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  • How Are Enzymes Regulated?

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    Kareen Mae Porras Biene
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    Enzymes are regulated through feedback control where a product inhibits an earlier reaction, through proenzymes which are inactive proteins transformed into active enzymes, and through allosterism where binding at a non-active site changes the enzyme's activity and shape. Allosteric enzymes can be negatively or positively modulated by regulators binding at regulatory sites. Protein modification and isoenzymes which have different structures but catalyze the same reaction also regulate enzymes.

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    Enzymes are regulated through feedback control where a product inhibits an earlier reaction, through proenzymes which are inactive proteins transformed into active enzymes, and through allosterism where binding at a non-active site changes the enzyme's activity and shape. Allosteric enzymes can be negatively or positively modulated by regulators binding at regulatory sites. Protein modification and isoenzymes which have different structures but catalyze the same reaction also regulate enzymes.

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    12 views8 pages

    How Are Enzymes Regulated?

    Uploaded by

    Kareen Mae Porras Biene
    Enzymes are regulated through feedback control where a product inhibits an earlier reaction, through proenzymes which are inactive proteins transformed into active enzymes, and through allosterism where binding at a non-active site changes the enzyme's activity and shape. Allosteric enzymes can be negatively or positively modulated by regulators binding at regulatory sites. Protein modification and isoenzymes which have different structures but catalyze the same reaction also regulate enzymes.

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    of 8

    HOW ARE ENZYMES REGULATED?

    Feedback control

    Is an enzyme regulation process in which formation of a product inhibits an earlier reaction in the sequence.

    PROENZYMES

    Or zymogens

    any of a group of proteins that display no catalytic activity but are transformed within an organism into enzymes, especially those that catalyze reactions involving the breakdown of proteins. To make them active, a small part of their polypeptide chain must be removed. (sa notes lng to di to ksli sa ppt :))

    Allosterism

    A change in the activity and conformation of an enzyme resulting from the binding of a compound at a site on the enzyme other than the active binding site.

    Allosteric enzyme

    Two ways:

    Negative modulation

    Positive modulation

    Regulator- substance that binds to the allosteric enzyme. Regulatory site- the site in which regulator attaches.

    Protein Modification

    The modification is usually a change in the primary structure

    Isoenzymes

    are proteins with different structure which catalyze the same reaction.

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