
A. Stallmach,1 T. Giese,2 B. Ludwig,3 M. Zeitz,4 S. Zeuzem,3 S.
Su1.114 - The Effect of Bifidobacterium on Murine Experi- Meuer. Gastroenterology, Catholic Clinics Essen-Nord, Essen,
2 1
Germany; 2Immunology, University of Heidelberg, Heidelberg;

mental Colitis. 3
Internal Medicine II, Saarland University, Homburg, Germany;
Aiping Bai, Qin Ouyang, Renwei Hu. 1Department of Gastro- 4
Internal Medicine I, Charite, Berlin, Germany.
enterology, The First Affiliated Hospital, Sun Yat-sen University,
Guangzhou, Guangdong, China; Department of Gastroenter-
2
ology, Westchina Hospital, Sichuan University, Chengdu, Su1.119 - Long TTer er

ermm Follow-Up of Ulcerative Colitis (UC)
Sichuan, China; Department of Gastroenterology, Westchina Treated with a Probiotic Containing the Pingel/BM Non-Patho-
3
Hospital, Sichuan University, Chengdu, Sichuan, China. genic Strain of E coli.

M. L. McCann, R. Buck.2; 2Microbiology, Kaiser Permanente,
Su1.115 - Anti-Murine TNF-alpha Reverses TNBS Colitis in Cleveland, OH, USA.
Mice but Not Oxazolone Colitis: Potential Role of Apoptosis
Induction. Su1.120 - Blockade of Interleukin 21 with Soluble IL21RFc
Chong Shen, Philippe Maerten, Gert VanAssche, Karel Reduces Inflammator
1 1 2 Inflammatory y Cytokines and Correlates with Sup-
Geboes, Paul Rutgeerts, Jan L. Ceuppens. Laboratory of pression of Disease in Mice Adoptively TTransplanted
3 2 1 1 ransplanted with
Experimental Immunology, Campus Gasthuisberg, Catholic Uni- CD45RBhi CD4+ T Cells.
versity Leuven, Leuven, Vlaams-Brabant, Belgium; 2Department M. Senices,1 L. Lowe,1 C. Groves,1 S. Benoit,1 X. Li,1 M. Leach,1
of Gastroenterology, Campus Gasthuisberg, Catholic University C. Nickerson-Nutter,1 M. Collins,1 D. Young.1 1Inflammation,
Leuven, Leuven, Vlaams-Brabant, Belgium; 3Department of Pa- Wyeth Research, Cambridge, MA, USA.
thology, Campus Gasthuisberg, Catholic University Leuven,
Leuven, Vlaams-Brabant, Belgium. Su1.121 - Role of ICOS in Regulating Mucosal TTolerance.olerance.
C. V. Arancibia, A. H. Sharpe. 1Department of Pathology,
Su1.116 - Evaluation of 5 vs 10 Granulocyteapheresis TTreat-reat- Harvard Medical School, Boston, MA, USA.
ments in Patients with Moderate Active Steroid Dependent
Ulcerative Colitis: A Prospective Multicenter Randomized TTrial.
rial. Su1.122 - A Critical Regulator y Role of Th2-Like TTranscrip-
Regulatory ranscrip-
E. Ricart,1 D. Monfort,1 J. Panes,2 M. Esteve,3 R. Lafuente,4 M. tion Factor c-Maf in Th1-Mediated Experimental Colitis.
Andreu,5 F. Casellas,6 M. Sans.2 1Gastroenterology, Hospital B. Weigmann,1 A. Nemetz,1 C. Becker,1 H.-A. Lehr,2 D. Strand,1
de la Santa Creu i Sant Pau, Barcelona, Spain; 2Gastroenterol- P. R. Galle,1 I.-C. Ho,3 M. Neurath.1 1Laboratory of Immunol-
ogy, Hospital Clinic i Provincial, Barcelona, Spain; 3Gastroen- ogy, I. Medical Clinic, Johannes Gutenberg University, Mainz,
terology, Hospital Mutua de Terrassa, Terrassa, Barcelona, Spain; Germany; 2Institute of Pathology, Johannes Gutenberg Univer-
4
Intensive Care Unit, Hospital General de L´Hospitalet, Hospitalet sity, Mainz, Germany; 3Harvard School of Public Health and
de Llobregat, Barcelona, Spain; 5Gastroenterology, Hospital Vall Harvard Medical School, Boston, MA.
d´Hebron, Barcelona, Spain.
117
2005
ANNUAL MEETING
Su1.123 - Dual Immune Suppressive Activity of 4AZA1378 Su1.127 - Immunohistochemical Localization of Copper/
Alleviates TNBS-Induced Colitis in Mice. Zinc-Containing Superoxide Dismutase in Normal Pan-
Chong Shen,1 Yuan Lin,2 Gavin Clydesdale,2 Ilse Sienaert,2 creas and in Pancreatitis.
Steven De Jonghe,2 Karel Geboes,3 Louis Boon,2 Paul Rutgeerts,4 H. Milnerowicz,1 M. Jablonowska,1 J. Rabczynski,2 K.
Jan L. Ceuppens.1 1Laboratory of Experimental Immunology, Grabowski.3 1Departament of Biomedical and Environmental
Campus Gasthuiberg, Catholic University Leuven, Leuven, Analyses, Wroclaw University of Medicine, Wroclaw, Poland;
Vlaams-Brabant, Belgium; 24AZA Biosciences, Leuven, Vlaams- 2
Department of Pathological Anatomy, Wroclaw University of
Brabant, Belgium; 3Department of Pathology, Campus Medicine, Wroclaw, Poland; 3Department and Clinic of
Gasthuiberg, Catholic University Leuven, Leuven, Vlaams- Gastointestinal and General Surgery, Wroclaw University of
Brabant, Belgium; 4Department of Gastroenterology, Campus Medicine, Wroclaw, Poland.
Gasthuiberg, Catholic University Leuven, Leuven, Vlaams-
Brabant, Belgium. Su1.128 - The Response of Blood Monocytes of Coeliac
Patients to Gliadin.
Su1.124 - Immunohistochemical Localization of Interleukin-6 L. Palova-Jelinkova,1 J. Cinova,1 B. Pecharova,1 M. Cerna,2 L.
in Pancreatitis and Normal Pancreas. Tuckova,1 H. Tlaskalova-Hogenova.1 1Department of Immu-
M. Jablonowska, 1 H. Milnerowicz, 1 J. Rabczynski, 2 S. nology, Czech Academy of Sciences, Prague, Czech Repub-
Milnerowicz.3 1Departament of Biomedical and Environmental lic; 23rd Medical Faculty, Charles University, Prague, Czech
Analyses, Wroclaw University of Medicine, Wroclaw, Poland; Republic.
2
Department of Pathological Anatomy, Wroclaw University of
Medicine, Wroclaw, Poland; 3Department and Clinic of Su1.129 - Eosinophilic Esophagitis (EE): Improved Clinical
Gastointestinal and General Surgery, Wroclaw University of
Responses without a Concomitant Reduction in Esophageal
Medicine, Wroclaw, Poland.
Eosinophilic Infiltration.
F. M. Schaffer, R. B. Pillai, K. A. Hetherington, R. Shannon, T.
Su1.125 - TTumor
umor Derived TGF-beta Suppresses Inflamma-
C. Hulsey, D. Lewin, S. N. Khubchandani, V. Tolia. 1Pediatric
tion Dependent Colon Cancer Development by Inducing Pulmonary, Allergy, and Immunology, MUSC, Charleston, SC,
FoxP3 in TTumor
umor Infiltrating CD4+ T Cells. USA; 2Pediatric Gastroenterology, MUSC, Charleston, SC,
C. Becker, M. C. Fantini, C. Schramm, A. Nikolaev, P. R. USA; 3Pediatrics, MUSC, Charleston, SC, USA; 4Pediatric
1 1 1 1
Galle,1 M. F. Neurath.1 1I. Dept. of Medicine, University of Gastroenterology, MUSC, Charleston, SC, USA; 5Pediatric
Mainz, Mainz, Germany. Epidimiology, MUSC, Charleston, SC, USA; 6Pathology,
MUSC, Charleston, SC, USA; 7Gastroenterology, Wayne State
Su1.126 - Cross-Linking of Lipid Rafts on CD4 T Cells+
School of Medicine, Detroit, MI, USA; 8Gastroenterology,
by an Epithelial Lectin, Galectin-4, Contributes to the Wayne State School of Medicine, Detroit, MI, USA.
Exacerbation of Intestinal Inflammation.
K. Shirane,1 A. Hokama,1 Y. Shimomura,1 A. Ogawa,1 M.
Yoshida,2 S. T. Rietdijk,3 S. B. Snapper,4 C. Terhorst,3 R. S.
Blumberg,2 A. Mizoguchi.1 1Department of Pathology,
Massachusetts General Hospital, Boston, MA, USA; 2Division
of Gastroenterology, Brigham and Women’s Hospital, Boston,
MA, USA; 3Department of Immunology, Beth Israel Deaconess
Medical Center, Boston, MA, USA; 4Department of Medicine,
Massachusetts General Hospital, Boston, MA, USA.
118
2005
ANNUAL MEETING
Poster Session 2 Su2.07 - The Prognostic Impor tance of V

Importance ariants of Allele Genes
Variants
Sunday,, May 15, 2005
Sunday HLA DRB1 and IL-4 in HIV -Infection.
HIV-Infection.
3:30 pm - 7:30 pm Loudmila P. Sizyakina, Julia V. Sokolova. 1Center of Clinical
Immunology, State Medical University, Rostov-on-Don, Russian
Immunodeficiency: Primar
Primaryy or Acquired Federation; 2Russian Federation.
Su2.01 - Rheumatic Manifestations in a South Italy Popula-
Su2.08 - Recurrent Infections and Cytokine Imbalance in
tion HIV Positive: Correlation with CD4 Count.
A. Caliri,1 L. G. De Filippis,1 G. Scibilia,1 C. Romano,1 G. F. Hyper -IgE Syndrome Are Not Due to a Defect in TToll-Like
Hyper-IgE oll-Like Re-
Bagnato.1 1Rheumatology Unit, Policlinico Universitario G ceptor Pathways.
Martino, Messina, ME, Italy. E. D. Renner,1 F. Hoffmann,1 I. Pawlita,1 V. Hornung,2 D. Hartl,1
M. Albert,1 A. Jansson,1 S. Endres,2 G. Hartmann,2 B. H.
Su2.02 - Quality Control of siRNA, Optimizing It’It’ss TTransfec-
ransfec- Belohradsky,1 S. Rothenfusser.2 1University Children’s Hospital,
tion Efficiency and Monitoring CD4 Gene Silencing Effect Dr. von Haunersches Kinderspital, Ludwig-Maximilians-Univer-
sity, Munich, Germany; 2Department of Internal Medicine, Divi-
with a Microfluidic Chip Device.
sion of Clinical Pharmacology, Ludwig-Maximilians-University,
T. Preckel,1 C. Buhlmann,1 M. Valer.1 1Liquid Phase Analysis, Munich, Germany.
Agilent Technologies, Waldbronn, BW, Germany.
Su2.09 - Defective Functioning of Dendritic Cells in Common
Su2.03 - Cardiac Thrombus in Omenn Syndrome.
Variable Immuno Deficiency (CVID): A Common Denomina-
S. S. Kilic.1 1Pediatric Immunology, Uludag University School of
Medicine, Bursa, Turkey. tor for the Multiple Symptoms Displayed by CVID Patients.
Jagadeesh Bayry, Olivier Hermine, Eric Oksenhendler, Michel
Su2.04 - The Frequency and Effects of Vitamin A Deficiency D. Kazatchkine, Srini V. Kaveri. Memory Group, The Edward
1
Jenner Institute for Vaccine Research; INSERM U681, Compton,

