Ensuring Quality Care

The Gerson Institute is a non-profit organization, established in 1977. s a publi! benefit, agen!y we are dedicated to healing and preventing chrome and degenerative diseases based on the vision, philosophy and successful work of Max Gerson. M.D. "e pursue this #ission by offering a range of progra#s and resour!es designed to pro$ide !urrent, a!!urate infor#ation to people %ho are interested in the Gerson Therapy&. 'a$ing fulfilled this role for () years %e ha$e be!o#e rightfully *no%n as the &starting pla!e& for all Gerson Therapy in+uiries, fro# both patients and #edi!al professionals ali*e. "e ta*e pride in this role and %e are !o##itted to prote!ting the ,Gerson, trade#ar* and the ,Gerson Therapy, ser$i!e #ar*, both of %hi!h be!a#e fully registered to the Gerson Institute in (--(. "hile o%nership of these #ar*s pro$ides us %ith !lear legal prote!tion, %e at the Gerson Institute $alue the# #ore as tools for ensuring +uality !are. "e are fully a%are of ho% daunting any health !risis !an be and %e re!ognize our responsibility in pro$iding +ualified endorse#ents for the prospe!ti$e Gerson Therapy patient. In adheren!e to our legal obligations %e %ill !ontinue to #a*e our resour!es in!reasingly useful to the publi! and %e %ill be proa!ti$e in prote!ting the integrity and our o%nership of the Gerson na#e. s you learn #ore about the Gerson Therapy %e en!ourage you to refer ba!* to the Gerson Institute for ad$i!e and ongoing support. 'ere are so#e of the progra#s offered by us that #ight help you on your %ay. Gerson Institute Approved Referral List This is perhaps the #ost utilized progra# offered by the Gerson Institute. /ur referral list !onsists of #any fully trained pra!titioners, !lini!s, support groups, !o#panions and ho#e set-up !oordinators. If your Gerson Therapy hospital, physi!ian or support group does not ha$e our &seal of appro$al&, %e do not endorse the#0 Edu!ation 1 /utrea!h /ur Edu!ation 1 /utrea!h 2rogra# !onsists of a $ariety of %or*shops and se#inars in!luding 0 'e Gerson Therapy Training Program for icensed Professionals. 3aun!hed in 1994 this training progra# in$ol$es a %ee* of instru!tion and an internship at a li!ensed Gerson !lini!. Graduates are eligible to 5oin the Gerson Institute ppro$ed 6eferral 3ist and future !lini!s %ill only be li!ensed on!e *ey #edi!al staff ha$e !o#pleted this progra#. /ther %or*shops offered by the Gerson Institute in!lude onsite Gerson Therapy !oo*ing !lasses, health #aintenan!e and &ho% to& se#inars and our in!reasingly popular Caregi$er Training "ee*end, the edu!ational prere+uisite for li!ensed Gerson !o#panions and ho#e set-up !oordinators. Gerson !ealing "ewsletter 74 issues a year8 9in!e 19:;, the Gerson !ealing "ewsletter has been the lin* bet%een the Gerson Institute and its patients and supporters. Ea!h issue in!ludes ne%s fro# the Institute, n updated e$ent !alendar, reports on alternati$e and idiopathi! trends, re!o$ered 2atient testi#onials and arti!les %ritten by Gerson e<perts in!luding Charlotte Gerson. Speakers Bureau Conta!t us to s!hedule a spea*er for your !o##unity organization, !hur!h or s!hool. 9e#inars !an be !atered to your needs and %e pla!e an e+ual e#phasis on disease pre$ention as %e do upon treat#ent. Gerson Therapy /$ersight 2anel lthough =a< Gerson de$eloped the Gerson Therapy o$er )- years ago, %e re!ognize that the %orld is e$er !hanging. This panel of re!ognized Gerson Therapy e<perts ensures that >r Gerson&s proto!ol refle!ts rele$ant !hanges %ithout losing sight of his !ore prin!iples. This panel dis!usses +uestions ranging fro# #ind-body #atters to dental pro!edures before sub#itting position state#ents to Gerson Institute #e#bers, patients and li!ensed !are pro$iders. Patient Support Programs

The Gerson Institute offers a !o#prehensi$e range of patient support resour!es. These in!lude regular telephone support, a !o#prehensi$e %eb site, the Gerson Therapy ?ollo% @p 2rogra#, 2atient 9upport Aet%or*, 2rodu!ts 6esour!es 3ist, 6e!o$ered 2atient 6eferral 3ist and an t 'o#e Gerson Therapy 2a!*et for the #any people %ho are su!!essfully healing the#sel$es fro# ho#e. 2lease !onta!t our staff to find out #ore about any of these progra#s and resour!es. "e loo* for%ard to hearing fro# you.

A Cancer Therapy
Results of Fifty Cases
and The #ure of $dvanced #ancer by Diet Therapy
A Summary of 30 Years of Clinical Experimentation

Ma !erson" M#$#
Gerson Institute

Copyright B 19):, 1999, (--( by The Gerson Institute il rights reser$ed. Ao part of this boo* #ay be reprodu!ed or utilized in any for# or by any #eans, ele!troni! or #e!hani!al, in!luding photo!opying, re!ording, or by any infor#ation storage and retrie$al syste#, %ithout per#ission in %riting fro# the publisher. /riginal !opyright. 19): by =a< Gerson, =.>. The Gerson Institute 1)7( 9e!ond $enue 9an >iego,C 9(1-1 Telephone. 419-4:)-)C)9, or 1-:::-;-GE69/A e#ail. #ailDgerson.org E %eb. %%%.gerson.org 3ibrary of Congress Cataloging-in-2ubli!ation >ata Gerson, =a< !an!er therapy. results of fifty !ases. a su##ary of C- years !lini!al e<peri#entation E =a< Gerson. p. C#. /riginally published. Ae% For* . "hittier Goo*s, H! 19):I I9GA --::(4:-(-C-( 7pb* . al*. paper8 I. Can!er->iet Therapy-Case 9tudies 1. Title H>A3=. 1. Aeoplas#s- therapy. Aot !+uiredI 6C(71.>)(G;7 1997 414.99&;-4>C(1 >A3=E>3C for 3ibrary of Congress 94-)-9)4 CI2 2rinted in the @nited 9tates of #eri!a The na#es GersonJ1 and Gerson Therapy are %orld%ide trade#ar*s, ser$i!e #ar*s, andEor registered trade#ar*s or ser$i!e#ar*s of the Gerson Institute. ll 6ights reser$ed. @sed by s5ennission. The infor#ation !ontained in this boo* is for edu!ational and s!ientifi! purposes only. >o not unden.a*i. any #edi!al uoainii#i or dietary !hanges %ithout the ad$i!e and supi5ori- of an appropriately li!ensed health!are pra!titioner.

2refa!e to the 9i<th Edition

=a< Gerson, =.>. had the %isdo#, foresight, and !ourage to loo* beyond the pre$ailing #edi!al $ie%s of his day. /ut of C- years of !lini!al e<peri#entation, he arri$ed at so#e thenradi!al !on!epts. K K K K >iet has a !onsiderable effe!t on al#ost all diseases The hu#an body !an heal itself gi$en the appropriate nutrients ny effe!ti$e treat#ent for degenerati$e disease #ust treat the %hole person 2eople %ith serious illnesses #ust help their body deto<ify

"hile these ideas sound sensible today, they %ere al#ost blasphe#ous in the 19;-s and 19)-s. =ore than ;- years ha$e passed sin!e =a< Gerson, =.>. died in =ar!h of 19)9. t that ti#e, #ost !an!ers %ere not !onsidered !urable by orthodo< #edi!ine, and the #eri!an =edi!al sso!iation and #eri!an Can!er 9o!iety both flatly re5e!ted the notion that diet !ould ha$e any effe!t on either the pre$ention or treat#ent of !an!er. In spite of the fier!e resistan!e to his ideas and #ethods, =a< Gerson %or*ed $irtually alone to treat and heal #any !an!ers !onsidered to be ter#inal, as %ell as nu#erous other diseases. 'e

%or*ed to publish and share infor#ation as best he !ould about the #ethods he had de$eloped. t the ti#e of this printing in 1999, !an!er sur$i$al rates re#ain $irtually un!hanged, and the nu#ber of ne% !an!er diagnoses has !ontinued to in!rease ea!h year. Certain diseases 7!an!ers of li$er, lung, and pan!reas, a#ong others8 are still $irtual death senten!es. Ae% diagnoses of pre$iously rare diseases are gro%ing at an alar#ing rate. The ,"ar on Can!er, de!lared by thenpresident Ai<on in 1971 has, for #ost !an!ers, neither de!reased the nu#ber of ne% diagnoses, nor i#pro$ed sur$i$al for those already diagnosed, ?or o$er (- years, the Gerson Institute has %or*ed to help patients re!o$er fro# these other%ise ,in!urable, diseases, and to share *no%ledge of, and !ontinue resear!h and de$elop#ent of the safe, effe!ti$e Gerson Therapy approa!h to healing !an!er and other degenerati$e diseases. "hen %e started in 1977, al#ost no one %ould listen to %hat %e had to say. "e %ere unable to treat patients in the @nited 9tates be!ause #edi!al boards threatened the li!enses of physi!ians %ho de$iated fro# !on$entional treat#ent #ethods. /nly the desperately ill and dying, ,gi$en up, by their do!tors, sought our help. In spite of the diffi!ulties, %e su!!eeded in helping hundreds of patients re!o$er fro# other%ise ter#inal diseases, tea!hing thousands #ore to ta*e steps to i#pro$e health and pre$ent the de$elop#ent of disease. Today, fortunately, #u!h has !hanged. =any patients are no% de#anding 7and re!ei$ing8 fro# their insuran!e !o#panies the option of pursuing holisti! treat#ent. gro%ing nu#ber of states ha$e established separate, independent li!ensing boards for pra!titioners using natural #ethods. /ther states ha$e passed la%s re+uiring insuran!e !o#panies to pay for alternati$e !are, or spe!ifi!ally prote!ting pra!titioners using natural #ethods fro# reprisals by their #edi!al boards. The Aational Institutes of 'ealth has established an /ffi!e of lternati$e =edi!ine, dedi!ated to resear!h and $alidation of holisti! #ethods of treat#ent. Independent #edi!al resear!hers ha$e do!u#ented and $erified the bio!he#i!al basis for #any i#portant ele#ents of the Gerson Therapy in #ore than C-- arti!les in the peer-re$ie%ed #edi!al literature. ll of these fa!tors ha$e led to a dra#ati! in!rease in interest in Gerson Therapy treat#ent. Today, our staff handles as #any as C-- in+uiries a day fro# those see*ing infor#ation on Gerson Therapy #edi!al edu!ation progra#s, referrals to pra!titioners, treat#ent !enters, half%ay houses, and therapy assistants. 2atients are see*ing Gerson treat#ent as a first !hoi!e, rather than a last hope. ?or those interested in #edi!al training, the Gerson Institute #aintains !ertifi!ation progra#s for physi!ians, treat#ent !enters, and ho#e !are assistants. "e are a!ti$ely %or*ing to establish !ertified treat#ent !enters and #edi!al pra!titioners %orld%ide. Conta!t us for !urrent offerings. "hile there are #any paths to %ellness, the Gerson Therapy is, in our opinion, the #ost !o#plete, all-en!o#passing approa!h for !o#prehensi$e healing. /ur !ontinuing resear!h is designed to ensure that %e #aintain and i#pro$e our ability to heal and pre$ent diseases, enhan!e %ell-being and longe$ity, and help indi$iduals operate at their pea* potential for a long and satisfying life into the (1st !entury and beyond.
Charlotte Gerson Founder, Gerson Institute une !"""

DEDICATED TO MY WIFE MARGARET

!*no%ledg#ents
I ?EE3 IA>EGTE> to e<press #y deep gratitude first to #y daughter, Gertrude 9elten, for her a!ti$e !ooperation as the #anager of the Can!er Clini! and her untiring help in the further de$elop#ent of this ne% therapy. #ong the physi!ians, I %ish to e<press #y indebtedness to >r. Loseph Miegler, 6oentgenologist, for his loyal help in preparing $aluable N-ray pi!tures and ob5e!ti$e

e<planationsO >r. Purt 'einri!h for his e<a!t urologi!al and !ystos!opi! findingsO the late >r. La#es Q. 6i!!i for his pre!ise gyne!ologi!al reports and the late >r. Lonas Gora* for his enthusiasti! intelle!tual sti#ulusO and 2rofessor >r. "erner Pollath, Ger#any, for his ideal #anner of transfor#ing proble#s into realisti! biologi!al #aterial. =y eldest daughter, Lohanna /berlander, helped energeti!ally in the translation and organization of this %or*. =y youngest daughter, 3otte 9traus, helped %here$er she !ould %ith great interest and understanding en!ourage#ent. =y se!retary, Erna 'arding, %or*ed diligently %ith enduring perse$eran!e in typing this #anus!ript. I %ish to a!*no%ledge %ith deep gratitude the !ooperation and en!ourage#ent re!ei$ed fro# the ?oundation for Can!er Treat#ent, In!., a non-profit organization for#ed #any years ago by grateful patients for the purpose of perpetuating the treat#ent as des!ribed in this boo*. To the follo%ing dire!tors of the ?oundation, I %ould li*e to e<press #y spe!ial than*s. 2rofessor >r. lbert 9!h%eitzer, 2rofessor 'enry 9!haefer-9i##e#, =r, Carl Gropler, 6e$. >r. Er%in 9eale, 2rofessor ?ul#er =ood, =r. 3ouis L. 6osenthal and =r. rnold L, /berlander. CPA/"3E>G=EAT9 "ithout the aid and en!ourage#ent of #y %ife, =argaret, I !ould not ha$e %ritten this boo*. To her, I ha$e dedi!ated this %or*. = N GE69/A, =.>.

Contents
This publi!ation is an e<e#plifi!ation of the %or* of =a< Gerson, =.>., on his treat#ent of !an!er as dis!losed to the @nited 9tates 9enate in publi! hearings held Luly 1, ( and C,19;4. It is designed as a report on his !ontinued %or* in !an!er treat#ent, and %ill be filed %ith the @nited 9tates 9enate %hen it again resu#es hearings on #eans of !uring and pre$enting !an!er. The title page of the @. 9. 9enate Co##ittee report, !ontaining ((7 pages, follo%s. #$"#%& &%'%$&#!
'E 6IAG9

before a 9ub!o##ittee of the

C/=#iTTTEE /A ?/6EIGA 6E3 TI/A9 @AITE> 9T TE9 9EA TE 9E$EATF-AIAT' C/AG6E99

9e!ond 9ession on 9. 1:7) Gill to authorize and re+uest the 2resident to underta*e to #obilize at so#e !on$enient pla!e in the @nited 9tates an ade+uate nu#ber of the "orld&s /utstanding E<perts, and !oordinate and utilize their ser$i!es in a 9upre#e Effort to >is!o$er =eans of Curing and 2re$enting Can!er. Luly I, ( and C, 19;4 2rinted for the use of the Co##ittee on ?oreign 6elations
:9;71 G/QE6A=EAT 26IATIAG /??ICE

2 6T I
C' 2TE6 2refa!e Introdu!tion 1 The ,9e!ret, of =y Treat#ent ( The Con!ept of TotalityR>e!isi$e in Can!er and other >egenerati$e >iseases C >ire!tions for General Autrition ; >e$elop#ent of the Co#bined >ietary 6egi#e in Can!er 79ur$ey8 ) The Theory 2 GE ( ) ** +* (* ()

4 7 : 9 111 *+ 1C 1; 1) 14 17 1: 19 ((1 /,+ (C

?e% 9i#ilar Can!er Theories 2ara!elsus& >ietary 6egi#e >ifferent uthors& Can!er Therapies by >iet 79ur$ey8 Early Can!er 9y#pto#s Can!er and 3i$er 9ur$ey of Treat#ent of 3i$er 2athology by 9e$eral uthors >e$elop#ent of 3i$er =edi!ation in Chroni! >egenerati$e >iseases 9!ientists Ter# 6adiation a 2eril to ?uture of =an =ineral =etabolis# in >egenerati$e >iseases >istribution of Enzy#es in /rgans =ineral !!u#ulations in the Thyroid The 'ealing of Can!er 6ole of llergy in the 'ealing 2ro!ess of Can!er Introdu!tion to the >iet Introdu!tion to Autrition and >iet The 9aitless >iet 9alt in Can!er >iet Inse!ti!ides

,) ,)) .* .( /* /0) 0*1) **( ***() *(*,) *)( *.( *./

(; The 9ignifi!an!e of the Content of the 9oil to 'u#an >iseases E /) () Can!er >iet and its 2reparation *0/ (4 The 2ra!ti!e of the Therapy*-( ** 6ea!tionsR?lare @ps +1* (: 9hort 2ra!ti!al E<planation of the =edi!ation +1) (9 6ehabilitation of the Can!er 2atient +*( C- =ost ?re+uent =ista*es of 2atients in the ppli!ation of the Treat#ent +*) Che!* 3ist for Can!er 2atients on the Gerson Therapy +*/ C1 =edi!ationR9o#e ?ailures+*C( Tables++( Total Treat#ent of a Typi!al Case +() 'ourly 9!hedule of Typi!al Treat#ent +(. CC Co#bined >ietary 6egi#e+(/ 9pe!ial Aotes to 2hysi!ian +,0
>I GA/9I9 2 GE

E<!eptionally large tu#or #ass of the pituitary gland. 9urrounding bones partly destroyed. +)* 9!h%anno#a of the left !erebellar pontine angle.+)) Aeurofibro#ata %ith rapid gro%th, #any #etastases of sar!o#a type, also brain tu#or %ith he#iparesis, left side. 9pongioblasto#a, left part thala#us, +.. Cerebellar pontine angle tu#or. +/+ 2ituitary tu#or. +// Cer$i!al and upper thora!i! intra#edullary glio#a. +0( Cer$i!al !ord angio#a. +0) Chorionepithelio#a, #etastases in abdo#en and lungs. +0/ Cho!olate !yst of left o$ary, s!lrrhus !ar!ino#a of right breast %ith regional ly#ph node in$ol$e#ent. 'yper parathyroidis#, high blood pressure, angina pe!toris. +-1

6ight testi!le terrato#a. SE#bryonal Cell Car!ino#a.8 6egro%th in right groin. =etastases in periaorti! glands and both lungs. +-) 9preading #elanosar!o#a. +-!ti$e #elanosar!o#a. (1+ 6e!urrent #elanosar!o#a spreading o$er the body. (1, !ti$e neurogeni! fibrosar!o#a %ith glands. (1. 14 6etro-peritoneal ly#phosar!o#a. (117 6e!urrent osteofibrosar!o#a 7Giant !ell tu#or of left #astoid pro!ess8. '*1 1: 6etro-peritoneal ly#phosar!o#a a!ti$e, spreading to glands all around, also bilateral bron!heal. (*( 19 3y#phoblasto#a or 'odg*in&s >isease. (*. (- 3y#phosar!o#a, spreading. C(7 (1 3y#phosar!o#a, regro%ing. (*(( 3y#phosar!o#a, subtotal o!!lusion. (+* (C =yosar!o#a, follo%ed by osteo#yelitis, subtro!hantheri! pathologi! fra!ture of left subtro!hantheri! area.C() (; 2aget Gone >isease. CC() Tu#or #ass in aorti! %indo%. CC( (4 6egro%th of #alignant tu#or of right parotis. Chroni! osteoarthritis. ((. (7 deno!ar!ino#a of both Thyroid and 9ig#oid. CC7 (: Car!ino#a of thyroid gland. ((0 (9 Car!ino#a of right breast, Grade III. ((C- deno!ar!ino#a of right breast %ith diffuse a<illary ly#ph node in$ol$e#ent and re!urren!e after radi!al #aste!to#y. (,, C1 naplasti! !ar!ino#a of the right breast %ith a<illary #etastases and a regro%th in the !artilage of the fifth rib. (,. C( 6e!idi$es of breast !ar!ino#a. (,/ CC 2aget&s >isease, right breast. (,0 C; 6e!urrent basal !ell !ar!ino#a. (,C) Gasal !ell !ar!ino#a %ith undiagnosed !o#pli!ations. ()* C4 Gasal !ell !ar!ino#a of right upper lip. (), C7 6e!urrent basal !ell epithelio#a, sole, left foot. C)) C: 6egro%th of left *idney sar!o#a. (). C9 2rostate !ar!ino#a %ith #etastases in lu#bar spine. rterios!lerosis and high blood pressure. C): ;- Can!er of prostate, #etastases in left sa!roilia! 5oint. C4( ;1 Gron!hiogeni! !ar!ino#a, total right pneu#one!to#y. Indi!ation of a!ti$e spreading !an!er. (.. ;( Gron!hiogeni! !ar!ino#a, inoperable, suspi!ion of neoplas#a pressing on spinal !ord. C4C ;C 3eft sub#a<illary gland tu#or, #etastases in right upper lung lobe. C7( ;; 6egro%th of adeno!ar!ino#a of upper re!tu# %ith #etastases in lo%er abdo#en. (/,
A/. >I GA/9I9

;) deno!ar!ino#a of sig#oid !olon. /bstru!tion ne!essi-

tating operation. ;4 Cer$i< !ar!ino#a %ith in$ol$e#ent of the $aginal $ault, #ore induration to the left $aginal $ault, +uite nodular. Induration also in the re!to$aginal septu#. ;7 Cer$i< !ar!ino#a, inoperable !ase. ;: 9+ua#ous !ell !ar!ino#a of left *idney, left ureter, re!urren!e in urine bladder. ;9 Can!er of the urine bladder. =igraine heada!he. )- deno!ar!ino#a of uterus and #etastases to urine bladder and $agina, %ith large urine fistula. ppendi< I. 'estonng the 'ealing =e!hanis# in other (-* Chroni! >iseases by Charlotte Gerson 9traus ppendi< II. >e$elop#ent of the Gerson Can!er ,1( Therapy - a 3e!ture by >r. =a< Gerson ppendi< III. Conte#porary Con!erns in 6a% 3i$er Lui!e Therapy 7=ar!h, 199-8 A =E A> @T'/69 IA>EN ,+( ,+*

#AR$ !
9@GLECT IA>EN

Introdu!tion
T'I9 G//P has been %ritten to indi!ate that there is an effe!ti$e treat#ent of !an!er, e$en in ad$an!ed !ases. ?or that reason it is ne!essary to a!+uaint the reader %ith obser$ations and data in the !an!er proble# %hi!h are used in the a!!epted !an!er treat#ents. The history of #edi!ine has sho%n that #any physi!ians adhere to their a!!usto#ed treat#ent %ith great tena!ity, and often e$iden!e $ery strong ,allergi!, rea!tions against e$erything that !ould possibly !hange their !usto#ary therapeuti! #ethods. It is $ery %ell *no%n that great diffi!ulties e<ist, and that #any ob5e!tions #ay be raised against publi!ation of a !an!er therapy %hi!h differs fro# the a!!epted #ethods. The ti#e is ripe, ho%e$er, to %ipe out the deep pessi#is# %hi!h #ost physi!ians ha$e about e$erything that assu#es to be therapeuti!ally effe!ti$e in degenerati$e diseases and espe!ially in !an!er. t this ti#e, of !ourse, it is not possible to repla!e a !entury-long pessi#is# %ith an o$er%hel#ing opti#is#, "e all *no% that e$erything in biology is not as pre!ise as in #athe#ati!s or physi!s. I fear that it %ill not be possible, at least in the near future, to repair all the da#age that #odern agri!ulture and !i$ilization ha$e brought to our li$es. I belie$e it is essential that people unite, in the old !onser$ati$e #anner, for the hu#anitarian purpose of produ!ing nutrition for their fa#ilies and future generations as natural and unrefined as possible. The !o#ing years %ill #a*e it #ore and #ore i#perati$e that organi!ally gro%n fruit and $egetables %ill be, and #ust be, used for prote!tion against degenerati$e diseases, the pre$ention of !an!er, and #ore so in the treat#ent of !an!er. C !!ording to present go$ern#ent statisti!s, one out of e$ery si< persons in our population %ill die of !an!er. It %ill not be long before the entire population %ill ha$e to de!ide %hether %e %ill all die of !an!er or %hether %e %ill ha$e enough %isdo#, !ourage, and %ill po%er to !hange funda#entally all our li$ing and nutritional !onditions. ?or ,Can!er is a pheno#enon !oe<istent %ith the li$ing pro!ess . . ., "e %ill again need real house%i$es, not eager to sa$e *it!hen ti#e, but ho#e#a*ers %ho %ill de$ote their li$es to the benefit of all, espe!ially the tas* of de$eloping and #aintaining a healthy fa#ily. Gabies %ould no longer be fed by a for#ula but %ould ha$e the natural #other&s #il*O they %ould gro% up %ithout being affli!ted %ith a fatal disease su!h as leu*e#ia, and %ithout being #entally retarded, both !onditions %hi!h are in!reasing rapidly at present. ?or the future of !o#ing generations, I thin* it is high ti#e that %e !hange our agri!ulture and food preser$ation #ethods. /ther%ise, %e %ill ha$e to in!rease our institutions for #ental patients yearly, and %e %ill see the hospitals o$er!ro%ded %ith degenerati$e diseases e$en #ore rapidly and in greater nu#bers than the hospitals the#sel$es !an be enlarged. 9e$enty years ago, leu*e#ia %as un*no%n in the @nited 9tates. ?ifty years ago, lung !an!er %as so seldo# obser$ed in !lini!s and autopsies that e$ery !ase %as %orthy of publi!ation. Gut todayR%hat a !hange for the %orse. 7/ 2uae mutatio rerum.3 The pra!ti!e of the treat#ent is a diffi!ult tas*. The treat#ent in the hospital as %ell as in the ho#e re+uires so#ebody&s help all day long, parti!ularly in ad$an!ed !ases %here a life is at sta*e and the patient is $ery %ea*. The fa#ily has to gi$e up so#e of the so!ial life and do this hu#anitarian %or* %ith deep de$otion. The de!line in our #ode# life is e$ident by this la!* of de$otion for the si!* #e#bers of the fa#ily. This is a short outline of the !ontents of this boo*.

?a!ts and proofs of fifty !an!er !ases ha$e been pla!ed in the foreground, %hile theories and e<planations ha$e been shortened.
1

Lesse Greenstein, 4iochemistry of #ancer, p. )9:, 19);.

