HIPOTALAMUS Corticoliberina MA- Cl+ CRH + recept membranari ai celulellor corticotrope ale Adenohipofizei cuplati cu prot G- active adenilatciclaza-

creste AMPc intracellular- stim secr si biosint ACTH Ind- diagn sindr Cushing, sindr ACTH, insuf corticosupr. RA- hyperemia fetei, deregl de respiratie Gonadorelina MA- GR + receptroii la nivleul celul gonadotrofe cupl cu prot Gq-stim infl ca in celulaform sin fosfoinozitol a inozitoltrifosfat- creste elib ca din depo-activ calmodulinei si proteinkinazei C- biosin gonadotropinelor INd- cancer de prostate, cancer mamar, endometrioza, polichistoza ovare, fibrimiom uterin RA- sarcini multiple, cefalee, congestive, disconfot abd Prolactina MA- stim D2 dopaminorecept ce suprima prolactina si somatotropina INd- hiperprolactinemie, suprimarea lactatiei, acromegalie, parkinsonism, sindr premenstrual CI- HTA, insuf hepatica, deregl psihice, hipersensab RA- Greata, ameteli, constipatii, xerostomie, angina pectoral, convulsii, somnolenta Protirelina MA- Protirelina+ recept din cellule tireotrope+prot G-hidroliza fosfatidilinozitolinositol trifosfat- proteinkinaza C- stim sint si elib tirotrofina Efecte stim sect prolactinei, tirotrofinei, Ind- diag maladiilor gl tiroide, gipofizei, hipotalamus CI- sensibil, angina pect, sarcina, aritmii, HTA, epilelpsie RA- parestezii, xerostomie, tahicardie, bronchospasm, cefalee, ameteli Soamtostatina MA- somatostatina+recept specifici cuplati ku prot G- inhib adenilatciklazeisi canalelor Ca voltak dep- stim canal K-scade AMPc-creste K Efecte- dimin h tireotrop, VC, scade motilitatea intest, steatoree, dispepsie, colelitiaza, diaree Ind- sind Zollinger-Ellison, insuloame, fistule pancreatice, diaree Ci- hipersensibilitate, RA- anorexie, greata, voma, colice, diaree, steatoree, hepatita acuta, colestaza, bradicardie HIPOFIZA Corticotropina MA- ACTH +recept corticosupraren + prot G- stim adenilatciclaza- creste AMPc Efecte- 1. Transf colesteroluli in pregnenolon 2. stim sretoidogeneza , stim secr corticosteroizi, Ind- boala Addison, elucidarea deficitului de 21-hidroxilazei, hidroencefalie, trauma cerebrale, epilepsie, parkinsonism, coree RA- sindr Cushing, ulceratii, atrofia pielii, intens catabolismului proteic Gonadotropine MA- + recept membranari+ proteina G cu activarea adenilatciclazei- crest AMPc Efecte- dezv foliculelor avarieni, secr estrogenilor, gametogeneza, decl ovulatiei, secr progesterone, form corpuli galben, dezv placentei , secr testosterone Ind- inducerea fertilitatii la femei, amenoree, hipogonadism, cicluri anovulatorii, galactoree CI- tumori hipofizare, tumori gonadice, pina la 18 ani, polichistoza ovarelor, tromboembolii RA- avorturi, tromboembolii, febra, cefalee, edeme, dezv sexuala precoce, ginecamastie Somatotropina Efecte- retentia lichidului, iod, saruri, creste abs Ca din tubul digestive Ci- tumori, sarcina, lactatie, hipertiroidism, DZ, RA- urticarie, hiperemie, lipoatrofie, hipotiroidism, leucoza, cefalee, slabiciune, claudicatie Vasopresina Efecte- VC, IM, angina pectoral Indic- diabet insipid, enureza nocturna, CI- angina pect, IM, aritmii, HTA, polidipsie, insuf renala

