micro mneumonics Protein Synthesis Inhibitors: Never Mix Them Up Again!

Aminoglycosides: A is the 1st letter, thus aminoglycosides inhibit Initiation (t he first step of translation) by preventing formation of the initiation complex. ChloramPhenicol: the only one with a "P", thus the only one inhibiting Peptide b ond formation (by peptidyltransferase) Macrolides: prevent the Movement of ribosomes (translocation) Clindamycin: makes ribosomes Cling to mRNA (prevents translocation) Tetracyclines (TTC): tRNA Tries but Can't (prevents the aminoacyl-tRNA from atta ching to the A site of the ribosome) Lincomycin: Like erythromycin (prevents translocation) Linezolid: Like an aminoglycoside (prevents initiation)