in Common V ariable Immunodeficiency Patients.
Variable
Nr Newbury, Berkshire, United Kingdom; 2CNRS – UMR 8147,
S. S. Kilic.1 1Pediatric Immunology, Uludag University School of Necker Hospital, Paris, France; 3Department of Clinical Immu-
Medicine, Bursa, Turkey. nopathology, Saint Louis Hospital, Paris, France; 4INSERM U681,
Institut des Cordeliers, Paris, France; 5INSERM U681, Institut des
Su2.05 - Pulmonar
Pulmonary y Abscess Due to Aspergillus spp. in Pa- Cordeliers, Paris, France.
tients with Chronic Granulomatous Disease.
S. S. Kilic.1 1Pediatric Immunology, Uludag University School of Su2.10 - Clinical Profile of Primar
Primaryy Immunodeficiencies Dis-
Medicine, Bursa, Turkey. eases Patientes Followed up at Hospital das Clínicas da
Universidade Federal de Minas Gerais.
Su2.06 - Hodgkin’
Hodgkin’ss LLymphoma
ymphoma Developing in a 4.5-Y ear
4.5-Year -Old
ear-Old
L. A.O. Cunha,1 D. B. Greco,2 J. A. Pinto.1 1Paediatrics,
Girl with Hyper-IgE Syndrome. Faculdade de Medicina da Universidade Federal de Minas
Mohammad Amin Kashef,1 Sara Kashef,2 Farhad Hanjani,3 Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Infectious and
Mehran Karimi.4 1Allergy Research Center, Shiraz University of Contagious Diseases, Faculdade de Medicina da Universidade
Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 2Immu- Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Bra-
nology and Allergy, Shiraz University of Medical Sciences, Shiraz, zil.
Fars, Islamic Republic of Iran; 3Dermatology, Shiraz University
of Medical Sciences, Shiraz, Fars, Islamic Republic of Iran; 4Pe-
diatric Oncology, Shiraz University of Medical Sciences, Shiraz,
Fars, Islamic Republic of Iran.
119
2005
ANNUAL MEETING
Su2.11 - New Single Nucleotide Polymorphisms in the Gene Su2.15 - The IgG 2F5-Like Antibody in Serum of Mexican
Encoding the Phagocyte Oxidase 67 kDa Protein. Patients with AIDS Progression Prior to and after the Highly
L. Gomez-Restrepo,1 M. T. Rugeles,2 P. J. Patino,2 A. Condino- Active Anti-Retroviral Therapy
Therapy..
Neto.1,3 1Pediatrics, State University of Campinas Medical Y. Palacios-Rodriguez,1 T. G. Gazarian,2 A. Majluf-Cruz,3 K.
School, Campinas, SP, Brazil; 2Immunology, University of G. Gazarian.1 1Department of Molecular Biology and Biotech-
Antioquia Medical School, Medellin, Colombia; 3Immunology - nology, Institute of Biomedical Research, Mexican National
Institute of Biomedical Sciences, University of Sao Paulo, Sao University(UNAM), Mexico-City, DF, Mexico; 2Department of
Paulo, Brazil. Public Health, Faculty of Medicine, Mexican National
University(UNAM), Mexico-City, DF, Mexico; 3AIDS Clinic, Re-
Su2.12 - Chronic Granulomatous Disease in Latin American gional Hoospital “Gabriel Mancera”, Mexico-City, DF, Mexico.
Patients: Clinical Spectrum and Molecular Genetics.
P. Agudelo-Florez,1 C. Prando-Andrade,1 J. A. Lopez,1 B. T. Costa- Su2.16 - Genetically Determined Deficiency of the Innate
Carvalho,2 A. Quezada,3 F. J. Espinosa,4 M. A. Souza-Paiva,5 Immune Defence Protein, MBL-Associated Serine Protease-2
P. Roxo,6 M. M.S. Carneiro-Sampaio,7 P. E. Newburger,8 A. (MASP-2).
Condino-Neto.1,7 1Pediatrics, State University of Campinas S. Thiel,1 J. C. Jensenius,1 L. Truedsson,2 M. Carlsson,2 W. K.
Medical School, Campinas, SP, Brazil; 2Pediatrics - Allergy, Im- Ip,3 Y. C. Lau.3 1Medical Microbiology and Immunology, Uni-
munology & Rheumatology, Federal University of Sao Paulo versity of Aarhus, Aarhus, Denmark; 2Clinical Microbiology and
Medical School, Sao Paulo, Brazil; 3Pediatrics, University of Chile Immunology, Lund University Hospital, Lund, Sweden; 3Paediat-
Medical School, Santiago, Chile; 4Immunology, National Insti- rics and Adolescent Medicine, The University of Hong Kong,
tute of Pediatrics, Mexico, Mexico; 5Pediatrics, Rio de Janeiro Hong Kong, China.
State Employees Hospital, Rio de Janeiro, Brazil; 6Pediatrics,
Ribeirao Preto Medical School - University of Sao Paulo, Ribeirao
Su2.17 - Phenotypic Analysis of Peripheral Blood and Tissue
Preto, SP, Brazil; 7Immunology, Institute of Biomedical Sciences -
University of Sao Paulo, Sao Paulo, Brazil; Pediatrics, Univer- Memor
8 Memory y B Cells in Common V ariable Immunodeficiency
Variable
sity of Massachusetts Medical School, Worcester, MA, USA. (CVID).
A. P. Williams,1 C. Stephens,1 L. Hedges,1 A. Mani,1 E. Hodges,1
y Angioedema in Childhood - A Practice J. Smith. Department of Clinical Immunology, Southampton
1 1
Su2.13 - Hereditar
Hereditary
General Hospital, Southampton, United Kingdom.
Guideline.
R. J. Boyle, M. L.K. Tang. Immunology, Royal Children’s Hos-
1 1 1
pital, Parkville, Victoria, Australia. Su2.18 - Plasma Interleukin-7 Levels before Highly Active
Antiretroviral Therapy May Predict CD4+ TT-Cells
-Cells Recover
Recoveryy in
Su2.14 - Abnor mal Neutrophil’
Abnormal Neutrophil’ss Chemotactic Activity in HIV -Children.
HIV-Children.
Children with Congenital Insensitivity to Pain with Anhidrosis A. Perez, S. Resino, A.A. Meca, M.D. Gurbindo, M.A
1 1 1 2
Munoz-Fernandez. Laboratorio de Immunobiologia Molecu-

1 1
(CIP A): The Role of Ner
(CIPA): Nerveve Growth Factor in Chemotactic Ac-
lar, Hospital “Gregorio Maranon”, Madrid, Spain; 2Servicio de
tivity
tivity.. Inmuno-Pediatria, Hospital “Gregorio Maranon”, Madrid, Spain.
A. Beigelman,1 J. Levy,1 N. Hadad,2 V. Pinsk,1 R. Levy.2 1De-
partment of Pediatrics, Soroka Medical Center, Beer Sheva, Is-
Su2.19 - Different Profiles of Immune Reconstitution in Chil-
rael; 2Infectious Disease Laboratory, Soroka Medical Center, Beer
Sheva, Israel. dren and Adults with HIV -Infection after HAAR
HIV-Infection HAARTT.
S. Resino,1 E. Seoane,1 A. Perez,1 E. Ruiz-Mateos,2 M. Leal,2
M.A. Munoz-Fernadez.1 1Laboratorio de Inmuno-Biologia Mo-
lecular, Hospital General Universitario “Gregorio Maranon”,
Madrid, Spain; 2Grupo de Estudio Hepatitis Virica y SIDA, Hos-
pital Universitario “Virgen del Rocio”, Sevilla, Spain.
120
2005
ANNUAL MEETING
Su2.20 - Understanding HIV Infection through Dynamical Su2.26 - Immunotherapy by Cytogenes in Patients with Ac-
Modeling: V accines W
Vaccines on’
on’tt W
Won’ ork, What W
Work, ill?
Will? quired Neutropenia.
I. Kramer.1 1Physics, Univ. of MD, Catonsville, MD. Vardan Sergey Aprikyan, Nata Adolf Otieva.
1
Neuroimmunology, Inst. of Biochemistry, Yerevan, Armenia;
ransplanted Pharmacology, State University, Yerevan, Armenia.
Su2.21 - Model for the Repopulating Capacity of TTransplanted 2
T Cells.
Sebastian Newrzela,1 Sanaz Taromi,1 Roland Zahn,1 Dorothee Su2.27 - Evaluation of Humoral Immune Responsein Children
Von Laer.1 1Georg-Speyer-Haus (Chemotherapeutisches with Otitis Media and Control Group.
Forschungszentrum), Georg-Speyer-Haus (Chemotherapeutisches Farzad Oreizi, Maryam Saleminik, Ahmad GhavamiNejad,
Forschungszentrum), Frankfurt AM Main, Hessen, Germany. Fereshteh Sahebfosul. 1Immunology, Isfahan University of Medi-
cal Science, Isfahan, Isfahan, Islamic Republic of Iran;
Su2.22 - Apoptosis and the Emergence of Clonal Dual Posi- 2Flowcytometry, BD Company, San Francisco, CA, USA; 3Immu-
tive CD4CD8 Cells in a Y ymphopenia. nology, Isfahan University of Medical Sciences, Isfahan, Isfahan,
oung Boy with CD4 LLymphopenia.
Young
M. T. Krishna, E. Hodges, S. Harris, S. M. Morgan,1 J. O. Islamic Republic of Iran; Immunology, Isfahan University of
4
1 1 1
Warner,2 J. Hourihane,2 J. L. Smith.1 1Wessex Immunology Ser- Medical Sciences, Isfahan, Isfahn, Islamic Republic of Iran.
vice, Southampton University Hospitals NHS Trust, Southampton,
Hampshire, United Kingdom; 2Division of Infection, Inflamma- Su2.28 - New Composition Immunotherapy in TTreatment reatment of
tion and Repair, School of Medicine, Southampton University Secondar
Secondary y Immunodeficiency Accompanied by V iral Infec-
Viral
Hospitals NHS Trust, Southampton, Hampshire, United Kingdom. tious Syndrome.
Nesterova V. Irina. 1Department of Family Medicine, Educa-
Su2.23-Hypogammaglobulinemia and tional-Scientific Centre of Medical Centre of MD of Russian Presi-
Lymphoproliferation in TTwo
wo Patients with Heterozygous dent, Moscow, Russian Federation.
Deleterious Mutation of the Caspase-9 Gene.
A. Chiocchetti,1 R. Mesturini,1 T. Bensi,1 A. Biava,1 M. Ferretti,1 Su2.29 - Therapeutic Efficacy of Gc Protein-Derived Mac-
C. Santoro,1 C. Pignata,2 F. Rieux-Laucat,3 I. Dianzani,1 U. rophage Activating Factor for HIV -Infected/AIDS Patients.
HIV-Infected/AIDS
Ramenghi,4 L. D. Notarangelo,5 U. Dianzani.1 1IRCAD and N. Yamamoto,1 M. Ueda.1 1Molecular Immunology, Socrates
Department of Medical Sciences, University of Eastern Piedmont, Institute for Therapeutic Immunology, Philadelphia, PA, USA.
Novara, Italy; 2Department of Pediatrics, University of Naples,
Naples, Italy; 3INSERM Unite 429, Hopital Necker-Enfants Su2.30 - Pathogenic Significance of
Malades, Paris, France; 4Department of Pediatrics, University of α-N-Acetylgalactosaminidase Activity Found in the Fusion
Turin, Turin, Italy; 5Department of Pediatrics, University of Brescia,
Protein gp160 of Human Immunodeficiency V irus TType
Virus ype 1.
Brescia, Italy.
N. Yamamoto. 1Molecular Immunology, Socrates Institute for
Therapeutic Immunology, Philadelphia, PA, USA.
Su2.24 - Haplotypes, Mutations and Phenotype Genotype
Correlation in TTurkish
urkish A-T Patients. Su2.31 - Clinical and Laborator
Laboratoryy Findings in TTwenty
wenty Eight
O. Sanal,1 B. Behjatnia,2 M. Mitsui,2 F. Ersoy,1 I. Tezcan,1 A. I.
Patients with a Primar y Immunoglobulin Deficiency Associ-
Primary
Berkel,1 R. A. Gatti.2 1Pediatric Immunology, Hacettepe Univer-
sity Scool of Medicine, Ankara, Turkey; 2Pathology and Labora- ated with LLymphadenopathy
ymphadenopathy
ymphadenopathy,, Hepatosplenomegaly and Pul-
tory Medicine, UCLA School of Medicine, Los Angeles, CA, USA. monar
monary y Infiltrates.
W. Ding,1 C. R. Weiler.1 1Internal Medicine, Mayo Clinic Col-
Su2.25 - Mechanisms of Immunotoxicity of Mycotoxins. lege of Medicine, Rochester, MN, USA.
Elena Dorofeeva,1 Roman Khanferyan.1 1Immunoregulation,
Institute of Allergy and Asthma, Krasnodar, Russian Federation.
121
2005
ANNUAL MEETING
Su2.32 - Thir teen Y

