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Project Title:
Princ1pal Inveatig4tol'1

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fb.nnaceY_t_k.l_aDd_Me_d_~ln.a_l_Ql~t_nn'._~11e~-of -~tDijcy;

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Date:

August 31. 1963 §RroPr1at~

P~fs--=En~branee8.

OI.\t.tand ins __lJnetll_<:~t~<!__

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!'enannel;

Associates,

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$ 4.420~36

$ 4.4~O.J6

$ .. 0=0,"".. .. _

SuppUes and Matedah

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Equipment
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309.43

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Project Pri.ncipal

Title:

The Synthesis

and BiocheJ1lical-=EXa1liiti6.rC~C>LP~ot_ential sychopha.l'1T>Ilcologj,G~l:~::::=-' P ~rofessor. and Head of the Pepartme!1tof-----==-,Co] lege_or~Enal'mo,.~y .-'~~~_~~~~

Agents.
Investigator: .-...... .....•..... ··?h.i1., ~~d-?:ed~cal-ChenU$tr.f •....

Date:

~ray31, 1962

011tstanding
Item Personnel: Associates, Assista.nt
& CC'nsultants~--

Unenc.\unbered
-

Encumbrances

Balance,~~~ -_...,_-

$--r,SWiOO-=-=~$f~499 .98 ~ ~~$

- -0- ~---~-$ 7,000.02 --

Supplil6's and }hterials

R' ... .",qU1.pmen"

4,745.00

Tra.-'lcl

-Budget; to cover-----

-----

$2,tI6);Jl __ $- 9,912~78·

7% of Personnel

Ret.·Soc.Sec.·rns.

15%

of Entire Budget; to COver Indirect Costs

-71.0- <"!-,-~-_:~-_~------------ ......- - -~- ;) 2 J ._l};;I~ _, ~6·~--~~--- Al 9-6r'

.

Total

$21;080.00

$6,284.00

$2 J L63. :n-----~ $12,332.69

.-

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Title:

The Synthesis Agents.

and Biocl"!_~mica1 Eva1u~tion of pofent~aLE..sycbQpharmaco~"gica1 ., Professor anu~Read -pf=the_))epartment-of==~=c~-~cc~ --_ nd-Medicina1 Chemistry, Col1ege~()f~h1!l'IDacy;

Principal Date:

Investigator:

August 31, 1963

~opriatio.!! Personnel: Assochtes, Supplies Assistants_&'::_C.9nsu1!"t!_hts

__-pa>'U1e~~

Ou tst~rBU,J:\g- Un~ttlcumb~red~ Encumbrances Balances

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$ -4,420.36

$ 4,420.36$

~9- -0--

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and Matedals 7;316;63~ 1;230-;-88 $-18,021:01 _ ];316.63 -_

Equipment Travel Subtotal:

7% of Par sonne 1 Budget; to=cover_::_ Ret.- Soc. Sec. - In$.~-'---15% of Entire

1; 2 30-';-8_8.~_-,----,-0..___ - $18,021.01

-$

~O..

309.43 -~---309

•43 --_~O..___~_ ... 0

-0 ..

Indirect Total

Budget; Costs

to cover-·-·-·-- -- __ ~~2,7~9.-56--.~-2,749.56---

l. ./ . II ._/
p",.~

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Project Title

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SJiDlhejll1 .&Q4.Y.l".~,oQof !)qt•• tl.1--PfJ~c.kOPtiU..

Category=~Ji~!!~;~r~~lrol

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Purpose:

Bluelda_tlbll~f-l1U4ifrt.latloNlhlP1-betw •• D 1I01ecular---con----8tltutiO.D. an4 blolo,lealnfaponee-of ;CI),'.1~a_l_~OIIpoclnd. or-~~

lut."st~w-_lllP.

- ---- --

Status:

1'•• "~Il_;:--=~Jl-bUttho flj)al=-phu~8 of, t-if.~fltsearcll baa bee;a-:-cOGp~_.ted-.bd~ the~-... porta 8u,*ltt"~. ~aepo~t. relating toflDal __ J;i~.--of p eOlltra~_t_ ,,1_lI::~_I'~~._lY.d UPOll coapl.tioo-;

Tendn.l_learo,--a _ tiaslc biocMt.lcal:

t"

Requirement:

.llittftn.-.l1tse"rated-ln"lSl> b, qeedtor_8~lal-.lilo1o~COI'ApoUUd8· bule ilitol'llatlo11of tlieiraDd charaete"l'Zatlon;-leall,_ activO

/0'/-/0
REVISED
Date'. 5 SeptElimber BEHAVIORAL-ACTIVITIES BraM~BB . 1963

SUPPOR'J.'=---=~~ ----;

Project

Category Behavioral-Control Ma.terials -- '. Synthesis-and' evaluation .. (formerly 'V'b) . of I>otential ps),chophar. '; Title maci:>'lil€:i¢l.'\l -comJ2oun<fS-C-It;~classific8.Woll-~! Uno_U.s!tified'
MKtffi'!!_A-- ~--_ crypto Classificatioll..-!.-.-

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Branch

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Contractor~

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Contract No__ Jfi(ULTRA __#~09

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Task N6.

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Type of Contract,

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Date Initiated

Cost _ __...;""..

Purpose:

Status:

Requirement:

character_i.~_a_tj_on. - ~ -_

ically~ctive compounds and Dasie informatiQn_o~their

- -~--~.~---'

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By-A i r::_MaLL

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Dat.e.

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Personnel. Assochtea,

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--=-~~..

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490.00 J.i?21; 91--

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Total

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RECEIP'l'_
Receipt is hereby ackno~ledged~fo!_the-f()lloWing

t....checKs: o

--

Daw.

ltemarks_r.ild_R_~f~reric_es~-

Obligations' Incurred __i

ObligaUO.QS.. - Vnliquidated Liquidated- Balance

21,080.00

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. of alLmO.nles:_r~_cel ved-ti'Ointhe.-AI$()
be return.ed_by

~expende~~sc.Y111

as soon asposdble-\1pOfl~ the .----fO.r a six -~.----months 'lfifo~(Il81 -.

