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Final test haematology

Soalan 18-24

18. Copper berkaitan dengan hal disebut di bawah ini:


jawapan: E semua betul.
Alasan:
Ada apa dengan copper..
- COMPONENT OF MANY ENZYMES
- OXIDIZING IRON BEFORE IT IS TRANSPORTED ( ceruloplasmin, copper
containing protein, required for normal mobilization of iron from its storage
site to the plasma)
- PLAYS ROLE IN MITOCHONDRIAL ENERGY PRODUCTION,
PROTECTION FROM OXIDANTS, AND SYNTHESIS PF MELANINE AND
CATHECOLAMINE
- Most diet provide 2mg/day
- RDA 1.5 - 3mg/day
- Food high in copper
o Oysters, shellfish
o Liver, Kidneys
o Chocolate
o Nuts
o Dried legumes, Dried foods
o Cereals
o Poultry
Rujukan : slide nutritional anemia, Nurputji Astuti MD, MPH Sp.GM

19. Cobalt berkaitan dengan hal berikut:


jawapan : E semua betul.
Alasan :
- A component of vitamin B12 (cobalamin)
- This vitamin is essential for maturation of red blood cells and normal
functioning of all cells
- Requirement expressed in terms of Vit B12 : 1.4-2 ug daily
- Toxicity : intake of 10 to 20 ug/kg Body weight : high intake cobalt in
animal diet produce polycytemia, bone marrow hyperplasia,
reticulocytosis, and increased blood volume
-Deficiency: related to Vit B12 deficiency ---macrocytic anemia
Rujukan : slide nutritional anemia, Nurputji Astuti MD, MPH Sp.GM
20. Vitamin B 12 selain dibutuhkan untuk mencegah terjadinya anemia gizi, juga
berkaitan dengan:
jawapan : C 2 dan 4
alasan :
- Involved in the metabolism of single carbon fragment
- Essential for biosynthesis of nucleic acid and nucleoproteins
- Role in metabolism of nervous tissue
- Involved with folate metabolism
- Related to growth
- most diet provide 3-5 mg/hari
Rujukan : slide nutritional anemia, Nurputji Astuti MD, MPH Sp.GM

21. Trombolitik yang menyebabkan lisis sistemik:


jawapan :A
-streptokinase
-rt-PA
-urokinase
alasan : no komen
Rujukan : FARMAKOLOGI DAN TERAPI FKUI.ms 757

22. Yang benar untuk protsmin :


jawapan A
1. antagonis Heparin
2. suatu antikoagulan
3. 1 mg menetralkan 100 unit heparin
masa kerja heparin lebih lama dibanding dgn protamin.
Rujukan : FARMAKOLOGI DAN TERAPI FKUI.ms 752

23. Yang benar untuk antikoagulan oral (soalan salah bukan koagulan)
jawapan: C
-sering menyebabkan pendarahan
-dapat disekresikan melalui hati
alasan :no komen.
Rujukan : FARMAKOLOGI DAN TERAPI FKUI.ms 753

24. Tanda-tanda anemia hemolisis adalah:


jawapan: B 1 dan 3
alasan :
- akibat hemolisis berlaku
o kerusakan eritrosit
o katabolisme Hb meningkat  efek hiperbilirubin ikterus
o regenerasi / komopensasi  eritropoiesis meningkat
 pada darah tepi didapati retikulositosis dan normoblastemia(
istilah ni cari sendiri kat uncle Dorland)
o berlaku splenomegali dan hepatomegali, tapi jika limfedenopati tak sure
Rujukan : diktat haematology, anemia hemolitik.