Thirteen ears of M. bovis-BCG Culture-Positive In-
Years Su2.37 - Immunological Characterization of Children with
fection in an IL-12R
IL-12Rββ1 Deficient Patient: TTreatment
reatment and Out- Transient Hypogammaglobulinemia of Infancy (THI): In V itro
Vitro
come. Immunoglobulin Production Is a Candidate Predictive Marker
Marker..
Sergio D. Rosenzweig,1 Judith Yancoski,1 Andrea Bernasconi,1 V. Moschese,1 S. Graziani,1 M.A. Avanzini,2 R. Carsetti,3 I.
Silvia Krasovec,1 Beatriz E. Marciano,1 Lidia Casimir,1 Norberto Quinti,4 A. Plebani,5 A. Soresina,5 S. Di Cesare,1 L. Chini,1 M.
Simboli,2 Griselda Berberian,1 Marcela Russeau,1 Graciela Marconi,2 G. Bossi,6 M. La Rocca,1 R. Maccario,2 P. Rossi,1,3
Calle.1 1Hospital Nacional de Pediatria, “J. P. Garrahan”, A.G. Ugazio.3 1Pediatrics, Policlinico Tor Vergata, University of
Buenos Aires, Argentina; 2Servicio de Micobacterias, INEI ANLIS Tor Vergata, Rome, Italy; 2Laboratorio Area Trapianti, IRCCS,
“Dr. C. G. Malbran”, Buenos Aires, Argentina. Policlinico San Matteo, Pavia, Italy; 3Ospedale Pediatrico
Bambino Gesu, Rome, Holy See (Vatican City State); 4University
Su2.33 - Equivalent Per for
Perfor mance of V
formance ACUT
VACUT AINER® CPT™to La Sapienza, Rome, Italy; 5Pediatrics, University of Brescia,
ACUTAINER®
Ficoll-Hypaque Gradient Separation in Maintaining the Qual- Brescia, Italy; Scienze Pediatriche, Policlinico San Matteo, Pavia,
6
Italy.
ity and Function of PBMC from HIV Seropositive Blood
Samples.
Su2.38 - Health-Related Quality of Life in Patients with Pri-
J. J. Ruitenberg,1 C. B. Mulder,2 V. C. Maino,1 A. L. Landay,2 S.
A. Ghanekar.1 1&1pGL2Immunology and Microbiology, RUSH mar mary y Immunodeficiencies in Nor th America Receiving Home-
North
University Medical Center, Chicago, IL, USA. Based Subcutaneous Immunologlobulin Replacement Therapy
Therapy..
Uwe Nicolay,1 Peter Kiessling,2 Ann Gardulf,1 Hans D. Ochs.3
e a P o l y p h e n o l , Department of Laboratory Medicine, Section of Clinical Immu-
1
S u 2 . 3 4 - B i n d i n g o f t h e G r e e n TTe
nology, Karolinska Institutet at Karolinska University Hospital,
Epigallocatechin Gallate, to the CD4 Receptor on Human
Stockholm, Sweden; 2Clinical Research & Development, ZLB
CD4+T Cells Resulting in Inhibition of HIV -1-gp120 Binding. Behring GmbH, Marburg, Germany; 3Department of Pediat-
HIV-1-gp120
C. L. Nance,1 M. P. Williamson,2 T. G. McCormick,1 W. T. rics, University of Washington, Seattle, WA, USA.
Shearer.1 1Pediatrics/Allergy and Immunology, Baylor College
of Medicine, Houston, TX, USA; 2Biochemistry, University of
Su2.39 - Host MHC Influences Susceptibility to Hypersensi-
Sheffield, Sheffield, England, United Kingdom.
tivity Reactions to TTwo
wo Drugs Commonly Used in HIV Therapy
Therapy..
F. T. Christiansen,1 A. M. Martin,1 D. A. Nolan,1 S. Gaudieri,1
Su2.35 - Defect in CRAC Ca2+ Channel Function Associated
C. A. Almeida,1 E. Phillips,1 P. U. Cameron,1 C. B. Moore,1 I.
with Altered K+ Channel Gating Properties in T Cells from James,1 S. A. Mallal.1 1Department of Clinical Immunology &
Immunodeficient Patients. Biochemical Genetics & Centre for Clinical Immunology & Bio-
S. Feske,1 M. Prakriya,2 R. S. Lewis,2 A. Rao.1 1CBR Institute for medical Statistics, Royal Perth Hospital, Perth, Western Austra-
Biomedical Research, Harvard Medical School, Boston, MA, lia, Australia.
USA; 2Dept Molecular and Cellular Physiology, Stanford Uni-
versity, Stanford, CA, USA. Su2.40 - Multisystem Disease in CAEBV Infection.
A. P. Williams,1 J. O’B Hourihane,2 E. Hodges,1 H. B. Gaspar,3
Su2.36 - Proposal for Diagnostic Criteria for Immunodefi- J. Smith.1 1Department of Clinical Immunology, Southampton
ciency Associated with DiGeorge Syndrome. General Hospital, Southampton, United Kingdom; 2Department
A. Sediva,1 A. Janda.1 1Institute of Immunology, University Hos- of Child Health, Southampton General Hospital, Southampton,
pital Motol, Prague, Czech Republic. United Kingdom; 3Molecular Immunology Unit, Institute of Child
Health, London, United Kingdom.
122
2005
ANNUAL MEETING
Su2.41 - Infants with Recurrent Infections and Low Immuno- Su2.47 - Efficacy and Safety of Subcutaneous
globulins: Analysis of Immunoglobluin Normalization. Immunologlobulin Replacement Therapy at Home in Patients
M. A. Whelan,1 S. J. Kung,1 S. J. McGeady.2 1Allergy/Immu- with Primar
Primaryy Immunodeficiency Diseases: Combined Analy-
nology, Thomas Jefferson University Hospital, Philadelphia, PA, sis of TTwo
wo Clinical Studies, One in Nor th America and One
North
USA; 2Allergy/Immunology, AI duPont Hospital for Children,
in Europe.
Wilmington, DE, USA.
Hans D. Ochs & Clinical Investigators,1 Ann Gardulf,2 Michaela
Praus,3 Peter Kiessling.4 1Department of Pediatrics, University
Su2.42 - The Role of Wiskott Aldrich Syndrome Protein in T of Washington, Seattle, WA, USA; 2Department of Laboratory
Helper Cell Function. Medicine, Section of Clinical Immunology, Karolinska Intitutet at
J. Aoki,1 A. Konno,2 D. Jankovic,3 J. Cannons,1 F. Candotti,2 P. Karolinska University Hospital, Stockholm, Sweden; 3Biostatis-
Schwartzberg.1 1Genetic Disease Research Branch, National tics, Accovion GmbH, Marburg, Germany; 4ZLB Behring GmbH,
Human Genome Research Institute, Bethesda, MD, USA; 2Ge- Marburg, Germany.
netics and Molecular Biology Branch, National Human Genome
Research Institute, Bethesda, MD, USA; 3Laboratory of Parasitic Su2.48 – Abstract Withdrawn
Diseases, National Institute of Allergy and Infectious Diseases,
Bethesda, MD, USA.
Su2.49 - Association of IgA Deficiency and Ciliar y Dyskine-
Ciliary
ymphopenia and Absence Interleukin- sia: Report of a Familiar Case.
Su2.43 - Cyclic CD4 LLymphopenia
D. Strozzi,1,3 M. Toledo-Barros,1,3 L. V. Rizzo,1,3 P. H.N. Saldiva,2
2: A Novel Immunodeficiency Presentation.
E. G. Caldini,2 J. Kalil,1,3 C. M. Kokron.1,3 1Division of Clinical
Ronit Herzog, Joan Berman, Shirley Fung, Arye Rubinstein. 1Al-
Immunology and Allergy, Department of Medicine, University of
lergy and Immunology, Albert Einstein College of Medicine,
Sao Paulo Medical School, Sao Paulo, São Paulo, Brazil; 2De-
Bronx, NY, USA.
partment of Pathology, University of Sao Paulo Medical School,
Sao Paulo, São Paulo, Brazil; 3Institute for Investigation in Immu-
Su2.44 - Novel Severe TT-Cell
-Cell Immunodeficiency Syndrome nology (iii), Sao Paulo, São Paulo, Brazil.
Involving Absent Thymus, Coloboma, Bullous Dermatitis, Eosi-
nophilia, and Elevated IgE. Su2.50 - Atypical Mycobacterial Infection and Chronic
K. P. Shanks,1 L. M. Noroski,1 C. Langston,2 E. M. McKay,2 M. Granulomatous Disease: Experience of One Center Center..
L. Levy,3 S. L. Abramson.1 1Department of Pediatrics, Baylor G. Uzel,1 H. L. Malech,2 S. M. Holland.1 1NIAID, Laboratory
College of Medicine, Houston, TX, USA; 2Department of Pathol- of Clinical Infectious Diseases, NIH, Bethesda, MD, USA;
ogy, USA; 3Department of Dermatology, USA. 2
NIAID, Laboratory of Host Defenses, NIH, Bethesda, MD.
Su2.45 - Isolated PCP Infection in Children – A Systemic or Su2.51 - Use of Subcutaneous Immunoglobulin for TTreatment
reatment
Specific Immunodeficiency? of Chronic W Warar ts in Patient with Common V
arts ariable Immuno-
Variable
A. P. Williams,1 J. O’B Hourihane,2 E. Hodges,1 G. Davies,3 J.
deficiency
deficiency..
Smith.1 1Department of Clinical Immunology, Southampton
J. H. Lin,1 R. L. Roberts.1 1Department of Pediatric Allergy, Im-
General Hospital, Southampton, United Kingdom; 2Department
munology, Rheumatology, University of California Los Angeles,
of Child Health, Southampton General Hospital, Southampton,
Los Angeles, CA, USA.
United Kingdom; 3Molecular Immunology Unit, Institute of Child
Health, London, United Kingdom.
Su2.46 - Combined Immunodeficiency with Defective Expres-