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agreed thAt the A.g~ey yill'

accountlngwhlcncon!orlll

accept- th~c-travel do~umentatlon_azl~__ tbeptaet1ees

of the

vi th

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retle~j;,lQg--=...__,=--

progre s s-=-O.t~t=h=e...e.:"'"'ar.._c=li.._~~p_:_ro.:'gr",,"' . ._-:_:sb:_:a=l=l-._b.._e.._'_:s._.-u..__bm1='tua].l.y_____ _.re._..,..s --=&Ill= :_jt,ted _at~w accept&ol~n~t~erv~~a=1=8~.~~~~~~~~~

10.- All ~rsonnel~e-cted
i tol'1ng'

With the-p18nnin~UH1~mon-_

of_::_tb1,J_proeram-possess TOP-sEcm-Ageney.

S~<Lu:rJ._t.~==---

approv8~====----------------------------

!IQLOQICAL!RANCH

DistributiQI1.

Orlg1nalon1Y_

-_::_-=~~-=-=========

-~

PROPOSED RESEARCH- PROJECr-i

Project Principal

Title:

The=Syntheds

and Biochemical

log lea l~Ag~~~=_ ,.... :_-_ ~ .•••• Investigator: ~ ~al macy.*

b:<_.'=-_.:. •.

Evaluation __ _ ._.._

of PotentiaLl'$y~hoph~;tl\~<:_o-

Ph. D., Professor a*<1~Head6f_·theDepartmen.t __ and M.edicinal Chemistry, C_qlte_g_e_of_ .Plla_r;,~

For the past severa Lyeats, the~appUcilrit has be-eo'-~enga-ged' in- research-.:in'l~_lYJng< ::= _ (1) the synthesis oLorgani~enntle-8-having potential efhctsupon the~central net' .. : vous system, and (nrtha evaluation ofconne';c iotfs- between the':::"chernl_c_d -andpb~tiUa- .. eodynamle propert ies_:_oLl:nes_e=-]:~oJ,lndS:::==-The=a,pp !!Cil!l;_i~ pr imartty= lIfter ested '-in the fundamental st:ud~ot::r:ela~t_1_QIrshigs~between molecular constitut1Qn __ at'l._d_Q_i~hemi~---=- __ cal response, and is_ part icu1ar1}'=-~Q_l\.c:etne({with theeffect_;_oLgra_d.JJ.al_c_haJ'lges_~Il the chemical str~~t'(~)~~!;~~';~!~1~!I~::iG~::ls~e'd 1-7 ,and (8) pubUshedaccounts 11_.els~ .. ~a-_ 8-19fo_t'_~upple-mental_il'lf()~inal;ion_-;:---==C----,V'"

The applicant planS_l:.o._c_onttnUJLb.iS=tnv-estigatlon in accordance-with::the set forth iil the cite'd-=cJ::llllJllunications. Sp~Ci!i~~1._!y,l1~_iptends=-t.o:,::-: 1.

principles ~

Syntheshe se\'eral_seiie.S~~o_f__ rlf~wcomp6Uhds patterned aftet~(a)OrgariicamitfO-~ known to a Hect.:: the. centralil.ervous sY~t~TII$,~n~_(~)~~oUties_:_acknowledged as substrates in enzym~--:rsy~~~'lII_s. ifilP li~t~d ~in - the phatrllacodynamics_of-::cOii\P~Qij:_t!_dsC])C)_ss~!;..sing psychopharmacologi(_ai~pr.9petties ~ The member-. orr.poun<1_s-6f c -"each serles,willbe designed wit~gtadual __hanges in-their, ~9nsfit~t_i(ln, or-physi¢~Tprop-ertfes;-c or both; fiJrtbennor~~hey-==~tll.'be_pl~nn.e_(r'i_ni\.lch~_m.aoMr_:_that_pot~qtciaL9J._ff~_~~ rences 1n the' interaction between the me.mhercompounds of a given-syothetic~cSel"iescc_and a given ertzyme::.may_b~e-=-irit~_rp!_gtEt~_j..n=!~m!t_Q.t_£(ll'l_cepts reasonably .. welLesCab1ished in contempgr<1-ryt.he-"r_e.t ical<:1t~isf_ry~=~':_, __ . .
u --

2. 3.

St.udy the effec.t_:_of~h-ese~ent1tie-supon=(a)-1s01~ftedEmzyme-::-Pt'epa.ratiQn_$J>jtU~Y~9 to be associated__1il_lth_bt'ain~func::ti6il, and Q>_)__Q_ther _pJausiblebioc::he,mi~l$yst_eJIlEl_'_ Explorerelatlonships between=tne biochelfilcalactivlty -of each seriesof-deYivatives, and the S\lccessiv-e=ehanged_n~th~ -chemi~al~and physicalchiliiacteriU_itsOf the~· member compounds.

_:_-

At present, our synthetic work-is centeredaroond series-q! arylalkylaminoalkylacetamfdes , and pyridine"_'and piperidineearb6xamiMs which couJd be visualized as moieties derived from the psychotomimeticcIriolecule LSD-(s-e:eFigure$ I,-I1, Ill-and IV; other series have been planned). Concurrently, the comp1eted(OInpounds are being eva loal: ed '1n Is01atedchol1nesterase systems in which LSDhas shown-remarkable specifiCity. OUr manometric- procedures

Effective

July 1, 1960 (on-leave

of absence July 1, 1960 throughJune~30J

1961).

·--~--

HN

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I

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~

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LSD:

,
H~ I 1---:.1 --

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FTGURE I.

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Page Four.

