Pharmacy Student Personal Drug Formulary Drug Name Generic Trade Class Chemical Therapeutic Main Structure Activity

Relationship Physicochemical Properties A/ B/ N Pka LogP Formulation Storage Mechanism of Action PK/ PD Prodrug Vd Cl t Fe CYP Active metabolites Major route(s) of elimination from the body Indication(s) and dose Tablets, soluble tablet, enteric coated tablet Room temperature, away from heat, moisture & light Analgesic, anti-inflammatory, antiplatelet, antipyretic Aspirin Aspro, Asproclear, Solprin, Cartia, Cardiprin

Inhibition of platelet Analgesic PBS Listed Y/ N Absolute Relative

75-150mg daily or acute 150-300mg 300-900mg q46h max 4g/day Scheduling S2 None GI effects, hepatic impairment, renal impairment

Contraindications

Side effects

Predictable (type A) Non-predictable (Type B)

Decreases platelet aggregation

Pregnancy Lactation Drug Interactions

Dose-related tinnitus, reduced cardioprotective benefits, Reyes syndrome (>16 years), GI effects Low dose can be used with caution if necessary during 1st and 2nd trimester Occasional or low doses risk of Reyes syndrome Drug Food CAMs Disease

Practice Points

Take 300-900mg every 4-6 hours. Maximum 4g in 1 day. If you develop pain or allergic reactions see your doctor immediately

Evidence