sion in MHC Class II Genes.
Anastassia P. Mihaylova,1 Kalina L. Penkova,1 Danilela N.
Baltadzhieva,1 Milena I. Ivanova,1 Elissaveta J. Naumova.1
1
Central Laboratory for Clinical Immunology, University Hospital
Alexandrovska, Sofia, Bulgaria.
123
2005
ANNUAL MEETING
Su2.52 - Distribution and Clinical Aspects of Pediactir Pri- Su2.56 - The Higher pH Level Present in the Skin of Patients
mar
maryy Immunodeficiencies in TTaiwan.
aiwan. with Atopic Eczema Stimulates the Release of Malassezia
Wen-I. Lee,1 Jing-Long Huang,1 Ming-Ling Kuo,2 Syh-Jae Lin,1 sympodialis Allergens.
Cheng-Jang Wu.2 1Department of Pediatric Allergy, Immunol- Annika Scheynius,1 Christine Selander,1 Omid Rasool,1 Reto
ogy and Rheumatology, Chang Gung University and Children’s Crameri,2 Arezou Zargari.1 1Department of Medicine, Clinical
Hospital, Kwei-Shan, Taoyuan, Taiwan; 2Department of Micro- Allergy Research Unit, Karolinska Institutet and University Hospi-
biology and Immunology, Graduate Institute of Basic Medical tal, Stockholm, Sweden; 2Swiss Institute of Allergy and Asthma
Sciences, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan. Research (SIAF), Davos, Switzerland.
Su2.53 - Experimental Study of the Complex Bi-Directional Su2.57 - TTuberculin

uberculin Skin TTesting
esting W idely Used as a Dianostic
Widely
Interactions between Human Immunodeficiency V irus TType
Virus ype 1 Aid for TTuberculosis,
uberculosis, False Negative Outcome Has Ques-
(HIV -1) and the Protozoan Parasite Leishmania.
(HIV-1) tioned Its Specificity & Sensitivity Inspite of TTuberculous
uberculous In-
Chenqi Zhao,1 Michel J. Tremblay.2 1Microbiology-Immunology, fection.
Centre de Recherche en Infectiologie, Ste-Foy, QC, Canada; M. Ishaq, I. M. Sameera, K. M. Miraj. 1Allergy/Pulmonology,
2
Microbiology-Immunology, Centre de Recherche en Infectiologie, Al-Junaid Hospital, Nowshera, NWFP, Pakistan.
Ste-Foy, QC, Canada.
Su2.58 - Absence of Draining LLymph
ymph Nodes Results in Th2
Su2.54 - Hereditar
Hereditary y Angioedema: A New Mutation and a
Immune Deviation and Loss of Resistance to Leishmania ma-
Search of Gravity Factor?
jor Infection.
Kamel Djenouhat, Veronique Fremeaux-Bacchi, Jacques Blouin,
T. W. Spahn,1,2 W. Domschke,1 J. Roth,3 C. Sorg,3 T. Kucharzik,1
Marie Therese Guinnepin, Jerome Laurent, Mario Tosi, Mohamed
J. M. Ehrchen.3 1Department of Medicine B, Muenster Univer-
Cherif Abbadi. 1Immunology, Institut Pasteur d’Alger, ElHamma,
sity Hospital, Muenster, NRW, Germany; 2Department of Inter-
Alger, Algeria; 2Immunology, Hopital Europeen Georges
nal Medicine and Gastroenterology, Marienhospital
Pompidou, Paris, Paris, France; 3Immunology, Hopital Europeen
Osnabrueck, Osnabrueck, Niedersachsen, Germany; 3Depart-
Georges Pompidou, Paris, Paris, France; 4Allergy, Institut Pas-
ment of Experimental Dermatology, Muenster University Hospi-
teur de Paris, Paris, Paris, France; 5Allergy, Institut Pasteur de
tal, Muenster, NRW, Germany.
Paris, Paris, Paris, France; 6Immunogenetic, Faculte de Medecine
et de Pharmacie, Rouen, Rouen, France; 7Immynology, I.P.ALGER,
Alger, Alger, France. Su2.59 - Dissociation of TTransactivation
ransactivation from TTransrepression
ransrepression
Activity by a Selective Glucocorticoid Receptor Agonist
Immuno-dermatology (SEGRA) Leads to Separation of Therapeutic Effects from Side
Effects.
Su2.55 - Bexarotene Gel 1% vs. V ehicle Gel in Combination
Vehicle H. Schaecke,1 A. Schottelius,1 W.D. Doecke,1 P. Strehlke,2 S.
with Narrow-Band Ultraviolet B Phototherapy for Moderate Jaroch,2 N. Schmees, 2 H. Rehwinkel,2 H. Hennekes,3 K.
to Severe Psoriasis V ulgaris.
Vulgaris. Asadullah.1 1RBA Dermatology, Schering AG, Berlin, Germany;
M. A. Magliocco,1 K. Pandya,1 V. Dombrovskiy,1 Y. Wong,1 L. 2
Medicinal Chemistry, Schering AG, Berlin, Germany; 3Corpo-
Christiansen,1 A. B. Gottlieb.1 1Clinical Research Center, UMDNJ- rate Project Management SBU Specialized Therapeutics,
Robert Wood Johnson Medical School, New Brunswick, NJ, USA. Schering AG, Berlin, Germany.
124
2005
ANNUAL MEETING
Su2.60 - The Effect of Bur

Burnn TTrauma
rauma in Rats on Neutrophil Re- Su2.66 - Expression of the Costimulator
Costimulatoryy Molecules on Anti-
cruitment and Antioxidant Enzymes Activity in Epidermis. gen-Presenting Cells in Atopic Dermatitis.
E. V. Mikhal’chik,1 S. M. Titkova,2 M. V. Anurov,2 A. P. Oettinger,2 G. N. Drannik,1 A. I. Kurchenko,1 L. M. DuBuske.2 1Dept. Clini-
L. G. Korkina.1 1Department of Molecular Biology, Russian State cal Immunology and Allergology, National Medical University,
Medical University, Moscow, Russia, Russian Federation; 2De- Kiev, Ukraine; 2Immunology Research Institute of New England,
partment of Physiology, Russian State Medical University, Mos- Gardner, MA, USA.
cow, Russia, Russian Federation; 3Deparment of Physiology,
Russian State Medical University, Moscow, Russia, Russian Fed- Su2.67 - Differential Distribution of LLymphocyte
ymphocyte Subpopula-
eration; 4Department of Physiology, Russian State Medical Uni- tions in Peripheral Blood and Muscle Biopsies in Untreated
versity, Moscow, Russia, Russian Federation; 5Department of Mo-
Juvenile Dermatomyositis (JDM).
lecular Biology, Russian State Medical University, Moscow, Rus-
C. Chuu,1 M. O’Gorman,1 L. M. Pachman.1 1Pediatrics, Feinberg
sia, Russian Federation.
College of Medicine, Northwestern University, Chicago, IL, USA.
opi-
Su2.61 - Quantitative Changes of Mast Cells Following TTopi-
Su2.68 - Thalidomide, an Anti-Inflammator
Anti-Inflammatory y Medication. In-
cal Application of Honey on Third Degree Burns in Rats.
Factor-- α (TNF
umor Necrosis Factor
hibits the Induction of TTumor α) in
(TNFα
Mohammad Bayat,1 Mojtaba Karimipour,1 Mohammadali
Almasieh.1 1Anatomy, Shaheed Beheshti University of Medical Ultraviolet B (UVB)-Irradiated Human Keratinocytes by Desta-
Siences, Tehran, Tehran, Islamic Republic of Iran. bilizing the TNF
TNFα α mRNA.
J. H. Lin,1 M. M. Bashir,1 W. Zhang,1 V. P. Werth.1,2 1Dermatol-
Su2.62 - Anti-IFN-gamma as a Universal TTreatment
reatment for Th1 ogy, U. of Penn., Phila., PA, USA; Dermatology, Phila. VA
2
Medical Center, Phila., PA, USA.