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Page Six
\

yield very precise measurement s ofactivity~it1 isolated pseudo- and acetyl~1l0_1itiesterase systems, and ena1)le:_]J~t9-=evali.iate theslgnificance of even=miJ)(:rLv_~r_ia~:i.Qns in activity due to small constitut1ollalcha~ges in~a se-rles_- o~-molec-=u_l~~.--=--=--=-

~~=

We are aware of the fact ::_that:the_e#ec-tivenen-of-a.~psychoph~rmacologi¢ala:gent-1!! vitro cannot be intel'prete.::l_a,s_:_jtyj:<lencefor-- the· inYolvement o~.:_the==-speciHcenz}'1I1e in the mechanism of psy~hotomimettc-"espoases;--=Yeteven with~utconclus1vecausal connect ion, this approochmay-furniSn'-"vdua1:)le infonniit ion-on' the _natl.l~e.Q.f])!)'cho .. ·' pharmacological agenta=~c-cc ------------

**~------------_
It is felt that this' inv_es_tigation may yield . (a) information asslS_tJl1g:_the elud_d_a_ ..__ tion of interrelationship.s_J~etw~e_n_molecular. c:onTtituUon and bio16gi~d_.rEtsPQnse, (b) better insight into_the_i>~tQc1iem~:aI.·.cfiaraet-eris tic-s.arid ~herapc~Q.t.l~po_~_~lltIaI(.;-- ••~~-~--•ties of certain type~=of=mott_tj;lfs,(c) ~ev~ralseHes -ornew organi(;-cOmpol.ll1.ds-aria~~·~~=-information about their~ phy~ic~l_cha rae teris-t i-cs,and (d) da ~a=-s_upp_l~metftin-gour knowledge of the neuroehemfca i~ processes~a-ss-oclatedw1th-the: action:-c>f-=psycllopnarma;"c cologieal agents.-

***
The refe'fences
ing page.

cited

in.::_the-=-f_irstparagraph· of ~hTOUtlineardis_te_d_o_tl_t~~~!!~~C_C_-~:·

January 22, 1960

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Chern., 11: 799, ,1956i-~-=-cc==

9.
10.

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Org.

chen,

21: 805, .1956.

Org.

criern.,21:

958,~1956:

1958.--~~ J. ! Org; 15 16 17 18 19.

... "" .' -.!, ""~. •• •

Chem.,--=-23 :-2005~1958.--

rharm;~Assoc.,

Sci.

sa.,

1922, 1959•.
st

ry, J. mc~. pharm.-Chem.,-2:

in press,

r; ~ ,

'.'

'.

med, pharm,

Chern., 2: 1n press,=1960.

c_

______

~~

_!_1_=e:f..-_2-

•
BY THE
AT

(Oec

Proj e cb Tit Ie:

Tha_Synthesis_a_l'I_d Bij)~hemical- Eva Iu~t l.on..of __ eot~1\_tj_aI Psychophal'maC9_1 09 ica I Agent s ~

PI' inc ipa I Invest igator:

-~~~~~~:~~P_~~~:t~:~~ clila_l_C_tJ~mi_-s_tj'y,_~91J~g~Q_f~ PharmocY'L~_

i~~1~~-~ i~:d7~
$;._..... 1." --~- ..... -.~.. ~." ·1.2000~oQ-C···-':
S'C""

Personnel Supp lies

Travel SUBTOTAL

(Associates,

Assistants-and

Con-suJtants)

and Mater i a I s__:_- ---

.. .11,890· "-----600.00:"'"

c·.,-·---.-

.. -.,

$ .:

7% of Personna I Budget {$-:::-J.?"OOo.oo··,} ;--to

retirement, etc. _
SUBTOTAL

cover-----'

$' . .

840~OO":'·'·_.

II in-indirect costs .

$;i8,~3Q;~~.....--==----. _

15% of Subtota I II ($-i8:33Q:~~');o cover t

participation
. TOTAL

***-.----Checks snou Id be-payab Ie to the

May 31,

1962

Project Title Project Crypto_

C~-=-==-C '~c' ternCClassification_:-~c: -,"~j-fli4,_---I

~_
Crypt6 Class,ificatio":\

~--------~·~··4.'1·~··~·"--~···.

VaclM.ll1~I4 ....._~----

\ .,

v· \.\

Status:

~.~~I'-------------------"tlft~~'

lQt$""'U1. ~.rate4

11l 'ISD \1 814 'bUl.-1M'w-\1~

"t4 tor.• ft~!&lWl>loescaU1 t~lr_d'..uut.r'I&!!~~:_

oa
\,
f

May__ 3I, __L9_6~

\
I cer-t e in Iy~e~njoy~_d 't-aJk ing-t-o-Y6u-thi for youc=c_o~ni ence,-I ern- encl osin9~Ei-qop)'_::of __ the proposed_budget forthenext--9j'~nt~-peri 9d_(Decembel" I, 1962~th-r-ou9h- November 30;-1963). - .. - --, . With the very best regar_ds,

s morn-i-ngl---=======~=li~._.

=~:.:~-.

Enclosure
8y
..~,-'''=,.".. -...

Air

.-~. r",
\../

Mai I

__

P.S.:: My home address

1862

AMERICA'S

LAND-GRANT

UNIVERSITIES

CELEBRATE A CENTURY

orSER

VICE

962--

·~

/01-//

TO THE
(Oe

t,
...-. ~Rt

Chern istry,

Co l le se

.. Ph ~O., . Professor and Che irmal'l of of--=Ptlarma<:ey_~~__Ci!l~Me-d ic ina 1

of=P-_t)armacy._.

--- --

$ 3~OOO.OO

May 31, 1962

,.

First

Year: Survey __t=pffijilsifil-compoUnds. . o L1 ters

ture r~vU'lC --- ------

-----------

~4uggestions

.~urce~se.llIin.-al"§--------·-.

Eftects to blhSQre-ened:=----·----. ----::--convulsants ·--an_t1.c~6ltwls_a_n.t:s==-~------------: speo1fi4-arter1al"':'dil.a_t_Qrs~c.QriS.tl'.i~.Q.1'.s~n_j,isel'otonin _efteo1L - .. ::.=~~--.-

eholineeterase-lnhtoftors

sympathomimetio~Mt'.lil.S~j,b~ime

tic

-_

Bt1DGE'1'--.=.DrI'l'lAt~ .
!!I"

STAFF'

Neurologist .:.=?r-incipal::'iny.estlgat~r Cli,nical ph3..:YJna.colog_lst·"c~~:~c_:c=c:c~-::-c-c--=- - ------------Research asststants~··=~====o====~===~

3,ooO_ lL,ooo

Statist.ic.\.an eervices._( par_t__ time) ~__ :o=-~ ~~_ Resident asslgnments=-(8:::,mo.';S)OO/mo;) --~.- -----

10,000 .

..

