‘ther volumes in the series ‘Volume 2: Neuropsychology’, Psychophysiology and Information Processing (Editors: J. Zubin, S. Steinhauer and JH curachemistty and Neuropharmacology iitors: F.A. Henn and L-E. DeLisi) Nosolony, Epidemiology and Genetics (Esitors: Ming T. Tsuang and J.C. Simpson) schosocial Therapies (Editors: J-P. Docherty, S.K. Keith and M. Herz) wzoier) ‘Volume 3: Volume Handbook of Schizophrenia Euited by H.A, NASRALLAH VOLUME 1 The Neurology of Schizophrenia Editors: Henry A. NASRALLAH Chairman, Deparment of Pschiaty, The Ohio Sate University, Daniel R. WEINBERGER Chie, Section on Clinical Neucopsschiatey and Neurobehation, Invamnral Research Progr, National Init of Mental Heath, Director, Behavioral Neurology Service, Sunt Ehzabeth's Hospi Washington, DC, US.A. 1986 ELSEVIER Amsterdam ~ New York ~ Oxford© eis Since Pabliers BL, 1986 uw All igh reserved. No part ofthis publication may be reproduce, ord na ei stem oe tanita in ay form orby any mean, leon, mechan, Poe, recording raters without the pir writen permis othe pla, see Sens Passer hV-/omedia! Davison, PO. Bon 1597, 1000 BM Armwersum, The Cops Clearance Center ns. (CCC), aie, Massacre Information can be obtained {rom the CCC ahost costons ander which photocopies of part of ths pusion may be made in the USA. Ail eter soyrght qtion, nly polocpying ode the US sould be refered to ne Pose. ISBN SERIES 0 44 907 9 Libary of Congress Caaogingsn-Pubieton Data eee Kd nda Published by EhevierSlece Pablirs BV. P.O. or 15 100) BNF Amer Sole disributrs fr th USA ond Canad 52 Vander Avene Nes York, NY 107 Prine in the Netelands by Casparie, Amsterdam bisLioTHEK Contributors K.F, BERMAN Section on Clinical Neuropsychiatry and Neurobehavior, Neuropeyhity ‘Branch, Ioramorat Research Program, National Iie of Meni Heal Sain Elizabeth's Hospital, Wiliam A. White Bulding, Washington, DC 20082, USA AL. CADE Sesion on Clinical Neuropsychiatry and. Neurobehavior, Neuropsychiatry Branch, Tauamural Reseach Program, National Insite of Mental Heath ‘Sain Eieneth's Hospital, Wiliam A. White Bung, Washingtons DC 2002, USA. LA, COFFMAN, Department of Pychiaty, The Oo State University, Collegeof Medicine, 473 West 12m Avenue, Columbus, OH 89210, USA, LE, DELISt Clinical Neuogereticn Branch, The National Insitute of Meal Health, Room 53N/220, Bulding 1, The National lsitutes of Heath, Bethesda, MD 20208, Usa! T.E, GOLDBERG ‘Section on Clinical Neuropsychiatry and. Newobehavior, Nedropsshiaey Branch, Tnvamural Reseach Program, National Insite of Mental Heath, Saint Girabeth's Hospital, Willam A, White Building, Washington, BC 20032, USA. LA, GREBB "Nathan Kline tastitute, Orangeburg, NY 10962, and Deparment of Pachity, [New York University Medial Cntr, $80 Fst Avenue, New York, NY 10016, USA, Dw JESTE Sesion on Clinical Newropsyehiaty and. Newrobehaior, Neuropsychiatry ‘anch, Invamural Research Program, National Lsiute of Mental Hel Sait Eizabeth's Hospital, Willa A. White Buling, Washington, DC 202, USA, ChA. KAUFMANN, Columbia Universiy College of Physicians and Surgeons, New York Sis Psyehate astute, 722 West 168th Steet, New York, NY 10032, U.S.A.DG. KIRCH Section on Clinical Neuropeychintty and. Newrobchavor. Neuropsychiatry Branch, Tniramural Research Program, National Intec of Mental Health, Saint Eliabet's Hospital, Wiliam A. White Building, Washingon, D.C 20032, US.A, LE, KLEINMAN Section on Clinical Brin Studies, Neuropsychiatry Branch Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Wiliam A. White Building, Washington, DC 20032, US.A. 1.8, LOHR Neuropsschiatty Branch, Inramural Research Program, National Intute of Mental Health, Saint Plizabeth’s Hospital, William’ A." White Bulding, ‘Washington, DC 20082, US.A 1.C, MANSCHRECK Laboratory for Clinical and Expecimentst Paychopathology, Department of Poyehiatty, Massachusets General Hota Erch Lindemann Mental Heath (Center, Boston, MA 02114, US.A. JM. MORIHISA, Department of Paychiatey, Georgctown University Schoo! of Medicine, and Department of Psychiatry, VAMC, Washingion, DC 30832, USA. 1A, NASRALLAH Deparinen of Psychiatry, The Ohio Sate Univenity Collegeof Meine, 473 West 12h Avenue, Columbus, OH 32-1238, USA, (CRICKLER, ‘Section on Clinical Neuropsychitry and. Neurobehavior, Neuropsychaty Branch, Intcamural Research Program, National Insitute ot Mental Health, Saint Elizabeth's Hospital, Wiliam A. White Bulding, Washington, DC 20032 USA, LC. SHELTON Department of Psychiatry, Vanderbilt University School of Medicine, Medical (Center Nom, Room A.2315, Nashville, TN 37232, U.S.A, F. TORREY ‘Neuropsychiatry Branch, laramurat Research Program, National Intute of Mental Heath, Sait Elizabeth's Hospital, Washington, DC 20032, USA, anteioaiors DAR, WEINBERGER Section on Clinical Newropchiatey and Neurobehavoe, Neuropsychiatry Branch, Intramural Research Program, National Insite of Mental Heath Behavioral Neurology Service, Saint Elizabeth's Hospital, Willam A. White Bullding: and Department of Neurology and Payehiaty, George Washinton University School of Medicine, Washington, DC 20032, USA. A. WISNIEWSKI ‘Neuropsychiatry Branch, ntramurat Research Program, Natoma lsu of Mental Health, Saint Eliabe’s Hospital, Willam A. White. Bul Washington, DC 20032, US. RE, ZEC Deparment of Psychiatry, Andrew MoFartad Mental Health Center, Southern Minis University Schoo! of Meicing, Spengfieldy TL 62708, USA.