Mediated Skin Diseases.
S. Skurkovich, B. Skurkovich, N. Korotky, N. Sharova, G.
1 2 3 3
Lukina,4 Y. Sigidin.4 1R&D, Adv Biotherapy, Inc., Rockville, MD, Su2.69 - Gene TTranscripts
ranscripts as Potential Diagnostic Markers
USA; Brown Med School, Providence, RI, USA; Dept of Skin for Allergic Contact Dermatitis.
2 3
Dis, Russian St Med U, Moscow, Russian Federation; 4Clinic, M. B. Hansen, L. Skov, T. Menne, J. Olsen. Department of
1 1 1 2 1
Rheumatol Inst, Moscow, Russian Federation. Dermatology, Gentofte Hospital, Hellerup, Denmark; 2Depart-
ment of Medical Biochemistry and Genetics, University of
Buschke’ss Scleredema: Atypical Onset and Evolu- Copenhagen, Copenhagen, Denmark.
Su2.63 - Buschke’
tion. Case Report.
Victor Cristea,1 Monica Crisan,1 Claudia Magurici,1 Ramona Su2.70 - Potent Anti-Inflammator
Anti-Inflammatoryy Effect of TTopical
opical Nuclear
Bologa,1 Nicolae Miron.1 1Immunology, Iuliu Hatieganu Uni- Factor kappa B Decoy in Skin Inflammation.
versity of Medicine and Pharmacy, Cluj Napoca, Cluj, Roma- B. Schryver,1 T. Muchamuel,1 A. Oo,1 J. Alleman,1 M. Dajee,1
nia. L. M. McEvoy,1 R. Ehrhardt.1 1Research, Corgentech.Inc, South
San Francisco, CA, USA.
Su2.64 - The Characteristics of Mucosal Immunity in Chronic
Adult Periodontitis Patients. Su2.71 - Dual Diagnosis of Pemphigus V ulgaris and Connec-
Vulgaris
I. Kaidashev,1 V. Shinkevich,1 L. M. DuBuske.2 1Ukrainian Medi- tive Tissue Disease.
cal Stomatological Academy, Poltava, Ukraine; 2Immunology Mohsin Malik,1 A. Razzaque Ahmed.1 1Oral Medicine, Infec-
Research Institute of New England, Gardner, MA, USA. tion and Immunity, Harvard School of Dental Medicine, Boston,
MA, USA.
Su2.65 - Acquired Angioedema and Coagulopathy Several
Years after Syphilis.
Soheil F. Chegini, Michael J. Davies, Timothy J. Craig. 1Medi-
cine, Division of Pulmonary, Allergy & Critical Care, Penn State
College of Medicine, Hershey, PA, USA.
125
2005
ANNUAL MEETING
Su2.72 - Production and Characterization of Human Mono- Laborator

Laboratoryy Immunology
clonal Antibody Against Desmoglein 3 from Pemphigus V ul-
Vul-
Su2.77 - Influence of Atopic Histor y on Cord Blood IgE.
History
garis Patient. Mohammad Amin Kashef,1 Sara Kashef,2 Narjes Pishva,3
Shih Wei Yeh,1 Kailash C. Bhol,1 Mukesh Kumar,2 Lisa A. Mozhgan Afshari, Zahra Amirgofran,4 Hamed Jalaeian.1 1Al-
Cavacini,2 Marshall Posner,2 A. Razzaque Ahmed.1 1Oral lergy Research Center, Shiraz University of Medical Sciences,
Medicine, Infection and Immunity, Harvard School of Dental Shiraz, Fars, Islamic Republic of Iran; 2Immunology and Allergy,
Medicine, Boston, MA, USA; 2Beth Israel Deaconess Medical Shiraz University of Medical Sciences, Shiraz, Fars, Islamic Re-
Center, Boston, MA, USA. public of Iran; 3Neonatalogy, Shiraz University of Medical Sci-
ences, Shiraz, Fars, Islamic Republic of Iran; 4Immunology, Shiraz
Su2.73 - Identification of Epitope for Autoantibody and Its University of Medical Sciences, Shiraz, Fars, Islamic Republic of
Role in Basement Membrane Separation in Oral Pemphig- Iran.
oid.
ymphocyte Adenosine Deaminase Activity in Chil-
Khwaja Aftab Rashid,1 Adnan Q. Usman,1 Shih Wei Yeh,1 Joel Su2.78 - LLymphocyte
N.H. Stern,1 Kailash C. Bhol,1 A. Razzaque Ahmed.1 1Oral dren with Idiopathic Nephrotic Syndrome.
Medicine, Infection and Immunity, Harvard School of Dental Om P. Mishra, Jayant K. Ghosh, Ziledar Ali, Malay R. Sen,
Medicine, Boston, MA, USA. Rajniti Prasad. 1Dept of Pediatrics, Institute of Medical Sciences,
Varanasi, Uttar Pradesh, India; 2Dept of Pediatrics, Institute of
Su2.74 - Effects of Electrical Microcurrent on Open Skin Medical Sciences, Varanasi, Uttar Pradesh, India; 3Dept of Bio-
Wound Healing in Rabbit. chemistry, Institute of Medical Sciences, Varanasi, Uttar Pradesh,
Mohammad Bayat,1 Zahra Asgari-Moghadam,1 Mohammad India; Dept of Microbiology, Institute of Medical Sciences,
4
Rakhshan, Fateme-sadat Rezai, Mohammadali Almasieh. Varanasi, Uttar Pradesh, India; Dept of Pediatrics, Institute of
1 1 1 5
1
Anatomy, Shaheed Beheshti University of Medical Sciences, Medical Sciences, Varanasi, Uttar Pradesh, India.
Tehran, Tehran, Islamic Republic of Iran.
Su2.79 - ESN: A Potent Natural Inhibitor of Proliferationg
Su2.75 - Morphometric Assessment of Nitrofurazone Oint- and Inducer of Apoptosis on K562 Cells.
ment on Healing of Infectous Second Degree Burns of Rat. Yang Ping Niu. 1School of Pharmacology, Zhejiang Univerisity
Mohammad Bayat, Hasan Bagheri-Yazdi, Mohammadali of Technology, Hangzhou, Zhejiang, China.
1 1
Almasieh.1 1Anatomy, Shaheed Beheshti University of Medical

Sciences, Tehran, Tehran, Islamic Republic of Iran. Su2.80 - An Automatic System for the Image Analysis and
Interpretation of HEp-2 Image Pattern.
Su2.76 - Effect of Low-Power Gallium Aluminum Arsenide Laser Petra Perner,1 Horst Perner.1 1Research Dept., ImageInterpret
Radiation on Mast Cells of Open Skin W ound Bed of Rats. GmbH, Leipzig, Germany.
Wound
Mohammad Bayat,1 Mohammadghasem Golmohammadi,1
Mohammadali Almasieh.1 1Anatomy, Shaheed Beheshti Uni- Su2.81 - Determination of ANA Autoantibodies with Multi-
versity of Medical Sciences, Tehran, Tehran, Islamic Republic of plexed Immunoassays.
Iran. J. L. Hadley,1 D. O. Onley,1 G. J. Harradence,1 N. F. Cahir,1 C.
Garey,1 P. A. Swarbrick.1 1R&D, SmartBead Technologies, Cam-
bridge, United Kingdom.
Su2.82 - Distribution of Killer Cell Immunoglogulin-Like Re-

ceptors Genes in Chinese Han Population.
K. Jiang, F. M. Zhu, Q. F. Lv, L. X. Yan. 1HLA Typing Laboratory,
Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.
126
2005
ANNUAL MEETING
Su2.83 - Problems of Immunodiagnostics of Hepatitis C in Su2.89 - Does the CD203c Basophil Marker Improve the Flow-
Senior Patients. Cytometr
Cytometryy Diagnosis of Immediate Allergy?
A. A. Potapova, P. G. Bogush, E. B. Redchenko. 1Laboratory of A. Ocmant,1 A. Michils,2 Y. Peignois,1 L. Schandene.1 1Depart-
HIV-Detection, Urban Sexually Transmitted Diseases Clinic N 1 ment of Immunology, Erasme Hospital, Brussels, Belgium; 2De-
of Moscow Health Care Department, Moscow, Russian Federa- partment of Chest Medecine, Erasme Hospital, Brussels, Belgium.
tion.
Su2.90 - Prospective Comparison of ELISA and Immunodiffusion
Su2.84 - The Novel Docosatriene, Protectin D1, Produced by for Detection of Antibodies to Extractable Nuclear Antigens.
TH2-Polarization Promotes Human T Cell Apoptosis Via Lipid- J. L. Schmitz,1 K. Freeman,1 S. Orton,1 J. D. Folds.1 1McLendon
Raft Clustering. Clinical Laboratories, UNC Hospitals, Chapel Hill, NC, USA.
Amiram Ariel,1 Pin-Lan Li,1,2 Wei Wang,1 Wang-Xian Tang,1,2
Song Hong,1 Katherine H. Gotlinger,1 Charles N. Serhan.1 Su2.91 - A Novel Proteomics Assay Employing Amplification
1
Center for Experimental Therapeutics and Reperfusion Injury, of Oligonucleotide TTags
ags from Monoclonal Antibodies.
Department of Anesthesiology, Perioperative and Pain Medi- M. G. Kattah,1 J. Coller,2 P. J. Utz.1 1Division of Immunology
cine, Brigham and Women’s Hospital and Harvard Medical and Rheumatology, Stanford University, Stanford, CA, USA;
School, Boston, MA, USA; 2Department of Pharmacology and 2
Stanford Functional Genomics Facility (SFGF), Stanford Univer-
Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA. sity, Stanford, CA, USA.
Su2.85 - FFACS-Based
ACS-Based Method TToo Evaluate Inhibitor
Inhibitoryy Antibod- Su2.92 - Identification of Major Histocompatibility Complex
ies in Patients Receiving Enzyme Replacement Therapy
Therapy.. (MHC) Class I-Realted Genes in Cattle.
K. Seiger,1 L. Cherry,1 V. Theobald,1 S. Richards.1 1Clinical C. De Juan Sanjuan,1 S. A. Ellis.1 1Immunopathology, Institute
Laboratory Science, Genzyme Corporation, Framingham, MA, for Animal Health, Compton, Berkshire, United Kingdom.
USA.
Su2.93 - an of Influenza Virus.
Su2.86 - Experimental (war) TType
ype System of Hemaimmune N. Yamamoto,1 M. Urade,2 M. Ueda.1 1Molecular Immunol-
Reaction Road Map. ogy, Socrates Institute for Therapeutic Immunology, Philadelphia,
Guo Feng. 1Department of Blood Transfusion, Chang Hai Hos- PA, USA; 2Oral Surgery, Hyogo College of Medicine, Hyogo,
pital Second Military Medical University, Shanghai, China. Japan.
Su2.87 - Activation of Red Blood Cell Innate Immune Reac- Su2.94 - Role of L-Arginine TTranspor
ranspor ter
ter,, Solute Carrier 7A2
ransporter
tion Main Road by Antigen. (SLC7A2), in the Immune System.
Guo Feng. 1Department of Blood Tansfusion, Changhai Hospi- R. M. Sanchez-Munoz,1 J. Kleeman,1 C. L. MacLeod,1 L. G.
tal Second Military Medical University, Shanghai, China. Ellies.1 1Cancer Center, University of California San Diego, San
Diego, CA, USA.
Su2.88 - Evaluation of the Effects of Different Freezing Proce-
dures on the Function and Composition of LLymphocyte
ymphocyte Sub- Su2.95 - Improved Immunological Methods Using Peptides:
populations from Blood and Synovial Fluid. Wester n Blots, Peptide Arrays, Kinase Assays and ELISAs.
estern
Mona Widhe,1 Nimrod Kiss,1 Therese Wallerskog,1 Andreas I. Ghosh,1 L. Sun,1 M.-Q. Xu.1 1Research and Development,
Fasth,1 Vivianne Malmstrom,1 Christina Trollmo.1 1Rheumatol- New England Biolabs, Beverly, MA, USA.
ogy Research Unit, Dep of Medicine at Solna, Karolinska
Institutet, Stockholm, Sweden.
127
2005
ANNUAL MEETING
Su2.96 - Characterization of Assay V ariability in Real-T