1-200~-----~ 2!liOO-. -~

Equipment andsupp).~:=~===~_~_~ .••• ··=.-:·~-~~-~-~~~~~~~== e.g. calculator,- camera" E. E.G' .cservtce,computQr-servtce

'!'ravel

4,000 600~=~C=C--~ $.3>,,200 -

ment

.and

To

the budget figures must-be added 7% of personnel budget tor retire15% or overal1ccosts~tor oVerhead. - .. ......~~-.-,

lor-It
. nsm TESTINO·(CQNTINUED

FACILJTIEscroR~PSYPHO'l'OUn1ETIC

)===:~~

Second Year:

--

Tri:alsof.· Mifcompounds----.

Screening potent.la~Uyval.UablQ effeotS

Chronic toJd.ci tl 1~n::.:i"':::·····=a .... n,...1m.,..:a=1"""s=. ============================ Hunan trials - double_bnna-an~lo_r concurrellt. trialSr-: psychological c.~ff~t;8 . ---autonom1o=ei'f_~t""s _ anticonvulsant =~~_==~_~~ "".... .===-: an tisP!sl!1ooJ:<L •.- .....•..••.•.... --~ -~ ..•. ant1choUnesteras_6_{Umi ted, on !llyastMn1agr:avil=pa-ti~nt,~).-~~~ antiserotonin{ltolusterll-headaches)--~
~c_~

~--.---:--~--·.--~7-·:
__ ~._.~~._._.

Neurologist

Clinical phannacologu ---Exper1.mental··psychologfst__ Research assistantsSta t.1stician sel"'ltceSi~::=::::::================::::::::':: Clerk-sta tisti~ia.n.· .-- -.- ...---.... -.-.-...
Resident..a5sigrunen_t.s_~~_-_·_-·-_-_-·_···_-_

- ,rtnctpa;r=-i.=D"::,:v::":e::st=i..,g,>:,,a=t=or========

Travel $50,700 (+ pel'~onne_!~foretirement) r (+lS%-:-overall· tor-=:Oferhec.d ) __

~.

It may be advisable also_to-c6nstder the adc1ition--of a basiC pharmacologist to t.he stall-in secon" (or third) year.

..

",

March~ 9,1962.=-==

Dear Sir~~~------~--------~~~-=~~~ Enclosed~isc:the· cqml..lht.iy~~aj\:nl.lal.-expehdi~ure report-~c on your_grant~tQ __l"_~__________ _ __ .•• Q Th i_S is f~r~the_perio~ __ July 1, 1960,-tO'NOV~~~-c--:-=-,::----=

._.~._=

¥ours=-very_trJJ_1YJ

1862

AMERICA'S

LAND-GRANT

UNIVERSITIES

-CELEBR,4TE XC8NTURY

OF SERVICE

1962

Budget Report :on-Reseal'ch,Project-

(JU ly~l, ~1960_throU9h_:Jlovembedo,---i%-t

Froject

Ii tle:

The Synthesis-imd-Biochemicc!1-Eva A~~s ••• Ph,D.,

lUaUon-of· Potential Professor

Psychopharmacological~---

C~~~~"~"_-_~~ ~~ .._
nd_:__f{:e-dicina E=Chemistry,~CollGge
and Head ·of.::-tnecDepartmenuf.~_c_:~~~c_~ _of Pharma-cY' _:_:_-_ __ - __ _ ···---_:E_····

Fr Inc lpa l Inve5tigato~: Date: November 30, 1961

Outstanding __UnenCUmoeted Appro-pricatiotFPaymeI1t£Er,cumbrances Balance $3,OOO~OO-$ 3,-000;00·l,-07]-;QO:::.c_.__::__~X;0_7]r_Qo-=

$
-Q-

Personnel:

Principal Investigator' Associates, Assistants and Materials

&

Consul tants-

-0-~.-. --c--0- -------------~-0.. =~~~-~-===

-Q-

Supplies Equipment Travel . Subtotal:

6 ,324~93
581-:57°-=-

~-;42~93_,....
SSl-='-5T $

-0- ~~~~.
-()-~~~~. --e-~~~.c$~-Q-

-0-·~~~=

-o-~~------------

$18J-QI15;Q5_' _$18,045";'6'5.,
to

7% of Personnel Budget; Ret.-Soc.Sec.-Ins.

cover

__ 2,7_49.56~~~:-c::2,7~9.56-:
$?1 , 080.~2-l-. I!I)V,_L_ 080. OO~

..~
.,

15% of Entire
Indirect

Costs

Budget; to cover

-o-~·-~~~~--o-~~~
$" ..

Total:

------======~------- .~--$-0 .• -----" --cc..•. 0- =. ------

I have

exnn:;':;:;d. i;r.d a:::rp'_'c,vl:'i

t~1~ sub.:nitted

expendi tUl'·33 •.

Dlte r

'J

/0 ?~:"2_

C)

29_:_Marcl:(_1962_

MEMORANDJJM_FOR:TneRecord
SUBJECT= MKljLTRA, Subp_f()je_c~ 109;-Cos t of Equ:ipmenr~x-c~~~edBudgetEifimare-----~--

;:

l:-:=_Th:e::_Budget Proposal!oi Subproject 109; dated 22 Januaryl960. !lad !_p~roposedfigureof'$SJ OOO-:_O(LfQ_l' supplies=an:dmaterialS.There was. no anticfpationo£an.y-~~CC' equipP1ent~ ~.