C' 2TE6 I
The ,9e!ret, of #y Treat#ent
/? C/@69E, there is none0 The heading is used be!ause I a# as*ed fre+uently, often reproa!hfully, by physi!ians about it. The har#ony in the #etabolis# of all internal organs and syste#s #ust be #aintainedO it refle!ts the eternal #ystery of life, e<pressed in our health and !ontinuan!e, ,Ea!h for# of life is a biologi! entity. Ea!h has only one purpose. to gro% and reprodu!e %ith the aid of the food to its disposal.,( The onset of #etaboli! disturban!e !onstitutes the beginning of disease. &The Eternal 3ife has been de$eloped o$er #illions of years,&& Pollath said, ,and it %ill !ontinue to de$elop endlessly. Ea!h of its parts is i#portant. Aone is pri$ileged, for the internal e+uilibriu# #ay not be disturbed.,C ?ollo%ing histori!al analysis, %e see in Pollath&s presentation that it %as #ainly s!ien!e and te!hnology %hi!h ha$e brought about the e$il, a part of it is ,o$ersi#plifi!ation., ,9y#pto#ati! treat#ent is har#ful %here$er in nature it is applied to the soil, plants, ani#als or hu#an beings, or in #edi!ine. ,Ea!h part is i#portant, but the %hole in its infinitely fine order is #ore i#portant.'istory sho%s that, fro# ti#e to ti#e, #en are s%ayed too easily by ne% thoughts and theories and by ne% de$elop#ents in te!hnology and !he#istry, %hi!h they use as their bases in #edi!al pra!ti!e.) This leads the# too far a%ay fro# nature,
Quote of L. ?. "is!hhusen, Cle$eland, /hio. C 9ee Introdu!tion to >r. "erner Pollath&s boo* Die 5rdnung 6nserer "ahmng. 'ippo*rates Qerlag, 9tuttgart, Ger#any, ;Ibid. 4 The 6e$erend Luenger, 7ailure of Technology.
+

Therefore, it be!o#es ne!essary fro# ti#e to ti#e to bring #edi!al do!trine ba!* nearer to nature. S9ee !hapter on 2ara!elsus. 8 9ee*ing an e<planation for the negati$e attitude of the #a5ority of physi!ians to%ard the idea of an effe!ti$e !an!er treat#ent, I ha$e !o#e to se$eral !on!lusions. ?irst, %e are all trained to belie$e that !an!er is an in!urable disease. 9e!ondly, se$eral pre$ious atte#pts to introdu!e a ne% !an!er treat#ent, in!luding theories and pro#ises, ha$e failed. The great falla!y lies in the #anner in %hi!h dietary tests are proposed and #ade, that is, by the use of one spe!ial substan!e at a ti#e, obser$ing its effe!t on the body, follo%ed by another substan!e, and so forth. long ti#e ago, I %or*ed along the sa#e lines. The result %as a failure. Thereupon I started to use al#ost the sa#e dietary regi#e de$eloped through years of e<perien!e, %hi!h I had pre$iously applied in #y %or* in tuber!ulosis. 8Diattherapie der ungentuberkulose, 19C;8 To obser$e e<ternally the rea!tions of the diet and its !hanges I !hose s*in tuber!ulosis, so-!alled lupus vulgaris. 3ater I used the sa#e pro!edure in !an!er patients by obser$ing the rea!tions of the diet and its !hanges in in$ol$e#ents of the s*in. These obser$ations sho%ed the treat#ent inade+uate for #alignan!ies of the intestinal tra!tO these need #ore intensi$e treat#ent. The #edi!ation for the tuber!ulosis treat#ent and that for !an!er treat#ent %ere de$eloped in a si#ilar #anner, but they are not the sa#e. ?ro# the beginning, the funda#ental idea %as and still is the follo%ing. nor#al body has the !apa!ity to *eep all !ells fun!tioning properly. It pre$ents any abnor#al transfor#ation and gro%th. Therefore, the natural tas* of a !an!er therapy is to bring the body ba!* to that nor#al physiology, or as near to it as is possible. The ne<t tas* is to *eep the physiology of the

#etabolis# in that natural e+uilibriu#. nor#al body also has additional reser$es to suppress and destroy #alignan!ies. It does not a!t in that #anner in !an!er patients, %here the !an!er gre% fro# the s#allest !ellular unit freely, %ithout en!ountering any resistan!e. "hat for!es !an suppress su!h a de$elop#entT =y ans%er is that this !an be a!!o#plished by the o<idizing enzy#es and the !onditions %hi!h #aintain their a!ti$ity. The best *no%n o<idizing enzy#es are. arginase, !atalase, <antine dehydrogenase, esterase, the urea o<idizing syste#s, !ystine-desulfurase, !yto!hro#e-!, !yto!hro#e o<idase and a#ino a!id o<idase and fla$in. ll these are lo%er in a!ti$ity in both fetal li$er and hepato#a than in nor#al or regenerating li$er. /tto "arburg4 %as the first %ho found the #etaboli! de$iations of #alignant tissue fro# nor#al tissue and for#ulated it by the !o-effi!ient 7anaerobi! gly!olysisE!ell respiration8 In nor#al tissue it is zero. In e#bryoni! tissue -.1 In benign tu#ors -.;) to 1.;) In #alignant tissue up to 1(. /n the !ontrary, al*aline phosphatases and the dea#inases are higher in a!ti$ity in fetal li$er and hepato#a than in nor#al and regenerating li$er. The $ery fre+uently e<pressed $ie% is that fetal and neoplasti! hepati! tissue sho% a si#ilar o<idizing pattern to e#bryoni!, #ore pri#iti$e, and less differentiated tissue. It is *no%n that in pri#iti$e for#s of life the energy of the !ells is deri$ed al#ost entirely fro# anaerobi! !onditions or through fer#entation. In higher ani#als, the lo%er fer#entati$e anaerobi! syste#s are #i<ed %ith o<idation syste#s, %hereby #ore and #ore #ole!ular o<ygen is utilized, transported fro# the respiration of the lungs. The #alignan!ies in hu#an beings !ontinuously fall ba!* deeper and deeper into fer#entation. The #a5or general part of the body be!o#es #ore poisoned and #ore redu!ed in its defense and healing po%er. The ideal tas* of !an!er therapy is to restore the fun!tion of the o<idizing syste#s in the entire organis#. This, of !ourse, is diffi!ult to a!!o#plish. It in$ol$es the follo%ing. 18 deto<i!ation of the %hole body, (8 pro$iding the essential #ineral !ontents of the potassiu# group, C8 adding o<idizing enzy#es !ontinuously as long as they are not rea!ti$ated and built in the body 7in the for# of green leaf 5ui!e and fresh !alf&s li$er 5ui!eJ8. This %ill !reate a near nor#al !ondition of the o<idizing syste# in the body, to %hi!h #alignant !ells %ith the fer#entation syste# !annot adapt. Autrition is generally an e<ogenous fa!tor, but the inta*e of food, slightly to<i!, belo% the le$el of a sti#ulant, brings about
/tto "arburg, The Metabolism of Tumors, Constable 1 Co. 3td 3ondon, 19C-. J 9ee ppendi< III. page ;(1
:

a disposition in the organis#, %hi!h #ay be regarded as pre#orbid. ,>iet, ho%e$er, appeared to ha$e no influen!e on li$er tu#ors in rats produ!ed by (-a!etylaniino-fluorene. The #anner in %hi!h diet produ!es pro!ar!inogeni! or anti!ar!inogeni! effe!t is un*no%n. Che#i!al differen!es bet%een #ito!hondria of nor#al li$er and #ouse li$er hepato#a ha$e been reported by 'ogeboo# and 9!hneider. ,9o#e interesting obser$ations in regard to the influen!e of diet on the de$elop#ent of spontaneous hepato#as in inbred CC' #i!e %ere #ade by Tannenbau# and 9il$erstone. These in$estigators ha$e sho%n that in!rease of fat in the diet fro# t%o per !ent to (- per !ent in!reased the rate of hepato#a for#ation fro# C7 per !ent to )C per !ent. 3o% ribofla$in inta*e resulted in a de!rease of hepato#a for#ation. This !an be attributed to the redu!ed !alori! inta*e, %hi!h has been sho%n to inhibit gro%th of hepato#as in this spe!ies. It has li*e%ise been sho%n that, !ontrary to the e<perien!es %ith indu!ed hepato#as in rats, the spontaneous tu#ors in #i!e

are not a!!elerated by a ri!e diet but on the !ontrary are a!!elerated by in!reased !asein !ontent. =ethionine has li*e%ise been sho%n to a!!elerate the de$elop#ent of these tu#ors in #i!e. The !on!lusion is dra%n that the sulphur-!ontaining a#ino a!ids, %hi!h are ne!essary for nor#al gro%th, are also ne!essary for gro%th and de$elop#ent of these neoplas#s. gain a startling indi!ation of the si#ilarity bet%een physiologi! gro%th and neoplasial,7 /ur #odern !i$ilization brings about a pre#orbid disposition in al#ost all hu#an beings, differing only in degree. It #ay be regarded 7in so#e of us8 as a pre-neoplasti! !ondition. !!ording to go$ern#ent statisti!s, this applies to one out of si<. The per!entage has a!!elerated in the last () yearsO !ar!ino#as and undefined !an!ers in #an*ind are in!reasing yearly. Gefore I %as ready to de#onstrate #y tuber!ulosis results in the =edi!al 9o!iety of Gerlin, '. Monde* as*ed #e to dis!uss the diet and its effe!ts %ith the best *no%n nutritional biologist, 2rofessor E. bderhalden, @ni$ersity 'alle aE9 . . . fter a short dis!ussion his ad$i!e %as. ,It is i#possible to e<plore one or another substan!e alone. "e need, as you did, a si#ple nutritional ground%or*. /n this basis you !an %or* out the therapy by
% Mitchell A# Spell&erg" Disease of the Liver, !rune and Stratton" '()*" p# '+,#

adding or subtra!ting one or another substan!e and obser$e the effe!t 'a$ing su!h results I %ould not !hange anything. The sa#e thing is true for #edi!ation. =ost of it %e !annot e<plain, the result is de!isi$e., ,Autrition is pri#arily an e<ogenous fa!tor, but a !onstantly !hanged unnatural nutrition brings about in our organis# that internal pre#orbid disposition.,: I #ay add. It is a slo%ly progressi$e internal adaptation %hi!h the body perfor#s, as each daily poisonous irritation le$el is #ost probably too lo% to !ause a defensi$e rea!tion until a tu#or !an gro% %hile the body is undefended and poisons !ontinue to a!!u#ulate.9 fter #y se!ond le!ture at the International Can!er Congress in Ger#any in /!tober, 19)(, 2rofessor "erner Pollath handed #e his latest boo* Die 5rdnung 6nserer "ahrung 7The /rder of /ur Autrition 19)(U %ith the ins!ription. ,"ith gratitude for your >o!trine. IAC@6 G3E I9 C@6 G3E., The se!ret of #y treat#ent is that the nutritional proble# is not %ell enough understood in $ie% of the *no%ledge and infor#ation on hand at present. bderhalden&s and other s!ientists& ad$i!e helped a great deal to sol$e the proble# in !lini!al pra!ti!e. I thin* the #edi!ation is a little #ore sub5e!t to #edi!al argu#entation. Goth #ay be t%o other unsol$ed proble#s in #edi!ineO our tas* is to a!*no%ledge this and to present the fa$orable results of the treat#ent. In a nor#al body all is ali$e, espe!ially the basi! substan!es built by the #inerals, they ha$e ionized or a!ti$ated potassiu# and #inerals of the potassiu# group %ith positi$e ele!tri!al potentials. In a si!* bodyR#ainly in !an!erRpotassiu# is inactive9sodium and #inerals of the sodiu# group are ionized %ith negati$e potentials. /n this basis all other abnor#al pro!esses de$elop as !onse+uen!es. ?or healing purposes the body #ust be deto<ifiedRa!ti$ated %ith ionized #inerals, natural food so that the essential organs !an fun!tion again. ?or healing the body brings about a *ind of infla##ation. That is a tre#endous transfor#ati$e rea!tion. This renders the body hypersensiti$e or allergi! to a high degree against abnor#al
Professor 9ieg#und, p. (77. Gan:heits behandlung der Geschwulsterkrankun9gen, '()+# -ippokrates .erlag# ( See Leonnard /ickenden%s OUT Daily Poison, $evin0Adafr Co#" '())#
:

or strange substan!es 7in!luding ba!illi, !an!er !ells, s!ars, et!.8, Conse+uently the #ore #alignant the !ells are the #ore effe!ti$e is the treat#ent. I thin* this is ,the end effe!t or se!ret of the treat#ent., The s!hool of $on Gerg#ar# did re$eal so#e of the features of the allergi! rea!tion.1#e!hani!al #ethod and se$eral types of sti#ulation !ould not a!!o#plish su!h a purpose.

The atte#pts of ugust Gier,, '. 3a#pert, Ger#any and /. 9ela%ry, Guffalo 1( and others did not su!!eed in helping degenerati$e diseases or !an!er. 19ee !hapter se$enteen. 11 !yperaemie ah !ellmittel. 1( Tumorbeeinfiussung dvrch !yperthermic und !uveraemle. Parl ? 'aue Qerlag, @l# a. >or.au, 19)7.

C' 2TE6 II
The Con!ept of Totality->e!isi$e in Can!er and /ther >egenerati$e >iseases
C ACE6 I9 a !hroni!, degenerati$e disease, %here al#ost all essential organs are in$ol$ed in the #ore ad$an!ed !ases. The entire #etabolis# %ith the intestinal tra!t and its adne<a, the li$er and pan!reas, the !ir!ulatory apparatus 7the !ellular e<!hange supporter 8, the *idneys and bile syste# 7as #ain eli#ination organs8, the reti!ulo-endothelial and ly#phati! syste# 7as defense apparatus8, the !entral ner$ous syste# and espe!ially the $is!eral ner$ous syste# for #ost #etaboli! and #otori! purposes. >r. Ai!hols %as probably one of the first in our ti#e %ho re!ognized the ,!on!ept of totality, as applied to disease. 'e !o#bined the follo%ing !lini!al appearan!es. E#otional, nutritional, poisons, infe!tions, a!!idents and inheritan!e as underlying !auses for diseases. ,Ao %onder %e are all si!* . . . and s!ien!e is no longer s!ien!e %hen it atte#pts to $iolate God&s natural la%.,1C 'e did not #ention degenerati$e diseases in general, and did not approa!h the !an!er proble# in his arti!le. 'o%e$er, his idea sho%s in #any respe!ts progress in the !on!ept of a!ute and !hroni! diseases. 9o#e !an!er biologists are of the opinion that ,!an!er is a pheno#enon !o-e<istent %ith the li$ing pro!esses,, ,that the !an!er !ell is not so#ething li$ing e<!lusi$ely fro# the body,, and that the !an!er !ell is not a spe!ial ,syste# isolated fro# the li$ing organis#., They are united with and part of the whole
1:

9ee The Texas 4ankers &ecord for =ay, 19)(, 3ee ?dt, Ao. ):. 11

the natural pro!essesO it is also the rule in art, in philosophy, in #usi!, in physi!s, %here the #ost learned s!holars found the !on!ept of totality ali$e in their fields of resear!h and %or*. s a fe% sa#ples, I %ould li*e to #ention first 'enry >ru#ond&s philosophi!al %or* "atural aw in the 'piritual ;orld 71::C8. The basis of it is e<pressed in his %ords. ,The !ontinuity of the physi!al %orld to the spiritual., This #eans the !oheren!e of the physi!al inorgani! po%ers as they are transferred basi!ally into the organi! %orld of plants and ani#als. In #an, there are the ele!tri!al potentials outstanding in the life of the !ells. They are espe!ially a!!u#ulated in the ner$ous syste#, %hi!h is ulti#ately our ,spiritual organ, !apable of !reating progress and great a!!o#plish#ents.
,/ur Daily Potion by 3eonard "i!*enden, >e$ia- dair Co., Ae% For*, 19)).

In physi!s, lbert Einstein&s first great %or* %as &elativity of 'pace and Time. t first the theory %as !onsidered fantasti!. 3ater it %as generally a!!epted. Einstein&s ad$an!ed studies dealt %ith a transfor#ation of light and the photoele!tri! effe!t. ?inally, his ,transfor#ation theory, atte#pted to in!lude gra$ity, #agnetis#, and ele!tri!ity into one basi! physi!al syste#, %hi!h he !alled the @nified ?ield Qie%Rmost difficult to prove. In art, as an e<a#ple of this !on!ept, is the %or* of 9!haefer-9i##ern, %ho too* the

e<planation of art out of the narro% li#itations of the old rational prin!iples and de#onstrated that art is a ,!reati$e po%er,, inherent in our brain fun!tions, de$eloping a!!ording to the body&s gro%th, #ental, e#otional and intelle!tual #aturity. 9!haefer-9i##e# said that ,The !reati$e potentialities in #en and in %o#en, in business and the professions, are al%ays present as an entity,, united %ith all other po%ers of the body. 9!haefer-9i##e# used art to ,unfold the inherent artisti! ability in the edu!ation of !hildren,, sin!e it #ay be!o#e the de!isi$e fa!tor in the ground%or* of a !ulture that rests on the !reati$e nature of #an.1Aorbert "iener, 2rofessor of =athe#ati!s at =.I.T., %rites. ,There are fields of s!ientifi! %or* %hi!h ha$e been e<plored fro# the different sides of pure #athe#ati!s, statisti!s, ele!tri!al engineering and neurophysiology, in %hi!h ea!h single notion re!ei$es a separate na#e fro# ea!h group, and in %hi!h i#portant %or* has been tripli!ated or +uadrupli!atedO %hile still other i#portant %or* has been delayed by the una$ailability in one field of results that #ay ha$e already be!o#e !lassi!al in the ne<t field.,14 =edi!al s!ien!e has eli#inated the totality of the natural biologi!al rules in the hu#an body, #ostly by di$iding resear!h and pra!ti!e into #any spe!ialities. >oing intensi$e, #asterly spe!ialized %or*, it %as forgotten that e$ery part is still only a pie!e of the entire body. In all te<tboo*s, %e find that single biologi!al pro!esses ha$e been studied and o$eresti#ated state#ents #ade about the#. The sy#pto#s of a disease ha$e be!o#e the #ain proble# for resear!h, !lini!al %or* and therapy. The old #ethods %hi!h
1) 9ee 9!haefer-9i##e#&s The 6nfolding of $rtistic $ctivity, 19)-. @ni$ersity of California 2ress. Ger*eley and 3os ngeles. 14 Aorbert "iener, #ybernetics, 19)C, p. :.

sought to !o#bine all fun!tional parts in a body into a biologi!al entity, ha$e been pushed aside al#ost in$oluntarily, in the !lini!, and espe!ially in institutions of physiology and pathology. ?inally, that idea be!a#e $ery re#ote in our thin*ing and therapeuti!al %or*. The opinion of the best !an!er spe!ialists is, as Lessie Green-stein stated, ,E#phasis #ust be laid on a direct study on the side of #alignan!y itself,,17 despite the fa!t that his boo* is an e<!ellent !olle!tion of physiologi!al !hanges in the other organs, espe!ially the li$er. In #y opinion, the appli!ation of the !on!ept of totality !an help us find the true !ause of !an!erO it !ould be best %or*ed out in pra!ti!al e<a#ples, not in ani#al e<peri#ents %here e$ery little sy#pto# is obser$ed singly 7by itself8. In the nutritional field, obser$ations for !enturies ha$e sho%n that people %ho li$e a!!ording to natural #ethods in %hi!h plants, ani#als and hu#an beings are only frag#ents of the eternal !y!le of Aature do not get !an!er. /n the !ontrary, people %ho a!!ept #ethods of #ode# nutrition on an in!reasing s!ale be!o#e in$ol$ed in degenerati$e diseases, in!luding !an!er, in a relati$ely short ti#e. In later #edi!al history, the best *no%n !an!er-free people %ere the 'unzas, %ho li$e on the slopes of the 'i#alaya #ountains and %ho use only food gro%n in their o%n !ountry and fertilized %ith natural #anure. I#ported food is forbidden. Qery si#ilar is the story of the Ethiopians %ho also ha$e natural agri!ulture and li$ing habits %hi!h see#s to pro$e that this type of agri!ulture *eeps people free of !an!er and #ost of the degenerati$e diseases. The da#age that #odern !i$ilization brings into our li$es begins %ith the soil, %here artifi!ial fertilization leads to the displa!e#ent of #ineral !ontents and !hanges in the flora of #i!robes !o#bined %ith the e<odus of the earth%or#s. Conse+uently, fre+uent erosion of arable land ta*es pla!e. These !hanges bring about, at the beginning, an irritation of the plantsO later they !ause their degeneration, 9praying %ith poisonous substan!es 7inse!ti!ides8 in!reases the poisons in the soil, and these poisons are transferred to plants and fruits. "e #ust !on!lude fro# these and #any other obser$ations that the soil and all that gro%s in it is not so#ething distant
17

Lesse Greenstein, 4iochemistry of #ancer, p. )9:, 19);.

fro# us but #ust be regarded as our external metabolism, %hi!h produ!es the basi! substan!es for our internal #etabolis#. Therefore, the soil #ust be !ared for properly and #ust not be depleted or poisonedO other%ise, these !hanges %ill result in serious degenerati$e diseases, rapidly in!reasing in ani#als and hu#an beings. The soil needs a!ti$ityRthe natural !y!le in gro%th and in restR and natural fertilizer, as %e ha$e to gi$e ba!* that %hi!h is ne!essary to replenish the !onsu#ed substan!es. This is the best prote!tion against erosionO it also #aintains the soil&s #i!robi! flora, produ!ti$ity and life. ?ood planted and gro%n in this %ay #ust be eaten partly as li$ing substan!es and partly freshly prepared, for ,life begets life., Qery signifi!ant are reports about Es*i#os %ho get degenerati$e diseases and !an!er in those parts of their !ountry %here !anned food and unnatural nutrition %ere introdu!ed and a!!epted. >r. lbert 9!h%eitzer, %ho built a hospital in 3a#barene, Central fri!a, ;- years ago, reported in his letters of /!tober, 19);, the follo%ing. ,=any nati$es, espe!ially those %ho are li$ing in larger !o##unities, do not li$e no% the sa#e %ay as for#erlyRthey used to li$e al#ost e<!lusi$ely on fruits and $egetables, bananas, !assa$a, igna#, taro, s%eet potatoes and other fruits. They no% li$e on !ondensed #il*, !anned butter, #eat- and fish-preser$es and bread., >r. 9!h%eitzer obser$ed in 19); the first operation on appendi!itis on a nati$e of this region. ,. . . The date of the appearan!e of !an!er and other diseases of !i$ilization !annot be tra!ed in our region %ith the sa#e !ertainty as that of appendi!itis, be!ause the #i!ros!opi! e<a#inations ha$e only been in e<istan!e here for a fe% years. ... It is ob$ious to !onne!t the fa!t of in!rease of !an!er also %ith in!reased use of salt by the nati$es. . , . Curiously enough, %e did not ha$e any !an!er !ases in our hospitals before., >r. 9alisbury reported, !on!erning the Aa$a5o Indians, that he had, in (C years, C),--- Indian ad#issions in the hospital, %ith only 44 !ases of !an!er. The death rate a#ong these Indians is one out of 1,---, %hile it is about one out of )-- a#ong Indians %ho ha$e a!!epted part of the nutrition of #ode# !i$ilization. The Gantu population of 9outh fri!a has (- per !ent pri#ary li$er !an!ers. Their diet, of a $ery lo% standard, !onsists !hiefly of !heap !arbohydrates, #aize and #ealy #eals. 9eldo# do they ha$e fer#ented !o%&s #il*. =eat is eaten only at !ere#onies. T%o physi!ians, >rs. Gilbert and Gil#an, studied their nutrition habits in ani#al e<peri#ents and pla!ed stress on the diet of the Gantus as a !ause of !an!er. The result %as that in al#ost all ani#als the li$er %as affe!ted and (- per !ent de$eloped a !irrhosis of the li$er later. "hen an e<tra!t of the li$er of a Gantu #an %as painted on the ba!* of #i!e, benign or #alignant tu#ors de$eloped. t the !on!lusion of this !hapter, the reader #ay %ell as*. ,"hat should I do %ith the idea of the !on!ept of totality in understanding the !an!er proble# and treat#entT, The ans%er is. the ,pre#orbid da#age, goes do%n to the basi! $ital pro!esses by poisoning the entire #etabolis# as it %as a!*no%ledged in Ger#any at the International Congress for Gan:heitsbehand9lung der Geschwulsterkrankungem.*0 2rofessor 9ieg#und, of the @ni$ersity of =uenster, e<plained that this poisoning o!!urs now as a general !onstitutional !ondition %hi!h is !aused by #odern !i$ilization and %hi!h is not only a preneoplasti! stage but also a pre#orbid general !ondition of the hu#an body.1Therefore, the treat#ent also has to penetrate deeply to !orre!t all the vital pro!esses. "hen the general #etabolis# is !orre!ted, %e !an influen!e again retrospe!ti$e fun!tioning of all other organs, tissues, and !ells through it. This #eans that there should be a treat#ent applied %hi!h %ill fulfill the tas* of totality in e$ery respe!t, ta*ing !are of the fun!tions of the %hole body in all its different parts, thus restoring the har#ony of all biologi!al syste#s. The treat#ent %hi!h %ill fulfill this !o#ple< proble# is des!ribed in detail later. 'ere it should #erely be e#phasized that the treat#ent has to fulfill t%o funda#ental !o#ponents. The first !o#ponent is tie deto<i!ation of the whole body %hi!h has to be !arried out o$er a long period of ti#e, until all the tu#ors are absorbed and the essential organs of the body are so far restored that they !an ta*e o$er this i#portant ,!leaning fun!tion&& by the#sel$es. If that is not effe!ted to the ne!essary degree, the entire body be!o#es the $i!ti# of a !ontinuously in!reasing poisoning %ith dire !onse+uen!es 7!o#a hepati!u#8. 9e!ondly, the entire intestinal tra!t has to be restored

si#ultaneouslyO i: 2rofessor ". Mabel, Totality Treatment of Tumorous Diseases, 'ippo*rates Qerlag, 19)C, 19 2rofessor 9ieg#und, op. ctt., p. (77. %ith the restoration of the intestinal tra!t, the #ost i#portant se!retory fun!tions %ill be repaired, as %ell as its !ir!ulation and #otility regulated by the $is!eral ner$ous syste#. In that %ay %e !an a!ti$ate, together %ith other fun!tions, defense, i##unity and healing po%er in the body. I##unity does not #ean here that the body is prote!ted against a spe!ial ba!teriu#O as in an infe!tious disease, it #eans that no abnor#al !ell !an gro% or de$elop in the body %ith nor#al #etabolis#. ?or that purpose, the degree of restoration of the li$er plays a de!isi$e role. "e should not forget that a body deto<ified !onstantly through the li$er and the best nutrition !an #aintain an a!ti$e #etabolis# %ith the help of the li$er. Thus, the !on!ept of totality %ill be obeyed in #edi!ine as it is a!ti$e in other li$ing and non-li$ing pro!esses of nature. The sa#e is true in the field of nutrition. !!ording to a report at the third International Congress of Gio!he#istry, , *no%ledge of the interrelationships a#ong nutrients in a diet is essential for an understanding of their +uantitati$e re+uire#ents for the ani#als. @tilization of one nutrient #ay be profoundly affe!ted by the presen!e or absen!e of another. ?or instan!e, under !ertain !ir!u#stan!es the to<i!ity of zin! in rats #ay be !orre!ted by !opper, the presen!e of both #olybdenu# and zin! in any diet #ay result in signifi!antly poorer gro%th than %as !aused by the addition of these ele#ents separately 7(-8. 9eleniu# poisoning #ay be redu!ed by arseni! 778O #olybdenu# poisoning in !attle #ay be !orre!ted by !opper 71(8. Intra$enously ad#inistered #ethionine pre$ented the to<i!ity of high doses of !obalt 7(18. There is less absorption of iron fro# the gastro-intestinal tra!t in rats defi!ient in !opper than in rats supplied %ith !opper 7((8. ,These obser$ations and #any others reaffir# the finding that an abnor#al !ondition of the ani#al #ay not refle!t #erely a lo% or a high le$el of dietary essential, but an e<!ess or a shortage of one or #ore other nutrients %hi!h interfere %ith the nor#al #etabolis# of the essential dietary !onstituent. ,/ne of the #ost stri*ing e<a#ples of this land !on!erns the assi#ilation and storage of !opper in sheep 7(C8. It %as found in ustralia that the addition of ferrous sulphide to the diet lo%ered the e<pe!ted !opper a!!u#ulation in the li$er by 7) per !ent. Min! gi$en in an a#ount of 1-- #g. a day had an effe!t %hi!h %as signifi!ant at the fi$e per !ent le$el, but %hen added in s#aller a#ounts %hi!h %ould be a$ailable to sheep grazing nor#al pastures, it had no effe!t on !opper retention. ,=olybdenu# gi$en in the for# of a##oniu# #olybdate %as found to ha$e a se$erly li#iting effe!t, but this effe!t %as only obser$ed %hen the diet also !ontained a suffi!ient +uantity of inorgani! sulphate.... ,The nature of the interrelationship of one #i!roele#ent %ith another and %ith other food !onstituents is still i#perfe!tly or not at all understood. It is #y opinion that it is %ithin the s!ope of the bio!he#ists& and nutritionists& #a5or duties to !lear up the obs!urity in this do#ain as soon as possible,,(These e<a#ples are !hosen to illustrate the biologi!al fa!t that not one fa!tor alone or a !o#bination of single fa!tors is de!isi$e, but %hat is de!isi$e is ho% they influen!e the whole body, mind and soul in their entirety. To the great !o#ple<ity of the biologi!al fun!tions of the body belongs also its capacity of adaptation. healthy body !an adapt itself to different types of nutrition. It reabsorbs the ne!essary #inerals, $ita#ins and enzy#es as %e *no% fro# e<peri#ents to deter#ine the ti#e for the !lini!al appearan!e of one or another $ita#in defi!ien!y. si!* body has lost this !apa!ity. The defi!ien!ies !annot be restored as long as the essential organs are poisoned. That is true in !an!er also, as de#onstrated by !lini!al obser$ations. Can!er, the great *iller, %ill be pre$ented and !an be !ured if %e learn to understand the eternal

la%s of totality in nature and in our body. Goth are !o#bined and ha$e to be united in an effe!ti$e treat#ent for !an!erO in that %ay %e !an learn to !ure !an!er in a higher proportion, e$en of ad$an!ed !ases. The i#itations of the totality of fun!tions of the %hole body, ho%e$er, also !o#e into a!tion here. The totality of fun!tions is lost if one or another $ital organ is too far destroyed. I sa%, in se$eral patients, tu#ors in the abdo#en absorbed, and in others, hundreds of nodules and nodes on the s*in and so#e at the base of the brain eli#inated, but the patients died of !irrhosis of the li$er in a period of one to three and a half years after%ards. The role of the li$er in !an!er, a!!ording to E%ing, is seen in the fa!t that there are about :) per !ent of pri#ary hepato#as
(- 3. 9ee*les in Proceedings of the Third <nternational #ongress of 4iochemistry, Grussels, 19)), p. ;7.