Variability ime
Real-Time Su2.102 - A Multi-Level Approach to Analyzing Immune Re-
and Batch Assays of Sequential Samples from the Same Do- sponses in TTargeted
argeted Cells by Combining Cytomic and
nors. Proteomic TTechniques
echniques of Cell Sor ting and Protein Fraction-
Sorting
J. L. Lathey,1 K. Martinez,1 S. Gregory,1 P. D’Souza,2 W. ation.
Lopaczynski.1 1Virology/Immunology, BBI Biotech, a Division of S. D’Costa,1 E. Betgovargez,1 C. Snow,1 M. Simonian.1 1Bio-
SeraCare Life Sciences, Gaithersburg, MD, USA; 2Vaccine, medical Research Division, Beckman Coulter Inc., Miami, FL,
NIAID, Bethesda, MD, USA. USA.
Su2.97 - HLA-T yped PBMC Samples with Established Anti-

HLA-Typed Su2.103 - Notch Modulation of Peripheral Immunity: A Novel
gen/Peptide Reactivity for Accelerating and Standardizing Approach to Antigen-Specific Immunotherapy
Immunotherapy..
Human Immunological Research. B. R. Champion,1 S. Ballantyne,1 A. Rust,1 L. Perry,1 H. Beacock-
P. V. Lehmann,1 S. Gregory,2 M. Ewell,2 W. Lopaczynski,2 T. Sharp,1 C. Howard,1 L. Green,1 A. Watkins,1 R. Bartram,1 G.
Watts,2 C. Shive,1 N. Sigmund,1 O. Targoni,1 J. Lathey,2 W.J. Martin,1 E. Briend,1 H. Harper,1 T. Tugal,1 S. Ragno,1 L. L. Young.1
Zhang.1 1&2BBI Biotech Research Laboratories, A Division of 1
Discovery Research, Lorantis Ltd, Cambridge, United Kingdom.
SeraCare Life Sciences, Gaithersburg, MD, USA.
Su2.104 - Serum Heat-Inactivation and Granulocyte Presence
Su2.98 - Cell Proliferation Index. A Reliable and V alidated
Validated Exerts a Differential Effect on the Antigen-Induced Prolifera-
Method That Quantifies Cell Proliferation According to CFSE tion of LLymphoid
ymphoid Subsets.
Dilution. N. J. Andersen,1 D. A. Lawrence.1 1Wadsworth Center, New
J. C. Crispin,1 M. I. Vargas-Rojas,1 J. Alcocer-Varela.1 1Depart- York State Dept of Health, Albany, NY, USA.
ment of Immunology and Rheumatology, Instituto Nacional de
Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Su2.105 - Provision and Integration of HLA Alleles into Sci-
Mexico. entific Research.
S. J. Cate,1 R. Tian,1 M. Jones,1 S. Chandrasekaran,1 W. H.
Su2.99 - Evaluation of CellPrep, an Automated Cell W ashing Hildebrand.1 1Microbiology, University of Oklahoma, Oklahoma
Washing
Instrument for Analysis of Surface Markers on Leukocyte Sub- City, OK, USA.
populations V ia Flow Cytometr
Via Cytometry y.
J. G. Wilkinson,1 C. Aparicio,1 C. Smith,1 E. Rabellino,1 S. Su2.106 - Potassium Channels IR, Kv1.5, and Kv1.3 Are Ex-
D’Costa.1 1Biomedical Research Division, Beckman Coulter Inc., pressed on Human Dendritic Cells and Have a Functional
Miami, FL, USA. Role in Maturation.
K. M. Mullen,1 M. Rozycka,2 L. Hu,1 H. Rus,2 J. Graber,1 M. W.
Su2.100 - Optimization of the Aspiration Dose of IL-1ra Prepa- Pennington,3 D. C. Johns,4 S. I. Judge,2 P. A. Calabresi.1 1Neu-
ration TTo
o Stop an Inflammation in the Mouse Respirator y TTract.
Respiratory ract. rology, Johns Hopkins University, Baltimore, MD, USA; 2Neurol-
A. M. Ischenko, B. P. Nikolaev, E. V. Vorobeychikov, L. Yu ogy, University of Maryland, Baltimore, MD, USA; 3Bachem Bio-
1 2 2
Yakovleva,2 T. V. Kotova,2 L. Ya Soloviova,1 V. G. Konusova.3 science, Inc, King of Prussia, PA, USA; 4Neurosurgery, Johns
1
Protein Biochemistry, Institute of Highly Pure Biopreparations, Hopkins Hospital, Baltimore, MD, USA.
Saint-Petersburg, Russian Federation; 2New Drug Formulations,
Institute of Highly Pure Biopreparations, Saint-Petersburg, Rus- Su2.107 - Monitoring the Effects of Immuno-Modulating Thera-
sian Federation; 3Immunopharmacology, Institute of Highly Pure pies.
Biopreparations, Saint-Petersburg, Russian Federation. J. B. Woodcock, J. A. Britz, D. R. Post, R. J. Kowalski.1 1Product
Development, Cylex Incorporated, Columbia, MD, USA.
Su2.101 - The Use of Arginine-Rich Peptide Conjugated
Antisense Oligomers TTo o Alter Immune Function.
N. B. Marshall,1 D. V. Mourich,1 H. M. Moulton,1 P. L. Iversen.1
1
Biology, AVI BioPharma Inc., Corvallis, OR, USA.
128
2005
ANNUAL MEETING
Su2.108 - Development of a Versatile Murine T Cell Expander

Versatile Su2.114 - Phenotypically and Functionally Distinct CD8+ LLym-
ym-
Bead: Combining Quality with Practicality
Practicality.. phocyte Populations in Long-T er
Long-Ter
ermm Drug-Free TTolerance
olerance in Hu-
E. Leung,1 A. Aas-Eng,2 G. Okern,2 A. M. Rasmussen,2 O. man Kidney Graft Recipients.
Amellem, 2 A. Simonsen, 2 O. A. Garden. 1 1Molecular D. Baeten,1 S. Louis,1 C. Braud,1 C. Braudeau,1 A. Pallier,1 M.
Immunoregulation Team, Dep. of Immunology, Imperial College Giral,1 S. Brouard,1 J.P. Soulillou.1 1INSERM U643, ITERT,
London, London, United Kingdom; 2Immunosystems, Dynal Nantes, France.
Biotech ASA, Oslo, Norway.
Su2.115 - Could Early Posttransplant Allosensitivity Predict
Su2.109 - Characterization of Endogenously Loaded Rhesus Patients at High Risk for Rejection and Graft Loss in Kidney
Macaque MHC Class I Peptides. Transplantation.
A. R. Gilb,1 H. D. Hickman-Miller,1 W. Bardet,1 A. D. Luis,1 D. I. Petia P. Boneva, 1 Anastassia P. Mihaylova,1 Daniela N.
Watkins,2 K. Jackson,1 W. H. Hildebrand.1 1Microbiology and Baltadzhieva,1 Kalina L. Penkova,1 Daniela L. Jordanova,1 Pepi
Immunology, University of Oklahoma Health Sciences Center, K. Angelova,1 Elissaveta J. Naumova.1 1Central Laboratory for
Oklahoma City, OK, USA; 2Wisconsin Regional Primate Center, Clinical Immunology, University Hospital Alexandrovska, Sofia,
University of Wisconsin, Madison, WI, USA. Bulgaria.
Su2.110 - NUSE and RLE: Quality Assessment of Oligonucle- Su2.116 - Humoral and Cellular Response to Influenza V ac-
Vac-
otide Microarray Data TTo o Quantify Systemic V ariation.
Variation. cination in Human Recipients Naturally TTolerant
olerant to a Kidney
F. Collin,1 A. L. Asare,1 S. A. Kolchinsky,1 T. P. Speed,2 V. L.
Allograft.
Seyfert-Margolis.1 1Immune Tolerance Network, University of
G. Roussey-Kesler,1 C. Ballet,1 J. T. Aubin,2 S. Brouard,1 J. P.
California, San Francisco, Bethesda, MD, USA; 2Department of
Soulillou.1 1ITERT, INSERM U643, Nantes, France; 2Centre
Statistics, University of California, Berkeley, CA, USA.
National de Reference du Virus Influenza, Institut Pasteur, Paris,
France.
Su2.111 - High Resolution HLA TTyping
yping for Vaccine and Au-
Vaccine
toimmune Studies. Su2.117 - Pharmacodynamic Monitoring of Calcineurin In-
R.Y. Tian,1 S. J. Cate,1 M. M. Jones,1 W. H. Hildebrand.1 1Mi-
hibitors by Quantitative Analysis of NF
NFAAT-Regulated Gene Ex-
crobiology and Immunology, University of Oklahoma Health
Science Center, Oklahoma City, OK, USA. pression.
T. Giese,1 M. Schoels,1 T. Dengler,2 M. Zeier,3 S. Meuer.1 1Im-
munology, University of Heidelberg, Heidelberg, Germany; 2Car-
Organ TTransplantation
ransplantation
diology, University of Heidelberg, Heidelberg, Germany; 3Neph-
Su2.112 - On the Possibility of Oral TTolerance o Be Used in rology, University of Heidelberg, Heidelberg, Germany.
olerance TTo
Graft TTransplantation.
ransplantation.
Xiao-Bin Zheng. 1Research and Development, Beijing Su2.118 - Profiling of “Operationally TTolerant” olerant” Kidney Re-
Zhongbangyumin Sci-trade Company Co.Ltd., Beijing, China. cipients Using SELDI-TOF Mass Spectroscopy
Spectroscopy..
Christophe Braud,1 Alexandre DuPont,1 Magali Giral,1 Jean-
Su2.113 - Evidence for Naturally Occurring and Induced Paul Soulillou,1 Sophie Brouard.1 1INSERM U643, ITERT-CHU
Regulator
Regulatory y TT-Cells
-Cells in Non-Human Primates. Hotel Dieu Nantes, Nantes, France.
K. G. Haanstra, J. A.M. Wubben, M. Jonker. Immunobiology,
1 1 1 1
Biomedical Primate Research Centre, Rijswijk, ZH, Netherlands.
129
2005
ANNUAL MEETING
Su2.119 - Mega Dose Allogeneic Hematopoietic Stem Cell Su2.122 - New Insights in Mechanisms of Action of Different
Transplantation, Natural Suppressor Cell Chimerism and TTol- ol- Immunosuppressive Drug Therapies by Assessing the Phar-
erance in Clinic- Ahmedabad Experience. macodynamics in HearHeartt TTransplant
ransplant Recipients.
H. L. Trivedi, A. V. Vanikar, P. R. Modi, V. R. Shah, J. M. Vakil, S. M. J. Barten,1 A. Rahmel,1 M. Richter,1 J. Garbade,1 H. B. Bittner,1
I. Khemchandani, V. B. Trivedi. 1Department of Transplantation S. Dhein,1 F. W. Mohr,1 J. F. Gummert.1 1Cardiac Surgery, Uni-
Medicine, Institute of Transplantaion Sciences and Institute of versity Leipzig, Heart Center Leipzig, Leipzig, Germany.
Kidney Diseases & Research Centre, Ahmedabad, Gujarat, In-
dia; 2Department of Pathology, Lab Medicine and Transfusion Su2.123 - Assessment of Peripheral Blood Dendritic Cell Sub-
Services and Dept. of Immunohematology, Institute of sets and Their Functions TTo o Monitor Immunosuppression af-
Transplantaion Sciences and Institute of Kidney Diseases & Re-
ter Hear
Heartt TTransplantation.
ransplantation.
search Centre, Ahmedabad, Gujarat, India; 3Department of
M. J. Barten,1 A. Rahmel,1 M. Richter,1 J. Garbade,1 H. B. Bittner,1
Urology, Institute of Transplantaion Sciences and Institute of Kid-
S. Dhein,1 F. W. Mohr,1 J. F. Gummert.1 1Cardiac Surgery, Uni-
ney Diseases & Research Centre, Ahmedabad, Gujarat, India;
versity Leipzig, Heart Center Leipzig, Leipzig, Germany.
4
Department of Anesthesia, Institute of Transplantaion Sciences
and Institute of Kidney Diseases & Research Centre, Ahmedabad,
Gujarat, India; 5Department of Transplantation Medicine, Insti- Su2.124 - T Helper Cells Produced Increased IL-6 and TNF- TNF-α α
tute of Transplantaion Sciences and Institute of Kidney Diseases Levels in Human Hear
Heartt TTransplant
ransplant Recipients.
& Research Centre, Ahmedabad, Gujarat, India; 6Department M. J. Barten,1 A. Rahmel,1 M. Richter,1 J. Garbade,1 H. B. Bittner,1
of Urology, Institute of Transplantaion Sciences and Institute of S. Dhein,1 F. W. Mohr,1 J. F. Gummert.1 1Cardiac Surgery, Uni-
Kidney Diseases & Research Centre, Ahmedabad, Gujarat, In- versity Leipzig, Heart Center Leipzig, Leipzig, Germany.
dia; 7Department of Pathology, Lab Medicine and Transfusion
Services and Dept. of Immunohematology, Institute of Su2.125 - The Expression of Sur vivin in T Cells and Its Pos-
Survivin
Transplantaion Sciences and Institute of Kidney Diseases & Re- sible Significance.
search Centre, Ahmedabad, Gujarat, India. Ning Zeng, Bicheng Chen, Zhonghua Klause Chen, Li Tang,
Shang Chang, Dunfeng Du. 1Key Laboratory of Organ Trans-
Su2.120 - Analysis of HLA Class One Alloantibodies in the plantation Ministry of Education, Key Laboratory of Organ Trans-
Sera of Sensitized Patients on Hemodialisis. plantation Ministry of Health, Institute of Organ Transplantation
Minoo K. Adib, Edna Abkarshahnazar. Immunology, Medi- Tongji Hospital, Wuhan, Hu Bei, China.
1 2 1
cal School, Isfahan, Isfahan, Islamic Republic of Iran; 2Immunol-

