31.05.

2013

Early Signs of Atherosclerosis in Obstructive Sleep Apnea (thoracic)

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Volume: 172, Issue: 5 (September 1, 2005)

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Volume: 172, Issue: 5 (September 1, 2005)
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www.atsjournals.org/doi/abs/10.1164/rccm.200503-340OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

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and body mass index were studied remodeling obstructive by using (1) full standard overnight polysomnography. (8.88-2003&rfr_id=ori:rid:crossref. Multivariate analyses showed that Adelaide C. and Geraldo Lorenzi-Filho (What is + Author Affiliations this?) Hypertension Unit and Sleep Laboratory. Figueiredo. 2/5 .1 ± 0.2013 Articles in Press Current Issue Available Issues Cover Gallery ???widget. and carotid diameter (6.44. Methods and Measurements: Twelve diseases healthy volunteers.0001).articletools. Luiz A.004. Drager. and 10. whereas minimal oxygen Geraldo Lorenzi-Filho saturation correlated with the carotid diameter (r = −0. Adelaide alerts C. 16. 15 patients with mild to moderate OSA. Heart Institute (InCor).2.200503-340OC?url_ver=Z39. Recent studies have shown that OSA is associated with multiple markers of endothelial damage.9 ± 161. diameter. the mechanisms are not completely atherosclerosis understood.9 events/hour.4 ± 25.2 μm. respectively).2.atsjournals. p = 0. the apnea–hypopnea index correlated independently with pulse wave velocity and intima-media thickness variability (r = 0. University of São Paulo. São Paulo.3.607. and 55.enhancedAbstract??? Full Text PDF Cited By Early Signs of Atherosclerosis in Obstructive Sleep Apnea (thoracic) Luciano F.3 ± 114.7 ± 5.2 ± Drager 1.2 ± 0. Maria Cecília Lorenzi. Figueiredo and r = 0. (2) carotidfemoral pulse wave velocity with a noninvasive automatic device. intimaBortolotto media thickness (604.2.8 ± 126. p < 0. and Geraldo Lorenzi-Filho "Early Signs of Atherosclerosis in Obstructive Sleep Apnea". We hypothesized that OSA cardiovascular affects functional and structural properties of large arteries. Related Brazil Publications Google Scholar Search for other articles By keyword arterial stiffness Abstract www. Main Results: Significant Krieger differences existed between control subjects and patients with mild to Luciano F. Eduardo M. 172. p Maria Cecília = 0.200503-340OC Site Tools Early Signs of Atherosclerosis in Obstructive Sleep Apnea Sign up for e. 3. and 722. and distensibility. and Lorenzi 7. Bortolotto. and 15 with carotid severe OSA matched for age.2 ± 29. Patients with OSA were naive to treatment. Krieger. However. Adelaide C.0. and sleep apnea (3) a high-definition echo-tracking device to measure intima-media By author thickness.31. Drager. sex. pp. p < 0. No.004). 613-618.0001.0001).org&rfr_dat=cr_pub%3dpubmed Background: Obstructive sleep apnea (OSA) is associated with several cardiovascular diseases.539. Luiz A. doi: 10. 7. Figueiredo.7. 580. Krieger. Pulmonary Division.152.2 ± 35.7 ± 0. p < 0. and were not on any medications. All participants were free of hypertension. contributing to atherosclerosis progression. 5 (2005). Eduardo M.Luciano F. American Journal of Respiratory and Critical Care Medicine.1164/rccm. Eduardo M. 9.2 μm. respectively) in pulse wave velocity Luiz A. diabetes.org/doi/abs/10. moderate and severe OSA (apnea–hypopnea index.7.0001).2 m/second.1164/rccm. Vol. Maria Cecília Lorenzi. and smoking.61.3 ± 0.4. Bortolotto. p < 0.60.05.