and )- per !ent of pri#ary !holangio#as asso!iated %ith !irrhosis of the li$er. The #a5ority of authors thin* these !hanges in the li$er ha$e arisen independently of, and probably before the gro%th of neoplas#, as !hanges are diffuse and far re#o$ed fro# the lo!al tu#or. >r. E%ing states, further#ore, that there is a unifor# gradual pro!ess bet%een nodular hyperplasia of the li$er, #ultiple adeno#as, and #ultiple !ar!ino#as. The usual progress fro# adeno#a to !ar!ino#a is abundantly supplied in literature. These obser$ations %ere $erified in e<peri#ental %or* %ith !ar!inogens %hi!h brought about an apparent progression fro# regenerati$e tissue of the li$er to hyperplasia and finally to neoplasia. 6ats fed butter-yello% %ith a ri!e diet sho%ed !irrhosis of the li$er in si<ty days and benign !holangio#as and hepato#as in ninety days, and, in 1)- days, !ar!ino#as in nearly all rats, da#aging espe!ially the li$er, produ!ing high anaerobi! gly!olysis, al*aline phosphatase and other abnor#alities. The prote!ti$e effe!t of a diet, !onsisting of G $ita#ins and !asein on for#ations of e<peri#ental hepati! !ar!ino#a, #ay per#it so#e !o#parison %ith the hu#an disease. It %as found, ho%e$er, that all these results greatly $ary %ith the type of ani#al and also %hether tu#ors %ere gro%n as indu!ed or appeared as spontaneous hepato#as, and $ary e$en #ore so in hu#an hepato#as. Therefore, it be!a#e i#possible to find a de!isi$e fa!tor in the $ast literature of the produ!tion of these #alignan!ies, as physi!ians loo*ed and are still loo*ing for one spe!ifi! fa!tor only. The solution is that it is not a single fa!tor but generally one of #any fa!tors or an a!!u#ulation of one poisoning for a long period of ti#e as the e<peri#ents of It!hi*a%a and Fa#agi$a sho%. They needed about nine #onths first to da#age the li$er, *idneys, et!.Ranother proof of rea!tions in their totality. That a $ery strong poison !an da#age the li$er in a fe% days and produ!e a hepato#a in ten days does not spea* against it. This !annot be !o#pared %ith the slo%ly progressi$e deterioration in our syste# !aused by #odern !i$ilization. ?ro# %or* in our !lini!, %e *no% that #any diseases do not appear independent of ea!h other, but #ore as ,nosologi!al entities., fe% e<a#ples. 7 8 9inus infla##ation is fre+uently !o#bined %ith !hroni! bron!hitis or bron!hie!tasis, also %ith laryngitis, nephritis, and other distant infe!tions. 7G8 Chroni! !ystitis is fre+uently united %ith appendi!itis. 9urely, !ystitis is asso!iated %ith a !o#bination of disturban!es in the digesti$e organs. 7C8 Gall-bladder diseases, #ostly !o#bined %ith li$er alterations, appear together %ith #yo!ardial !hanges and later !ause !irrhosis of the li$er. Conse+uently, %here the defense of the body is essentially redu!ed there fre+uently are ba!terial infe!tions of one or se$eral organs. These !lini!al findings bring us to the !on!lusion that se$eral different types of pathologi!al !hanges #ay o!!ur as the !onse+uen!e of a deep general !ause in the body %hi!h %e !an subordinate under one leading idea, the la% of totality or the loss or di#inished degree of ,healing po%er, in a #ore !lini!al sense. >espite our great progress in #odern bio!he#istry, %e !annot depart fro# the old 'ippo!ra-tian do!trine of dire!t and ob5e!ti$e !lini!al obser$ation. to !oordinate the# under one !lini!al pi!ture. In infe!tious diseases, there %ould not ha$e been trans#issions to neighboring or distant organs, in #alignan!ies not #etastases, if there %ere enough healing po%er present. Thus, the de$elop#ent of disease, its !ourse and healing pro!ess, do not depend so #u!h on the type of tissue or organ in$ol$ed, but #ore on the general healing po%er of the entire organis#, united or !entralized in

all its #etaboli! pro!esses for the #ost part !on!entrated in the li$er. Contrary to this !on!ept, our te<tboo*s and 5ournals ha$e separated different diseases and e$en !an!ers as #alignant tu#ors of the nose and paranasal sinuses, #alignan!ies of the sto#a!h or the *idney, !an!er of the lungs, et!. There are, of !ourse, differen!es in the type, de$elop#ent, !o#pli!ations, prognosis, et!., but the basi! idea #ust be #aintained that the defense and healing po%er is an essential part of the whole body and #ust be restored, %hate$er organ or organs #ay be in$ol$ed or %hate$er !ause the #alignan!y #ay ha$e had. I repeat. In general, the re!o$ery fro# a #alignan!y #eans the restoration of the %hole body fro# a *ind of degeneration. In so#e !ases of e<ternal !an!ersRs*in and breastRthe lo!al treat#ent #ay be suffi!ient, but the !on!ept of totality is a superior and farther-rea!hing approa!h as the fa!ts indi!ate in !ases listed in this $olu#e. 79ee part II8

C-APT1R III $irections for !eneral 2utrition

IA ?/6=E6 ti#es, nutrition %as traditionally de$eloped by the !onditions of the parti!ular !ountry and histori! e$ents. It %as !ontrolled by religion or states, and #aterially adapted to the finan!es of fa#ilies or indi$iduals. The #odifi!ations in our !ulture and the progress in s!ien!e and te!hni+ue are altering our food !onstantly by its produ!tion in agri!ulture, by preser$ation and distribution, and also by adaptation to the i#pro$e#ents of li$ing !onditions. These proble#s(1 #ust be disregarded here, sin!e I !an gi$e only the essential general dire!tions. To des!ribe the funda#entals of a general nutrition for healthy people %hi!h guarantees an uninterrupted daily flu< of energy, strength and reser$es for %or* and other duties, is a responsible tas* and diffi!ult to for#ulate in a !o#prehensi$e for# %ithout #any tables, literature and e<planations. The %ay in %hi!h the funda#entals are des!ribed here is deri$ed fro# #any long years of e<perien!e %ith people re5e!ted fro# #ilitary ser$i!e or denied life insuran!e. They %ere #ade a!!eptable by follo%ing these dire!tions. Thousands of patients %ere gi$en this ad$i!e after their re!o$ery fro# !hroni! si!*nesses, and #ost of the# in!luded their fa#ilies in this pattern of nutrition for #any years. The results %ere satisfa!tory. The #a5ority re#ained in good health, %ere a!!eptable for life insuran!e and other ser$i!es and in!reased their strength and %or*ing po%er. =y fa#ily and I, too, ha$e follo%ed these dire!tions for #ore than thirty years.
9ee !istory of "utrition by lfred ". =!Cann, 9!ien!e of Eating, >resden, 19(7 and >ie Geschickte Der %rnahning, by 2rof. 3i!htenfelt, Gerlin, 191C.
(1

This outline per#its suffi!ient #argin for personal li$ing habits, fa#ily feasts and holidays, as one-+uarter of all of the food should be to one&s !hoi!eO the re#ainder should be ta*en for the purpose of prote!ting the fun!tions of the highly essential organsRli$er, *idneys, brain, heart, et!.Rby storing reser$es and a$oiding an unne!essary burden on these $ital organs. To sa$e our body fro# e<tra %or* in the disposal of e<!essi$e food, espe!ially fats %hi!h are diffi!ult to digest, the destru!tion of poisons, et!, is a pre!aution that #ay pre$ent #any *inds of early degeneration, pre#ature old age, and all *inds of a!ute and !hroni! si!*ness in organs so#e%hat %ea*er in origin and de$elop#ent or pre$iously da#aged. That this outline is %ritten to pre$ent si!*ness, not to !ure it, #ust be stressed beforehand. The purpose of healing de#ands a #u!h deeper dieteti! en!roa!h#ent and a #edi!ation dire!ted to the pathology of the body&s !he#istry after a diagnosis is established. The funda#entals %ill not be presented as an enu#eration of !arbohydrates, fats, proteins, $ita#ins, hor#ones and enzy#es as they are des!ribed in physiology te<tboo*s, together %ith the ne!essary a#ount of gra#s or !alories. These old te<tboo* arrange#ents #eet only the needs of

a #etabolis# based largely on the entire a#ount of eli#ination, ta*ing into a!!ount only so#e less essential re+uire#ents. s s!ien!e is not yet de$eloped to the point of *no%ing all the enzy#es, $ita#ins and #any biologi!al fun!tions of hor#ones and #inerals, it is safer to use foods in the #ost natural for#, !o#bined and #i<ed by nature and raised, if possible, by an organi! gardening pro!ess, thus obeying the la%s of nature. This obser$ation helped the hu#an ra!e for thousands of years before any s!ien!e %as de$eloped. In this %ay %e bring in all *no%n $ita#ins and enzy#es, both the dis!o$ered and the undis!o$ered ones, and espe!ially the un*no%n, to +uote 2rofessor Pollafh, ,life sti#ulating substan!es,, gi$en best as fresh as possible and not da#aged by refining or preser$ing pro!esses, su!h as !anned food, These !ontain all of the ne!essary substan!es in their proper +uantity, #i<ture and !o#position, and are regulated by instin!t, hunger, taste, s#ell, sight and other fa!tors. Three-+uarters of the food %hi!h should be !onsu#ed in!lude the follo%ing. ll *inds of fruits, #ostly fresh and so#e prepared in different %aysO freshly prepared fruit 5ui!es 7orange, grapefruit, grape, et!.8O fruit saladsO !old fruit soupsO #ashed bananas, ra% grated apples, applesau!e, et! ll $egetables freshly prepared, so#e ste%ed in their o%n 5ui!es and others either ra% or finely grated, su!h as !arrots, !auliflo%er or !eleryO $egetable salads, soups, et!.O so#e dried fruits and $egetables are per#itted but not frozen ones. 2otatoes are best %hen ba*edO the !ontents #ay be #ashed %ith #il* or soupO they should seldo# be fried and preferably boiled in their 5a!*ets. 9alads of green lea$es or #i<ed %ith to#atoes, fruits, $egetables, et!. Gread #ay !ontain %hole rye or %hole %heat flour, or these #ay be #i<edO it should be refined as little as possible. /at#eal should be used freely. Gu!*%heat !a*es and potato pan!a*es are optional, as are bro%n sugar, honey, #aple sugar and #aple !andy. =il* and #il* produ!ts, su!h as pot !heese and other *inds of !heese %hi!h are not greatly salted or spi!ed, butter#il*, yoghurt and butter. Crea# and i!e !rea# should be redu!ed to a minimum or restri!ted to holidays 7i!e !rea# is ,poison, for !hildren8. The re#aining one-fourth of the dietary regi#e, %hi!h allo%s for personaI !hoi!e, #ay !onsist of #eat, fish, eggs, nuts, !andies, !a*es, or %hate$er one li*es best. Ai!otine should be a$oidedO li+uors, %ine and beer should be redu!ed to a #ini#u# in fa$or of fresh fruit 5ui!esO !offee and tea should be !ut to a #ini#u# %ith the e<!eption of the follo%ing teas. pepper#int, !a#o#ile, linden flo%er, orange flo%er, and a fe% others. 9alt, bi!arbonate of soda, s#o*ed fish and sausage should be a$oided as #u!h as possible, as should sharp !ondi#ents su!h as pepper and ginger, but fresh garden herbs should be usedonions, parsley lea$es, !hi$es, !elery and e$en so#e horseradish. s for $egetables and fruits, they should, I repeat, be ste%ed in their o%n 5ui!es to a$oid the loss of #inerals easily dissol$ed in %ater during !oo*ing. It see#s that these $aluable #inerals are not so %ell absorbed %hen they are out of their !olloidal state. ll $egetables #ay be used. Espe!ially re!o##ended for their #ineral !ontent are !arrots, peas, to#atoes, 9%iss !hard, spina!h, string beans, Grussels sprouts, arti!ho*es, beets !oo*ed %ith apples, !auliflo%er %ith to#atoes, red !abbage %ith apples, raisins, et!. The best %ay to prepare $egetables is to !oo* the# slo%ly for one and one-half to t%o hours, %ithout %ater. To pre$ent burning, pla!e an asbestos #at under the sau!epan. Fou #ay also use so#e sto!* of soup 7see >iet. spe!ial soup8 or else sli!ed to#atoes #ay be added to the $egetables. This also %ill i#pro$e the taste. 9pina!h %ater is too bitter for useO it generally is not li*ed and should be drained off. /nions, lee*s and to#atoes ha$e enough li+uid of their o%n to *eep the# #oist %hile !oo*ing. 7Geets should be !oo*ed li*e potatoes, in their 5a!*ets and %ith %ater.8 "ash and s!rub $egetables thoroughly, but do not peel or s!rape the#. 9au!epans #ust be tightly !o$ered to pre$ent stea# fro# es!aping. Co$ers #ust be hea$y or !lose fitting. Coo*ed $egetables #ay be *ept in the refrigerator o$ernight. To %ar# the#, heat slo%ly %ith a little soup or fresh to#ato 5ui!e. n e<planation for the i#portan!e of the absorption of these #inerals %as propounded by Q.

Gunge, %ho said that there #ust be #ore P or potassiu# in the organs in general than Aa or sodiu#, and that a !ertain relationship bet%een P and Aa #ust be #aintained. P has to be predo#inant !hiefly %ithin the !ells 7!alled, therefore, intra!ellular8 %hile Aa has to stay outside the !ells in seru#, ly#ph, !onne!ti$e tissue 7therefore !alled e<tra!ellular8. 3ater obser$ations led to the opinion that the #inerals do not rea!t singly but in groups. s a !onse+uen!e, >r. 6udolph Peller established the do!trine of t%o #ineral groups, the intra!ellular 7potassiu#8 or anodi! group tra$eling to the anode, and the e<tra!ellular 7sodiu#8 or !athodi! group tra$eling to the !athode under biologi!al !onditions. further !onse+uen!e %as the dis!o$ery that hor#ones, $ita#ins and enzy#es obey the sa#e rule as the t%o #ineral groupsO this #eans that their fun!tion depends upon the pre$alen!e of the P-group %ithin the !ells of the organs and tissues su!h as the li$er, #us!les, brain, heart, *idney !orte<, et!., %hereas the Aagroup re#ains outside of the#. The Aa-group is stationed in fluids and tissues. seru#, ly#ph, !onne!ti$e tissue, thyroid, bile du!ts, et!. 'ere are also the !athodi! or negati$e $ita#ins and enzy#es, of %hi!h the #ain fun!tions, #etabolis# and storage, are !onfined to this e<tra!ellular group. It is i#possible to $isualize a #etabolis# %ithout the #entioning of hor#ones, $ita#ins and enzy#esO their parti!ular fun!tions shall not be ite#ized. Generally hor#ones gi$e indi$iduality to tissues and !ellsO $ita#ins, or !/-enzy#es, help #etaboli! differentiation and $itality, and enzy#es bring about, step by step, #etaboli! a!ti$ity and spe!ifi! digesti$e pro!esses 7general dehydro-genation and o<idation8, pre$ent inter#edial #etabolites of %hi!h so#e are poisonous and #ay lead to !atara!t, stone for#ation or !hroni! infla##ations. The nor#al #etabolis#.depends upon the !o#bined fun!tion of all of the#, e$en if ea!h of the# possesses $arious %ays and #eans of fun!tioning. To the P-group belong about 4- per !ent of body tissues and to the Aa-group C- per !entO 1per !ent are on the borderline. ll of the# are *ept in their proper pla!e, probably by #eans of their ele!tri!al potentials. >uring the day, so#e Aa penetrates the potassiu# tissues, and this is follo%ed by !hloride and %ater, a pro!ess %hi!h brings on fatigue, a little hea$iness or s%elling. t night, it is reabsorbed and in the #orning it is eli#inated in urine, and the person feels refreshed.

These biologi!al rules are $ital for the maintenance of health inas#u!h as a defi!ien!y, defe!t or !hange #eans si!*ness. l#ost all a!ute and !hroni! si!*nesses begin %ith an in$asion by Aa, !hloride and %ater of the anodi! organs, !ausing the so-!alled ede#a produ!ed by poisons, infe!tions, trau#a, et!. It see#s to #e, therefore, that so#e tables %ith short e<planations are indispensable to #ar* ho% deeply the fun!tions of the #inerals are i#planted in the ani#al&s body. (( . 9hobI, Mineral Metabolism, 19C9, pp. 19-(-.

Table 1 represents the #ineral groups in the de$elop#ent of the body fro# fetus to adult, pro$ing that the fetus, ta*en as a %hole, is first an ani#al pre$alent in Aa-group but later Aa, !hloride and %ater de!rease fro# 11( #illie+ui$alents Aa to ;:, %hile fro# the P-group, P in!reased fro# )1 #e+. to 4:O phosphorous in!reases fro# 49 to C7;, et!. This relationship has to be #aintained throughout our life be!ause, as #entioned abo$e, the fun!tion of the essential hor#ones, $ita#ins, and enzy#es is adapted and based on that PEAa relationship or better, on the t%o groups of P and Aa, the p' !ontent, !o-enzy#es, et!. Table ( indi!ates the great i#portan!e of the PEAa relationship in %o#an&s #il* !o#pared %ith the #il* of rats and !o%s.

Tables ; and ) #ay pro$e that this relationship is re$ersed in si!*ness. "hile the tissues lost the po%er to retain the P-#inerals and gly!ogen, these de!reased 7see Table ;8 fro# (-.4 to ).-:, then sodiu# !hloride and %ater in$ade the tissue !ells fro# e<tra!ellular fluids, thus !ausing an in!reasing rise in the #il* of Aa fro# 1C.-( to ;(.C7.
(C Ibid., p. 7C. (; Ibid., p. C(7.

The hu#an body has a %onderful reser$e po%er and #any possibilities of ad5ust#ent, but the best defense apparatus is a 1-- per !ent fun!tioning #etabolis# and reabsorption in the intestinal tra!t in !o#bination %ith a healthy li$er. 2eople #ay !on!lude, needlessly, that it is not i#portant to pla!e so #u!h e#phasis on nutrition. This #ay be so under nor#al !onditions and if these persons are not da#aged through heredity, !i$ilization, si!*ness, trau#a or other a!!u#ulations 7ni!otine and other poisons8. Ci$ilization has partially ta*en a%ay this natural besto%al. E<peri#ents on test groups to produ!e different $ita#in-defi!ien!ies by o#itting food !ontaining these $ita#ins sho%ed that one third !an be #ade defi!ient in about four #onths and t%o thirds in si< #onthsO only fi$e to si< per !ent resisted ten #onths of defi!ient feeding here in the @nited 9tates. These nutritional e<peri#ents and others sho% that only a #inority possesses a !o#plete inta!t reabsorption apparatus and at the sa#e ti#e
(9

E. 2. ?is!her, 5phthalmologic. 11;.1, 19;7.

enough ad5ust#ent and reser$e po%er for healthy and unhealthy periods in their li$es. It is not ne!essary for healthy persons to !are so #u!h about enough or too #any !arbohydrates and proteins, and their !alori! $alue should be ignored. 'o%e$er, one !annot ignore the absolutely ne!essary #inerals, $ita#ins and enzy#es in their #ost natural !o#position and in suffi!ient a#ounts for a relati$ely long ter# and re#ain unpunished. The #inerals ha$e to be in the tissues %here they belong, as they are the !arriers of the ele!tri!al potentials in the !ellsO and there they enable the hor#ones, $ita#ins and enzy#es to fun!tion properly. This gi$es the body the best %or*ing po%er and reser$es for a sound #etabolis# and life. 9@== 6F The best ad$i!e is to use fresh $egetables and fruit organi!ally gro%n as #u!h as possible. =others should pay #ore attention to their !hildren and their *it!hen. /ne&s o%n garden %ould be a great help in su##erti#e. Qaluable and pra!ti!al infor#ation !an he found in the follo%ing publi!ations. ,9oil and =en., =earbook of $griculture, 19C: ,?ood and 3ife., =earbook of $griculture, 19C9 5rganic Gardening, L. I. 6odale, 'ano$er 'ouse, Garden City, A. F., 19)) 5ur Daily Poison, 3eonard "i!*enden, The >e$in- dair Co., A. F., 19)) 5ur Plundered Planet, ?airfield /sborn, 3ittle Gro%n 1 Co., Goston, 19;: The iving 'oil, E. G. Galfour, ?aber 1 ?aber 3td., 3ondon, 19;: !unsa, 6alph Gir!her, 'ans 'uber, Gern, 9%itzerland, 19)( &oad to 'urvival, "illia# Qogt, "#. 9loane sso!iates, A. F., 19;: !andbuch der Diaetetik, Lohannes 9!ala, ?ranz >euti!*e, "ien, 19); 'tudies in Deficiency Diseases, 6obert =!Carrison, =.>., 3ee ?oundation, =il%au*ee C, "is., 19;) Degeneration &egeneration, =el$in E. 2age, >.>.9., 2age ?oundation, 9t.

2etersburg, ?la., 19)1 ;hat Price #ivili:ation> Charles Eliot 2er*ins, =odern 9!ien!e 2ress, "ashington, >.C., 19;4 The Drama of 7luorine, $rch %nemy of Mankind, 3eo 9pira, =.>., 3ee ?oundation, 19)C Prolongation of ife, >r. le<ander . Gogo#olets, >uel0 9loan 1 2ear!e, In!., A. FV 19;4 "utrition 4- Physical Degeneration, "eston . 2ri!e, 2aul G. 'oeber, 19;9 !unger 'igns in #rops, 9y#posiu#. #eri!an 9o!iety of grono#y ". Pollath, ?ur %inheit der !eilkunde. 'ippo*rates Qerlag, 9tuttgart. 19;( ". Pollath, Die 5rdnung 6nserer "ahrung, 'ippo*rates Qerlag, 9tuttgart, M%eite uflage, 19)G. $. "endt, @ost und @ultur. Thie#e, 3eipzig 19C4 =. Gir!her-Genner, %rnaehrungskrankheiten. "endepun*t-Qerlag. Mueri!h und 3eipzig. ?uenfte uflage. 19;C. >. 3i!hti-$. Gras!h und . Punz-Gir!her, Die @linische 4edeutung der 7rischkost. 'ippo*rates Meits!hrift. C-.11. 19)4 >uane ". 2robst, =.>. ,The 2atient is a @nit of 2ra!ti!e,, 2art /ne, "ature of Disease. Charles C. Tho#as, 9pringfield, 111. 19C: !andbook of "utrition. $ 9y#posiu#. #eri!an =edi!al sso!iation, 19;C The Aitamins. $ 9y#posiu#. #eri!an =edi!al sso!iation. 19C9 'ymposium 5n &espiratory %n:ymes. The @ni$ersity of "is!onsin 2ress. 19;( Ed%ard 'o%ell, The 'tatus of 7ood %n:ymes in Digestion and Metabolism, Aational Enzy#e Co#pany. 19;4 Parl =yrba!*, The %n:ymes. !ade#i! 2ress In!., Ae% For*. 19)1 . I. /parin, The 5rigin of ife on the %arth. !ade#i! 2ress In!., Ae% For* 19)7, 9ee espe!ially The %or* of 2asteur, p. (:, Con!lusion, p. ;:7 =a< Gerson, =.>., ,?eeding the Ger#an r#y,, "ew =ork 'tate Bournal of Medicine. 1;71.;1.19;1 RR-. ,>ietary Considerations in =alignant Aeoplasti! >isease,, &eview of Gastroenterology. Qol. 1(, Ao. 4, pp. ;19 to ;() Ao$.->e!. 19;) - -. ,Effe!t of a Co#bined >ietary 6egi#e on 2atients %ith =alignant Tu#ors,, %xperimental Medicine and 'urgery. Ae% For*, Qol. QII, Ao$. ;,19;9 - -. ,Ao Can!er in Aor#al =etabolis#,, Medi:inische @linik, =uni!h, Lan. (9, 19);, Ao. ), pp. 17)-179 W . ,Can!er, a 2roble# of =etabolis#,, Medi:inische @linik, =uni!h, Lune (), 19);, Ao. (4 RR. ,Can!er 6esear!h,, 'earings before a 9ub!o##ittee of the @nited 9tates 9enate, 9. 1:7). Luly 1, (, and C, 19;4

C-APT1R I. $evelopment of the Com&ined $ietary Regime in Cancer 3Survey4

T'E 'I9T/6F of the de$elop#ent of the !o#bined dietary regi#e in !an!er follo%s briefly. fter the dieteti! treat#ent of lung tuber!ulosis %as established 719(7-19(:8 I treated, during 19(:-(9, #y first three !an!er !ases all %ith fa$orable results. The dietary regi#e as it %as used in tuber!ulosis !onsisted essentially of a saltless, properly prepared diet of fresh fruit and $egetables, predo#inantly ra%, finely grated, arid #any freshly prepared 5ui!es, su!h as orange, grapefruit, and espe!ially, apple and !arrot 5ui!es. ?re+uent ene#as %ere applied and =ineralogen Sa !o#position of #inerals8 %as ad#inistered. 3ater there %as added daily. butter#il*, pot !heese, yoghurt and t%o ra% egg yol*s. stirred up in orange 5ui!e. =y first !an!er !ase %as a !ar!ino#a of the bile du!ts %ith t%o s#all #etastases of the li$er.

Laundi!e and high fe$er %ere present. The ne<t t%o !ases %ere both sto#a!h !an!ers %ith adhesions and #etastases in the surrounding glands. In all three !ases, surgery had been tried in $ain and biopsies had been #ade, /ne of the !an!er patients died of an a!!ident by sliding in the #ountains t%o years later. 9he %as brought to a s#all #ountain $illage hospital in Quedlinburg and operated on for a ruptured spleen. The organ did not sho% any bleeding. 2rofessor 3angeGre#en, %ho had operated on her the first ti#e for !an!er !a#e the ne<t day, found the ruptured left *idney but !ould not sa$e the patient. The autopsy pro$ed that she %as free of !an!er. In Qienna during 19CC-19C;, si< !an!er !ases %ere treated by #e. ll si< %ere failures despite the fa!t that I had added the $aluable li$er in5e!tions. The *it!hen of the 9anatoriu# %as not ade+uately e+uipped for su!h a stri!t regi#e. ll the other patients %ere treated for other diseases, %ithout #u!h regard to diet. It %as diffi!ult to o$er!o#e the ob5e!tions on the part of the physi!ians, the nurses, the *it!hen personnel and others. In 2aris during 19C)-19C4, I sa% three fa$orable results in se$en !an!er !ases. There I applied the sa#e dietary regi#e as in #y first !ases, but %ith the addition of li$er in5e!tions and three to four glasses a day of green leaf 5ui!e. In Ae% For* I had to treat all #y patients, in!luding !an!er !ases, a#bulant until 19;C. 9in!e 19C:, after se$eral setba!*s, I ha$e been able to de$elop a #ore su!!essful therapy by adding other #edi!ations. t first I re!ognized that the G.=.6. %as $ery lo% in a nu#ber of !an!er patientsO I interpreted this as a !lini!al sy#pto# indi!ating a loss of iodine. Therefore I applied iodine-#edi!ation, first in organi! for# as thyroid, and later also in inorgani! #ineral, in lugol solution, half strength, starting %ith three drops three ti#es dailyO later, the dosage %as in!reased to 4<C drops in the first t%o to three %ee*s, and still later the dosage %as de!reased until the #etabolis# !ontinued to stay at plus si< to plus eight. I found this the best range for the healing po%er. Iodine is a de!isi$e fa!tor in the nor#al differentiation of !ells, and !an be used in order to !ountera!t the de!rease of !ell differentiation as seen in the !an!erous tissues. Iodine is also regarded as !ountera!ting so#e adrenal hor#ones. The results !an be further i#pro$ed by adding nia!in %hi!h dilates the !apillaries 7M%iegeba!*8 and in that %ay is helpful in the e<!hange bet%een seru# and !ells. Aia!in is also ne!essary for the fun!tion of the o<idation syste#. These additional #edi!ations helped re#ar*ably in !he!*ing the !an!erous gro%th and aiding the surrounding tissues to regain their ele!tri!al potentials and resistan!e. ?inally, it %as obser$ed in #ore ad$an!ed !ases that potassiu# in spe!ial !o#position sti#ulates the $is!eral ner$ous syste# 76raus-Monde*8 and helps to restore the fun!tions of the organs of the intestinal tra!t. t the sa#e ti#e it !ountera!ts so#e adrenal hor#ones. The #ore I treated !an!er !ases the #ore the patients and their relati$es re!ognized that so#ething !ould be a!!o#plished for those ad$an!ed !ases %ho had been sent ho#e. Gradually the nu#ber of so-!alled ter#inal !ases a#ong #y patients in !reased to #ore than 9- per !ent of the total, ha$ing !o#e to #e after the applied treat#ents had failed. s a result of ha$ing attra!ted su!h a large nu#ber of greatly ad$an!ed !ases, I %as urged to e<plore the !an!er treat#ent in #any dire!tions and to i#pro$e it as far as possible. bout )- per !ent of these !ases !ould be i#pro$ed and sa$edO this per!entage !ould be higher if there %ere better !ooperation fro# the fa#ily physi!ian, the patient hi#self and less resistan!e fro# the fa#ily against su!h a stri!t regi#eRone %hi!h had to be !arried out o$er a rather lengthy period. The initial per!entage of i#pro$e#ent is higher, but often %ith a period of one to t%o #onths-a nu#ber of patients present !lini!al sy#pto#s %hi!h indi!ate that the li$er andEor other $ital organs are too da#aged to be suffi!iently rea!ti$ated to #aintain the healing pro!ess. #a5or portion of the day is needed to prepare this treat#entO it is also #ore e<pensi$e than the nor#al three #eals. "here affe!tion and de$otion in the fa#ily e<ist, all diffi!ulties are disregarded for the sa*e of sa$ing a life.

C-APT1R .

T-1 T-15R6
=F T'E/6F is not presented to gi$e a general s!ientifi! e<planation of the !an!er proble#, nor to !o#pare it %ith the #any e<isting theories and e<planations. It is supposed to be a guide %hi!h helps physi!ians to apply the treat#ent properly. The theory %as deri$ed fro# !lini!al obser$ations during %hi!h %as re!orded %hat %as #ost !hara!teristi! of the disease and %hat see#ed to be #ost de!isi$e in the !ourse of the treat#ent. In short, it is this. "hat is essential is not the gro%th itself or the $isible sy#pto#sO it is the da#age of the %hole #etabolis#, in!luding the loss of defense, i##unity and healing po%er. It !annot be e<plained %ith nor re!ognized by one or another !ause alone. In #y opinion, !an!er is not a proble# of defi!ien!ies in hor#ones, $ita#ins and enzy#es. It is not a proble# of allergies or infe!tions %ith a $irus or any other *no%n or un*no%n #i!roorganis#. It is not a poisoning through so#e spe!ial inter#edial #etaboli! substan!e or any other substan!e !o#ing fro# an outside, so-!alled !ar!inogeni! substan!e. ll these !an be partial !ausati$e agents in #an, !ontributing ele#ents, !alled se!ondary infe!tions, et!. Can!er is not a single !ellular proble#O it is an a!!u#ulation of nu#erous da#aging fa!tors !o#bined in deteriorating the %hole #etabolis#, after the li$er has been progressi$ely i#paired in its fun!tions. Therefore, one has to separate t%o basi! !o#ponents in !an!erO a general one and a lo!al one. The general !o#ponent is #ostly a $ery slo%, progressing, i#per!eptible sy#pto# !aused by poisoning of the li$er and si#ultaneously an i#pair#ent of the %hole intestinal tra!t, later produ!ing appearan!es of $itally i#portant !onse+uen!es all o$er the body. The pro!ess in the pre-stage of !an!er has not been pro$en !lini!ally. That #ay be $ery diffi!ult, e$en i#possible, as li$er da#age is #ost probably a predisposition of #any other degenerati$e diseases. In !an!er, one or the other li$er fun!tion #ay be predo#inantly #ore da#aged or !o#bined %ith so#e other disturban!e in another organ. 'o%e$er, %e should *eep an eye on the li$er as the first e<peri#ents of Fa#agi$a and It!hi-*a%a de#onstrated that !an!er de$eloped, after the liver, the *idneys and ly#ph glands sho%ed pathologi!al !hanges. In the poisoning of the li$er, !lini!al sy#pto#s are not noti!eable for a long period of ti#e, e$en for #any years. ,The li$er is the largest single organ in the body and is surpassed by none in the #ultipli!ity and i#portan!e of its $arious physiologi! a!ti$ities. !!ordingly, the state of the li$er and le$el of its fun!tional effi!ien!y are of great signifi!an!e to the general bodily e!ono#y both in health and in disease.,(9 The li$er %eighs se$en to ten pounds and has a fun!tional !apa!ity far in e<!ess of ordinary needs. Gefore the fun!tional reser$es are used up, it is $ery diffi!ult to dete!t a deterioration of fi$er fun!tion, The li$er is a dyna#i!, a!ti$e organ, and has #anifold fun!tions. =ost of these are inti#ately asso!iated and !orrelated %ith the a!ti$ities of the other organs. It is i#possible to test a li$er by a single fun!tion, e$en by se$eral, to find the degree of hepati! deterioration. That is the reason %hy the initial de$elop#ent of !an!er re#ains hidden for su!h a long ti#eO this inter$al #ay be !alled the ,pre-!an!erous or pre-sy#pto#ati! period., If a person gets ner$ous, feels %ea*er, has less energy and loses %eight during that ti#e, no physi!ian !an #a*e a spe!ifi! diagnosis as a !an!er test does not e<ist and there is no early spe!ifi! sy#pto# !o#ple<. 2hysi!ian and patient ha$e to %ait until a tu#or is far enough de$eloped in one or another area of the body to sho% lo!al sy#pto#s or signs %hi!h !an no longer be o$erloo*ed !lini!ally. This is %hen %e use all #odern e+uip#ent su!h as N-ray e<a#inations, bron!hos!opy, !ystos!opy, and 2apani!olaou tests at e$ery spot %here %e !an rea!h the different organs. 9u!h sy#pto#s !an be !aused by s#aller or larger destru!tions %ith se!retions or bleedings fro# the lungs, sto#a!h, intestinal tra!t, *idneys, bladder, uterus and other organs or #etastati! glands. There #ay be a
(4 ". . >. nderson, Pathology, 19;:, p. :41.

great $ariety of spe!ial signs fro# the brain, spinal !ord, bones and other sy#pto#s. ?inally, in

so#e !ases, a diagnosis !an be established only %ith the help of e<ploratory operations. The s!ientifi!ally a!!epted #ethod is that these sy#pto#s alone %ill be treated locally %here$er they appear. That is %hat %e physi!ians learn and ho% %e are trained in uni$ersity !lini!s. ll resear!h %or* adheres #ostly to these lo!al sy#pto#s. This is, in #y opinion, the reason %hy de!isi$e progress in !an!er treat#ent has been i#peded, espe!ially in the last )years, during %hi!h #odern #edi!ine #ade re#ar*able progress in #any other fields. The lo!al !o#ponent is !aused, in #y opinion, by abnor#al !ells, i##ature !ells, for#erly da#aged !ells, transitional !ells %hen they fall ba!* or are for!ed to fall ba!* into a type of e#bryoni! life, be!ause they are no longer supported suffi!iently by the a!ti$ated 7ionized8 #inerals of the potassiu# group and a suffi!ient a#ount of rea!ti$ated o<idizing enzy#es si#ultaneously united %ith the nor#al regulations of hor#ones, $ita#ins and. the i#pulse of a nor#al fun!tioning $is!eral ner$ous syste#. ?inally the fun!tions of sub!utaneous, reti!ular ly#ph !ell tissue and reti!ulo-endothelial syste# are di#inished in fun!tion and defense po%er. s #entioned abo$e, the general !o#ponent is i#portant, and it %ill be treated. It !o#prises #ainly the deterioration of the essential organs of the digesti$e tra!t, !hiefly the fi$er. There, the da#age is done by a per#anent daily poisoning brought about by our #odern !i$ilization. This starts %ith the soil %hi!h is denaturalized by artifi!ial fertilizers and depletion, thus gradually redu!ing the top soil. In addition, the soil is poisoned by sprays %ith >>T and other poisons. s a !onse+uen!e, our nutrition is da#aged by a de!rease in the i#portant P-group !ontent of fruit and $egetables gro%n on su!h poisoned soil. ?urther#ore, the food substan!es are da#aged as they are refined, bottled, blea!hed, po%dered, frozen, s#o*ed, salted, !anned, and !olored %ith artifi!ial !oloring. Carrots are sold in !ellophane bags after ha$ing been treated for better preser$ation. /ther foods !ontain da#aging preser$ati$esO finally, !attle and !hi!*ens are fed or in5e!ted %ith stilbestrol to a!!u#ulate #ore %eight and be +ui!*ly ,ready for #ar*et., If %e approa!h the !an!er proble# fro# a #ore pra!ti!al Qie%point - the !lini!al side - based on the !on!ept of totality, %e learn t%o things. firstly, %e ha$e to li$e near nature,(7 a!!ording to our natural de$elop#ent. 9e!ondly, s!ien!e !annot help us to sol$e the deep, underlying !ause of !an!er.(: ,The #ost basi! property of the heart is that it is a #us!le, and the !hief property of #us!le is that %e do not understand it. The #ore %e *no% about it, the less %e understand and it loo*s as if %e %ould soon *no% e$erything and understand nothing., The situation is si#ilar in #ost other biologi!al pro!esses and pathologi!al !onditions, su!h as the degenerati$e diseases 7!an!er8. This suggests that so#e $ery basi! infor#ation is #issing. The story of #yosin #ay illustrate this point. It see#s as if %e *no% too little about the ,life pro#oting substan!es, 3ebensstoffe Ras ". Pollath has !alled the#,(9 re!ognizing their enor#ous i#portan!e. lbert 9!h%eitzer re!ognized the greatness of the ,a%e for life, or the need to ha$e the deepest respe!t for e$erything that is ali$e 7,>ie Ehrfur!ht $or# 3eben,8. The li$ing being, %hether large or s#all, plant or ani#al, is in e$ery respe!t perfe!tly !reated or de$eloped, in all its fun!tions and in all its parts, best in its totality. E$erybody respe!ts and needs s!ien!e, resear!h, and laboratory %or*, but their !on!lusions should not be o$eresti#ated. 2arti!ularly, the dire!tion of therapeuti! a!tion should al%ays be based on the idea of the body as an entity, %hi!h has to be supported and restored in its silent perfe!tion. It is unne!essary to understand the %hole life in its #inute biologi!al parti!les and effe!tRbut it is ne!essary that, for the proble# of therapy, the entire si!* hu#an organis# be atta!*ed in its totality, espe!ially in degenerati$e diseases. It %ould be a great #ista*e to apply the therapy only as far as %e understand the !orresponding biologi!al rea!tions or as far as they !an be pro$en in ani#al e<peri#ents. In parti!ular, in degenerati$e diseases and in !an!er, %e should not apply a sy#pto#ati! treat#ent or only one that %e !an fully understandO %e need a treat#ent that %ill !o#prise the %hole body as far as %e *no% or
(7 9ee G. ". Geadle, 9!ien!e, Lan. ;, 19)7, Qo0. 1(), Ao. C(C4. (9 9ee lbert 9!ent-Gyorgyi, & Gioenergeti!s,, 'cience, Ao$. (, 19)4, Qol. 1(;, Ao. C((7.

(9 9ee Pollath&s Die 5rdnung 6nserer "ahrung. 'ippo*rates-Qerlag 19)(, pp. 1)-1:.

!an i#agine it. These thoughts %ere %ell *no%n by the physi!ians of Gree!e and 6o#eO the an!ient physi!ians *ne% that there are no si!*nesses but only si!* hu#an beings 7see !hapter on 2ara!elsus8. The best phar#a!ologists realize ho% diffi!ult it is to understand the a!tions of the phar#aea and often #ust use pra!ti!al or !lini!al e<perien!e. =odern te!hnology has al#ost unli#ited possibilities but it !annot transfer these a!!o#plish#ents into the biology of the hu#an being. In The 7ailure of Technology, 6e$. Luenger $ie%s our #odern !i$ilization as disastrous, al#ost opposite to the $ie%point of >r. Aorbert "iener, %ho hopes for far greater a!!o#plish#ents.C- 'e says, ho%e$er, at the end of his boo*, ,there is #u!h %hi!h %e #ust lea$e, %hether %e li*e it or not, to the un &s!ientifi!& narrati$e #ethod of the professional historian., This boo* does not propose to dis!uss other !an!er theories, but I %ould li*e to #ention the $ie%point of Lesse Greenstein.C1 Greenstein !o#es nearer to a general assu#ption that ,!an!er is a pheno#enon !oe<istent %ith the li$ing pro!ess, that %ill be present for so#e ti#e to !o#e, or, in other %ords, ,!an!er is not a syste# isolated fro# the li$ing uni$erse., >espite all these general !on!eptions, he !o#es to a so#e%hat !ontrary-sounding !on!lusion for the resear!h %or* Rna#ely, ,that e#phasis #ust be laid on a dire!t study on the site of #alignan!y itself., In the edition of 19;7, he is $ery pessi#isti! about the future in saying that ,!an!er #ay only be pre$ented by pre$enting hu#an beings.,C( Ao %onder that su!h $ie%points, %hi!h are #ore or less generally a!!epted hinder physi!ians in seeing the !an!er proble# other than behind the %all of the sy#pto#sR%rapped up in eternal dar*ness. fe% !an!er e<perts start to e<plore e$ery ne% #ethod of in$estigation, then !ling to the old s!ientifi! resear!h studies. le<ander 'addo%, reporting on findings at the 6oyal Can!er 'ospital in 3ondon, finally !on!luded, after being unable to find any pro#ising solution, , s in e$ery other field, !an!er resear!h is not only dependent upon a long-range strategyRin this !ase !entered upon patient in$estigation of the !ar!inogeni! #e!hanis#Rbut is also affe!ted by !han!e, the a!!idental obser$ation,
ao

>r. Aorbert "iener, #ybernetics, edition 11, 19)C. Lesse Greenstein, 4iochemistry of #ancer, 19);, p. ):9. :( 9ee Greenstein, 19;7 edition, p. C7C.
:1

or the unanti!ipated si#plifying prin!iple. "hi!h is li*ely to be #ore de!isi$e, it is i#possible to tell, yet ea!h is !o#ple#entary to the other, and both are essential in the ad$an!e#ent of our *no%ledge of the !an!er !ell.CC 'ere, as else%here in the boo* the assu#ption is e<pressed that !an!er is one of the degenerati$e diseases. This is diffi!ult to pro$e and it is e$en #ore diffi!ult to find out %hy one organis# de$elops this degenerati$e disease and the other organis# de$elops one or se$eral different types of a so-!alled degeneration at the sa#e ti#e. In !an!er patients, fre+uently, a !o#bination of se$eral degenerati$e diseases is obser$ed. I found !an!er fre+uently !o#bined %ith !hroni! osteo-arthritis, high or lo% blood pressure, !hroni! sinus trouble, or other !hroni! infe!tions although seldo# %ith arterios!lerosis, e<!ept in older people, or asso!iated %ith !oronary disorders, diabetes and rarely %ith tuber!ulosis, asth#a, s*in diseases, gout, et!. I thin* that the origin of the !an!erous disease is #ore probable %here the rea!ti$ation of the o<idizing enzy#es, one of the finest de$eloped fun!tions in the li$er, is i#paired.C; This #ay be the reason %hy indi$iduals %ho ha$e inherited a %ea*er li$er-intestinal syste# get !an!er in earlier years, of a #ore a!ute or #alignant type, %ith se$ere allergi! rea!tions, #ore ede#a, less tenden!y to prote!t the surrounding tissue by a ly#pho!yti! %all or build s!ar for#ation later, %ith and %ithout !al!ifi!ation. The e<peri#ental !ausation of !an!er, first a!!o#plished by Fa#agi$a and It!hi*a%a, through rubbing tar substan!e on the ears of rabbits for about nine #onths, is of i#portan!e insofar as they found that before the !an!er started to appear, the li$er %as da#aged and sho%ed

pathologi!al !hanges, together %ith the *idneys, spleen and the ly#phati! apparatus. The long period %as re+uired to poison the li$er, before the da#aged !ells !ould perfor# the ,#utation, into !an!er. nother e<peri#ent pro$ed that !an!er is not a !ontagious disease. 3ater, %e learned to transplant !an!er under spe!ial
:C 9ee sur$ey arti!le of le<ander 'addo%, ,The Gio!he#istry of Can!er,, in the $nnual &eview of 4iochemistry, Qol. (;, p. 4:9. :;J 9ee 6udolf 9!hoenhei#er, The Dynamic 'tate of 4ody #onstituents, 'ar$ard @ni$ersity 2ress, 19;(.

!onditions in ani#als. 3eo 3oeb %as the first %ho su!!eeded in ino!ulating rat sar!o#a of the thyroid gland to se$eral generations of rats.:) The +uestion %hether hu#an beings !an be i##unized against !an!er has to be ans%ered negati$ely. There is no a!ti$e nor passi$e i##unization thin*able in a body %here !an!er is gro%ing by itself as a part of its o%n organis#. The type of !an!er 7#ostly $irus tu#ors 8 against %hi!h i##unization su!!eeded do not e<ist at all in hu#an beings.C: The first physi!ian %ho tried to transplant !an!er %as #ost probably >r. L. 3. libert, a fa#ous surgeon in 2aris at the ti#e of Aapoleon. /n /!tober 17, 1:-:, >r. libert perfor#ed an e<traordinary operation at the 'ospital of 9t. 3ouis in 2aris. 'e too* !an!erous #aterial fro# a fe#ale breast tu#or, bro*e it into s#all parti!les and finally #ade an e#ulsion %hi!h he in5e!ted into hi#self and three of his students. se$ere fe$erish infla##ation appeared and lasted a fe% daysO there %as no other rea!tion. fe% days later, >r. libert repeated the sa#e e<peri#ent on hi#self and a !olleagueRagain no other results. "e *no% that Aapoleon, %hose father died of !an!er of the sto#a!h, %as $ery #u!h interested in the !an!er proble# and assu#ed that he %ould die of the sa#e disease, %hi!h he did. 'e dis!ussed the sub5e!t $ery often %ith his physi!ian >r. 3u!ien Cor$isart. In re!ent years, >r. E. "eiss of Chi!ago tried to in5e!t a s#all a#ount of %atery e<tra!t obtained fro# hu#an !an!erous tissue into !an!er patients, on!e a %ee* for si< !onse!uti$e %ee*s. The result %as an in!rease in appetite and a slight gain in %eight for a short ti#e only. ?ro# these first e<peri#ents and fro# nu#erous later ones, %e learned ho% diffi!ult it is to #a*e !an!er transplantations effe!ti$e in the sa#e type of ani#al and ho% #u!h #ore diffi!ult it is to transplant it into other types. The +uestion %hether the healthy body has the po%er to pre$ent its ,ta*ing, 7in!orporation8 %as negle!ted for a long ti#e, in the follo%ing respe!t. in general %e *no% that the healthy body has the po%er to defend itself against in$asion by foreign
:)

L.=. 6esear!h (:.1). 19-1. :4 9ee P. '. Gauer, Das @rebsproblem, 19;9, pp. ;C:-;;1

bodies or li$ing ba!teria, !o!!i, $iruses, et!. by a defense rea!tion, or to destroy the# after they ha$e entered the body, by an infla##atory rea!tion as a #eans of healing. I repeatRa defense or healing rea!tion o!!urs in the healthy body %hen !an!er tissue or e<tra!ts of !an!er tissues are in5e!ted. 'o%e$er, the rea!tion %as different in !an!er patients. There, all different types of e<peri#ents had only a #ini#u# or te#porary effe!t, as the !an!erous body had lost its defense and healing po%er. 9e$eral outstanding authors, su!h as ugust Gier, 2ir+uet, and $on Gerg#ann, thought the #alignan!ies !ould be in!luded in the proble# of the infla##ation, sin!e the !an!er body !ould no longer bring about a nor#al infla##atory healing rea!tion. In the beginning, 6udolf Qir!ho% thought that the !hroni! infla##ation %as also a pro!ess of degeneration, %hile today the infla##atory pro!ess is re!ognized as a #esen!hy#al rea!tion, %hi!h #ay turn out to the ad$antage or disad$antage of the body. G. $on Gerg#ann, head of the =edi!al @ni$ersity Clini! in Gerlin and 2resident of the Gerlin =edi!al sso!iation, %as the first to e<a#ine at his !lini! the fun!tional !he#i!al !hanges in

!an!erous tissue and !an!er-bearing bodies in their rea!tions, but he did not dare to use these findings for therapeuti!al e<peri#ents. 'e e<plained in his boo* that there are differen!es in the $arious types of infla##atory #etabolis# %hi!h %ere studied in details at his hospital.C7 The !ells in an infla##atory e<udate ha$e aerobi! gly!olysis e$en greater than the nor#al blood leu*o!ytes, %hile the leu*o!ytes in leu*e#ia ha$e only an anaerobi! #etabolis#.C: Ge!ause of the i#portan!e of these findings for the ne% approa!h to the !an!er proble#, i.e., regarding it as a disturban!e of the total #etabolis# and its essential fun!tions, I should li*e to +uote a passage fro# >r. $on Gerg#ann&s boo*. ,E$en if a syste#ati! therapeuti! use of this idea is i#possible at this ti#e, a !an!er #etabolis# starts %here the body is no longer able to produ!e a healing infla##ation. It is possible to sho% distin!tly antithesis of the t%o #etabolis#s in their rea!!# von Bergmann Pathologic, pp. 17C-17;. ::- 9ee 2es!hel .3eu*n!osten,, 7lin# /o#" '(+8" 2o# 9+" and Ruth Lohmann :7re&sstoff;echsel": 7lin# /o#" 2o# +(#
C7

tions. E<peri#ents are #ade by 6uth 3oh#ann under super$ision of >r. Pe#pner %hi!h pro$e that sli!es of tissue, ta*en fro# #alignant rat tu#ors or hu#an !an!er tissues, are *illed fast in an infla##ation e<udate si#ply be!ause the spe!ifi! #etabolis# of the !an!er !ell !annot be #aintained in those surroundings. The e<a!t $alues for sugar, bi!arbonate and the a!id-degree #easured by the p' figure sho% that no !an!er !ell !an li$e there any longer. 79ee Table II, Ao. 18 ,Table ( !learly sho%s the +ui!* eli#ination of the !an!er !ells in infla##ation fluid after a fe% hours, %hile they %ere perfe!tly able to li$e in seru#. It #eans that %here the infla##ation #etabolis# begins, the !an!er #etabolis# stops and the !an!er !ells ha$e to die in the area of su!h a fa$orable infla##ation #etabolis# %ith high o<idation po%er.,

?ehleisen 71:(C8, Coley 71:9(-19198 and others !ould not enfor!e a suffi!ient infla##atory rea!tion by ino!ulating infe!tions or infe!tious #aterial in !an!er patients %in!h %ould produ!e enough high fe$er for healing rea!tion. >rs. libert, "eiss, >uro$i!, 7Prebiozen8 and others did partially su!!eed in their long endea$ors to produ!e a suffi!ient defense rea!tion in the body by ino!ulating !an!erous tissue or e<tra!ts fro# !an!er tissues, infe!tious #aterials, et!. Thus, %e begin to re!ognize the disease of !an!er as a pathologi!al degenerati$e $ariation of the total #etabolis#, si#ilar to $ariations of other degenerati$e diseases. The therapeuti!al endea$ors !on!entrate on three essential ite#s. 718 far-rea!hing and #aintained deto<i!ation. 7(8 6estoration of the %hole enteral #etabolis#, in!luding the li$er, as far as possible.