ogy, Medical School., Isfahan, Isfahan, Islamic Republic of Iran. Su2.126 - Anti-CD132 Monoclonal Antibodies Inducing Acti-
vated T Cells Apoptosis after Alloantigen Stimulation.
Su2.121 - IgG Monitoring Can Predict the Development of Fu-li Xiang,1 Chang Sheng,1 Bicheng Chen,1 Dunfeng Du,1
Infection in Hear
ransplantation. Zhonghua Clause Chen.1 1Organ Transplantation, Tongji Hos-
E. Sarmiento,1 J.J. Rodriguez-Molina,1 J. Fernandez-Yanez,2 J. pital, Tongji Medical College, HUST, Wuhan, Hubei, China.
Palomo,2 P. Munoz,3 E. Fernandez-Cruz,4 E. Bouza,1 J. Carbone.1
1
Immunology Department, University Hospital Gregorio Su2.127 - Cytomegalovirus-Specific CD4 TT-Cell -Cell Immunity Is
Maranon, Madrid, Spain; 2Cardiology Department, University Associated with Protection from Human Cardiac Allograft
Hospital Gregorio Maranon, Madrid, Spain; 3Microbiology Rejection and Negative Coronar Coronary-Ary-Ar ter
y-Arter
teryy Remodeling.
Department, University Hospital Gregorio Maranon, Madrid, W. Tu,1 L. Potena,2 P. Stepick-Biek,1 L. Liu,1 K. Y. Dionis,1 L.
Spain. Bashyam,3 W. Fearon,2 H. A. Valantine,2 E. S. Mocarski,3 D. B.
Lewis.1 1Department of Pediatrics, Stanford University School of
Medicine, Stanford, CA, USA; 2Department of Medicine, Stanford
University School of Medicine, Stanford, CA, USA; 3Deaprtment
of Microbiology and Immunology, Stanford University School of
Medicine, Stanford, CA, USA.
130
2005
ANNUAL MEETING
Su2.128 - Immunological Evaluation of LLymphocyte

ymphocyte Activa- Su2.132 - The Role of Indoleamine 2,3-Dioxygenase (IDO) in
tion, Cytokines and Apoptosis on TTacrolimus-Sirolimus-In-
acrolimus-Sirolimus-In-a Murine CTLA4Ig-Based Mixed Chimerism Model.
duced Long-T
Long-Ter erm Allograft Sur
erm vival in Nonhuman Primates.
Survival I. Pree,1 S. Bigenzahn,1 P. Nierlich,1 Z. Koporc,1 P. Blaha,1 F.
MA/Anlun,1 Qi/Shijie,1 Xu/Dasheng,1 Daloze/Pierre,1 Chen/ Langer,1 E. Selzer,2 D. Fuchs,3 C. Winkler,3 G. Brandacher,4 M.
Huifang.1 1Laboratory of Experimental Surgery, Research Cen- Sykes,5 F. Muehlbacher,1 T. Wekerle.1 1Dept. of Surgery, Div. of
tre Hospitilier de l’University de Montreal (CHUM), Hopital Notre- Transplantation, Medical University of Vienna; 2Dept. of Radio-
Dame, Universite de Montreal, Montreal, QC, Canada. therapy and Radiobiology, Vienna Gernal Hospital; 3Inst. of
Medical Chemistry and Biochemistry; 4Dept. of General and
Su2.129 - Baohuoside-1, a Novel Immunosuppressive Mol- Transplant Surgery, University of Innsbruck, Austria; Transplan-
5
tation Biology Research Center, MGH/Harvard Medical School,

ecule, Inhibits LLymphocyte
ymphocyte Activation In V itro and In V
Vitro ivo.
Vivo
Boston, USA.
MA/Anlun,1 Qi/Shijie,1 Xu/Dasheng,1 Daloze/Pierre,1 Chen/
Huifang.1 1CHUM, Notre-Dame Hospital, University of Montreal,
Montreal, QC, Canada. Su2.133 - Evaluation of Immuknow-Immune Cell Function As-
say as a New Parameter of Net State of Immunosuppresion
Su2.130 - Cellular Reactivity to Human Hsp60 in Murine Skin in Monitoring Renal TTransplant ransplant Recipients.
and Hear
ransplantation. Alex Yussim,1
Moshe Israeli,2
Eytan Mor,1 Dan Krest,2 Tirza Klein.2
Veronica Coelho,1,2,3 Ernesto Luna,1,2 Luiz A. Benvenuti,1 Luiz R. Department of Transplantation, Research Unit, Rabin Medical
1
Mundel,1 Valquiria Bueno,4 Leo K. Iwai,1 Cristina Caldas,1 Jorge Centre, Affil. 2to Tel Aviv University School of Medicine, Petach
Kalil.1,2,3 1Heart Institute (Incor), University of Sao Paulo, Sao Tikva, Israel; Tissue Typing Laboratory.
Paulo, Sao Paulo, Brazil; 2Division of Allergy and Clinical Im-
munology, Internal Medicine Department, University of Sao Paulo, Su2.134 - CD80 but Not CD86 Costimulator
Costimulatory y Molecules Sup-
Sao Paulo, Sao Paulo, Brazil; 3Institute for Investigation in Immu-presses Xenogeneic Humoral Rejection by Regulation of
nology-Millenium Institute, CNPq, Brazil; 4Nephrology Division, Complement C3dg Generation.
Department of Medicine, Paulista School of Medicine, Paulista K. A. Hosiawa,1,2 H. Wang,3 B. Garcia,3 R. Zhong,2,3 D. J.
School of Medicine UNIFESP, Sao Paulo, Sao Paulo, Brazil. Kelvin.1,2,4 1Division of Experimental Therapeutics, University
Health Network-Toronto General Research Institute, Toronto, ON,
Su2.131 - Evaluation of Skin Graft Sur vival Using the Encap- Canada; 2Microbiology and Immunology, University of Western
Survival
sulated Hsp60 Peptide (p277) in a Murine Model of Minor Ontario, London, ON, Canada; 3Surgery, University of Western
Antigen Disparities. Ontario, London, ON, Canada; 4Immunology, University of
Ernesto Luna,1,2 Edilberto Postol,1 Luiz A. Benvenuti,1 Jose M. Toronto, Toronto, ON, Canada.
Rodrigues,4 Karla M. Lima,4 Cristina Caldas,1 Jorge Kalil,1,2,3
Veronica Coelho.1,2,3 1Heart Institute (Incor), University of Sao Su2.135 - Lack of Correlation between the Presence of Anti-
Paulo, Sao Paulo, Sao Paulo, Brazil; 2Division of Allergy and Human Panel Reactive Antibodies (PRA) and Anti-Swine Non-
Clinical Immunology, Dep.Internal Medicine, University of Sao Galactose-
Galactose-α α1,3-Galactose (NonGal) Cytotoxic Antibodies in
Paulo, Sao Paulo, Sao Paulo, Brazil; 3Institute for Investigation Patients A waiting Life-Saving Organ TTransplantation.
Awaiting ransplantation.
in Immunology, Millenium-Institute, Brazil; 4Center for Tuberculo- B. S. Wong,1 P. E. O’Malley,1 Y.-L. Tseng,1 F. J.M.F. Dor,1 S. L.
sis Research, School of Medicine of Ribeirao Preto, Ribeirao Saidman,2 K. Yamada,1 D. H. Sachs.1 1Transplantation Biol-
Preto, Sao Paulo, Brazil. ogy Research Center, Massachusetts General Hospital/Harvard
Medical School, Boston, MA, USA; 2Department of Pathology,
Massachusetts General Hospital/Harvard Medical School, Bos-
ton, MA, USA.
131
2005
ANNUAL MEETING
Su2.136 - TIRC7 Is Expressed upon Immune Activation Early

