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    Norhayati Yusop
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    A researcher tested a new substance called salubrinal that promotes bone growth for treating osteoporosis and healing bone fractures. In rat experiments, salubrinal increased bone thickness and healing of surgical holes in the rats' bones more than in control rats. The researcher is studying how to deliver salubrinal and its effects on the body to determine if it can help treat bone diseases in humans.

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    A researcher tested a new substance called salubrinal that promotes bone growth for treating osteoporosis and healing bone fractures. In rat experiments, salubrinal increased bone thickness and healing of surgical holes in the rats' bones more than in control rats. The researcher is studying how to deliver salubrinal and its effects on the body to determine if it can help treat bone diseases in humans.

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    6 views7 pages

    2011ctsi Yokota Presentation

    Uploaded by

    Norhayati Yusop
    A researcher tested a new substance called salubrinal that promotes bone growth for treating osteoporosis and healing bone fractures. In rat experiments, salubrinal increased bone thickness and healing of surgical holes in the rats' bones more than in control rats. The researcher is studying how to deliver salubrinal and its effects on the body to determine if it can help treat bone diseases in humans.

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    of 7

    New Bone Growth Substance for Treatment of Osteoporosis and Bone Fracture Healing

    Hiroki Yokota, PhD Biomedical Engineering, IUPUI

    Make bone strong!


    ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

    www.indianactsi.org

    Rationale

    various stress sources stress to nutrient endoplasmic deprivation reticulum (ER) hypoxia oxidation ischemia damage/aging eIF2a phosphorylated eIF2a rest/recovery

    salubrinal

    ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

    www.indianactsi.org

    Rat Experiment
    anterior surgical hole (day 20)
    salubrinal injection harvest harvest

    posterior hole
    1 2 3 4 5 6 7 8 9 10 20 day salubrinal injection side

    anterior hole

    posterior cortical thickness (mm)

    control salubrinal

    2.000 2.0 anterior wound size (mm)

    ***

    ***

    salubrinal

    placebo

    surgery

    1.0 1

    ** *

    1.000 1.0

    0.5 0.5

    0.000 0 10 days day 20 days day

    0 0 days 10 day 20 days 20 day

    ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

    www.indianactsi.org

    Selection of vehicles (RISC support)

    Non toxic Good solubility

    ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

    www.indianactsi.org

    Pharmacokinetics
    subcutaneous tissue diffusion
    injection molecular transport

    blood circulation
    molecular turnover

    convection

    ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

    www.indianactsi.org

    ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

    www.indianactsi.org

    Acknowledgements
    Ping Zhang, IUSOM; Andy Chen, UCSD; Guofeng Wang, U. Pittsburg Matt Rubin, IURTC IU Kelly School of Business, Business of Life Sciences students

    DoD Congressionally Directed Medical Research Program Teresita Bellido, Anatomy & Cell Biology, IUSOM Munro Peacock, Endocrinology, IUSOM Jeffrey Anglen, Orthopedic Surgery, IUSOM
    ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

    www.indianactsi.org

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