Soriano 2 . Patrick Levy1–3. Conflict of Interest Statement : None of the authors have a financial relationship with a commercial entity that has an interest in the subject of this manuscript.2. JeanLouis Pepin1–3. Haddad 1 . Marin 1 . Christophe Ribuot1. Hypertension Unit. 5 . Av Dr Enéas Carvalho de Aguiar. American Journal of Respiratory and Critical Care Medicine 184:6. Heart Institute (InCor). Abstract | Full Text | PDF (411 KB) | Supplemental Material Jose M.D. and Maurice Dematteis1. p < 0. Cited by Claire Arnaud1.org&rfr_dat=cr_pub%3dpubmed 3/5 . Khayat 1 .usp.drager@incor. (2011) The Inflammatory Preatherosclerotic Remodeling Induced by Intermittent Hypoxia Is Attenuated by RANTES/CCL5 Inhibition. 44.200503-340OC?url_ver=Z39. François Mach8.10. Ana www. Vanessa Buatois9. E-mail: luciano. Sylvie Lantuejoul2. 3 . (2011) Leukotriene B4 Receptor-1 Mediates Intermittent Hypoxia-induced Atherogenesis. Zerbini Foundation.. David Jarjoura 2 .6. Christiane Guillermet4.2.1164/rccm.60. Santiago J. Chandan K. and Rami N.br Accepted May 10. 2005 Received March 3.5. CEP 05403-900 São Paulo. 2 . Patt 1 . Sashwati Roy 3 .31..2. (2010) Endothelial Dysfunction in the Microcirculation of Patients with Obstructive Sleep Apnea. All vascular abnormalities correlated significantly with the severity of the OSA.7.org/doi/abs/10. 1540-1545 Online publication date: 15-Dec-2010. Conclusions: Middle-aged patients with OSA who are free of overt Search in cardiovascular diseases have early signs of atherosclerosis. 724-731 Online publication date: 15-Sep-2011. and the E. Search KEYWORDS: arterial stiffness.0001).2013 Early Signs of Atherosclerosis in Obstructive Sleep Apnea (thoracic) Lorenzi-Filho saturation correlated with the carotid diameter (r = −0. J. American Journal of Respiratory and Critical Care Medicine 182:12. Joan B. Diane N. Pauline C.. carotid remodeling. cardiovascular diseases. Beguin1. Flavahan 4 . obstructive sleep apnea Correspondence and requests for reprints should be addressed to Luciano F. Sen 3 . 2005 © 2005 The American Thoracic Society Supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Carrizo 1 . and David Gozal1. Mathis2. Abstract | Full Text | PDF (661 KB) | Supplemental Material Brian T. M. University of São Paulo Medical School.2.atsjournals. Jean-Philippe Baguet2. Drager. which thoracic further supports the hypothesis that OSA plays an independent role in CrossRef atherosclerosis progression. Nicholas A.05. Brazil.. CNPq. Steven P.4. atherosclerosis. American Journal of Respiratory and Critical Care Medicine 184:1. Graziano Pelli8. Jinkwan Kim1.. Fabienne Burger8. 124-131 Online publication date: 1-Jul-2011. Bodduluri Haribabu2. Li1. Abstract | Full Text | PDF (676 KB) | Supplemental Material Richard C.88-2003&rfr_id=ori:rid:crossref.

1300-1308 Online publication date: 15-Jun-2006.1164/rccm.31. Luciano F.88-2003&rfr_id=ori:rid:crossref. 1219-1221 Online publication date: 15-Jun-2007. and Geraldo Lorenzi-Filho 2 . Drager 1 . Eduardo M. Philip L. . and Luciano F. Shannon Bevans 1 . Abstract | Full Text | PDF (690 KB) | Supplemental Material Kátia C. American Journal of Respiratory and Critical Care Medicine 177:4. Annabelle Rodriguez 2 . Abstract | Full Text | PDF (192 KB) 4/5 Marin 1 . 1290-1297 Online publication date: 15-Jun-2007. (2010) Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea. Krieger 1 . Jianguo Li 1 . Soriano 2 . . Citation | Full Text | PDF (51 KB) T. 363-364 Online publication date: 15-Feb-2008. Smith 1 . American Journal of Respiratory and Critical Care Medicine 175:12.org/doi/abs/10. (2007) Pathogenesis of Atherosclerosis. American Journal of Respiratory and Critical Care Medicine 179:10. American Journal of Respiratory and Critical Care Medicine 178:9. American Journal of Respiratory and Critical Care Medicine 176:7. (2006) Treatment of Sleep Apnea in Heart Failure. Ana Boldova 1 .05. Joan B. Guimarães 1 . Bortolotto 1 . Citation | Full Text | PDF (439 KB) Michael Arzt. (2009) Effects of Oropharyngeal Exercises on Patients with Moderate Obstructive Sleep Apnea Syndrome. . Drager. Bianca F. (2008) Is the Cardiovascular System the Primary Target of Obstructive Sleep Apnea?. Luiz A. (2007) Effects of Continuous Positive Airway Pressure on Early Signs of Atherosclerosis in Obstructive Sleep Apnea. American Journal of Respiratory and Critical Care Medicine 175:12. Polotsky 1 . Adelaide C. Abstract | Full Text | PDF (1106 KB) | Supplemental Material Geraldo Lorenzi-Filho. Figueiredo 2 .200503-340OC?url_ver=Z39. Douglas Bradley. American Journal of Respiratory and Critical Care Medicine 182:3. Abstract | Full Text | PDF (120 KB) | Supplemental Material Geraldo Lorenzi-Filho. and T. Early Signs of Atherosclerosis in Obstructive Sleep Apnea (thoracic) www.2013 Jose M. American Journal of Respiratory and Critical Care Medicine 173:12.atsjournals. (2008) Respiratory Sleep Medicine. American Journal of Respiratory and Critical Care Medicine 176:7. Ashika Nanayakkara 1 . and Bartolome R. 634-635 Online publication date: 1-Oct-2007. . and Vsevolod Y. and Luciano F. T. . (2007) Chronic Intermittent Hypoxia Induces Atherosclerosis. 2 . Celli 4 . Douglas Bradley. Marcondes 1 . 706-712 Online publication date: 1-Oct-2007. . (2007) Obstructive Sleep Apnea and Atherosclerosis. 325-331 Online publication date: 1-Aug-2010. Pedro R. Santiago J. Genta 1 . Abstract | Full Text | PDF (346 KB) Dai Yumino. Citation | Full Text | PDF (48 KB) Luciano F. 3 . 892-893 Online publication date: 1-Nov-2008. Douglas Bradley. and . Drager. Drager 1 . and Geraldo Lorenzi-Filho 1 . 962-966 Online publication date: 15-May-2009.org&rfr_dat=cr_pub%3dpubmed . Citation | Full Text | PDF (42 KB) Vladimir Savransky 1 . Carrizo 1 . .

and T.1164/rccm. James B. Bassetti.org www. 1447-1451 Online publication date: 1-Dec-2005.org/doi/abs/10. NY 10004 • 212-315-8600 • www. Laurel Finn. American Journal of Respiratory and Critical Care Medicine 172:11.thoracic.31. 518-519 Online publication date: 1-Sep-2005.200503-340OC?url_ver=Z39.05.atsjournals.88-2003&rfr_id=ori:rid:crossref. (2005) Association of Sleep-disordered Breathing and the Occurrence of Stroke. Douglas Bradley. Terry Young. Citation | Full Text © 2013 American Thoracic Society • 25 Broadway. Abstract | Full Text | PDF (86 KB) Claudio L. and T. 827-832 Online publication date: 15-Apr-2006. American Journal of Respiratory and Critical Care Medicine 172:5.org&rfr_dat=cr_pub%3dpubmed 5/5 . (2005) Obstructive Sleep Apnea and Atherosclerosis. Skatrud. American Journal of Respiratory and Critical Care Medicine 173:8. (2006) Update in Sleep and Control of Ventilation 2005.2013 Early Signs of Atherosclerosis in Obstructive Sleep Apnea (thoracic) Richard L. Citation | Full Text | PDF (95 KB) Michael Arzt. Horner. . Douglas Bradley. New York.

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