in Peripheral Blood LLymphocytes
ymphocytes and Remains Induced in In-
flammator
flammatory y Cells during Rejection after Kidney TTransplanta-
ransplanta-
tion as W ell as in Joints from Patients with Established Rheu-
Well
matoid Arthritis.
S. G. Tullius,1 H. D. Volk,2 A. Tamura,2,3 M. Winter,2 P. Fraser,5
R. S. Blumberg,5 N. Utku.2,4 1Department of General and Trans-
plantation Surgery, Charite-Campus Virchow Clinic, Humboldt-
University, Berlin, Germany; 2Institute of Medical Immunology,
Humboldt-University of Berlin, Berlin, Germany; 3School of Medi-
cine, Keio University, Tokyo, Japan; 4GenPat77 Pharmacoge-
netics AG, Berlin, Germany; 5Department of Medicine, Rheu-
matology and Gastroenterology, Brigham and Women’s Hospi-
tal, Harvard Medical School, Boston, MA, USA.
Su2.137 - Peripheral and Graft Infiltrating T Cell Responses

to Self Heat Shock Protein 60 in Renal TTransplant
ransplant Patients.
C. Caldas,1 M. Spadafora-Ferreira,1 S. E. Oshiro,1 J. A. Fonseca,2
E. Luna,1,5 P. L. Ho,3 J. Kalil,1,4,5 V. Coelho.1,4,5 1Heart Institute
(InCor), University of Sao Paulo Medical School; 2Renal Trans-
plantation Unit, University of Sao Paulo Medical School;
3
Butantan Institute; 4Institute for Investigation in Immunology-
Millenium Institute; 5Clinical Immunology and Allergy,
Departament of Clinical Medicine, University of Sao Paulo Medi-
cal School, Sao Paulo, SP, Brazil.
132
2005
ANNUAL MEETING
CME Self-Reporter
SELF-REPORTING SYSTEM:
The 5th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS) will offer
Continuing Medical Education (CME) credits for physicians jointly sponsored by the Clinical Immu-
nology Society (CIS) and FOCIS. Please note that not all FOCIS sessions and activities offer CME
credit. The amount of credit offered for each session is included on the back of this form. Please
circle the corresponding CME credits (other side) and total at the bottom of the CME form.
Base credit will not be offered at the FOCIS meeting. Each delegate will be required to complete
this Self-Reporter Form in order to receive a certificate of credit. This form lists all sessions offered
for credit, as well as the amount of credit available per session from the Clinical Immunology
Society (CIS) and FOCIS.
PLEASE FOLLOW THESE INSTRUCTIONS TO RECEIVE YOUR CER TIFICA
CERTIFICA TE OF CREDIT
TIFICATE CREDIT::
1. Complete this Self-Report Form, tear it out of the final meeting program and return it to the
FOCIS Information Booth, 3rd floor of the Westin Copley Place. Certificates will be issued only
upon completion of this form.
OR
2. Mail your completed Self-Report Form to the FOCIS office
(555 East Wells Street, Suite 1100, Milwaukee, WI 53202)
3. Please print your name and address in the box below:
PLEASE NOTE: that this information will

be used to issue CME certificates. Your
name will be printed on your certificate the
way it appears in this box.
4. Please transfer the TOTAL NUMBER OF CME CREDITS from the bottom of the other side to the
space below.
________________________
TOT AL CME CREDITS
TOTAL
5. Signature: ____________________________________________ Date: ________________
*PLEASE NOTE: Delegates must complete this Self-Report Form in order to receive their certificate
of credit for the 5th Annual Meeting of the Federation of Clinical Immunology Societies. Delegates
not completing this form will not be issued a certificate.
133
2005
ANNUAL MEETING
THURSDAY, MA
THURSDAY Y 11, 2005
MAY CREDITS SUNDAY, MA
SUNDAY Y 15, 2005
MAY CREDITS
Society Satellite Sessions Plenary Session
8:30am-12:30 pm 8:30-10:00am
CIS: Emerging Lab Technologies ......................................... 4 Tracking Pathogenic & Therapeutic Immune Responses ....... 1.5
8:00am-5:00 pm Thematic Symposia
CIS: Primary Immune Deficiency Disease Conference ............ 8 10:30 am-12:30 pm
In Vivo Imaging ................................................................ 2
8:00am-5:00 pm Costimulation and Tolerance .............................................. 2
FOCIS: Basic Immunology for Clinicians: Update 2005 ........ 8 Mast Cell, Eosinophils, Allergic Reactions ........................... 2
Living with the Bugs: Good or Bad ..................................... 2
FRIDAY, MA
FRIDAY Y 13, 2005
MAY Industry Symposium
Plenary Session 1:30-3:00 pm
8:30-10:00 am Genentech Symposium .................................................... 1.5
Regulation of T Cell and Differentiation ............................. 1.5
Oral Abstract Sessions
Thematic Symposia 3:30-5:30 pm
10:30 am-12:30 pm ................................................................ New Animal Models:
Regulatory T Cells in Transplant and Autoimmunity ............... 2 Defining Antigens Recognition by Animal Models .............. 2
FCR and Complement ........................................................ 2 Costimulation .................................................................... 2
Dendritic Cells .................................................................. 2 Immunotherapy .................................................................. 2
Antibodies in Disease Pathogensis and Therapy .................... 2 Trafficking and Adhesion .................................................... 2
Industry Symposium Cytokine Mediated Immunoregulation .................................. 2
1:30-3:00 pm
Biogen IDEC Symposium: ................................................ 1.5 MONDAY, MA
MONDAY Y 16, 2005
MAY
Concurrent Oral Abstract Sessions Plenary Session
3:30-5:30 pm 8:30-10:00am
Antibodies and B Cells ...................................................... 2 Genetics and Genomics .................................................. 1.5
Innate Immune System Regulating Disease ............................ 2 Thematic Symposia
T Regs and Regulations of Immunes Responses ..................... 2 10:30am-12:30 pm
New Pathways of Immune Regulation .................................. 2 Therapeutic Vaccines ......................................................... 2
NK and NKT Cells ............................................................ 2 Development of Immune-Based Therapeutics ......................... 2
Roles of Interferons in Defense and Disease .......................... 2
SATURDA
SATURDAY, MA
TURDAY Y 14, 2005
MAY Immunodiagnostic Disease Predictors .................................. 2
Plenary Session
8:30-10:00 am
Genetics and Gene Therapy ............................................ 1.5
Thematic Symposia
10:30 am-12:30 pm
Genetics of Immune Mediated Diseases & Transplantation ..... 2
TLR, NK, Innate Immunity ................................................... 2
Immunodysregulation and Immunoreconstitution .................... 2
Disease Regulation: Role of Antigens, Cytokines, Chemokines 2
TOTAL CREDITS (T
TOTAL ransfer Credits to For
(Transfer Formm on Page): _________
Industry Symposium
1:30-3:00 pm
Centocor Symposium: ..................................................... 1.5
Oral Abstract Sessions
3:30-5:30 pm
Genetics and Genomics ..................................................... 2
Immunodiagnosis ............................................................... 2
Tolerance ......................................................................... 2
Dendritic Cells and Regulation of Disease ............................ 2
Immunodeficiency .............................................................. 2
134
NOTES
NOTES
NOTES
NOTES
NOTES
NOTES
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Immunogenicity and Immune Competence
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Saturday, May 14, 12:45 p.m. – 1:45 p.m. Lunch served.
at booth #20, and join us for these Monitoring Vaccine Response:
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revolutionary Industry Tutorials:
Enrique Rabellino, MD, Medical Officer, Beckman Coulter, Inc.
Sunday, May 15, 7:00 a.m. – 8:00 a.m. Breakfast Served.
www.beckmancoulter.com/immunomics

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Photograph by Peter Vanderwarker

• Satellite Programs • Plenary Session

Thank you to the 2005 Industr

Thank you to the FOCIS 2005 Major Supporters...

National Institutes of Health

Thank you to the FOCIS 2005 Contributing Supporters...

FOCIS Annual Meeting

2005-2008 Strategic Plan

FOCIS Centers of Excellence

FOCIS Executive Committee

FOCIS Committee Chairs

2005 Program Committee

2005 Program Committee

Abul Abbas, MD Jane Buckner

David Fiorentino, MD PhD Juha Kere, MD PhD

Stephen J. Galli, MD Samia Khour

Raif Geha, MD Hirohita Kita, MD

David Lee, MD PhD Lorenzo Moretta, MD

Angus Thomson, PhD DSc FRCPath Sander J. van Deventer

Friday, May 13 7:00 am-5:00 pm

7:00 a.m. Industry Tutorials Industry Tutorials

8:30 a.m. Planary Session Planary Session Planary Session

Sponsored by Abbott Laboratories (www.abbott.com)

4:10 – 5:00 pm Panel Discussion: Future Avenues and Strategies

Idea, Goals and Synopsis:

Contact Inf ormation:

Clinical Genomics - IT Strategies to Enable TTranslational

Presented by Beckman Coulter

Presented by Agilent Technologies

Multiplex Serum Cytokine Analysis for Immunogenicity and Immune Competence

Presented by Beckman Coulter

Presented by Beckman Coulter

FOCIS Centers of Excellence Directors Meeting

FOCIS Inter national Advisor

FOCIS 2006 Organizing Committee Meeting

Clinical Immunology Society Annual Business Meeting

FOCIS Steering Committee Meeting

Exhibit Hall - Essex Ballroom, 3 rd

13th International Congress of Immunology ALPCO Diagnostics

FOCIS 2005 TTravel

FOCIS 2005 TTravel

FOCIS 2005 Par ticipation A

Abstracts in Order of Presentation

University, Baltimore, MD, USA. France.

F1.44 – Abstract Withdrawn F1.50 - Cross-Presentation of Minor Histocompatibility Anti-

University Graduate School of Medicine, Nagoya, Aichi, Ja-

F2.05 - Complement Activation as a Mediator of Recurrent F2.09 - The Changes of T LLymphocyte

F2.10 - Binding of Phage Displaying Multimeric CD147 on

F2.12 - Surgical TTrauma

F2.13 - The Theor

F2.16 - Don’t Judge a Cell by Its Surface Only: Combina-

cal Center, Leiden, Netherlands; 2Renal Immunopathology Cen-

cine, Technion, Haifa, Israel.

Sa1.06 - CD4+CD25+FoxP3+ Regulator

Sa1.18 - Anti-Myelin Antibodies as an Immune-Modulator

Sa1.29 - CD4+CD25+ Regulator

sity, Philadelphia, PA. A. E.R. Fasth, A.-K. Ulfgren,1 L. Klareskog,1 C. Trollmo,1 V.

Care Unit, Hospital De L´Hospitalet, Barcelona, Spain;

Sa1.61 - Isolated TType

Sa1.62 - FOXP3+ Regulator

tal, Brussels, Belgium; 4Department of Internal Medicine, Erasme

of South Carolina, Charleston, SC, USA.

Sa1.110 - Dendritic Cells Pulsed with TType

land; 3Hospital for Children and Adolescents, University of

F2.16 - Don’t Judge a Cell by Its Surface Only: Combina-

Sa1.149 - Thrombospondin 1 Mediates a Contact Depen- Sa1.154 - Increased Ratio of Activating:Inhibitor

Sa2.22 - Novel Pan-DR Binding TT-Cell

Su2.72 - Production and Characterization of Human Mono- Laborator

5. Signature: ____________________________ Date: