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  • Hobbs 1981

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    Cati Jurca
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    Piroxicam, a new nonsteroidal anti-inflammatory drug, was administered at 20 mg/kg doses to rats, dogs, and monkeys. Metabolites were isolated from excreta and identified using chromatography, mass spectrometry, and comparison to authentic samples. Piroxicam was found to be metabolized through cyclodehydration, hydroxylation of the pyridyl moiety, amide hydrolysis, decarboxylation, ring contraction, and N-demethylation in these animals. Rats additionally metabolized piroxicam through hydroxylation at two positions on the benzothiazine nucleus.

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    Piroxicam, a new nonsteroidal anti-inflammatory drug, was administered at 20 mg/kg doses to rats, dogs, and monkeys. Metabolites were isolated from excreta and identified using chromatography, mass spectrometry, and comparison to authentic samples. Piroxicam was found to be metabolized through cyclodehydration, hydroxylation of the pyridyl moiety, amide hydrolysis, decarboxylation, ring contraction, and N-demethylation in these animals. Rats additionally metabolized piroxicam through hydroxylation at two positions on the benzothiazine nucleus.

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    8 views1 page

    Hobbs 1981

    Uploaded by

    Cati Jurca
    Piroxicam, a new nonsteroidal anti-inflammatory drug, was administered at 20 mg/kg doses to rats, dogs, and monkeys. Metabolites were isolated from excreta and identified using chromatography, mass spectrometry, and comparison to authentic samples. Piroxicam was found to be metabolized through cyclodehydration, hydroxylation of the pyridyl moiety, amide hydrolysis, decarboxylation, ring contraction, and N-demethylation in these animals. Rats additionally metabolized piroxicam through hydroxylation at two positions on the benzothiazine nucleus.

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    Drug Metab Dispos. 1981 Mar-Apr;9(2):114-8.

    Metabolism of piroxicam by laboratory animals.


    Hobbs DC, Twomey TM.

    Abstract
    Piroxicam, a potent new nonsteroidal antiinflammatory agent, was radiolabeled in a biologically stable position by tritium exchange and administered at doses of 20 mg/kg to the rat, dog, and rhesus monkey. Metabolites were isolated from excreta by chromatographic methods and identified by their mass spectra and by comparison with authentic samples. Piroxicam is metabolized by cyclodehydration, by hydroxylation on the pyridyl moiety, and by a sequence of reactions involving amide hydrolysis, decarboxylation, ring contraction, and N-demethylation. In the rat, piroxicam is also metabolized by hydroxylation in two positions on the benzothiazine nucleus. PMID:6113108[PubMed - indexed for MEDLINE]

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