ALS (Amyotrophic Lateral

Sclerosis ) Prognosis:
Phase Angle a Prognostic Factor for survival

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1)Amyotrophic lateral sclerosis (ALS), often
called as "Lou Gehrig's Disease," is a
progressive neurodegenerative disease that
affects nerve cells in the brain and the spinal
cord. It is a form of motor neuron disease.

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2)The progressive degeneration of the motor
neurons in ALS eventually leads to their death.

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3) When the motor neurons die, the ability of the
brain to initiate and control muscle movement
is lost. With voluntary muscle action
progressively affected, patients in the later
stages of the disease may become totally
paralyzed.

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Symptoms of ALS
• Initial stage symptoms of ALS often include
increasing muscle weakness, especially
involving the arms and legs, speech,
swallowing or breathing.

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• When muscles no longer receive the messages
from the motor neurons that they require to
function, the muscles begin to become smaller.
Limbs begin to look "thinner" as muscle tissue
atrophies.

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•Although the cause of ALS is not completely
understood, the recent years have brought a
wealth of new scientific understanding regarding
the physiology of this disease.

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Based on a research done at the Nutrition Unit ,
ALS Center, Limoges,CHU it was concluded that
Phase Angle as a prognostic Factor for survival
in ALS.

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1)PrognostiCheck® illustrates where the
patient is on the trajectory of the progression of
ALS and shows the ‘Burden of the Illness’ the
patient is experiencing. For instance if the
normal Scoring value for the patient is 7 and
their value is 5 the loss of 2 is the burden of
disease experienced by this patient.

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2) Phase angle of an entity provides a reliable
and objective index and is a survival
prognostic factor in several diseases.

increasing
frequency
Reactance ( )

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3)Phase angle was measured on a sample
of 168 ALS patients and an analysis between
PA and factors like neurological, respiratory
and nutritional status are considered to
determine whether PA is an independent
prognostic factor for survival in ALS.

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4) The Phase Angle is the relationship between
resistance (R) and body reactance (Xc)
defined mathematically (arc tangent Xc/R
expressed in degree.)
: Is a fluid Indicator
Resistance (R) 1
: R=
Water Content of Body.

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5) To access the prognostic role of phase angle
in ALS patients,survival analysis based on
Kaplan-Meier method using log rank test and
on univariate and multivariate COX
Proportional hazard model was used.

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6) Baseline time was time from multidisciplinary
visit(T1) to death or censoring time.
7)Studies have confirmed that Phase Angle (PA)
was always significantly lower in ALS patients.

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8) Phase Angle was lower in ALS malnourished
patients than in non-malnourished patients.
9) Patients with PA < 2.5 degree had a
significantly poorer survival rate than patients
with PA >2.5.

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 R
PrognostiCheck
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By IPGDx, LLC
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