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Early Signs of Atherosclerosis in Obstructive Sleep Apnea (thoracic)

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Volume: 172, Issue: 5 (September 1, 2005)

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Volume: 172, Issue: 5 (September 1, 2005)


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Early Signs of Atherosclerosis in Obstructive Sleep Apnea (thoracic)

Luciano F. Drager, Luiz A. Bortolotto, Maria Ceclia Lorenzi, Adelaide C. Figueiredo, Eduardo M. Krieger, and Geraldo Lorenzi-Filho "Early Signs of Atherosclerosis in Obstructive Sleep Apnea", American Journal of Respiratory and Critical Care Medicine, Vol. 172, No. 5 (2005), pp. 613-618. doi: 10.1164/rccm.200503-340OC

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Early Signs of Atherosclerosis in Obstructive Sleep Apnea

Sign up for e- Luciano F. Drager, Luiz A. Bortolotto, Maria Ceclia Lorenzi, Adelaide alerts C. Figueiredo, Eduardo M. Krieger, and Geraldo Lorenzi-Filho (What is + Author Affiliations this?) Hypertension Unit and Sleep Laboratory, Pulmonary Division, Heart Institute (InCor), University of So Paulo, So Paulo, Related Brazil

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Abstract

www.atsjournals.org/doi/abs/10.1164/rccm.200503-340OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Background: Obstructive sleep apnea (OSA) is associated with several cardiovascular diseases. However, the mechanisms are not completely atherosclerosis understood. Recent studies have shown that OSA is associated with multiple markers of endothelial damage. We hypothesized that OSA cardiovascular affects functional and structural properties of large arteries, contributing to atherosclerosis progression. Methods and Measurements: Twelve diseases healthy volunteers, 15 patients with mild to moderate OSA, and 15 with carotid severe OSA matched for age, sex, and body mass index were studied remodeling obstructive by using (1) full standard overnight polysomnography; (2) carotidfemoral pulse wave velocity with a noninvasive automatic device; and sleep apnea (3) a high-definition echo-tracking device to measure intima-media By author thickness, diameter, and distensibility. All participants were free of hypertension, diabetes, and smoking, and were not on any medications. Eduardo M. Patients with OSA were naive to treatment. Main Results: Significant Krieger differences existed between control subjects and patients with mild to Luciano F. moderate and severe OSA (apneahypopnea index, 3.1 0.3, 16.2 Drager 1.7, and 55.7 5.9 events/hour, respectively) in pulse wave velocity Luiz A. (8.7 0.2, 9.2 0.2, and 10.3 0.2 m/second; p < 0.0001), intimaBortolotto media thickness (604.4 25.2, 580.2 29.0, and 722.2 35.2 m; p Maria Ceclia = 0.004), and carotid diameter (6,607.8 126.7, 7,152.3 114.4, and Lorenzi 7,539.9 161.2 m; p < 0.0001). Multivariate analyses showed that Adelaide C. the apneahypopnea index correlated independently with pulse wave velocity and intima-media thickness variability (r = 0.61, p < 0.0001, Figueiredo and r = 0.44, p = 0.004, respectively), whereas minimal oxygen Geraldo Lorenzi-Filho saturation correlated with the carotid diameter (r = 0.60, p < 0.0001).

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Early Signs of Atherosclerosis in Obstructive Sleep Apnea (thoracic)

Lorenzi-Filho saturation correlated with the carotid diameter (r = 0.60, p < 0.0001). Conclusions: Middle-aged patients with OSA who are free of overt Search in cardiovascular diseases have early signs of atherosclerosis. All vascular abnormalities correlated significantly with the severity of the OSA, which thoracic further supports the hypothesis that OSA plays an independent role in CrossRef atherosclerosis progression.
Search KEYWORDS: arterial stiffness, atherosclerosis, cardiovascular diseases, carotid remodeling, obstructive sleep apnea

Correspondence and requests for reprints should be addressed to Luciano F. Drager, M.D., Hypertension Unit, Heart Institute (InCor), University of So Paulo Medical School, Av Dr Enas Carvalho de Aguiar, 44, CEP 05403-900 So Paulo, Brazil. E-mail: luciano.drager@incor.usp.br Accepted May 10, 2005 Received March 3, 2005 2005 The American Thoracic Society Supported by the Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP), CNPq, and the E. J. Zerbini Foundation. Conflict of Interest Statement : None of the authors have a financial relationship with a commercial entity that has an interest in the subject of this manuscript.

Cited by
Claire Arnaud1,2, Pauline C. Beguin1,2, Sylvie Lantuejoul2,4,7, JeanLouis Pepin13,,, Christiane Guillermet4, Graziano Pelli8, Fabienne Burger8, Vanessa Buatois9, Christophe Ribuot1,2, Jean-Philippe Baguet2,5,10, Franois Mach8, Patrick Levy13,,, and Maurice Dematteis1,2,6. (2011) The Inflammatory Preatherosclerotic Remodeling Induced by Intermittent Hypoxia Is Attenuated by RANTES/CCL5 Inhibition. American Journal of Respiratory and Critical Care Medicine 184:6, 724-731 Online publication date: 15-Sep-2011. Abstract | Full Text | PDF (676 KB) | Supplemental Material Richard C. Li1, Bodduluri Haribabu2, Steven P. Mathis2, Jinkwan Kim1, and David Gozal1. (2011) Leukotriene B4 Receptor-1 Mediates Intermittent Hypoxia-induced Atherogenesis. American Journal of Respiratory and Critical Care Medicine 184:1, 124-131 Online publication date: 1-Jul-2011. Abstract | Full Text | PDF (661 KB) | Supplemental Material Brian T. Patt 1 , David Jarjoura 2 , Diane N. Haddad 1 , Chandan K. Sen 3 , Sashwati Roy 3 , Nicholas A. Flavahan 4 , and Rami N. Khayat 1 , 5 . (2010) Endothelial Dysfunction in the Microcirculation of Patients with Obstructive Sleep Apnea. American Journal of Respiratory and Critical Care Medicine 182:12, 1540-1545 Online publication date: 15-Dec-2010. Abstract | Full Text | PDF (411 KB) | Supplemental Material Jose M. Marin 1 , 2 , Joan B. Soriano 2 , 3 , Santiago J. Carrizo 1 , Ana www.atsjournals.org/doi/abs/10.1164/rccm.200503-340OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

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Jose M. Joan B. Soriano 2 , 3 , Santiago J. Carrizo 1 , Ana Boldova 1 , and Bartolome R. Celli 4 . (2010) Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea. American Journal of Respiratory and Critical Care Medicine 182:3, 325-331 Online publication date: 1-Aug-2010. Abstract | Full Text | PDF (690 KB) | Supplemental Material Ktia C. Guimares 1 , Luciano F. Drager 1 , Pedro R. Genta 1 , Bianca F. Marcondes 1 , and Geraldo Lorenzi-Filho 1 . (2009) Effects of Oropharyngeal Exercises on Patients with Moderate Obstructive Sleep Apnea Syndrome. American Journal of Respiratory and Critical Care Medicine 179:10, 962-966 Online publication date: 15-May-2009. Abstract | Full Text | PDF (120 KB) | Supplemental Material Geraldo Lorenzi-Filho, , and Luciano F. Drager, . (2008) Is the Cardiovascular System the Primary Target of Obstructive Sleep Apnea?. American Journal of Respiratory and Critical Care Medicine 178:9, 892-893 Online publication date: 1-Nov-2008. Citation | Full Text | PDF (51 KB) T. Douglas Bradley, . (2008) Respiratory Sleep Medicine. American Journal of Respiratory and Critical Care Medicine 177:4, 363-364 Online publication date: 15-Feb-2008. Citation | Full Text | PDF (48 KB) Luciano F. Drager 1 , Luiz A. Bortolotto 1 , Adelaide C. Figueiredo 2 , Eduardo M. Krieger 1 , and Geraldo Lorenzi-Filho 2 . (2007) Effects of Continuous Positive Airway Pressure on Early Signs of Atherosclerosis in Obstructive Sleep Apnea. American Journal of Respiratory and Critical Care Medicine 176:7, 706-712 Online publication date: 1-Oct-2007. Abstract | Full Text | PDF (346 KB) Dai Yumino, , and , T. Douglas Bradley, . (2007) Pathogenesis of Atherosclerosis. American Journal of Respiratory and Critical Care Medicine 176:7, 634-635 Online publication date: 1-Oct-2007. Citation | Full Text | PDF (42 KB) Vladimir Savransky 1 , Ashika Nanayakkara 1 , Jianguo Li 1 , Shannon Bevans 1 , Philip L. Smith 1 , Annabelle Rodriguez 2 , and Vsevolod Y. Polotsky 1 . (2007) Chronic Intermittent Hypoxia Induces Atherosclerosis. American Journal of Respiratory and Critical Care Medicine 175:12, 1290-1297 Online publication date: 15-Jun-2007. Abstract | Full Text | PDF (1106 KB) | Supplemental Material Geraldo Lorenzi-Filho, , and Luciano F. Drager, . (2007) Obstructive Sleep Apnea and Atherosclerosis. American Journal of Respiratory and Critical Care Medicine 175:12, 1219-1221 Online publication date: 15-Jun-2007. Citation | Full Text | PDF (439 KB) Michael Arzt, and T. Douglas Bradley. (2006) Treatment of Sleep Apnea in Heart Failure. American Journal of Respiratory and Critical Care Medicine 173:12, 1300-1308 Online publication date: 15-Jun-2006. Abstract | Full Text | PDF (192 KB)
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Early Signs of Atherosclerosis in Obstructive Sleep Apnea (thoracic)

www.atsjournals.org/doi/abs/10.1164/rccm.200503-340OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

31.05.2013

Early Signs of Atherosclerosis in Obstructive Sleep Apnea (thoracic)

Richard L. Horner, and T. Douglas Bradley. (2006) Update in Sleep and Control of Ventilation 2005. American Journal of Respiratory and Critical Care Medicine 173:8, 827-832 Online publication date: 15-Apr-2006. Citation | Full Text | PDF (95 KB) Michael Arzt, Terry Young, Laurel Finn, James B. Skatrud, and T. Douglas Bradley. (2005) Association of Sleep-disordered Breathing and the Occurrence of Stroke. American Journal of Respiratory and Critical Care Medicine 172:11, 1447-1451 Online publication date: 1-Dec-2005. Abstract | Full Text | PDF (86 KB) Claudio L. Bassetti, . (2005) Obstructive Sleep Apnea and Atherosclerosis. American Journal of Respiratory and Critical Care Medicine 172:5, 518-519 Online publication date: 1-Sep-2005. Citation | Full Text

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