--

------

2~- Ana(~c_Q1.U\ting~eport beerirec-ei'le~d~f~o~r,;.···~th~e::-======== has period_Llijl~9_6JU_}J'ougb. __Q_-NQ_Y~mQ~_r1961.! Tllisreport 3 refie<;tedexp~ndi~l'~~_()t$t061~ 5~ J()~Suppu,es-:andmaterialS,·· and $6. 3Z4~93 [or amount$:-exceededthe_u f'igure-s in~theoriginal proposed Oudget.·
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eqUlpment.-Thes-e-

3.--,-,,--ThhLt'cquiprnent was expendablea.ridt1ie_expendi=-~=--c tures. have-the~appi_(,.y_a~_~:<>[_'I§:OI.R:Ba$ b~ing es sentialfor:__ the success(ul:::CQrhpl~tioIi--()!thereseal"ch wor:k-that_was

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Date

Obligations ~ Incurred

Obligations LiquiMte<i

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APPROV1<:D Ii'GEt OBLIGATION OF FUNDS:

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t, InvOice-l'tQ. lcovenng th.4-3.b~vo-nd.)?roJ~1_1~_~_tta¢h.ad.-P.Tme(~~-.hou1<l1a--rriadJ.r cas !OU4)W$! - -- _------_

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m>':'O'f~,~

~~~u~)m,p.li%ihi!!;d lli ~(;(;'t;rd;.n~<\'tti'Jf,h ml!'t~1i',~1 \ 4P,~f'~~.~ tJ1'~~ l& d,"jt~U·.\"i:<i 4~~.n~ (J fb:: p.~_yr."H~llh~i~d U~f!iipt'S '~->G:t\ in~ 1ft TSD{Rn.; r:\-~"$.t ~\'!-.. billh jtt~t%r,d -=~©Jt'tl'd....mdJb)l,t p;1i¥mm~'!ih@I~~i
,sG', n''1.'f,c~ tq'~ i1t:~~J( t.\_'-Jl

!gJ~",--c=_d-~U<Ut;TR.A0~~t-p~;t@~M~~i.~ ~~i\~t~~t~·.fY~tn}.·!.;t;,,--

ill ", ~",);Ui\,;..'!;d ~~,t:~U'l i~ !h~,,,, .;,..'

__.. _ •

1i ' .kA~i©~'f_!!l-~-

'=ri.

1. '" --" ,\t,P.)~ll~g t~

bH

y~~,b~.;:t'#

".U

I! ~" h(!r~:by {:~I~.U:~~d t tb1.~ Inv(,!!f;~~pplhi!il S'Jbr;t'oj~~t ~ lg,2..;;;t~,?\ '.0 •• d ~~~KUL-n'.1\~·t!.1d.i "lllly 4PP~'f:o,I·!';d,,"'j1d ih.."!t lh~ pt'ej{l:.~.tl,~ bt';it:l~ ~",.'f!i~dO;-'\ll~ i~"'~:~'VH'~.n~:~with th~m~mt.'t'~d,:,tn (~f tl April t9t'~) ft~r,... 1~~~)C~ t9 tt;~ OD! A" ~n4 the t'.J.\.'~;tl·:'!!~{H·i! ·()f H\.!Li ~?--ith~Jity if; ,iJ;~lb~~«l~'~I.1lr.

""""'~J

.T~st:n~a i.t~~;\..lo ...

":=R"~~:",""'_'~~':"""~""_~'~'j,\"'''~~';;'''''i<'o''-~'''''''%':>~

R~'''r'~t·;t;'i

t}:it:'!'.dt:f'

10'1-2.. 1

"

D. R A,F_c::T~~=="~~=c;c'=-c·

Z_Novemb_(l:J."_19_6.1 _

MEMORANDUM· SUBJECT

FOR:-

THE RECORD

:,=MKUl~TR.A,-Subpr6ject

109 ------

1.

T6.e PUTP~S~fofthis-subproject

is to pr_o_vide_!und=s"'---=!o_.._:J."====-::=

_:_

the continuationo!a.:-_study

oft>ote~tialpsychopha,rmacological

agents .: Inparticula;r-;=st\1<ii~s~~ll~be·directedto-the-el\l~i!iati(5n_--:--:-"--_of interrelationship§J)~~tweenmolecular

---------------' -

constifU.tion-and .
------

biQlogi_c~!_
.....

-~

response.-·

Studies willb-e-c()nducted

into the biC:chetnical_:c.ha.r~c-

c..~e""'lL.l'\··
teriStiCS-.OLc-e_t'tajn.tYPes·o~~!~_~~S

.
wh~~~.~::f>f_intet~_S_t__10_:_· _._--

TSD/~'f..
",.,..A~

.-.{;cc:Crc't;.~. 1-.~~. l:-- The._a.t~clledBudget

iw~~O:'_~;

",,'F

~~f.~c
41<t'~"'-'"
indicafes

,"",,~·"-"k&-"'_"i1
the extentof

'1-'"

.:

the iny~sti----~--

Of.·Or:-~-C-··-----··
The

funds
."
~ :. "'"

{or-tbis_ PJ'~j~et:wilJ_!>.,_lr=ail-'£ernd .
r, ~ ~ ~., • ~ •

-USi$~Jf,""""': --C:'z.,.. investigator. wiU-b-e---budget item-and

,'.....
..,'0

',

.-.'" ":':
t _.

as a cutout./fror administrative_":
of l:h-eprin~ipal
---------

purposes

in this Pl'oj~(~t;the

(,

salary

----

Dr,,_--~ill

be c_al'rie~~s~_sep~rate

paid directly- to him_bythec:utout.

~-

~.-.-

/07-2..1

~,

The-eost .. f-tnisp1'9gl'a:jj'ffor.aperiod.ofone-year-:_wtllnoe~~:===:::'=_~-=-o

exceed $2"080;'-00-to

.2.1, o'iQ.-

which must

be addedthefo~r_per=centfeEf-t-octl'1_e_~

I!lu ........ !.UK

the total arnount~5-.~~".--ZU._:Ceh~a~rg~e~_s~_~~~~~~~

'-."ql-l."W

! ~.~The

requires

that

be retur the grant

. year. ie-qUire~ment::f9_r'__a._sixtnonths'irlfor_mal accountingc~c -----

f.:,
~

_Y:A

on the part of the pdncipal=in:v_~st!g3:~~!,=-if!_\V<\iy_ed.-

1£- It is not __ anticipM~<lt_l\_M_:l_riY'_p~tTll_afl._~~tequipll1~l1t will--------_

be neededfol"_this_progl'am. (b( In connection with:...ll'ay_d __ Uilderthii-p:roject. itia

agreed

that the Agency wilt=acceprthe

traveldocunienfaUon-:andac::counting=_~=~======~c _ re}_)9:rls-reflectirfgCtneP!'9Sress----at_mutually acceptable~

which Coluorrcf"wn;lllh~rTcti~~s=6fthe~

01,,1
Intezval a,

It Isag reed that technical

of the researchprogfam~shal1_b~8ubmitted

P.f/: AlLp~E!J'AAnnel connected with theplann.i.ng and monitoring of this program I>Q]rsess'I'9P~~~E9~~_'l:'=-~g_ency ~~curity_approva].

IIJ!

Tlils_I>J:'_oiectwilrb~la.ssHieda!ter

it leaves the

c,".
_

TSD/Resea rch-::Bra.nch.__
APPROV
OF FUN s~------~-=====,==-=-=,==---=-"c

~=-

Date:

/
__,.:...-.~~ ;

G ,.9"

ttq'\

/ Attachrn ant.;

---........--------

--

Proposal:_LB_udget _c______--'-=____c

Distl'ibution'L -:_:_orlginalonly--------

'~--__ ---:-------~-------------_-_1\111
/01-2.1

BY THE AT

(0

Project

Tit I e:~<·The-'..gyn~llesJ~=Cln(.[J~loc::li~emcaCE va lu ot: ion~:_o_f_"ot_"en l tLa Psy~hopharRlaco I 09 L<Lal=_.a.9~1'It:~;===:-:::_-_--, .

---

[===~=

Ph.O., Professo~n_d__H_e..d_o",-,f,--· of Pharmaceut icaL-and~Mid ict '----.----CoTI ege o f--:-PFi'aI"lItacy .-.~c- .. •. ~ Personne Suppl ies Travel

=_~ _
_

I (Associ ates,

~Assi$t~nts'

aod Consu Itants) _

$ -12~000. OO~-~$ ~c4, 890~44c 600.00-. -_. $'-17,490-;44-'--

and Materials'-----

SUBTOTAL
7% of Personnel 8udget~($ retiremer~t, etc.; U;OOO~OO); to cover

t
I.

840.00

SUBTOTAL II
15% of Subtotal II ($~18~330:44); part icipat ion in ind irect-costs to cover

$ 18,330.-44

1-

2.749·52

TOTAL ***~- Checks should be payable_to_th

$ 21,080.00

October

2,

1961

cc

• '.

.'

"" • •. 1'.

f'_.· ...,

..

'.

. .'"

.' '"

TO THE
(Oe

Oepartment Chemi stry,

of Pharmaceut

~h.O~; Professor and Head of-the icel and Med ic i no I Co t I ege-_QfJ)har",acy.

$ 3,000;00

**4*-·=============

October

2,

1961!

.~

i-

..

.,4!IL.~_~~--"-~~

....,

~...:..t '-•. .r

"'~""

~...

J...

ATTENTION
SUBJECT

subproject's

e::;p<::-m.Gcs ~,n~hOltl.!i!.b~~h~,l.".g'}d to cost C~i1.t0r

______

aw·U,O.'901
,_......... ~;~~~~~.",..'~--.--;oo

_.~_~~~---'.-_

APPROVED FOtCOBLIGA'II0N OF FuNDS:

__

-'*------...... Dir'Oco~QK - -- .. -,.... ~------...---__,..-~--------Iteoaa.ch

Di:}t~ibll~:iouo O·r~gin.~-l a ;z.t

__---_-

~~Addze s ses

- -----/(YI:"?3'; -

~~:~;_!~~~p~~~~~~;~~~~;-~~~ -''''-Ca oual-_.

.

---

•• _--nm------ . -==~-~i:nclosur-e -

---------

Date. December ~l,

1960.'

ITEM
Peroonno1 Pr1ncipe.l Invest.igator:7~cC~~~$~3,OOO-;OO~~$C=lt500.00 $~-'-~'-0... • ....$:-l,?OO.OO~~ Associa tes. Assis tants ..nd_-c_:_-_~-;;;:;~-;::;;:c--:c-=:-;---===_---=c~~ Oonsultants: 1,000.00 -G8tO_OO~._9Q___~ StlppUes and lofs.terials: : 4,890.44 600.00
13 .,)Or--~-~----'--o------

__ =--~-.~~-

--

Travel:
SUBTOTAL:

7% of Personnel

Budget; ,to_:~ cover insurance, -retirO"!,-,=--=-=-~~ mant, etc.:

-,

840.00 _

_17§.00----====-· -e---~~~~665.00

TOTAL:

$21;080.QG

·$~~.i232a~-""',"$~'3""::;;. -0-

u$17;847~83:-~_:--~-:-:--:'.C--

'''1'1-1-

So ...

"

co

Dr

" I

•
", :: I

III.'
• \ .... ~

"

'.,

...

o
,

~"'''' ... :~! .~ .. . ," : . '.'.. .. Adm. Assto=tocthe- Vice ...Pre$idenL~=~._

'

~"

f' ,. l

• I .'

~(,. {

c.~--~~~-~-----_
The {rr-n~a;l'terlygrant-innald ~be·CKn(OI'O-t~·~ researc1Lshould be forwarded. Each quarterly payment ls$~Quarterly_p_o!y!!!enta are--:dlle on~July' I, 1960. oc~oh_erlJ-lj~Qi_J_a~n'!a.l'y_l'_

1961; ancEAi>:tlrl,

!91,1·__--

-_

Date

Obligations

Liquidated

Unliquidated
-

Balance

.LL-

c~,~

~.~;..y~.~-

-,

~~ ~
-

-~

----=

-~~

~~

...

"
.
(

SUBJECT.

OMt. tile ..au.uUtll'_"*H IQ'~' W.mo~"M$lAd&t" U A,rlll,n -from tla.J)_gJ.J~'n!?_()(!~ ,u aM

.Ul._tO.

of "il.

--

.. "tIl•• lly Ja=-,\\b ,oeat 1tl~~,aQ1S.~ ~~~p1'.J.d ••

i ;,

•"rOT" .. 4_$11. 91).100'-tl&.

lq9Il1' .....

oyu·.aU-P".Jed )Jl(ULTrA-{Qo.d'

~ ~-

.....

,. -.. ",,'

T~"Ch.mlc.l D1Yl.lolll
APpaOVED_:_fi)a::_QltLlGATION -------

eM.,

.: ~

.-

~~ ..
,

'.

'

Of' rUNDSi'=- =-

==

...,___,...~<~,..,.-,-.-~
,

.. t!!,,j(.:)"';C~~~:G Gn1CfR:

..--:::~.--~~-.:_:_
-

Date:

:_'9_~9_~~O~~~~~===========
'f<;.EI

DhtribuUODI -01'1, "2.!OAddr ..... 1 • TSS/O. =-.-TSS/F ASS

e_ .•

_-~- ,_",_
----

Z_.. TSS[J:;,D

TSS/CD/~19

Feb 60)

"

'\

VIA
SUBJECT

I:C_ TSD/8Ildgi'-O-=-·_'ll__ c_e::_1'

LMKU_LTaA, S~~ptojiet fl09, Allotm.a'9S~5~10~"'Ol .llol11d

lav.let 11
--

I. Payrneat

lAv91e.-fl-coyerlci Utt abotve ."l)ptoJed lliUacb.tit.

loUow.: ' C&.Id~.'j-.- ...b..e~ID

.,.'ma4.-•.-

-----

OQ·~_E

~.-amo\JQ'-ottal; 080;

00;.1

drin

__

&mOlt.' of $.~)-;lO, d~a". R

=-.~-=~:::_

- J. Pl•••• =-foIIa'fa'tie ct..ck. lO Chi.l, TstfJlh .. arc"B':£l\~"Ihro-aib. TSJ)/B\icljltOfl1cej bylS-AijiGit 1960;-= -- .. -; '"I 1. Tbl;" .. njjrlayolce. HOw.vtl', .lace It-l'::_&QUdp~~I~ c .... ----addltloDa' !u-tidiwIU beo})Uiati<l fO-rtbtl pro]m~--~h. fili. Ibo\llCS -e

Got 'be clot eel.

.,
r' ...... ~,

,!~'
•

....

Cild _ TsnLau lucb- lll'aacb

If·· - r

«:• .-

._

"." ~

Att&clU'nent;

IAvoie. It Ce,tUlcaUoa. _

DlItrlbQctoD: Odg. " J • Addl'.....

/~SD/FASS Z• TSD/RB-=--------

RECEIPT Re

\.

n~(_e~-_...--.f---C""--

.-----

I' A"""Jl'o MEMORANDUM "Olh~an};F, VIA

SUBJECT

~==--

1'1NANCE DIVISION -. Office ..

11'5D/a"d,"
F~UCUL1'aA.

S..bproJ'-dll09'-1Q~otc._f_l_---~ A11otlne .., 05U.l0~4'Oa I, .~t.c1t..cJ.------

1. !cLvoic.l1. C~4trli-I:'h.at)Ov-.-IQbproJ'c\ p&ymeo' ..... l.b.:m.a44t_~~ loUow.-:

C& .... ~~,'

',:

"~€

"

,.-, ',~'"

• am, O\lD' of $11,080-;00,'

i

.,a'IR

~~T"'''''.I.f
ua .. '........

$14'. ZO.~ 4n".~j!~

to tb

fOl'w.rcl t".clink' to Chl.f,- TSD/R.... arc:lI llia,ilell th,ou,1l TSD/8\\cli.'_9tf!~_.r 1i11nUi\l·~1'60. : ,. Thll II-a flau-lo.vote.. Hoy,-ever •• 1ac• It .11:=,&Ql1c1patccJ-- that aUlUooal_,,,ii4I_'4d11H obU,atiGfo, ".11 project,; thetn"lIbOQld--~--

J. Pl .....

-- - -_ ..
-

"ot \.. clo.ed..

/1
Attaetmle.l1h ,

tn.,olc ••

CerU(l~,.'tOQ' ----,

J)lIlrllHltloal 01'1& I ~Addr_'_""'---=------------•• 1 .. TSJ)/FASS~

Z-TSD1~B===='================~

___ --~--------~;~....._----

INYOICE
For Seme ..

~--

• • • • • • • • • • • • .:

-••

_ •••

_ ••

-. -_ ••

-. ~- ••

-._ ~t'!

CEl(TlFICATIONS==(1) 11 1I b.... by c... Ullid:::-ttiaLtIiILlLIl'ly_olcJJl

.pplY!~'to SubproJ.~!~ _ 109 01 MKULTBA, __lli.t-~doimaDce t li.atllCact()ry.t~ ..t .. tvlc .. _are._ bellli &ccompl_.b.d __ _&t_c_o_rdij"c. __ l_tJl_z_n~tw 'I~ •• ~'Dt., thit-a-~I_Q _ W ---- ---d.taU.d ai.ftda::_oLtb:._~~.tSt.aijd I'jcelpt. lion file iti~-TSDIRB, that tbit bill it Ju.l and_eol'_~._c;_t_.rid_l_b.j_~ym.nt thereof bill-noty.t b •• o---- -

--

mad ••

CtiIef.TSD1R Date:
(1) It h h ... eby::certUl,atnat

••• arcb BraQcb

_tbl,ln\,olc. appllu to Sg1)proJ!_~~~J_Qt__ of MKULTRA 'Whlcb-wi' duly IPPI'~,,~5!;~!~cS_)~ __ ~,=tlle fifoJect "1;-.10'--------=-==---=-_ carried out 10' .c_~~Ldanc. wUb til_' m.m-Ofindum-o{-13- Ap!_l_[l'l~~J_r~_ ___ _ lh. DCI to tbe DOJ _~nd-t6' lIte-filion of Ibhautho~ltyJ~_ A. .u~!~ql.l'll~ _ memoranda.

Ruearch Date:. ~~~~~~~~~~

Dlr.ctor

,.:".'

"

WEWOIlANI>OK-rOa'

__ CONP1'1l0LL$a- ------,

SUBJECT-

UII4.,,_,llt_&lltlaO,_'lY_
U A,rll

,tot" IAtil-. Wiijio,u4GmQr"==~-==

---

- - --~-

""-tlom

th.- DeliO tti. DOl A, "4 11l.!lld"tlOA~'Il1._

&lIl.0~lt,.1D.'\1~'-t:cl • •

,. m.m.9raoCla,- -$9lt,rojle' lot_b., ...

"HJ:O".ct .... 4$IJ;tU-;H of_}__~_~vlJ' .al[ ~l"oJ ~d_,MK1JLTI\7,- (1104_1-= __

A
APPROV ED__:_r_Ol\:__OD LlQA't.10_.._,.N,_-OF FUNDSt t.:':

TSS/CflemlcalOlvbloa-_

Oat.:

DbtrlWlO"I-- --------01'1, • 1• Ad41'.' ... --1 ~ Tss/OC_~_~__

---~-~------------~-~~~- --1 • Tss/FASB__:_-~~

Zi;~TSS/CD~_.- .. ,4- _ -------------

TSS/CD"_(lfFeb60) -

,.

-.

& ...

DR A FT 19 Feb-fuary

_ 1960 __

SUBJECT

between moiecular::__co_osUtuUQn biologi~a.ll·Jlsp9ns Er.=Stuq ies and

as a cut out. 3.-The~costoLthiifptogi'~ail1for_~_

1)

-,

~~l'_~odof oneyear
..._ -~.. . ..

will not fee to the

exceed $2.Y,080. OO towhich must be added-Ufefour-percent __ ~nakl[l~_t_h-~j~t~1~_';~~~-n-t-$i~,!~i3'{:;o.

.. "~_ 1~ ~'J<.J$

:t4-

01Q1 rJ _1)_-

~__

...__

"'.0-

~ Ch-a;rg-es-shollid ..

be ma.de against_AllQ_trn_tU)LN_o~~~_?~~":l():QI;"390Z-~" .. • 4. '1'h-....... . q~h~t the .....

=:

submit to-them a summary account1~g ~_o~~.n_aJ!!lu~J:).asiS~oi-.~=__

"

be returned_by

the

soon as possible-~\pon

tbeclose

on the pill'Lofthep~i_ncipa.l

investigator

iswaiv~d;-==='

==

[6.
7

It is not -anticiJ?~ted~fMXarfype-i'nYanent _eq,!!p_rn~nt .wiU--C--_c ..

be needed~for-_tbis_pr9gra.rn.7
1-

In_~_qnnecll0n wlth-tra.vel

under thi~p:roject.

j_t!~~gl'eed

that the Agency· will accept tnetuv_el-d6climeht!f,tionand.::.accQ\ln~ing-whieb con£ormwitb tne ractices-o

intervals

10.-- Tilis project

will b-e unclas8ified-after_it_1eay~_~_jhe

-----

APPROVED-FOR-..-OBLIGATION OF FUN'[)S:'-:~c=-.::,_'_'=--,~c

Date:

Attachment:

Proposal

&

/~7'-1

:-;

Personnel ..

Associates,

Pr1ncipaLInV'es_t_t~~t~or~~~~~~~~~~~~

$3,000~OO

Asststants and Consultants

-'---C__~~~~~----=~-=-::__::_:-_:__:C_:::_:::_:-_:__==:_:_:

$- 9,000-.00---~--$~~5;OOO~00
$~ __00-:00 6
d! 'f

Supplies and Ma teria.l ... -~ Travel

-17 I~(OO'.00_----~~~" '---' " __ _ ,840.00,

7% ofPeraonnel Budget-:c($-12,OOO.OO); to cover insurance, retirement I social securlty,etc, .~~~~_ l~ of Entire Budget ($17,600.()O) ; to cover part1cipation in indirect costs
TOTAL
=c

~ do ~2F08O .00-",-, -----of , -, -, - ,..

$ 2, 640 .oon~~- __
n

----

Checks should be pa;rable

to

January 22, 1960

cc

e./-Effective July 1, 1960

ProJect Tit!.:

The Szn\h.U'-Gbd Bioobtll1oal fialuaUOilot-PPt.ntlal_hjchophara • .' colOC1_oal s·nta. A . .. . : - ~~--.!'Wl~'QtU~l~~"_!L~_K_'~!_~~~

.P., Prof,lIol'

Pti:t..lUC1.----

----:-_=__

am. ~e34.ot-t.h.J>epaitlW_n_t _ .. Chtll:1ltl7, qoll.ge of ----;----=,._

--"

hHomel

PrincIpal Il'ln.tl~t'Or:- -----~Aelocle.t •• , A.. lat8.lit ... na.-COMUt&nt.

!__ 3,OOO~OO • 9,000.00·---• "OOO~OO

SuppUea and M&ttl'tal.==~-=c .J. ------Yranl

L
J toOOVll"ln&Ura.nce,

~.OO

• 17;600.00-~-~

7~ ot Personnel Bu48It-C$_l.?,OOO.OO)
ret.1reunt, looial 81eul'1tl,_~~tc. l~ ot btire fOTAL

$ -- 840~OQ

Budget.(f_.l1;600.00); to conI' participation-.

in indirect cOlt. $21,080.00

J a.nual'1 22, 1960

.. G
00

I .

..

I07-2.t7

Project Principal

Title:

The Synthesis_and cologica LAgents .......-... ~~

~i6cMrri1~~l-_]va!1.la.~ion P6te.ntiaLPsy~h9phal:nla~ ()f

~CC __ ~

~---C

.-

Investigator:

...

.D., Professor and z.tedicinal

and He8:d-:::of~heDepartmentChEl11l_i~try,C611egeof

PhaXllla~YJL*~_~ __ ~_~_~_

Personnel

Associates,·

Principal

Investigator .

AsSistants~and

~~"~

Consultants

$=' 3-;OOO~OO $ ._ 9 J ()_QO~QQ

Supplies and Materials

$-5;OOO~OO $. 600~.00==~-~ ..-_-.

Travel SUBTOTAL
7'7:"'of Personnel Budget ($::12;QOO-:-Og)f-t6~c_s>""_e_r insurance, retirement, social security,-etc;-::-:

'$ 17;600~OO

840~QQ

_ ----..

15%of Entire Budget ($17;600~OO);foUcover

in indirect costs

particfpati-on

~640~OO$ 2l;080~OO

TOTAL

***

e'

January 22, 1960

cc

Effective July 1, 1960 (on leave

of absence July
c

1,,1960 thr ough June 30, 1961)

a:...

.M~~·~·~·--·~·lJt'v· ... ·-,-~,~·,-=-~,--~t,(.(L:/.ljl'>t·'lIlJ'8t~""!i~4.~l~_t;~

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