Tiroida Efecte intensifica cresterea si dezvoltarea, dezv capacitatii intelectuale, sinteza mielinei, creste consumul de oxygen si metabolismul energetic, cresdte metabolismul bazal, efect ionotrop-cronotrop-batmotrop-dromotrop+, stim trecerea cholesterol in AB, stim lipolizei, hiperglicemie, gluconeogeneza, creste secretia HCl si pepsin, stim peristaltismul, osteoliza. IND- hipotiroidism, b Hasimuto, tireotozicoza, gusa endemic, carcinoma tiroidian, CI- tiroidite, hipertiroidism, cancer tiroidian RA- IM, aritmii, HTA, DZ, tuberculoza, insuf suprarenale INSULINA IND- DZ tip I, precoma, coma, sarcina, lactatia, casexie, accidente CV, retinopatii, neuropatii, nefropatii CI- hipers, insuf adenohipofizei, miocardita, insu corticosupr, hipoK, ang pectoral, hiperacididtate gastrica RA- hipoglicemice( paliditate, palpitatii card), oboseala, teama, iritatie, vertijh, G/V, cefalee, lipoidodistrofie, reactii alergice locale, edem insulinic, abcese Sulfanilureicele INd- DZII CI- DZI, DZ II forme grave, sarcina, lactatie, infectii, come, precome RA- hipofglicemie, leucopenie, trombocitopenie, icter colestatic, obezitate, edeme, efect antabus- asociere cu alcool Biguanidele CI- forem grave diabet, IM recent, hipersensib, come, sarcina, lactatia, asocier ku alcool RA- deregl dispeptice, lactacidoza, tahicardie, anemie B12, hipoglicemie Tetrazaharide CI- sarcina, lactatie, meteorism RA- meteorism, crampe abd, diaree Tiazolodindionele CI- affect hepatice, hipers, DZI, sarcina, lactatia, cetoacidoza diab RA- hipoglicemie, anemie, edeme perif, mics hematocritului, edem pulm, obezitate Anticorticoizi iNd- testarea capac adenohip, sind Cushing, cancer mamar, hiperaldost RA- Aminoglutetimida deregl GI, neurologice, prurit, Metiropana- cefalee, sedatie, pruruit, HTA, Ketokanazol- hepatotoxicitate, Mitotat- greata, anorexie, affect R, H, hematopoetice Estrogeni Ind- hipogonadism, tulb de menopauza, oligo si amenoree, osteoporoza, cancer de prostata, suprimarea lactatiei, singerari uterine, anticoncept CI- sarcina, lactatioe, HTA, hepatite, tumori de sin, tromboembolii, porfirie, hemoragii genital, DZ, insuf R, obeziatate, galactoree, anemii, osteoscleroza RA- deregl digestive, hepatobiliare, CV, neurologice, teratogene, sexuale Progestative IND- menometroragii, avort, postmenopauza, sterilitate, amenoree. Anticonceptionale, cancer endometrial, renal. De sin, endometrioza CI- sarcina, IM, HTA, disipidemii, tromboflebite, astm, migrena, depesie, metroragii RA- edeme, virilizarea fetusului feminine, flebite, tromboembolii, HTA, hipercolesterolemii, seboree, acne Androgeni IND- hipogonadism, boli endocrine, singerari uterine, osteoporoza, endometrioza, anemii CI- cancer testicul, prostate, sarcina, lactatie, IC, hepatite, RA- fenomene de virilizare, priapism, dimin spermatogenezei, ginecomastie, edeme, hiperCa, tumori hepatice, incer colestatic, hiperbilirubinemie Anticonceptionale CI- sarcina, tromboembolii, tumori, affect hepatice, deregl metab lipidic, DZ, obezitate, insuf hepatica, RA- G/V/C, HTA, tromboflebite, tromboembolii, edeme, amenoree, cefalee, greata, crestere ponderala, depresie