7C8 The restoration of the %hole parenteral #etabolis# ne!essary for infla##atory rea!tions and healing po%er. The treat#ent is effe!ti$e only as long as the li$er %ith the #etabolis# is restorable.

C' 2TE6 QI
?e% 9i#ilar Can!er Theories
T'E IATE6A TI/A 3 C/AG6E99 for Totality-Treat#ent in =alignant >iseases 7in Ger!htesgaden, 'ippo*rates Qerlag, 19)C. 9tuttgart8 re$ealed that #any authors and parti!ularly 2rofessor Mabel, !hair#an, held to the state#ent that ,before the gro%th starts, the fun!tion of the organis# #ust ha$e been abnor#al. . . . This is a real blo% to the !on!eption that the tu#or is a lo!ally li#ited disease., 2rofessor 3a#bert !a#e to the follo%ing !on!lusions. ,In the tissue !ulture the !an!er !ell %ill be da#aged by a te#perature of C9X C. and dies at ;(X CO the nor#al !ell %ill be da#aged by ;CX C. and dies at ;4-;7X C. The findings of se$eral authors sho% later aberrationsR#ost probably !aused by different #ethods.,C- . . . ,the ne<t tas* of our %or* %ill be first the in!rease of our *no%ledge about the dire!t influen!e of te#perature on the gro%th, and se!ond, an intensi$e study about the !onne!tion of indire!t influen!e of higher te#perature on the rea!tions of the lo!al and general bodily differen!e, espe!ially on the rea!tion of the neighboring tissue of the tu#or. The fa!tors of the disposition and !onstitution should not be negle!ted.,;>r. Lohannes Puhl reported. ,I started fro# the funda#entals of the !ell #etabolis#, the o<idation and the gly!olysis, the burning do%n and the spreading of the end produ!ts. I found in the fer#ents, $ita#ins, hor#ones and other $ital substan!es only se!ondary #eans., ;1 >r. Puhl regarded the !an!er !ell end prods C9 2rofessor 3a#bert, 4odily &esistance and Malignant Growth,
Parl 'aug Qerlag, @l#E>onau, 19)7, p. 11.
;;1

Ibid., p. 14-. >r. Lohannes Puhl, 'uccessful Medication and Dietary &egime in the Treat9 rnent of 4enign and Malignant Growth, p. 14;.

u!t, the la!ti! a!id, as a sti#ulant of gro%th. 'e re!ognized ,the !onstant #a5orities of o<idation at the de$elop#ent of the !ell and its le$els. That #eans the !onstant #a5ority of gly!olysis in the pathologi!al regenerati$e gro%th., 'e sa% in addition, ,the transition of the stronger gly!olysis to #a5or o<idation at the end of the nor#al regenerati$e gro%th., Puril&s theory is built on $on Euler&s finding that the total la!*ing of the !yto!hro#e syste# in the !an!er !ell is signifi!ant for the !ar!ino#atous enzy#e syste#. That #eans that the !an!er !ell is a so-!alled !yto!hro#e defi!ient !ell. This is the reason %hy the !an!er !ell is not nor#ally differentiated and !ould only de$elop a breathing fer#enting syste#, other%ise it is a real body !ell %ithout #utation and %ithout other stru!tural !hanges. /ne of the leading !an!erbiologists, 2rofessor 3ittle says. ,Can!er de$elops in a body %here there is a general brea*do%n of the %hole body., nd in another state#ent, 3ittle says. ,The !an!er proble# %ill not be sol$ed by spe!ialists, rather by a pra!titioner., This #eans by a physi!ian %ho !onstantly obser$es the %hole body and tries to help the entire syste#. The pra!tioner is not so #u!h burdened %ith an i##ense literature on spe!ial !an!er fields and is #ore open to reasonable argu#entation. 2rofessor Ernest 3eupold has stated 7translation8. ,all !ells in the body, the nor#al and the tu#or !ells, stay biologi!ally in !onta!t and e<!hange rea!tion to the general #etaboli!, pro!esses %hi!h are funda#entally all the sa#e for all !ells, %hether they produ!e nor#al !ells or si#ple proliferations. Tumors are, therefore, only systems of a general disease %hi!h are different in their degree and te#porary !ourse fro# other proliferate produ!ing #etaboli!

pro!esses.,;( 'e also thin*s that the general disease is present before the tu#or appears as 2rofessor Mabel assu#es. ,"e should not regard the tu#or as a spe!ial type of disease. That !annot be pro$en by the fa!t that not only the ripe and unripe tu#or !ells !an be influen!ed by the sa#e !onditions of the #etabolis#, but also #any other seg#ents are influen!ed at the sa#e ti#e and in the sa#e %ay., I obser$ed the sa#e !lini!al appearan!es in !an!er patients %ho also i#pro$ed or restored !o#pletely se$eral !hroni! diseases in the organs during the

2rof. Ernest 3eupold, The 'ignificance of 4lood #hemistry in &egard to Tumor Growth and Tumor Destruction, Georg Thle#e Qerlag, 9tuttgart, 19);, p. (-(.

;(

treat#ent. su!h diseases as !hroni! arthritis, !hroni! sinusitis, !hroni! gall bladder disorders, arterios!lerosis, asth#a, !raurosis $ul$ae, e!ze#as, et!. 9o#e !hroni! or degenerati$e diseases, in!luding !an!er, ha$e been negle!ted in the last Cyears. Can!er %as !onsidered in!urable in the #inds of physi!iansO therefore, it al#ost see#ed not %orth%hile to put intensi$e %or* into it. Internal physi!ians left !an!er %or* to surgeons, biologists, and pathologists. These, ho%e$er, %ere deeply interested in finding out %hat !auses !an!er and %hat it does in ani#als and hu#an beings in the field of their !o#peten!e, biologi!al or !he#i!al spe!ialty. 2atients ha$e reported that after unsu!!essful operations and N-ray treat#ents that physi!ians ga$e the# sedation only, thereby adding ne% poisons to the large a#ount %hi!h the disease is !ontinuously produ!ing. "hen papers report that a surgeon re!o##ends #ore operations for the purpose of pre$enting the loss of the patient to the non-physi!ians, %e all should feel gra$ely !on!erned. 9u!h aberrations fro# s!ientifi! beha$ior should be an in!enti$e to apply any pro#ising treat#ent, regardless of %ho %or*ed it out or ho% diffi!ult it #ay be. "here li$es are at sta*e our surgeons and physi!ians should not re!o##end only surgery or non-surgery, but should !onsider all #eritorious possibilities. /f !ourse, this boo* des!ribes #any obsta!les %hi!h ha$e to be o$er!o#e in this #ode# !i$ilization.

C-APT1R .II Paracelsus% $ietary Regime<

IA 'I9 %or*s, 2ara!elsus 71;9--1);18 e#phasizes that #an is a #i!ro!os# in the #a!ro!os# of the uni$erse, depending on all the la%s %or*ing therein. Goth #en and nature ha$e a fre+uent and re!ipro!al influen!e upon one another %hi!h rea!hes into the s#allest parti!les through %ater, earth, sun, season, #o$e#ent of stars, food, soil, et!. bo$e all %e #ust realize that there is nothing in hea$en or on earth that does not also e<ist in #an hi#self. "e !an say, therefore, that the syste# %hi!h go$erns the hu#an being itself is ,Great Aature., 7Qol. I, p. ()8 The body needs nutrition through %hi!h it is bound to nature. 'o%e$er, that %hi!h %e ha$e to gi$e to the body as nutrition also !ontains to<ins and da#aging substan!es. In order to deal %ith the har#ful things %hi!h %e ha$e to use to our disad$antage, the 3ord ga$e us an al!he#ist 7sto#a!h8 not to absorb the poisons that %e eat together %ith the good nourishing food, but to separate it fro# the fa$orable substan!es. The hu#an being has to a!+uire *no%ledge of %hat to eat and drin*, and %hat he has to %ea$e and %ear, be!ause nature ga$e hi# the instin!t of self-preser$ation. ?or the things that one does for the prolongation of one&s life are ordained by Great Aature. If so#eone eats %hat is useful for

his health and a$oids other things that #ay shorten his life then he is a #an of %isdo# and self!ontrol. ll that %e do should ser$e to prolong our life. =any undis!o$ered +ualities are hidden in our nutrition and
K Ta*en fro# the translation by >r. G. 19C-. s!hner, Ae% For*RQerlag $on Gusta$ ?is!her. 9tuttgart, ;9

they are able to !ountera!t the da#aging for!es of the stars 7su!h as sunburn8. !!ording to 2ara!elsus, so#e of the Great Aature&s for!es help produ!e ani#al urges and bad instin!ts in #an %hi!h God-gi$en reason and 5udg#ent !an !ountera!t and o$er!o#e. ?ood and drin* !an !ause #orbid !onditionsO he belie$es that nutrition aids the de$elop#ent of all !hara!teristi!s. good or bad, gentle or !ruel. =an in his !hara!ter and disposition rea!ts to his food li*e the soil to fertilizer. s a garden !an be i#pro$ed %ith the right fertilizer so !an #an be helped %ith the right food, In the hand of the physi!ian nutrition !an be the highest and &est remedy# 3Arcanum4 Diet must be the basis of all medical therapy, yet diet should not be a treatment in itself. Gut it ;ill enable Great Aature to de$elop and fully unfold its o%n healing po%er. Gut e$en nutrition is sub5e!t to the influen!e of hea$en and earthO therefore, the physi!ian #ust study its !o#binations in order to apply the# at the right ti#e and brea* the po%er of the disease. 7II, p. 4998 >iet should also be pres!ribed differently for ea!h se<, for it should not ser$e to a!!u#ulate blood and flesh. It should rather effe!t the eli#ination of the foodstuffs %hi!h ha$e spoiled and poisoned blood and flesh. Therefore #edi!ation and spe!ial nutrition are ne!essary. In the treat#ent of a patient the physi!ian #ust !onsider that the nutrition as %ell as the #edi!ation is in agree#ent %ith the patient&s se<, this is not ne!essary in the !ase of a healthy person. 2ara!elsus gi$es greatest !onsideration to diet in !onstitutional diseases %hi!h, in the %idest sense, !ould also be !alled diseases of the #etabolis# 7he !alls the# the tartari! a!id or stonefor#ing diseases8. Tartari! a!ids are !ontained in our food but they do not belong in hu#an beings. These parti!les are tiny pie!es of #inerals, sand, !lay or glue %hi!h in the hu#an body turn into stone. The hu#an sto#a!h is not !reated %ith the ability to separate these substan!es. This separation is a!hie$ed by the ,subtile sto#a!hs, %hi!h are built into the #essenteriiun, li$er, *idney, bladder and all other intestines. If their fun!tion !eases, $arious diseases %ill result in the organs !on!erned through the !oagulation of these tartari! substan!es by the ani#al spirits of #an 7the sper#a or ,9piritus des 9alzes,8. There%ith 2ara!elsus puts into this group of diseases the stone-for#ing ones, as %ell as the 2hleboliths, $as!ular !ra#ps, dental diseases, !hroni! digesti$e disturban!es, sto#a!h and intestinal ul!ers, diseases of the li$er and spleen, gout and arthritis, bron!hie!tasis and bron!hitis, 7not tuber!ulosis8, for he separates it fro# this group, at least in its #ore serious for#s8 and finally brain diseases. t that early period 2ara!elsus had re!ognized that the endogen and e<ogen sti#ulants are $ery !losely !onne!ted in !onstitutional diseases. 'e pla!es the e<ogen sti#ulants e<!lusi$ely into nutrition and %ith that he !o#es !lose to our #odern thoughts in respe!t to a therapy of nutrition. "e !onsu#e tartari! a!id #ainly in legu#inous plants and grains, stal*s and roots. Those transfor# into a tough s%eet sli#e, %hile #il* foods, #eat and fish !ontain a !lay-li*e #ass, %ine for#s a tartar 7%inestone8 and %ater a sli#y stone. s prophyla<is against tartari! diseases, the physi!ian #ust pay spe!ial attention to the preparation of the food. 7I, p. 1C:8 ,The nutrition of #anRfood and drin*Rshould be espe!ially !leansed fro# tartar., ?urther#ore, the spe!ifi!ally guilty tartars in the different regions should be as!ertained and e<!luded fro# the food. ?or instan!e, the ,Pehlhei#er %ine %ould !ause the body a large a#ount of tartari! separation %or* but not the Ae!*ar %ine, therefore the Pehlhei#er should be forbidden., ?ro# #any obser$ations I %ould li*e to #ention one. ,as far as I a# !on!erned, I ha$e ne$er seen a !ountry %here there are so fe% tartari! diseases as in &Qeltlin& 7a $alley in the Italian lpsO south of 3a*e Co#o8 %here there are less than in Ger#any or Italy, ?ran!e or the /!!identor, the European /rient. In this !ountry, Qeltlin, the inhabitants ha$e neither podagra nor !oli-!a#,

!ontra!tura# nor !al!ulu#. It is su!h a healthy !ountry that e$en that %hi!h gro%s there is healthy, and not #any better, healthier lo!ations !ould be found in all #y far tra$els., 7I, p. 4--8 ?or the !ure of so#e diseases 2ara!elsus suggests spe!ial dietary pres!riptions. ?irst for the bladder and *idney stones 7I, p. :;98 the follo%ing are forbidden. #il* produ!ts, !heese, al*ahne or lead-!ontaining %aters, rain %ater, sour sea sla!*s, sour "ine, #eat !rabs and fish. 9ubstan!es of ri!h #ineral and purin !ontent are intuiti$ely forbidden to pre$ent phosphati! and uri! a!id stone for#ations. 7"hen pains are present poppy seed 7#orphine8 is re!o##ended to render the bladder insensiti$e.8 /n the other hand, there are the follo%ing re#edies 7I, p. 1)(8 %hi!h redu!e and do not trans#ute or pre!ipitate, for pre$ention of bladder and gall stones. ,There is nothing so #u!h to re!o##end as butter and oli$es., 'eartburn 7II, p. )9C8 deri$es fro# %ine, salty #eat and $enison. These should be a$oidedO as a re#edy he suggests #u!h #il*, 9t. Lohn&s bread, !hal* 7al*ali08, ,sealing earth, 7#agnesiu#T8, ar#eni! !lay and o!ean !hal*. Then he pres!ribes daily $ita#in doses through !onsu#ption of #elon 5ui!e and fruit, !ontinuous usage of %in!h should pre$ent the for#ation of stones in the intestinal tra!t. In a !onsiliu#, 7II, p. ;7(8 2ara!elsus re!o##ends against 2odagra and i##inent stro*e besides the #edi!al !ures of the %atering pla!es su!h as 2feffers and "ildbad 7Gastein8 as the follo%ing. ,%hen you are ta*ing the baths you should be abste#ious %ith food and drin*, and %ith %o#en you should ha$e little or no inter!ourse., ?ish is forbiddenRbut %hen fried it does the least da#ageO no tough, hard #eat and nothing fro# the pig is per#itted. s drin*, an old, #ild, !lear red %ine %ould ser$e bestO beer should be ta*en only rarely and then it should not be !onsu#ed %ithout nut#eg and fer#ented bread., s prophyla<is, he re!o##ends. 7II, p. ;:78 ,this is #y ad$i!e ho% you !an . prote!t yoursel$es, na#ely, four things should you a$oidR strong s#elling %ineRlas!i$ious foodRangerR%o#enO and the #ore abste#ious you shall li$e in these things the better., ?or pre$ention against stro*e of brain or spinal !ord, dizziness and pleurisy, he 1 ad$ises that the follo%ing foods should be a$oided as #u!h as possible. spi!es, strong %ine, herb %ine, garli!, #ustard, $inegar O and fish, espe!ially the fried foods. bstention is good, but one #ust not suffer hunger or thirst and should sti!* to one&s daily habits at all hours. This is not a re!o##endation for fastingR!ures. In a !ertain aetiologi!al !ontrast to the tartari! diseases he puts the infe!tious diseases. In 2ara!elsus& ti#e an atta!* of disease through infe!tion by ba!illi %as not yet *no%nO in his astrologi!al *ind of !on!eption he tra!es the origin of infe!tious diseases ba!* to the effe!t of the stars. These !onsu#e the patient I through their fires, they !ause the body to dry up and %itherO therefore, the ar!anu# in these patients is #oist food and !onsu#ption of large a#ounts of #oisture. ?or the patient si!* %ith the plague, he says SI, p. 7(98 that one should not gi$e the# any #eat, eggs, fish and nothing fried. ?or drin*, they should be gi$en only soup of %ater or barley sau!e %ith rose $inegar. The #ost 2 6 CE39@9& >IET 6F 6EGI=E )C useful drin* is barley %ater 7#ost of this is the original tea!hing of 'ippo!rates8.

CONCLUSION
In the#sel$es, the state#ents of 2ara!elsus about diet are not unifor# but one !an noti!e e$ery%here in the# the thought that !o#bines the#O their !he#i!al effe!t. E$ery%here in his %ritings it !an be per!ei$ed ho% he %ould li*e to disse!t e$erything into the finest parti!les 7ato#s8 and find an interpretationO it see#s as if he %ould li*e a penetrating po%er to enable hi# to loo* into things #i!ros!opi!ally. The lay#an only sees the surfa!eO the physi!ian #ust be able to $isualize the inside and the hidden fa!ts %hi!h !o#bine to for# the %hole, regardless of %hether it is a pie!e of %ood or bone. =ar$elous are his ideas about the !he#i!al rea!tions and his passionate lo$e for all !he#i!al o!!urren!es %hi!h he applied to the rea!tions of the body

long before his ti#e. 2ara!elsus see*s to de$elop e$erything fro# its origin. In that he al%ays obser$es three things. the hea$en, the earth and the #i!ro!os#O it is si#ilar %ith healing. =an !an only be !o#prehended through a #a!ro!os#O not through hi#self alone. /nly the *no%ledge about this har#ony perfe!ts the physi!ian. This short !ondensation does not ta*e a !riti!al stand in the histori!al sense to%ards the state#ents of 2ara!elsus as #easured against the *no%ledge of his ti#e. It #erely see*s to sho% ho% sti#ulating his %ritings are and the %ealth of ideas %hi!h shines through e$ery%here, ho% intense his urge to find !ausal !onne!tions or at least to inti#ate the# in his passionate %ay and bring the# in a!!ordan!e %ith the eternal la%s in nature outside of the body and the sa#e la%s ruling inside the #i!ro!os#.

C-APT1R .III $ifferent Authors% Cancer Therapies &y $iet 0 A Survey

P. '. G @E6 %rote that ,%e #ust distinguish sharply bet%een nutritional prophyla<is and !an!er therapy by diet.,JC >r. Gauer ta*es a stri!tly negati$e attitude to the +uestion of dietary therapy in !an!er, ?or this reason, he lists the dietary regi#es of a nu#ber of authors. 718 ?is!her-"asels 719C--19C)8 re!o##ended the a$oidan!e of o$ereating, nutrition poor in sugar, %ater and salt, poor in $ita#in G, !holesterol, al*aline, and a higher a!idity to be rea!hed by inta*e of a!id foods and addition of a!ids. 79ee >r. Puhl.8 7(8 uler 719C7-19;18 re!o##ended a non-sparing diet, ri!h in salt and spi!es, ra% #eat se$eral ti#es %ee*ly, 5ui!es of $egetables and fruits and oils to repla!e ani#al fats. 7C8 ?reund and Pa#iner, %hose dietary e<peri#ents %ere highly regarded for a long ti#e, suggested repla!e#ent of ani#al fats by $egetable oils to a$oid gro%th of the si!* ba!teriu# !oli and pre$ent the for#ation of nor#al fatty a!ids. Carbohydrates %ere to be redu!ed and the intestines %ere to be !leansed by #eans of physi!s and #edi!ation. ?reund and Pa#iner %ere the first to list per#itted and prohibited foods 7191(-19()8. 7;8 Pretz, Qienna 719C98 leaned !losely on the re!o##endations of ?reund for the i#pro$e#ent of the general !ondition of the !an!erous organis#. 7)8 Gruenings, ?ran*furt aE=ain 719C-&s8 re!o##ended a diet poor in !arbohydrates and ri!h in proteins, aided by insulinO he belie$ed in i#pro$e#ent by an a!idifying effe!t.
;C

P. '. Gauer, Das @rebsproblem 7The Can!er 2roble#8, 9pringer Qerlag, Gerlin, 19;9, p. 4-).

748 E. 9alzborn, Qienna 719;-8 ad$o!ated a dietary regi#e for inoperable !an!er patients %hi!h !onsisted of little protein and fat, fe% $ita#ins, #inerals and foods %ith a redu!ed a#ount of !arbohydrates be!ause of fer#entation and gas produ!tion. 778 Ingebos 719;(8 re!o##ended a regi#e based on the ideas of =ason in 3oe%enO the regi#e a$oided fats and foods ri!h in fats, espe!ially those ri!h in !holesterol, and also a$oiding artifi!ially !olored foods and drin*s. 'e prohibited salt and #eat and fishRfrozen, s#o*ed or sterilized. Easily digestible foods %ere per#itted. lean fish grilled or broiled, !hopped lean #eat, brains, and thy#us %hi!h !ould be !oo*ed. ll $egetables should be ser$ed ra% or !oo*ed in %aterO $egetable soup and oat#eal, $egetable oils, fruit and potatoes %ere part of the regi#eO bread %as per#itted. l!oholi! be$erages, pepper, #ustard and papri*a %ere forbidden, as %as s#o*ing. Gauer presents a su##ary of ans%ers to +uestionnaires sub#itted to C; physi!ians by the Monatschrift fuer @rebsbekaemp9fung.CC "ith the e<!eption of 2rofessor >en* of Qienna, all the physi!ians sho%ed a negati$e attitude to dietary therapy in their ans%ers. 9o#e loo*ed upon diet #ore as a #eans of pre$enting ,!auses of !an!er, than a #eans of treating !an!er.

In his boo*, #ancer and Diet, >r. ?rederi!* 3. 'off#an rea!hed the !on!lusion that !an!er is not lo!al in its originO treat#ent should, therefore, not be li#ited to the lo!al lesions. , deranged #etabolis# is the result of dietary and nutritional disorders #anifesting the#sel$es in $arious %ays, not diffi!ult of as!ertain#ent by #ode# #ethods of e<a!t s!ientifi! deter#ination, !hiefly gastri! and blood analysis, or other pre!ise #ethods of indi!ating blood disorders. ,I a# absolutely !on$in!ed that the underlying !ause of !an!er is to be found in an e<!essi$e inta*e of foods of a high organi! or #ineral !ontent, or generally of an al*aline base instead of a!id In brief, the tea!hing of #ode#-day nutritional s!ien!e should be the urgen!y of #oderation in all thingsR#oderation in food inta*e, parti!ularly as to highly-spi!ed foods, #oderation in bodily fluids, in!luding al!oholi! be$erages, !offee and tea, as %ell as #oderation in the use of toba!!o. I##oderation in any one parti!ular dire!tion fa$ors the lo!al de$elop#ent of #alignant
Y Monatschrift fuer @rebsbekaempfung, Qol. 9, 19C4, p. ()7

gro%ths. ... I !onsider #y o%n duty dis!harged in presenting the fa!ts as I ha$e found the#, %hi!h lead to the !on!lusion that o$ernutrition is !o##on in the !ase of !an!er patients to a re#ar*able- and e<!eptional degree, and that o$erabundant food !onsu#ption un+uestionably is the underlying !ause of the root !ondition of !an!er in #ode# life.,;) In Dietotherapy #linical $pplication of Modern "utrition, !ar!ino#a of the sto#a!h is des!ribed as essentially a surgi!al proble#. post-operati$e diet is re+uired only after subtotal or total gastre!to#y. ,/n!e the patient has sur$i$ed the operation and the !on$ales!en!e has follo%ed, the diet is $ery liberal and pra!ti!ally without restrictions. 2atients %ho ha$e suffered partial rese!tions of the sto#a!h !an #anage pra!ti!ally the sa#e diet as nor#al persons.;4 Purt 9te# and 6obert "illhei# %rote, ,In regard to the relation bet%een food +uantity and tu#or gro%th, the pre$ailing #a5ority of authors ha$e e<pressed the opinion that food restri!tion is follo%ed by a depression of neoplasti! gro%th.,;7 3i*e ?. 3. 'off#an 719C78, E. ?riedberger 719(48, . Tan-nenbau# 719;--;(8, ". Caspar 719C:8 and others e<pressed the sa#e opinion and ad$o!ate #oderation in food. real therapy is nowhere to be found, although so#e authors are not as pessi#isti! as others. The different dietary propositions #ade at the International Congress for Totality Treat#ents of Tu#ors in 19)( %ere not put into pra!ti!e, although #any of the propositions had the !orre!t approa!h. It is not ne!essary here to pay attention to the #any proposals for applying one or #ore $ita#ins, or enzy#es or those #i<ed %ith #inerals. It %ould be a pri#iti$e !on!ept to propose that the ad#inistration of one or another enzy#e, $ita#in or #ineral or their !o#position %ould !hange or !ountera!t the enzy#ati! disturban!e or intra!ellular nature. Aearly 1-- years ago, /tto Qoel*er %rote. ,The degree to %hi!h a disease is open to therapeuti! atta!* is in$ersely related
;) ?rederi!* 3. 'off#an,3.3.>.,Can!er and Diet, "illia#s and "il*ins Co., Galti#ore, 19C7. ;4 Dietotherapy #linical $pplication of Modern "utrition, edited by =i!hael G "ohl, =.>., ". G. 9aunders, 2hiladelphia, 19;4, p. )7C and ff. Purt 9te# and 6obert "illhei#, The 4iochemistry of Malignant Tumors, 6eferen!e 2iess, Groo*lyn, 19;C, p. C91.

to the nu#ber of re#edies that %e possess.,;: Ao%here is this #ore true than in !an!er, for %hi!h treat#ents ha$e been ad$an!ed by the thousands. The older ones in!luded. !rab or !rab soup, no doubt an early appli!ation of the #ista*en theory that ,li*e !ures li*e,O purgationO yeast treat#entO different dietary regi#esO hypere#ia and its oppositeO bloodlettingO sal$esRfirst bla!* and later, if this pro$ed ineffe!tual, red onesO !austi! pastesO hot iron-burningsO pipe !layO blood-!leansing teasO sil$er and goldO #er!uryO !opperO phosphorusO arseni!Re<ternally and internallyO nar!oti!sO !o#pressionsO .!oldsRlong before the re!ent $enture into !he#otherapyO a!idsO al*alisO diaphoresisO $egetable produ!ts of all sorts, in!luding $iolet

lea$es and toadsO auto-$a!!ine 7Glu#en-thal8O polysa!!haride 7'att8O i#planting of erysipelas strepto!o!!i, et!. The #ode# !an!er re#edies in!lude. surgery, N-ray treat#entO radiu#O ionized #inerals 7gold, phosphorus, iodine, !obalt8O !o#binations of $ita#insO hor#onesO 6e$i!i&s lodoa!etateO Prebiozin, and the ne%est proposal of ,!reation of !an!er fo!!i on the s*in as !an!er of one organ shields other organs to a !onsiderable e<tent.,;9 s !an!er author "illia# '. "oglo# %rites, ,If %e ha$e no !ure of !an!er today, surely it is

not fro# la!* of trying.,;:

To present a histori!al sur$ey of all the therapeuti! atte#pts to influen!e the !an!er gro%th, or at least to alle$iate pain, %ould be e<tre#ely diffi!ult. !o#plete sur$ey #ay run into thousands of enu#erations, as old popular !an!er re#edies, based on natural obser$ations, #ay be found in al#ost all !ountries of the %orld. E$en in #odern s!ientifi! therapy, al#ost all atte#pts ha$e failed, %hether in the fields of ba!teriology, i##unology or bio!he#istry. In su##arizing the relations bet%een tu#ors and enzy#es, Purt 9tern and 6obert "illhei# said that ,of the therapeuti!al uses of enzy#es in tu#or pathology it %ould be an e<tre#ely pri#iti$e !on!ept if ad#inistration of one enzy#e or the other %ere to be proposed as an effe!ti$e #eans of !ountera!ting an enzy#ati! disturban!e of ne!essarily intra!ellular nature. s a #atter of fa!t, no instan!e is *no%n in general pathology, %ith the e<!eption of gross intestinal defi!ien!ies of enzy#es, in %hi!h
;:

Quoted by "illia# '. "oglo#, $pproach to Tumor #hemotherapy, 19;7, p. 1. ,- '. 2eller, =.>. #ancer in Man, 19)(, p. ;::.

an enzy#e therapy has pro$en useful 7pepsin and trypsin8 )-.,2rofessor 3eupold had so#e results by !hanging the ,blood-!he#is#usRthe !holesterin-sugar-phosphati! syste#.,J1 ?eller brought up a theory for !an!er !ure in his boo* by saying, ,!an!er of one organ shields other organs to a !onsiderable e<tent. !ured !an!er lea$es an in!reased resistan!e to the de$elop#ent of another pri#ary tu#or in so#e other part of the body, lthough the nature of this resistan!e is un*no%n, its utilization for !an!er !ontrol is possible. . . . The pri#ary tu#or is a lo!al #anifestation of a general disposition to !an!er.,)( 2eller arri$ed at this notion fro# so#e obser$ations in tuber!ulosis. It %as !on!luded by se$eral authors that tuber!ulosis of the s*in 7lupus8 prote!ts the other organs, espe!ially the lungs, against the tuber!ulosis infe!tion. fe% %ords #ay be added to the abo$e-#entioned !ontradi!tions in !an!er treat#ent. s!ientists ha$e s*irted the nu!leus of the proble# throughout the !enturies as des!ribed in the history of #edi!ine. s soon as one of Aature&s se!rets is un!o$ered, apprehension and s*epti!is# appear. The history of #edi!ine is filled %ith tragi! errors %hi!h allo%ed su!h a long ti#e to elapse bet%een the ti#e of dis!o$ery of a basi! prin!iple and the a!tual #edi!al appli!ation of the dis!o$ery for the good of #an*ind. To +uote fro# a re!ent paper by 'a##et, ,Ao%here today is this delay #ore unhappily e$ident than in the field of !an!er resear!h. The a!!u#ulated data of 6ous, 9hope, Coley, Gittner, 9trong, nder$ont, Green, Greene, "illia#s, Taylor, ?urth, T%o#bly, Co%dry, >iller, Ga%den, 2irie, 9tanley, "y!*off, Punitz, and others indi!ate beyond per-ad$enture the path for getting at so#ething of pra!ti!al benefit to the !an!er patient of the future other than surgery and ra)- Purt 9tern and 6obert "illhei#, The 4iochemistry of Malignant Tumors. )1 2rof. Ernst 3eupold, The 'ignificance of 4lood #hemistry in &egard to tumor Growth and Tumor Destruction, Georg Thie#e Qerlag, 9tuttgart, p. 1;. )( 9. 2eller, =.>., #ancer in Man, 19)(, International @ni$ersities 2ress, Ae% For*, p. ;::. )C 'cience, Aol. 1-C, Ao. (4:), 19;4, p. 71;.

C-APT1R I=

1arly Cancer Symptoms

IA T'E beginning, there is a general %ea*ness %ith loss of pep and energy and !o#plaints of easy fatigue or e<haustion, as #ay be seen in #any different diseases. Get%een su!h early sy#pto#s and the later diagnosed !an!er there #ay be a period of years, %ee*s, and daysO or else the !an!er presents itself at the first !onsultation. It is of pra!ti!al i#portan!e to note that so#e of the beginning !an!ers of the sto#a!h are not indi!ated by !lini!al sy#pto#s, but found by !han!e be!ause of operations for other reasons. I ha$e seen a nu#ber of !an!er patients %ho had been e<a#ined in e<!ellent !an!er pre$ention !lini!s only a fe% #onths earlier, in %ho# nothing pathologi!al or suspi!ious had been found. The publi! appeal for pre$ention and the atte#pt at early dete!tion see# to be pra!ti!ally una!hie$able. . /n the basis of the pre!eding e<planation that !an!er is a disease of the entire #etabolis#, !on!entrated essentially in the li$er I do not belie$e that there %ill be a !an!er-spe!ifi! test for diagnosis. /n the !ontrary, I ha$e found si#ilar, al#ost identi!al !lini!al sy#pto#s in other degenerati$e diseases, su!h as tuber!ulosis, diabetes, arterios!lerosis, #us!ular dystrophy, li$er !irrhosis and #any others. Fet the #etaboli! disturban!es in !an!er !ases, espe!ially in #ore ad$an!ed !ases, so#eho% see# to be different fro# #etaboli! disturban!es in other degenerati$e diseases, although so far I do not ha$e enough ob5e!ti$e #aterial to present the# as suffi!iently !lear e$iden!e. !!ording to #y e<perien!e it see#s i#portant that the physi-!an infor#s the patient either right at the beginning, or i##ediately after the first noti!eable i#pro$e#ent, of the seriousness of the disease. 2atients #ust learn %hat they ha$e to do for the restoration of their $ital organs. The treat#ent is diffi!ult and dra%n-out, and proper understanding is ne!essary for patients to ad5ust to it and !arry it out. The restoration of the teeth is an absolute re+uire#ent for the treat#ent, to pre$ent infe!tion and to<i! disturban!es fro# defe!ts of the teeth and infla#ed gu#s. Prevention of &ecurrence fter the restoration, I found that t%o !o#ponents %ere ne!essary for prophyla<is. the #aintenan!e of potassiu# and iodine in the body and the #aintenan!e of the fun!tion of the li$er and the essential organs. The potassiu# !ontent in the seru# !an not be #easured e<a!tly but it is i#possible to test it in the organs. The e<perien!e thus gained, ho%e$er, enables us gradually to dra% so#e !on!lusions, on the basis of %hi!h %e !an gi$e the patients $aluable dire!ti$es for the future. ?or this reason, I repeat so#e of #y findings as follo%s. 9o#e patients #aintain a lo%er potassiu# le$el in the seru# for yearsO the #a5ority e$en go a bit belo% the #ini#u#, but !ontinue to feel %ell and re#ain !o#pletely free of sy#pto#s. "hen the potassiu# !ontent goes 1.) to ( #g. belo% the #ini#u#, and re#ains there for so#e ti#e, patients #ust be %arned to ta*e up part of the #edi!ation and diet again to pre$ent a re!urren!e.

C-APT1R

Cancer and Liver

$ General 'urvey ,T'E 3IQE6 is the largest single organ in the body and is surpassed by none in the #ultipli!ity and i#portan!e of its $arious physiologi! a!ti$ities. !!ordingly, the state of the li$er and the le$el of its fun!tional effi!ien!y are of great signifi!an!e to the general bodily e!ono#y, both in health and in disease.,4; 2hysiologi!ally, it #ay be stated. the li$er !an re#ain da#aged for a long ti#e be!ause the

deterioration of the li$er !annot be dete!ted before the great fun!tional reser$es ha$e been !onsu#ed. In addition, the fi$er has great !apa!ity to regenerate, therefore, a partial destru!tion #ay be restored if lie deterioration is not e<tensi$e and rapid. The fi$er has #anifold fun!tions, and #ost of the# are !losely asso!iated %ith the fun!tion of other organs. /ne is for!ed, therefore, to ta*e se$eral fun!tional tests to #easure the fun!tional degree of the fi$er. The !onstant up%ard and do%n%ard trend of this large dyna#i! organ #a*es it ne!essary to repeat the tests before a #ore positi$e state#ent !an be for#ed. The i#portan!e of the li$er %ill be best des!ribed by !o#parison %ith the !hlorophyll !ontained in the !ells of lea$es R#aintaining #etabolis# and the life of the plant. "hen se$eral authors e<a#ined the fun!tion of the li$er of )- patients %ith $arious types of !an!er of the gastro-intestinal tra!t, they found a pronoun!ed hepati! dysfun!tion. )) fter re#o$al of the tu#ors, the li$er re!o$ered to a !ertain degree, for so#e ti#e. Thus, the !hanges sho%ed that the deterioration !an
); ))

". . >. nderson, Pathology. 19;:, p :41. 9ee bels, 6e*ers, et al, nnal of Internal =edi!ine, 14, ((1 719;(8.

be re$ersed. =ay I anti!ipate that the treat#ent des!ribed here does the sa#e. The absorption of the tumor mass and glands and the restoration of the function of the liver. Lesse Greenstein stated that, ,there see#s to be little doubt that hepati! insuffi!ien!y is a !on!o#itant pheno#enon %ith !an!er and, as the authors e#phasize, su!h da#aged li$ers i#pose an additional hazard to those nor#ally a!!o#panying operati$e pro!edures.,): In so#e bio!he#istry boo*s on !an!er, the li$er deterioration in !an!er is di$ided into three stages. The first stage represents the ti#e of the de$elop#ent and the appearan!e of !an!er. >uring that ti#e the dysfun!tion of the li$er is, as #any authors assu#e, present but undete!table by #eans of tests or palpation. I belie$e, ho%e$er, that the fi$er has lost P and P-group #inerals so that the o<idizing enzy#es !an no longer be reo<idized in suffi!ient +uantities to !ontrol all !ell gro%th. >uring the second stage, the tu#or gro%s and so#e #etastases appear in glands. /ne !an palpate an enlarged li$er 7hypertrophy8 and find so#e ede#a in the organs. t that ti#e, %e assu#e that the a!ti$ity of the !an!er has in!reased %hile the defense and the healing po%er of the body has de!reased !orrespondingly. In the third stage, in %hi!h the !an!er has gained supre#a!y, rapid poisoning and destru!tion of essential organs set in %ith later dissolution of these organs, in!luding the li$er %hi!h !an no longer #aintain its substan!e and fun!tions. In the first stage, the tu#or protein %ould see# to be supported by nor#al foodO in the se!ond stage, #ost probably, the protein is supported to a greater or lesser degree by the #us!le tissue. t this ti#e there is !onsiderable hyperlipe#ia present, %hi!h re#ains until the reser$es of the body&s lipids are !onsu#ed. In the third ter#inal stage, there is an a!ute, rapid loss of #us!le and li$er substan!e, sin!e $ery little defense or resistan!e is left. 'o% the tu#or produ!es su!h a !ondition is un*no%n. Lesse Greenstein assu#es the produ!tion by the tu#or of a !ir!ulating to<in, %hi!h a!!elerates the !atabolis# of the body tissues. 6udolf Peller thin*s that the progressi$e loss of potassiu# and the #inerals of the potassiu# group lo%er the ele!tri!al potentials
)4 Lesse Greenstein, 4iochemistry of #ancer, 19);, p. )-9. )7 Ibid., p. )1C.

and the defense of the !ytoplas# in #us!le and li$er !ells. The sti#ulation of the $is!eral ner$ous syste# by the loss of potassiu# and the in!rease in tu#or poisons also see#s to be a !ontributing fa!tor to this deleterious effe!t. high per!entage Rabout 9- per !entRof our patients are ter#inal !ases. These patients !annot %ait for treat#ent to be de$eloped. This %as the reason that for!ed #e to bring #y treat#ent to its highest effi!a!y in e$ery respe!t. The first physi!ian %ho dre% attention to the !o#bination of !an!er and the fi$er or gallbladder syste# probably %as ?reri!hs, in 1:41. 3ater, #any physi!ians agreed %ith hi#, su!h as Men*er,

?uetterer, 9iegert, Parnot, Glond, et!. The e<isten!e of the relationship %as denied by Prehl, 'eller and others. The pathologists %ere also of different opinions. s!hoff and Ga!*#eister de!ided that the disease of the fi$er and bile syste# %ere a!!idental findings. 3ubars!h and others opposed this $ie%. Aeither !lini!ians nor pathologists nor biologists %ere able to sol$e the proble# which was the first or the !ausati$e fa!tor. The great diffi!ulty is that %e !annot deter#ine %hen the pathology of the li$er or bile syste# starts. The ne%er labeled e<a#ination %ith C1; gly!ine by Aorbert E. and >. =. Greenberg): pro$ed that the li$er and plas#a of tu#or-bearing ani#als ha$e an in!reased protein #etabolis#. The sa#e effe!t o!!urs also in pregnan!y 7#easured by gly!ine C1; and 2C( in li$ers of tu#orbearing ani#als8 %hi!h refle!ts a +ui!*er gro%th so#e%here else in the body. This #eans that this !ondition is not spe!ifi! for !an!er and is not !aused by spe!ifi! to<ins. It is i#portant to re!ognize that, in our body, all the inner#ost #etaboli! pro!esses %or* together, are dependent upon one another, and %ill be deranged %ith ea!h other in diseases. 9. 9piegel#an said in an arti!le as %ell as at the Third International Congress of Gio!he#istry in 19)). 7p. 1:)8 ,?or o$er 4- years there ha$e e<isted in the #i!ro-biologi!al literature a series of obser$ations subsu#ed under the title of &enzy#ati! adaptation,& in %hi!h a parti!ular !o#pound apparently e$o*es a %ell-defined !hange in the enzy#e patterns of !ells, gro%n in its presen!e. The last de!ade has %itnessed a rene%ed interest in these analogous
6eported in #ancer, ;. C:C, 19)1.

findings. There, geneti! and enzy#ologi!al aspe!ts ha$e been ree<a#ined %ith the aid of #ore rigorous te!hni+ues and #ethodology than those that %ere a$ailable to the earlier %or*ers. These ne%er pro!edures #ade it possible to sho% in a nu#ber of !ases that the pheno#enon of enzy#ati! adaptation possessed the follo%ing i#portant features. a8 the !hanged enzy#ati! a!ti$ity %as not due to the sele!tion of pre-e<istent #utant types but rather to an in!luded enzy#ati! #odifi!ation against a !onstant geneti! ba!*groundO b8 the obser$ed !hange in enzy#ati! a!ti$ity !ould be as!ribed to the appearan!e of a!ti$e apoenzy#e rather than to the a!!u#ulation of !o-fa!tors or inter#ediates, uni+ue to the #etabolis# of the indu!ing substrate. ... It %as ne!essary, therefore, to re$ise su!h state#ents as genes !ontrol potentiality of enzy#e synthesis., The proble# of the li$er %as, and still is, partly #isunderstood and partly negle!ted. The #etabolis# and its !on!entration in the li$er should be put in the foreground, not the !an!er as a sy#pto#. There, the out!o#e of the !an!er is deter#ined as the !lini!al fa$orable results, failures and autopsies !learly de#onstrate. There, the senten!e %ill be passedR%hether the tu#ors !an be *illed, dissol$ed, absorbed, eli#inated and, finally, %hether the body !an be restored. The progress of the disease depends upon the possibility of %hether and to %hat e<tent the li$er !an be restored, of !ourse, unless there are so#e !o#pli!ations and destru!tions in the $ital organs. The treat#ent of the li$er is generally #ore sy#pto#ati!, but not %ith the des!ribed treat#ent. ,It has be!o#e in!reasingly e$ident that li$er !irrhosis is inti#ately asso!iated %ith pri#ary li$er !an!er, and that en$iron#ental fa!tors play an i#portant part in the pathogenesis of both diseases,, Ger#an stated. Pasper Glond said. ,In the li$er %e ha$e tried to sho% that !irrhosis of the li$er is not a disease sui generis, but only a sign of a disorder of #etabolis# %hi!h !auses a !hain of e$ents leading to #any !onditions %hi!h the #edi!al generation of today !onsiders to be diseases sui generis. The %hole syndro#e of #etaboli! disorders %hi!h %e !all oesopha-. gitis, gastritis, duodenitis, gastri! and duodenal ul!er, !hole!ystitis, !holangitis, pan!reatitis, pro!titis, and others are !onsidered only stages of a dyna#i! pro!ess, starting %ith li$er failure and portal hypertension, and resulting in !irrhosis of the li$er tissue and in !an!er. Can!er is a #utation of so#ati! tissues !aused by !hroni! da#age of the li$er. The stru!tural !hanges of the so#ati! tissues are the result, not the !ause, of the #etaboli! disorders.,):

Glond has studied this proble# sin!e 19(: to e<plain !an!er physiology and pathology through bile produ!tion, absorption, se!retion, and storage as a disorder of the !ooperati$e organs. 'e !a#e to the !on!lusion that %e !an sol$e #ost of the in$ol$ed proble#s if %e study the physiology of man as a whole, rather than !ells, stru!tures, or single organs. In that respe!t, he goes !ontrary to #ost !an!er authors %ho e#phasize ,a dire!t study of the site of #alignan!y itself,, as, for e<a#ple, Lesse Green-stein.:Glond did not try to de$elop a therapy on that basis but too* his $ie%point fro# statisti!s and !a#e to the !on!lusion that ,9:Z of all !an!ers of the internal organs su!!u#b not to the !an!er but to the li$er disorder.,41 'e does not e$en #a*e any suggestion to help the li$er in the fight to defend or #aintain the body. Glond&s !on!eption see#s to be right and reasonable. 'is enu#eration of the li$er syndro#es, ho%e$er, see#s to be too strongly pronoun!ed. I find the# #u!h less a!!entuated e$en in the #ore ad$an!ed !ases. Aot all !an!er !ases ha$e !irrhosis, although the #a5ority sho% a ,pre!irrhoti!, stage of li$er hypertrophy. >r. George =edes reported to the #eeting of the #eri!an Che#i!al 9o!iety in 19)) that !hanges in the !he#istry of the li$ing !ells all o$er the body ha$e been deter#ined in rats %hen li$er-!an!er stri*es. 'e suggested that the dis!o$ery %ill shed ne% light on the %ay !an!er for#s in the body and the %ay it #ay be pre$ented. >r. =edes !on!entrated on the synthesis and utilization of fats by li$ing and gro%ing tissues under $arious dietary !onditions. !eti! a!id, %hi!h is *no%n to be for#ed fro# both fats and !arbohydrates, has been used to represent foods. Earlier, >r. =edes found that, %hile all tissues !ould use both of these substan!es for the produ!tion of fats, there %as a differen!e in nor#al tissue and tu#ors. The nor#al li$er of the rat utilized a!eti! a!id to synthesize and o<idize it to !arbon
)9

Pasper Glond, The iver and #ancer, 19)), p. 1C4. no Lesse Greenstein, 4iochemistry of #ancer, p. )9:. 41 Pasper Glond, The iner and #ancer, p. 197.

dio<ide and %ater at se$eral ti#es the rate at %hi!h the tu#or did, %hereas the re$erse o!!urred %ith glu!ose in nor#al and tu#or-bearing rats. In 19(4, the =ayo Clini! reported the $ery lo% in!iden!e in li$er !ar!ino#a of -.-:C per !ent. That in!reased till 19;9. The highest in!iden!e %as reported during 19;: to 19)(. It is generally a!!epted that the rising in!iden!e of pri#ary !ar!ino#a of the li$er #ay be due to an in!reasing in!iden!e of li$er diseases and !irrhosis in general. These are regarded as !auses of the neoplasti! transfor#ation. The latest statisti!s of the in!iden!e of pri#ary !ar!ino#a of the li$er sho% the predo#inan!e of this disease for !ertain ra!ial groups and geographi! areas. In general, pri#ary !ar!ino#a of the li$er is #u!h #ore !o##on in !olored ra!es than in the %hite ra!e, %hile #alignan!ies in general are less fre+uent in !olored people. The per!entage of li$er !ar!ino#a to other !ar!ino#as is one to t%o per !ent in Europe and #eri!a %hile Chinese ha$e CC per !entO La$anese, C4.1 per !entO ?ilipinos, ((.( per !entO Lapanese, 7.) per !entO and9outh fri!ans in the Gold =ines, :4.4 per !ent. E%ing and other authors found that pri#ary hepato#as and )- per !ent of pri#ary !holangio#as are asso!iated %ith !irrhosis. The >a#o!les s%ord of !irrhosis hangs o$er all !an!er patients %ho ha$e far ad$an!ed #alignan!ies in their abdo#inal organs. "e *no% that all these organs send their blood through the portal $eins into the li$er %here tu#or !ells settle $ery fre+uently as soon as the li$er, %or*ing as a filter, has lost its defense po%er. Terato#as of the li$er are e<tre#ely rare. ?or li$er fun!tion tests, see spe!ial te<tboo*s. bels, 6e*ers and others reported a-high in!iden!e of hepati! dysfun!tion in patients %ith !an!er of the intestinal tra!t. In his boo*, 9pellberg says that ,2ri#ary !an!er of the li$er o!!urs so #u!h #ore fre+uently in the !irrhoti! li$er as !o#pared %ith the nor#al li$er that !irrhosis has been referred to as a pre!an!erous lesion.,-( nd, he also says, ,There is no dispute that an ade+uate diet is essential in the treat#ent of li$er diseases.4C 9e$eral authors ha$e obser$ed that if the surgeon re#o$es a tu#or of one of the abdo#inal

organs, the li$er is the first organ 4( =it!hell . 9pellberg, Diseases of the iver, p. ;(7. Gri#e and 9trattoa, A. F., 19);.
4: Ibid., p. 1(9.

%hi!h re!o$ers. This obser$ation sho%s that the poisoning fro# the tu#or see#s to be the underlying !ause of the li$er disease 7in later stages8. E<peri#ents ha$e re$ealed that in the se!ond stage of !an!er the sour!es for nitrogen %ill be ta*en, #ore or less, fro# the !an!er-bearing body. >uring this !ondition the li$er sho%s enlarge#entO the enlarge#ent !orresponds to the %eight of the ani#al plus that of the tu#or. Gefore death, ho%e$er, the li$er loses rapidly in size and %eight, and the li$er !ells ha$e to pro$ide the body %ith its last reser$es. ?inally, it #ay be #entioned that li$er perfusions ha$e sho%n that in the li$er !ells #any redu!tions of hor#ones and #etaboli! pro!esses ta*e pla!e, The presen!e of androgens and a!ti$ated $ita#ins and enzy#es has pro$en that the li$er !an a!!o#plish reo<idations and #etaboli! regenerations. 9o#e authors thin* that #ost of the o<idizing enzy#es are rea!ti$ated in the li$er. The fun!tions of the li$er !ells are so $itally i#portant for the body that they !ould be !o#pared %ith the a!ti$ity of the !hlorophyll of the plants. The li$er is regarded so uni+ue biologi!ally that re!ently it %as !alled the ,balan!e %heel of life.,

C-APT1R =I Survey of Treatment of Liver Pathology &y Several Authors

>ET"EI3E6 "6ITE9 regarding portal !irrhosis. ,It is by no #eans un!o##on for portal !irrhosis to e<ist unsuspe!ted during life and only bo found after death fro# a!!ident, inter!urrent infe!tion, or other diseases. The early re!ognition of the disease, therefore, #ay be e<tre#ely diffi!ult. 9o#eti#es !areful e<a#ination re$eals loss of appetite, loss of %eight, nausea, flatulen!e and o!!asional $o#iting.,4; In #alignan!y of the li$er or in the intestinal tra!t, the sy#pto#s are des!ribed. ,The onset is $ery insidious and is #anifested in %ea*ness, loss of appetite, and failure in general health . . . there is usually progressi$e loss of %eight and in!reasing se!ondary ane#ia 7!hara!teristi! of any !hroni! or degenerati$e disease8.,:) ,9y#pto#s referable to the li$er itself #ay be absent, but a sense of fullness and dis!o#fort in the hepati! region is often noted. Laundi!e, as!ites and pain are absent in si#ple !ases. Qague gastro-intestinal disturban!es #ay o!!ur.,4: Three different syste#s !losely !onne!ted %ith ea!h other are in the li$er. 18 The li$er paren!hy#a, (8 the bile syste# and C8 the reti!ulo-endothelial syste# ), 9ee Textbook of Medicine, Ce!il, 19C:, p. 791. 4) /p. !it., g. :--. 44 /p. !it.. >egenerati$e >iseases of the 3i$er,, p. :-9.
7( C ACE6 T'E6 2F

,The li$er perfor#s $arious deto<i!ation pro!esses, but it is not *no%n e<a!tly %here and ho% these ta*e pla!e.,47 The sa#e is true %ith referen!e to $arious enzy#e syste#s, $ita#ins and #inerals 7!opper, !obalt, #anganese, iron, potassiu#, et!.8. Enzy#es and $ita#ins are !o#bined, stored and rea!ti$ated #ostly in the li$er. lbu#in is also for#ed in the li$er, probably in the Pupffer !ells, %hile globulin is for#ed in the ly#pho!ytes, but is in!reased %hen

the li$er is i#paired. The reason has not yet been found. The ratio of Salbu#inEglobulinU is therefore lo%ered in the li$er diseases and used for one of the tests. "eoplasiaD bout 1.(-- #alignant tu#ors arise pri#arily in the li$er. =ost #alignan!ies are #etastati! in origin and are deri$ed fro# the intestinal organs.

Pathology0Liver
?ifty patients %ith $arious types of !an!er of the general intestinal tra!t presented pronoun!ed hepati! dysfun!tions.4: fter re#o$al of the tu#ors the li$er re!o$ered to a !ertain degree for so#e ti#e, but the !hanges sho%ed that the deterioration is re$ersible. =ay I anti!ipate here that the des!ribed treat#ent does the sa#e. re#o$al of the tu#or-#ass, glands, et!. and an o$er!o#ing of the dysfun!tion of the li$er. !!ording to Green-stein, ,There see#s to be little doubt that hepati! insuffi!ien!y is a !on!o#itant pheno#enon %ith !an!er and, as the authors e#phasize, su!h da#aged li$ers i#pose an additional hazard to those nor#ally a!!o#panying operati$e pro!edures.,49 >uring the first stageEde$elop#ent and appearan!e of the diseaseRthe li$er dysfun!tion is undete!table. >uring the second stageRtu#or gro%th and so#e #etastases in glandsRone finds the li$er #ostly hypertrophi! and, as %e see in so#e !ases, also hypertrophy or ede#a of other organs. In the third stageEan al#ost entire ruling 7autono#y8 of the !an!er-%ith rapid poisoning, destru!tion and later dissolution of the organs, in!luding the li$er, %hi!h !an no longer #aintain its substan!e and fun!tions.
47 Lensen, Modern #oncepts in Medicine, #. Q. =osby Co., 19)C, p. 17;. 4: gee bels, 6e*ers, et. al, $nnual of <nternal Medicine, 14.((1, 19;(. 49 Lesse Greensfein, 4iochemistry of #ancer, p. )-9.

In the first stage the tu#or-protein %ould see# to be supported by the foodRin the second stage #ost probably a part of the protein is supported by the #us!le tissue and at that ti#e there is !onsiderable hyperlipe#ia present %hi!h stays there till the reser$es of the body&s lipids are !onsu#ed. In the third 7or ter#inal8 stage there is an a!ute loss of #us!le and li$er substan!e and all resistan!e is lost. 'o% the tu#or produ!es su!h a !ondition is un*no%n. Greenstein assu#es ,the produ!tion by the tu#or of a !ir!ulating to<in %hi!h a!!elerates the !atabolis# of the body tissues&7- 6udolf Peller thought that the progressi$e loss of P-and P-group #inerals are responsible for it by losing the ele!tri!al potentials and defense of #us!le !ytoplas#a. The sti#ulation of the $is!eral ner$ous syste# by the loss of P and the tu#or poisons see#s also to be !ontributing to this deleterious effe!t. The ne%er labeled e<a#ination %ith C1; gly!ine by Aorberg and >. =. Greenberg pro$ed that the li$er and plas#a of tu#or-bearing ani#als ha$e an in!reased protein #etabolis#.71 The sa#e effe!t also o!!urs in pregnan!y 7#easured by gly!ine C1; and 2C( as in the li$er of tu#or-bearing ani#als8 refle!ting a +ui!*er gro%th so#e%here else in the body. That #eans that this pro!ess is not spe!ifi! for !an!er and is not !aused by spe!ifi! to<ins. The benefi!ial influen!e of large a#ounts of !arbohydrates in the diet has been re!ognized. Gesides the prote!ti$e a!tion of gly!ogen upon the li$er !ell, further benefit is deri$ed fro# !arbohydrate by $irtue of its protein-sparing a!tion. The prote!ti$e $alue of !arbohydrate appears to be t%i!e that of protein %hen suffi!ient protein is already present in the diet to pro$ide plenty and ne!essary a#ino a!ids for reparati$e purposes. n iso!alori! a#ount of !arbohydrate !annot be substituted for proteins %ithout deterioration of the !lini!al and bio!he#i!al state. ?ifty-eight gra#s #ay be spared by !on$ersion to !arbohydrate %hen 1-- gra#s of protein are fed if the !arbohydrate inta*e is enough to satisfy the i##ediate need for sugar. Ae$ertheless, the additional re+uir#ent of high ,biologi! $alue, protein in patients %ith li$er disease are not *no%n, the indi!ations are that there is a great protein %astage. nore<ia, hypoproteine#ia, and loss of %eight

7- Ibid., p)1C.
9ee report by Aorberg and Greenberg, #ancer, ;.C:C, 19)1.

are positi$e e$iden!e of protein depletion. @n!o#pensated li$er !ell protein !atabolis# also i#plies rapid loss of enzy#e proteins. of all types. 2rotein repletion #ay help, therefore, in restoring the ne!essary enzy#es. There is little ris* of protein surfeit e$en if the patient !onsu#es protein beyond satiety. This reassuran!e is %el!o#e sin!e there is so#e relu!tan!e in so#e +uarters to o$erload the insuffi!ient li$er. >o!* has de#onstrated that the li$er differs fro# the *idney in the !apa!ity to handle protein e<!ess. The hepati! artery !ir!ulation !an ta*e up the in!reased de#and for o<ygen %hen the protein !ontent of the diet is in!reased to 7; per !ent. dietary for#ula %hi!h patients a!!ept e$en %ith #ar*ed anore<ia !onsists of C)- to )-gra#s of !arbohydrate, 1-- to 1(- gra#s of protein, and )- to :- gra#s of fat. This !o#position of diet is re!o##ended by 9nell, 9tare and Thorn, 2ate*, 2ate* and 2ost, ?le#ing and 9nellO Ingelfinger and 'olt follo% this general for#ula %ith #inor $ariations. =orrison pres!ribed a #a<i#u# protein regi#en %hi!h !o#prises a daily diet of ()-- to ;--- !alories %ith (-- to C-gra#s of protein, C-- to )-- gra#s of !arbohydrates and )- to 1-- gra#s of fat. Good#an and Gar$in su!!eeded in ad#inistering a diet %ith a !alori! $alue of )--- !alories deri$ed fro# 1)to ()- gra#s of protein, 4-- to :-- gra#s of !arbohydrate and 1)- to (-- gra#s of fat to 1: !ases %ith a!ute hepatitis. 'ourly feedings supple#ented three regular #eals. n al#ost ,ele!tri!, response in the patients& physi!al and #ental appearan!e %as noted. >iets planned in e<!ess of these a#ounts are not li*ely to be !onsu#ed in their entirety. It is a better poli!y to offer a diet %hi!h is a!!eptable regularly and !onsistently. The #a5or proble# is not to pres!ribe a diet of a, parti!ular !o#position but to insure the ingestion of a #a<i#al a#ount of nutritious food. =issing a #eal is a serious handi!ap in serious li$er trouble. It is best repla!ed pro#ptly by an intra$enous infusion of glu!ose, se$eral authors thin*. E$ery effort is #ade to #a*e food attra!ti$e. ?at and #eat add to palatability. ?or this reason 'oagland re!ently +uestioned the %isdo# of restri!ting fat. It appears that patients a!tually ha$e little diffi!ulty in digesting fats in spite of theoreti!al !onsiderations. The fa!t should not be lost fro# sight that the prote!ti$e effe!ts of !holine and #ethionine !an be re$ersed by e<!ess fat supple#ents. #ple fat, ho%e$er, i#pro$es the effi!ien!y of utilization of !arbohydrate and protein in the diet. The ob5e!ti$es of i#pro$ed appetite and in!reased !alori! inta*e are readily a!hie$ed by a liberalized #enu. self-sele!ted fare is a step for%ard in this dire!tion. The dietitian and physi!ian are in$ariably guided by #atters of a$ailable food sto!*s and prin!iples of dietO the patient *no%s his personal li*es and disli*es better than anyone else. single unappetizing ite# in a #eal #ay !o#pletely abolish a !apri!ious appetite. ppearan!e or odor #ay de!ide a patient against ta*ing food. Interest in the diet #ust not lag for a single #ealO the anoreti! patient is only too %illing to s*ip the ne<t feeding. /n!e a #eal is !onsu#ed, there appears to be no diffi!ulty in handling foodstuffs. @nder !onstant goading, anoreti! patients !onsu#e prodigious #eals regularly, yet suffer no unusual distress. The dietary plan #ust be fle<ible enough, ho%e$er, to per#it $ariations depending on !hanges in the !ondition of the patient. ?or instan!e, %ith in!reasing as!ites, !irrhoti!s find it diffi!ult to s%allo% large #eals. 9#all !on!entrated feeds are preferred. 6egular-sized #eals are resu#ed after para!entesis. In the a$erage !ase of li$er disease %here food inta*e is a proble#, the #id-day repast is usually the ,best #eal,, and the e$ening #eal the %orst. It is ad$isable therefore to offer a light supper supple#ented by a generous sna!* later in the e$ening. bdo#inal distention tends to in!rease in the latter part of the afternoon and subside after supper. This #ay influen!e daily $ariations in appetite. It is not a good poli!y to gorge the patient during one #eal only to !ope %ith a disin!lination to eat se$eral #eals thereafter. 3arge helpings of fatty foods, although they te#porarily i#pro$e the appetite, #ay only pay a li#ited di$idend. ?ats delay gastri! e#ptying. En!roa!h#ent upon the ne<t #eal #ay pro$e a net loss in total daily !alori! inta*e.

The protein, fat, and !arbohydrate rations are dis!ussed in detail belo%. The indi!ations and !ontraindi!ations for parenteral glu!ose, plas#a, %hole blood, purified hu#an albu#in, protein hydrolysates, syntheti! a#ino a!id #i<tures and $ita#ins are re$ie%ed. >iet, ho%e$er, appeared to ha$e no influen!e on li$er tu#ors in rats produ!ed by (-a!etyla#inofluorene., The #anner in %hi!h diet produ!es its pro!ar!inogeni! or anti!ar!inogeni!
1 9- 9. 3i!hhnaii, =.>. Diseases of the iver, Gallbladder and 4ih Ducts, 3ea 1 ?ebiger, 2hiladelphia, 19)C

effe!t is un*no%n., Che#i!al differen!es bet%een #ito!hondria of nor#al li$er and #ouse li$er hepato#a has been reported by 'ogeboo# and 9!hneider. 9o#e interesting obser$ations in regard to the influen!e of diet on the de$elop#ent of spontaneous hepato#as in inbred C': #i!e %ere #ade by Tannenbau# and 9il$erstone. These in$estigators ha$e sho%n that in!rease of fat in the diet fro# t%o per !ent to (- per !ent in!reased the rate of hepato#a for#ation fro# C7 per !ent to )C per !ent. 3o% ribofla$in inta*e resulted in a [ de!rease of hepato#a for#ation. This !an be attributed to the. lo%ered !alori! inta*e, %hi!h has been sho%n to inhibit gro%th of hepato#as in this spe!ies. It has li*e%ise been sho%n that, !ontrary to the e<perien!es in the indu!ed hepato#as in rats, the spontaneous tu#ors in #i!e are not a!!elerated by a ri!e diet but, on the !ontrary, are a!!elerated by in!reased !asein !ontent. =ethionine has li*e%ise been sho%n to a!!elerate the de$elop#ent of these tu#ors in #i!e. The !on!lusion is dra%n that the sulphur-!ontaining a#ino a!ids, %hi!h are ne!essary for nor#al gro%th, are also ne!essary for gro%th and de$elop#ent of these neoplas#s. gain a startling indi!ation of the si#ilarity bet%een physiologi!al gro%th and neoplasial Con!erning lipotropi! substan!es, 9pellberg held that the ob5e!t of the treat#ent is to re#o$e the fat fro# the li$er and to reinstitute the nor#al hepati! histology and physiology. "ith the tre#endous a#ount of e<peri#ental %or* done on lipotropi! agents, and their effe!ti$eness in dietary fatty li$er in ani#als, it is only natural that !lini!ians should turn to these substan!es in the treat#ent of fatty li$erO ho%e$er, the only type of fatty li$er that !holine Sthe #ost i#portant of the lipotropi! substan!es8 !an !ure is the one due to !holine defi!ien!y. It is li*ely that at least so#e of the fatty li$ers in #an are due to !holine defi!ien!y, but in the fatty li$ers of prolonged infe!tion or those due to to<ins, no defi!ien!y of !holine in the diet !an be postulated, and therefore, no benefi!ial effe!t fro# !holine !an be e<pe!ted.&; "ith regard to diet, 9pellberg has said that the diet should be high in proteins of good +uality, su!h as #eat and fish. protein inta*e of 1)- g#. a day should be ai#ed at. The bul* of the !alories should be pro$ided by !arbohydrates and, therefore, 6uth 3oh#ar#, Pli. "o., 19C1, Ar. C9. 7; =it!hell . 9pellberg, Diseases of the iver, p. C-9. this should be !lose to C)- g#. a day. The dietary fat should be *ept to a #ini#u#. 9in!e a palatable natural diet high in protein !annot be de$ised fat free, at least 7- g#. of fat #ust be in!luded. I !annot see ho% one !an !ondone a high fat diet, espe!ially in the ease of fatty fi$er. "hat is the logi! of supplying #ore of the substan!e that %e are trying to re#o$e fro# the fi$erT "hen so#e of this e<ogenous fat rea!hes the li$er, it re+uires #ore lipotropi! substan!es and #a*es the ob5e!t of therapy #ore diffi!ult. The diet should be lo% in salt if there is e$iden!e of ede#a or as!ites.7,This is prin!ipally sy#pto#ati! but the diet is of great i#portan!e. It should !onsist entirely of #il* and sugar or other !arbohydrates. ni#al proteins should be redu!ed to a #ini#u#, as the li$er has lost to a great e<tent, if not entirely, its deto<i!ating fun!tion, Intestinal antisepsis by #eans of bis#uth, salol or !alo#el #ay be atte#pted but %ithout #u!h hope of su!!ess. The fluid inta*e #ust be #aintained at t%o liters or #ore a day. The $o#iting is best treated by gi$ing fluids half hourly in s#all +uantities but if persistent all foods by #outh should be stopped and intra$enous, re!tal or sub!utaneous ad#inistration of glu!ose saline substituted.., 74 7)
Ibid.

74

Lonathan Ca#bell =ea*ins, The Practice of Medicine, C. Q. =osby Co., 9t. 3ouis, 19;;, p. 7C1.

C-APT1R =II $evelopment of Liver Medication in Chronic $egenerative $iseases

T'E C3 99IC 3 nutrition %as de$eloped under the influen!e of the dis!o$eries of Lustus $. 3iebig 71:-C-1:7C8 and !ontinued by se$eral authors up to the ti#e of $. Aoorden, %ho regarded hu#an nutrition #ore or less as #aterial for o<idation and restoration. 2rior to $. Aoorden, the tas* of the physi!ian %as #ostly the organization of !alories a!!ording to the needs of the patient, to gi$e hi# strength and po%er to resist !hroni! degenerati$e diseases for a longer period of ti#e. In !ontrast to this #ore superfi!ial pro!edure, the #odern physi!ian has the tas* to adapt +uality and +uantity of nutrition to other fa!tors su!h as defi!ien!ies in #inerals, $ita#ins and hor#ones, sele!tion of spe!ial proteins, fats, et!. The +uantity of food is !onsidered in #ost !ases or adapted to the !hanging needs of the patients. The nutrition of the healthy hu#an being is no longer dee#ed basi! for any dietary regi#e, as $. 3iebig had regarded it. The #odern !on!ept of e<a#ining e$ery ite# of the diet by itself before sele!ting it for a spe!ial regi#e produ!ed only failures in #y e<perien!e. The #a5ority of nutrients are regarded as ,phar-#a*on, a!!ording to the do!trine of 'ippo!ratesO this #eans a #edi!ation pres!ribed for a spe!ial purpose in a spe!ial dosage. The dietary regi#e, therefore, does not atte#pt to !o#pose spe!ial Autritional prin!iples of general $alue. It e<a#ines and tests the effe!t of a properly dosaged diet on the rea!tion and !ourse of the disease. The fa!t that the li$er therapy brought about the restoration of ne% red blood !orpus!les 7reti!ulo!ytes8 #ade it a #edi!ation. It see#ed reasonable to assu#e that su!h a po%erful substan!e, ri!h in a!ti$ated enzy#es, %ould also ha$e si#ilar strong phar#a!ologi!al effe!ts on other degenerati$e diseases. /ur e<peri#ents sho%ed that patients %ho follo%ed a dietary-regi#e, ri!h in potassiu#, saltless, poor in protein and fatO. responded #u!h #ore strongly and positi$ely to different types and doses of li$er #edi!ation. /n that basis %e redu!ed the protein !ontent of the regi#e #ore and #ore and finally !a#e to the !on!lusion that %e should dis!ontinue all ani#al proteins in the beginning, as far as possible. "e studied the response to different doses of li$er #edi!ation and found the da#aging influen!e of ani#al proteins. "e found that additional s#all protein nutrients redu!ed urine se!retion and sodiu# eli#ination, e$en if the urine test sho%ed nor#al *idney fun!tion. "e also obser$ed that the deto<i!ation pro!ess %as retarded and the disappearan!e of allergi! har#ful rea!tions delayed. ?inally, %e felt that it #ay be possible to dra% !on!lusions\ fro# the effe!ts of the treat#ent on $isible pro!esses in s*in !an!ers to analogous rea!tions in the internal organs of the body. E<perien!es %ith diabeti! patients re$ealed that additional protein nutrients burden li$er and *idneys and #a*e in!reased doses of insulin ne!essary. The end produ!ts of the general protein #etabolis# %hi!h is urea nitrogen, and uri! a!id %hi!h is fro# the !ell #etabolis#, !ould be eli#inated in greater a#ounts the less ani#al proteins %ere ad#inistered. ?re+uent o!!urren!es of spas#s in the diaphrag#, the intestinal tra!t and e$en in the heart $essels pointed to o$ersti#ulation of the $is!eral ner$ous syste# by additional ani#al proteins under the !onditions of degenerati$e diseases. The nu!lei of li$er !ells !ontain a greater a#ount of nu!lei! a!ids %hi!h ha$e to be bro*en do%n to uri! a!id and purin bases. The fa$orable results obtained %ith a saltless diet and large doses of li$er therapy in the for# of ra% li$er, li$er in5e!tions, and best %ith liver FuiceC

e<!eeded by far the results seen by the appli!ation of the nor#al nutrition plus the usual li$er therapy. 2ra!ti!al e<perien!e taught us that in #alignan!ies it is ad$isable to apply i##ediately larger doses of liver FuiceC and in5e!-& tions %ith the !rudest li$er e<tra!t li*e 3illy Ao. C7- C!!. !o#bined %ith $ita#in G1( 1!! e+ual )- #!g. Qita#in G1( see#s to help the body #a*e the !orre!t use of a#ino a!ids, so that they %ill not be burned unne!essarily but used instead for !onstru!ti$e purposes. In !an!er, it is one of the essential pro!esses to restore the !onditions under %hi!h foodstuffs !an be used in the !orre!t #anner. In the last se$en to ten years %e treated a great nu#ber of patients, #ostly diffi!ult or ter#inal !ases, %ith relati$ely fa$orable results. The appli!ation of the li$er therapy in!reased the effe!t of the therapy to a !onsiderable degree. 9o#e indi!ations %here the therapy %as found fa$orable #ay be #entioned here. a8 Into<i!ation during pregnan!y. b8 Tuber!ulosis of the lungs and other organs. !8 rthritis defor#ans in #ore ad$an!ed stages. d8 =ental diseases and bodily asthenias. e8 9pasti! !onditions, espe!ially angina pe!toris. f8 =alignan!ies. It #ay be added that leu*e#ias and #yelo#as need greater doses of li$er 5ui!eJ and $ita#in G1( too. In #y opinion these t%o types do not really belong to the ,!an!ers, 7so !alled by E%ing8 as their #etabolis#s are #u!h ,deeper, and #ore differently deranged than %e see it in other !an!er types. In the !ase of all of these diseases, %e ha$e !ause to assu#e that !on!o#itant da#age to the li$er has o!!urred as a result of per#anent into<i!ation or fun!tional disorders of the neighboring organs 7dropped sto#a!h8 or by vagus9sympaticus disturban!es 7in allergies8. Casi#ir ?un* pointed to the !lose !onne!tion bet%een li$er dysfun!tion, digesti$e disturban!es and allergi! diseases #any years ago. In the beginning of the treat#ent so#e patients $o#it a great a#ount of bile and suffer fro# a *ind of to<i! diarrhea. They be!o#e e<!ited, franti! and %ant to dis!ontinue the treat#ent. These strong rea!tions are a!tually indi!ations of the beginning of i#pro$e#ent, %ith in!reased bile produ!tion, greater a!ti$ity of the li$er and eli#ination of to<ins and poisons. fter a period of one or t%o days, patients feel greatly relie$ed, sho% better !ir!ulation, !o#ple<ion and !olor, and ha$e #ore appetite. Then it %as found out that deto<i!ation !an be a!!elerated by the in!rease of !offee ene#as and additional !astor oil treat#ents 7!astor oil by #outh and !astor oil ene#as8, and these $iolent rea!tions no longer o!!urred.
9ee ppendi< III. page ;(1

"e see again the funda#ental i#portan!e of the li$er for re!o$eryO but %e should not forget that the fun!tion of the li$er depends upon the regulation of the $is!eral ner$ous syste#. Therefore, the dis!ontinuan!e of all sedati$es and #ost intensi$e eli#ination of to<ins and poisons are indispensable. that #eans li$er and pan!reas apparatus ta*en as a %hole and the $is!eral ner$ous syste# #ust be able to fun!tion freely. 3i$er !an be ta*en as nourish#ent e$en by those allergi!O patients %ho are highly hypersensiti$e to ani#al proteinsO as therapy, ho%e$er, li$er nutrition is not suffi!ient, but #ust be supported by a #ore spe!ifi! li$er therapy. "here stronger li$er sti#ulation appears ne!essary, as in !ases of serious into<i!ation and degenerati$e diseases, e<tensi$e li$er in5e!tions and li$er 5ui!eJ therapy are ne!essary. The !o#bination of li$er therapy and diet %as ne!essary in serious !ases of osteoarthritis, asth#a angina pe!toris and #alignan!ies. The !o#bination of a saltless diet, poor in fat and proteins, %ith the li$er therapy, regularly lo%ers the blood sugar !onsiderably, so that the diet in!reased the effe!t of the li$er enzy#es, in!reased the effe!t of insulin, and de!reased the adrenalin effe!t to a great e<tent. !!ording to Ernst 3eupold, the

lo%ering of the blood sugar le$el is of great signifi!an!e in !an!er patients, and the de!rease of the adrenalin effe!t is regarded so i#portant, that in the last de!ade e$en both adrenals %ere re#o$ed by operation, %hi!h is too radi!al and pre$ents the restoration., The !on!lusion of >r. Ed%ard '. 6ay %as that ,the benefits of the adrenale!to#y are so #eager and of su!h short duration that further use of this pro!edure should be dis!ouraged 7: , fter oophore!to#y the adrenal glands are the #ost signifi !ant sour!e of estrogens. 9e$entynine patients %ith ad$an!ed #etastati! breast !ar!ino#a under%ent bilateral oophore!to#y and adrenale!to#y as a !o#bination treat#ent-prophyla<is te!h ni+ue. There %as no ob5e!ti$e i#pro$e#ent in C:.7 per !ent of the patients and sub5e!ti$e i#pro$e#ent in )7.C per !ent. Indi!ations for this type of surgi!al #anage#ent in!lude ob5e!ti$e 77 Prof" 1rnst Leupold" Die Bedeutung dss Blutchemismus zur Tumor ildung und Tumor ! au 3Significance of Blood Chemistry0 in Tumor Production and Tumor A&sorption" !eorg Thie#e Qerlag. 9tuutgart, 19);. 7: ,Endo!rine Thcrapy of 2rostati! Car!ino#a" fro# The. Bournal of the !"!, March 9+0'()>" p# '88,#

de#onstration of disse#inated #etastases. Laundi!e fro# e<tensi$e #etastases has been !onsidered the only !ontraindi!ation as far as the lo!ation of the #etastati! lesions is !on!erned.,79 9@== 6F s a %hole, the li$er therapy #ay be loo*ed upon as a *ind of hor#one-enzy#e therapy, but in a $ery #ild dosage and natural #anner. It %as found helpful in returning gly!ogen, P-group #inerals and $ita#ins to the li$er and other tissues and finally in preparing the !onditions for the fun!tion of the o<idizing enzy#es.
Reported &y Maurice !alante" M#$# and others" :Adrenalectomy for Metastatic Breast Carcinoma": The #ournal of the !"!, March 9+" '()>" p# '8''#
>(

C-APT1R =III Scientists Term Radiation A Peril to ?uture of Man<

#umulative %ffect 9'/CP A> surprise %ere e<pressed by the !o##ittee on geneti!s in its finding that the #eri!an publi! %as using up about one third of the safety li#it in #edi!al and dental N-rays. Its #e#bers !alled on the #edi!al profession to redu!e the use of N-rays to the lo%est li#it !onsistent %ith #edi!al ne!essity. This !o##ittee also urged a national syste# of personal re!ords %hereby e$ery #eri!an %ould *no% his total a#ount of e<posure. The effe!t of radiation is !u#ulati$e, it is said, no #atter ho% long the period o$er %hi!h it is e<perien!ed. The si< !o##ittees studied the radiation proble# in the fields of geneti!s, pathology, #eteorology, o!eanography and fisheries, agri!ulture and food supplies, and disposal and dispersal of radioa!ti$e %astes. . . . 2athologi!al effe!ts. >r. 9hields "arren, Chair#anR6e!o##endations %ill be #ade in the future. The !o##ittee !on!luded in agree#ent %ith geneti!ists that radiation, no #atter ho% s#all the dose, shortens life in so#e degree. . . . >r. "ea$er&s geneti!s !o##ittee re!o##ended as a general population safety li#it that e<posure to radiation should be held do%n to 1- roentgens for the first C- years of a person&s life. roentgen is a unit for #easuring the har#ful ga##a ray fro# =edi!al and dental N-ray e+uip#ent, nu!lear %eapons e<plosions and fro# natural !auses li*e !os#i! rays and natural radiu#.
J nthony 3e$iero, "ew =ork Times, Lune 1C, 19)4. 9ur$ey of a report held in the Aational of 9!ien!es, "ashington, >. C. on the ,Giologi!al Effe!ts of to#i! 6adiation., !ade#y

s a result of #edi!al N-rays it is esti#ated that ea!h person in this !ountry re!ei$es on the a$erage a total a!!u#ulated dose to the gonads or se< glands about three roentgens in C- years. ,/f !ourse, so#e persons get none at allO others #ay get a good deal. .. ., >r. "ea$er de!lared it %as ,stupid geneti!ally, to use N-ray for the fitting of shoes. 'e %as referring to the N-ray de$i!es that ha$e be!o#e !o##on in shoe stores and into %hi!h !hildren often stare in a%e, so#eti#es %ithout regard to ti#e at the shado%s of the bones of their feet. >r. "ea$er also !onde#ned obstetri!ians %ho #a*e N-ray pi!tures of pregnant #others to sho% the# ho% ,beautifully for#ed, is the s*eleton of their baby %ithout realizing the ,hazards, of the dose of three or four roentgens that is being ad#inistered. In addition to si< long su##ary reports of the !o##ittees, the s!ientists also issued ,a report to the publi!, in the si#plest lan guage possible. 'ere the lay#an #ay read ho% radiation da#age ine$itably results fro# e<posure, no #atter ho% s#all the dose. 6adiation !auses #utation or har#ful !hanges in the genes or ger# !ells of the reprodu!ti$e organs. >a#age #anifests itself in shortening of the life span, redu!es ability to produ!e !hildren, and so#eti#es, but not often, produ!es defor#ed or frea*ish !hildren. E$en if the #utations is in one gene, there is so#e har#ful effe!t that #utation %ill go on through e$ery generation until the line that bears it be!o#es e<tin!t. The report e<plained ho% ,e$ery !ell of a person&s body !ontains a great !olle!tion, passed do%n fro# the parents, the parents& parents, and so on ba!*, of di$erse heredity units !alled genes., The lay#an&s report %ent on to e<plain. ,?ro# the point of $ie% of the total and e$entual da#age to the entire population, e$ery #utation !auses roughly the sa#e a#ount of har#. This is be!ause #utant genes !an only

disappear %hen the inheritan!e line in %hi!h they are !arried dies out. In !ases of se$ere and ob$ious da#age this #ay happen in the first generationO in other !ases it #ay re+uire hundreds of generations. ,Thus, for the general population, and in the long run, a little radiation to a lot of people is as har#ful as a lot of radiation to a fe%, sin!e the total nu#ber of #utant genes !an be the sa#e in the t%o !ases., Gut da#age to future generations due to radiation %ill be diffi!ult to identify. The study of geneti!s da#age has only 5ust begun, %ith a report due on geneti! effe!ts obser$ed in the populations of 'iroshi#a and Aagasa*i, the Lapanese !ities destroyed by #eri!an ato# bo#bs in "orld "ar II. . . . The !o##ittee said the radiologists ,#ay %ell re!ei$e doses in the !ourse of their o!!upation ranging fro# $ery slight to about 1,--- roentgens., In fi<ing a ,reasonably safety, li#it of 1- roentgens, the "ea$er panel !o##ented, ,not har#less, #ind you, but reasonable., /f this safety li#it, the panel said, ,%e are no% using on the a$erage so#e three or four roentgens for #edi!al N-rays., ,This is roughly the sa#e as the una$oidable dose re!ei$ed fro# ba!*ground radiation,, the "ea$er panel added. ,It is really $ery surprising and disturbing to realize that this figure is so large, and !learly it is prudent to e<a#ine this situation !arefully. It is folly to in!ur any N-ray e<posure to the gonads %hi!h !an be a$oided %ithout i#pairing #edi!al ser$i!e or progress., "hile there e<ists no %ay of #easuring a dose of radiation sustained by se< organs, the "ea$er !o##ittee said that unless shielding %as used so#e part of e$ery dental or #edi!al Nray rea!hed these organs. They said a dental N-ray %ould deli$er about -.--) roentgen to the gonads, and a general fluoros!opi! e<a#ination t%o or #ore roentgens. In the last 1- years s!ien!e has introdu!ed into the !an!er therapy isotopesO radioa!ti$e iodine, !obalt, phosphorus, strontiu#, as %ell as proteins and hor#ones. In the beginning there %as a lot of opti#is# about the ne% #ethods, but a great disillusion soon follo%ed. 7End of report.8 =y o%n e<perien!es sho% that the #a5ority of patients %ho had ;- to :- deep N-ray treat#ents and, in addition, 14 to ;- !obalt treat#ents !ould not re!o$er at all. 9o#e i#pro$ed after a #u!h longer period and others only partially, The follo%ing appeared in an arti!le on radiation in the "ew =ork Times on Luly (1, 19)7.

Safety limit is set

s a safety li#it, the Aational !ade#y of 9!ien!es has re!o##ended, that the a$erage person re!ei$e not #ore than ten roentgens of #an-#ade radiation to the reprodu!ti$e organs fro# !on!eption to the age of C-. The roentgen is a unit of #easure#ent of radiation dose. The report also lends ne% support to the repeated %arnings of ato#i! offi!ials and s!ientists that #an fa!es a far greater danger fro# #edi!al use of radiation than he does fro# the radio-a!ti$e fall-out fro# ato#i! testings. si#ilar %arning !a#e last #onth fro# >r. 3eroy E. Gurney, 9urgeon General of the @nited 9tates 2ubli! 'ealth 9er$i!e, %ho said that in $ie% of the in!reasing sour!es of radiation in the nu!lear age, the ti#e had !o#e to reassess the safe le$els of radiation fro# #edi!al treat#ent. In re!ent years there has been an in!reasing a%areness in the #edi!al profession of the potential danger of radiation fro# N-ray treat#ents, and steps ha$e been instituted to li#it the radiation dose. 1STIMAT1 S112 -I!The report states that the esti#ate is probably a!!urate to %ithin a fa!tor or t%o. In other %ords, the thirty-year dose to the gonads !ould be as lo% as t%o 6oentgens and as high as eight 6oentgens. The belief a#ong so#e radiation e<perts is that, if anything, the esti#ate is on the high side.

Ge!ause of the ine$itable un!ertainty of statisti!al analyses of li#ited data, s!ientists are re!o##ending that a population sa#pling progra# be underta*en to deter#ine #ore e<a!tly ho% #u!h N-ray radiation is re!ei$ed by the a$erage person. 9u!h sa#pling progra# is to he re!o##ended to the @nited Aations 9!ientifi! Co##ittee on the Effe!ts of to#i! 6adiation by the International Co##issions on 6adiologi!al 2rote!tion and 6adiologi!al @nits and =easure#ents.

C-APT1R =I. Mineral Meta&olism in $egenerative $iseases

T'E GEAE6 3 approa!h to the treat#ent of patients %ith degenerati$e diseases should ha$e as its purpose the o$er!o#ing of the bio!he#i!al abnor#alities %hi!h are #ore or less responsible for the de$elop#ent of the disease. I a# !on$in!ed that the proble# of !hroni! diseases is not one of bio!he#istry, !he#istry or the sy#pto#s %e obser$e in and on the body. 6ather, it is produ!ed by deeper-lying for!es %hi!h !ause ,defi!ien!y of energies., 2hysi!ians obser$e biologi!al sy#pto#s and %or* only %ith the#. The real a!ting for!es behind the $isible !he#i!al !hanges are physi!al energies, e<pressed by Einstein as the ,ele!tro-#agneti! field., To a !ertain degree, this is !losely !onne!ted %ith the ele!tri!al potentials %hi!h are lo%ered in !an!er, a!!ording to al#ost all in$estigators 7about C-8 and also a!!ording to the obser$ations of >r. 6udolf Peller. The abo$e-#entioned bio!he#i!al sy#pto#s are e<pressed in 'astings& ,Ter#inology, as ,intra-!ellular, or ,P-group #inerals in essential organs, and the ,e<tra-!ellular, or ,Aa-group #inerals in the fluids., 3aboratory findings re$eal that in !hroni! diseases, sodiu# and !al!iu#, both negati$ely !harged, in$ade the %ea*er positi$ely !harged organsO a!!ordingly, P is lost fro# these organs, opening the door to further negati$e #etaboli! transfor#ations. !ere the disease starts, but not the symptoms. It is #y opinion that P and Aa also play an i#portant role in the !an!er proble#. These t%o #inerals are the leaders of the t%o ele!tri!ally opposite groups. They are in !lose !onne!tion %ith the de$elop#ent and #aintenan!e of the hu#an body as %ell as %ith the origin and progress of the disease. The hu#an organis# is, in e#bryoni! life and early infan!y, a sodiu#ani#al, due to the relati$e preponderan!e of Aa throughout the entire organis#, but, in adult life, a potassiu#-ani#al. The potassiu# predo#inan!e #ust be #aintained throughout life. To a !ertain degree it gi$es the basis for i#portant de$elop#ents in both dire!tionsRnonnal and abnor#al. In this respe!t, the a#ount ofO #inerals is ne!essary but the degree of their ionization is e+ually i#portant, parti!ularly in !an!er. "e *no% no% that %hat %e ha$e inherited is not a set of !he#i!al substan!es, but a ,pattern of dyna#i! energies,, %hi!h dire!tly distribute and ionize the #inerals, hor#ones and enzy#es, et!., for har#oni! !ooperation %ithin li$ing !ells and tissues, %here they belong and in %hi!h %ay they ha$e to a!t and influen!e the gro%ing tissue. 9een fro# this point of $ie%, the !he#i!al fa!ts as they appear in the laboratory findings ha$e the follo%ing line in our de$elop#ent. The unfertilized hu#an egg !ell is 1E1- ## in size, full of P-group or intra!ellular #inerals 7P, 2, =g, =n, Cu, ?e, u8, ele!tro-positi$e and has the !orresponding enzy#es, $ita#ins and protein-!o#pounds, but the %hole is ina!ti$e, %aits and longs for ani#ation. The sper#, %hi!h is 1E(-- ## in size, !ontains the Aa-group #inerals ana is ele!tro-negati$e 7Aa, CI. ' (/, I, Gr. l and the ionized part of Ca8, together %ith the other group of enzy#es and $ita#ins, but is a!ti$e and brings on enli$en#ent. The fertilized egg be!o#es, through a pro!ess of dis!harging so#e !o#positions and absorbing a great deal of Aa fro# the surrounding ly#ph fluid, distin!tly negati$ely !hargedO a ,Aa-ani#ai, is !reated and re#ains one throughout the entire pregnan!y and up to si< #onths after birth 7?ran* Golland8. The tables on pp. (), (4, (7 of

Chapter C illustrate the different stages of de$elop#ent by ta*ing the AaEP ratio as a guide. In studying these figures, %hi!h are based on laboratory findings, one has to a!!ept the strange fa!t that these Aa-ri!h e#bryonal !ells ha$e, a!!ording to 9pe#an, ,organisator, po%er, %hi!h !arry in the#sel$es the dyna#i! patterns of the ,prefor#ed future ani#al. The #onths of pregnan!y and si< #onths of e<trauterine life 7?ran* Golland8 are only a ,transitional stage, of a li$ing being, %hi!h !ontinues to pass o$er into nor#al life %ith an e<!ess of P-group #inerals in $ital organs, until disease or old age #a*es it lose so#e of the P-#inerals, together %ith the !orresponding enzy#e-fun!tions, et!. Ea!h !ell !arries in itself so#e potentialities of a nor#al li$ing !ell under nor#al internal and e<ternal en$iron#ental !onditions, or else they fall ba!* to their original e#bryoni! state. 6. 6. 9pen!er and other in$estigators, %ith *een foresight, !o#pare !an!er !ells not to the !ells of old age but, rather, to e#bryoni! ones. /ne i#portant differen!e, ho%e$er, is that !an!er !ells are not supplied %ith ner$es and therefore la!* ner$ous regulation. The e<peri#ents of 3oh#ann re$ealed that #agnesiu# and #anganese, both #inerals of the P-group, inhibit the 2asteur effe!t there. In The 4iochemistry of Malignant Tumors, the 2asteur effe!t is des!ribed as follo%s. ,The in!reased !on$ersion of #ethylgly-o<al to la!ti! a!id %hi!h thus #ay be indu!ed by the a!ti$ated enzy#e %as belie$ed to be responsible for the a!!u#ulation of la!ti! a!id in neoplas#, and the rapid disappearan!e of #ethyl-glyo<al %as thought to interfere %ith the re-synthesis of this !o#pound to he<ose.,:Inas#u!h as our #ineral #etabolis# is dependent upon the food produ!ed by the soil, I %ould li*e to refer to an introdu!tion to this sub5e!t by Charles E. Pellogg. ,The soil is the li$ing #atter at the surfa!e, and of the #ineral #atter beneath the surfa!e, and of the at#osphere abo$e and the solid ro!* beneathRessentially all li$ing #atter depends upon it, dire!tly or indire!tly, is, in fa!t, a part of those $ery pro!esses that produ!e the soil upon %hi!h life depends. ,2lants and soils ha$e gro%n up together, ea!h partly a !ause of the otherR#an has so#e%hat the sa#e relationship to the soils. 'e #ay !hange the#, either for better or for %orse.,:1 $%&O'!L("I! The leading #ineral of the negati$e group, potassiu#, plays an i#portant role in !lini!al sy#pto#atology, for e<a#ple, in The Bournal of the $M$, %e find the follo%ing su##ary. :( It is *no%n that P-defi!ien!y #ay o!!ur %hen the
::1 :(

Purt 9tern and 6obert "iLlhei#, The 4iochemistry of Malignant Tumors, Charles E. Pellogg, The 9oils That 'upport 6s, The =a!#illian Co., 19)4. 9ee The Bournal of the $merican Medical $ssociation, 1;C, 19)-. p. ;C(.

718 food sho%s di#inished !ontent of this #ineral. 718 in !ases of $o#iting, !aused by #any reasons, also by ob stru!tion in !an!er. 7(8 in leu*e#ia, as leu*o!ytes attra!t large a#ounts of P. 7C8 in e<!essi$e diureses. 7(8 adreno-!orti!al hor#one fa$ors re-absorption of Aa and loss of P. If this hor#one is o$er-a!ti$e, the !onse+uen!e is e<!es--si$e loss of P. !=P%&@$ %M<$ 718 usually does not o!!ur as a result of oral ad#inistration as long as the *idneys are inta!t. 7(8 in !an!er, in ad$an!ed !ases, one finds hyper*ale#ia not too rarely, !aused by loss of P fro# tissuesRnow e<tra!ellular in the seru#, on the way to elimination. 7C8 in so#e !ases of renal insuffi!ien!y, also in depression, in dehydration and in so#e for#s of nephritis. Gased on other arti!les and #y o%n e<perien!e, I %ould li*e to gi$e the follo%ing su##ary of hypo*ale#ia and hyper*ale#ia.

'F2/P 3E=I 718 7(8 7C8 diabetesR#ore during insulin therapy. intra$enous glu!ose and other in5e!tions, %hen free of P. Cushing&s syndro#e, Glau!o#a 2aralysis agitans ?re+uently in !hroni! arthritis, !hroni! sinusitis and other !hroni! diseases. follo%ing ad#inistration of Cortisone 7 drenal !orte<8 undernourished patient, also fasting loss of P in $o#iting, diarrhea, gastri! su!tion. fa#iliar periodi! paralysis. !an!erR#ostly in #ediu# or far ad$an!ed !ases.

7;8 7)8 748 778 7:8

!=P%&@$ %M<$ 718 loss of fluidsRblood, in #a5ority of !ases dehydration. 7(8 epilepsyR#ost !ases. 7C8 !an!er patients #ore often in the period before they go o$er to the ter#inal stage 7on the %ay to eli#ination8. 7;8 ne$er in !an!er patients during restoration ti#e. 7)8 ddison&s disease. 748 anuriaRure#ia 7inability of fi$er and *idneys to e<!rete e<!ess potassiu# in solutionR lost fro# essential organs8 778 a!ute and !hroni! asth#a, and other degenerati$e allergies 7also !raurosis $ul$ae8. The !ontent of potassiu# in the seru# is, in #any !ases, #isleading. The latest arti!le of Gu#ell and 9!ribner also tends in this dire!tion but starts to dra% attention to the obser$ation that ,!hanges in the seru# potassiu# !on!entration refle!t !hanges in body need.,:C =y e<perien!es are #ostly li#ited to !an!er !ases. The !ur$es of these patients o$er years are $ery diffi!ult to e$aluate. 7Aot one e<a#ination, but the !ur$e de!ides.8 9ingle e<a#inations !an not be regarded as ,an e<!ellent guide to the potassiu# need of patients,Ras the abo$e-#entioned authors say. It does not gi$e any definite indi!ation of an in!reasing or de!reasing a#ount of potassiu# present in the tissues of essential organs. There are only a fe% e<a#inations #ade in seru# and tissues at the sa#e ti#e. =ore !oin!ident e<a#inations of P #ade at the sa#e ti#e in seru# and tissues and in different stages of the disease, are ne!essary for su!h de!isions. 2otassiu# appears to play an indispensable and uni+ue role in tissue protein synthesis, although the #e!hanis# of its utilization is at present un*no%n. 2otassiu# ions are indispensable in !ertain enzy#ati! rea!tions, and this #ay be a further reason for its urgent need. It appears that the hea$y isotope @,* is definitely lo%er in tu#ors, as %ell as in tissues of tu#orbearing ani#als., =us!les, brain and li$er nor#ally ha$e a #u!h higher potassiu# !ontent than a sodiu# !ontent. It !an be a!!epted as a
:C

9ee The Bournal of the $merican Medical $ssociation, Qol. 14;, Ao. 9, Lune (9, 19)7, p. 9)9. JJ-9ee , 3asnitz*i and 9. P. Gre%er, #ancer &esearch, (.;9;,19;(.

general rule that as long as potassiu# is nor#ally in the #a5ority, sodiu# is in the #inority. si#ilar relationship e<ists bet%een #agnesiu# and !al!iu#, so that %here #agnesiu# is in!reased, !al!iu# is di#inished. Purt 9tern and 6obert "illhei# %rote that , tu#or pro#oting property of potassiu# salts ad#inistered perorally or parenterally has been #ade $ery probable. The i#peding a!tion of !al!iu# salts is #u!h #ore proble#ati! and the alleged anti-plasti! +uality of #agnesiu# #ust be regarded as %holly unfounded.,:) In the older literature, !ontro$ersial opinions %ere

e<pressed regarding one of the #ost i#portant #ineral !onstituents of food, sodiu# !hloride. 9o#e authors suspe!ted this salt as the #ost sti#ulating neoplasti! gro%th agent and a!!ordingly, re!o##ended its restri!tion in the !an!er diet. :4 /ther !lini!al obser$ations indi!ated that regi#es e<tre#ely poor in salt, su!h as ha$e been used for dietary treat#ent of tuber!ulosis,:7 e<ert a ,rather unfa$orable influen!e on hu#an neoplasia.,:: The effe!ts of sodiu# !hloride on tu#ors %ere studied in a nu#ber of ani#al e<peri#ents %hi!h %ere not !on!lusi$e. "hether !an!er %as sti#ulated by al*alosis or %as hindered by a!id for#ation has been long disputed. ?inally, 6agnar Gerg strongly re5e!ted the $ie%point that diets produ!ing al*alosis !ould be responsible for !an!er de$elop#ent,:9 In e$aluating #ost of these studies, one finds that all these atte#pts to !hange the hydrogen ion !on!entration in blood and tissues by spe!ial dietary !o#binations en!ounter great diffi!ulties, sin!e e$ery author used so#e other food for that purpose. 9o#e of the authors used thy#us, an organ ri!h in protein and nu!lei! a!ids, but $ery poor in #ineralsO others used *idneys, li$ers and e<tra!ts prepared fro# different organs. !!ording to the !lini!al obser$ation that the in!iden!e of #alignant tu#ors in the duodenu# and s#all intestines are e<tre#ely rare, they used for their e<peri#ents
Purt 9tern and 6obert "illhei#, The 4iochemistry of Malignant Tumors, p. ;1-. . 3orandO 7irst <nternational #ancer #ongress, =adrid, (.;:, 19CC. :7 >r. =a< Gerson, Dietary Therapy of ung Tuberculosis, 19C;. :: ?. Glu#enthal, ?irst <nternational #ancer #ongress, =adrid 1.79C, 19CC, E'esse, Deutsche Medi:inische ;ochenschrift, 41.797, 19C). :9 9ee ?eitschrift fuer Aolksernaehrung, 9.(77, 19C;.
:4 :)

these organs in ani#als bearing transplanted tu#ors and in others to pre$ent any gro%th. Glu#enthal and La!obs used a spe!ial e<tra!t of s#all intestines %ithout #u!h of a fa$orable result.9- slightly #ore fa$orable result %as obtained by the feeding of the brain or e<tra!ts of this organ. These obser$ations, #ade by . '. 6offo, '. Qassiliades and C. 6ouss$ during 19C)19C7 are e<tre#ely interesting sin!e the substan!e of these organs are ri!h in lipids %hi!h ha$e generally been found to sti#ulate tu#or gro%th. ,The de$elop#ent of tar !an!er in #i!e %as found enhan!ed by the feeding of li$er or pan!reas to the ani#als,, 91 and the tu#or-sti#ulating effe!t of li$er feeding %as !onfir#ed in nu#erous studies of $arious tu#or-bearing ani#als. n entirely different effe!t of li$er feeding %as obser$ed by the produ!tion of li$er tu#ors in rats by feeding butter yello%. This type of !ar!inogenesis !ould be pre$ented by a li$er diet. It is interesting that feeding of li$er !ould only pre$ent !ar!inogeni! de$elop#ent of butter yello%, but it !ould not pre$ent the tu#or produ!tion by benzpyrene or #ethyl!holanthrene. The !ause of these influen!es, %hi!h differ in $arious for#s of neoplas#s, %as not gi$en. Purt 9tern tentati$ely assu#ed that the effe!ti$e un*no%n fa!tors #ay be of an enzy#ati! nature and that $ita#ins and ,these hypotheti!al agents #ay interfere %ith tu#or de$elop#ent and tu#or gro%th $ia #etaboli! #e!hanis#s., I ha$e e<pressed a si#ilar opinion in se$eral arti!les, and in this boo* e<plained the use of fresh !alf s li$er 5ui!eJ in !an!er therapy. These !ontro$ersial obser$ations and des!riptions are !hosen to de#onstrate ho% !ontro$ersial the biologi!al literature in !an!er is. ?or ea!h positi$e effe!t one !an find a negati$e one. Generalizations in !an!er are #ost diffi!ult to for#ulate. In #y opinion, the area %herein they #ay be possible %ill be in the biologi!al field of ele!tri!al potentials, ionization of #inerals and rea!ti$ation of enzy#es. Greenstein has stated that ,In tu#ors in rats, #i!e or #an, the !atalyti! syste#s in$ol$ed in aerobi! o<idations are !onsiderably redu!ed as !o#pared %ith nor#a0 tissues and, indeed, in ea!h spe!ies, are redu!ed to nearly the sa#e e<tent. high rate of gly!olysis, an in!reased %ater !ontent, and a lo% a!ti$ity of9- 9ee ?eitschrift fuer @rebsfbrchung, ".);), 19CC. :1 . ?
"atson, $merican Bournal of #ancer, 19.C:9, 19CC. 9ee ppendi< III. page ;(1

!yto!hro#e are a#ong the !hara!teristi!s of pra!ti!ally all tu#ors in all spe!ies studied. Aearly all rapidly gro%ing tu#ors in #i!e. and rats produ!e identi!al syste#i! effe!ts in the host ani#als, as

sho%n by the #ar*ed redu!tion in li$er !atalase a!ti$ity., 9( Can!er is the #ost $ariable disease %e ha$e for %hi!h there are thousands of different na#es. The beginning !an be #ost a!ute or $ery !hroni!, the !ourse tedious or rapid, the !o#pli!ations innu#erable, and it !an be !o#bined %ith #any different defi!ien!ies, %ith high or lo% blood pressure, %ith diabetes, arterios!lerosis and other diseases of old age. t the end, the into<i!a-tion in!reases and the li$er deteriorates. =ost of our life is built upon the a!ti$ation and #aintenan!e of the li$ing pro!esses. These are based on the #ineral #etabolis# and fun!tion of the li$erR%hi!h a!ts li*e !hlorophyll in plantsRa!!epting ions front the sun and transfor#ing the# as ,life begets life., "hat Aature does in that %onderful, subtle for# by transfor#ations and !o#binations %ith these ions we !annot i#itate biologi!ally. Therefore, it see#s to #e ad$isable not to attack the cancer directly %ith N-6ays, radiu# or !obalt and da#age at the sa#e ti#e the other parts of the body and its healing po%er. The #ore the %hole body is deto<ified, replenished and a!ti$ated, the #ore the !an!er is doo#ed. The rare in!iden!e of #alignant tu#ors in !ountries %here garli! is used in greater a#ounts 7southern Italy, Gree!e, =ontenegro, Fugosla$ia8 !annot be e<plained. I ha$e seen t%o !an!ers of the breast disappear %ith the use of ?enugree* seeds tea in large a#ounts, !o#bined %ith a saltless $egetarian diet. T%o others %ere !ured after the patients dran* green leaf 5ui!e only for si< to eight #onths. The transfor#ation of the #inerals in the body and bringing the# in suffi!ient nu#bers into the organs, %here they belong, is a $ery diffi!ult and !o#ple< tas*. spe!ial relationship e<ists bet%een sodiu#, !hloride, and a#ino a!ids, %hi!h see# to parallel the a#ount of ede#a in the body. /n the other hand, potassiu# belongs to a group %hi!h is asso!iated %ith phosphori! a!ids and !arbohydrates and is able to !o#bine %ith these !ol loids. It is, therefore, #ore reasonable to spea* of the potassiu# group and the sodiu# group as 6udolf Peller does.
9(

Lesse Greenstein, 4iochemistry of #ancer, p. ):9, 19);.

The effe!t of the diet is that the potassiu# group is enri!hed in the essential organs and the abnor#al sodiu# !ontent in these organs redu!ed to a #ini#u# and eli#inated into the e<tra!ellular fluids, %here they belong. The e<tra!ellular fluids %hi!h !o#prise the blood plas#a, the tissue or interstitial fluid, ly#ph and fluid in serous !a$ities, a#ount to about (- per !ent of the body %eight. The plas#a %ater !onstitutes only about four and one-half per !ent of the body %eight. The fluids %ithin the !ells a#ount to )- per !ent of the %eight of the body, or t%o and one-half ti#es the e<tra!ellular fluids. The s*eletal #us!les !ontain about )- per !ent, the s*in about (- per !ent, and the %hole blood only about 1- per !ent of the total body %ater. In general, the intra!ellular fluids ha$e a high potassiu# !ontent and a lo% !on!entration of sodiu#, %hereas the e<tra!ellular fluids ha$e large a#ounts of sodiu# and s#all a#ounts of potassiu#. The %ater !ontent of $arious tissues in a$erage per!entage is ta*en fro# a table.9C

The higher sodiu# !hloride !ontent in the urine of !an!er patients during the first %ee*s of the saltless treat#ent pro$es that sodiu# !hloride and %ater are retained in !an!er patients. The #a5ority of the patients did not sho% any type of definite ede#a on the s*in. fe% of the# %ere e$en undernourished, see#ingly dried out and e#a!iated, but still eli#inated $ery large +uantities of sodiu# !hloride in their urine, espe!ially at first. The retention %as probably in the internal organs.
9: Gest and Taylor, The Physlological 4ash of Medical Practice, "illia#s and "il*ins Co., Galti#ore, 19)-, p, 19.

If %e !onte#plate the #ineral #etabolis# as the basis for the !onstru!tion of !ells, %e ha$e to loo* into an in$isible #ineral !ir!ulation %ith a great storage po%er of the #inerals of the potassiu# group and gly!ogen in the li$er and e+ually for iodine and the #inerals of the sodiu# group in the thyroid gland. If these #ineral groups are partly displa!ed as %e see in #ost a!ute as %ell as !hroni! diseases, %e find si#ultaneously lo%er ele!tri!al potentials in the tissues and seru#. Conse+uently, the storage po%er is s#aller and the flo% from, the storage #agazines is greater as the !ells lose their nor#al attra!tion po%er %ith the lo%ered potentials. This s#aller attra!tion po%er results in redu!ed storage of gly!ogen in li$er and #us!les and also in fe%er #inerals of the potassiu# group, %hile in the thyroid, the s*in and other #ainly negati$e tissues, the iodine and e<tra!ellular ele#ents, sho% defi!ien!ies or displa!e#ents. The i#portan!e of potassiu#, iodine and blood sugar leads the physi!ians #ore and #ore to pursue these tests in al#ost all patients, as they gi$e us $aluable infor#ation not only about these #entioned substan!es but also about #any other !lini!al pro!esses. To ha$e a better insight into the !lini!al pro!esses of our patients, it is not suffi!ient to e<a#ine single substan!es, sin!e %e learn that a single substan!e does not tra$el alone fro# the blood to the tissue !ells or in$ersely. To !onfir# this, one #ay stain a !ell %ith #any dyesO one single #i!ros!opi! !ell or part of it %ill not a!!ept the stain of one dye only. Gehind the #etabolis# of #inerals and #atter there is a po%er of energy, an ele!trostati! and an ele!trodyna#i! one, and probably se$eral other energies, %hi!h are the sti#ulating po%ers for all #o$e#ents of #atter. /ne should not thin* of #atter in +uantities or +ualities only but also should ta*e into a!!ount the +uantities of energies %hi!h radiate fro# ionized #inerals, and should sti#ulate and *eep all i#portant and $ital fun!tions of the !ells a!ti$e. s '. Paunitz and G. 9!hober ha$e sho%n, the ele!tri!al potentials of li$er and #us!les %ent do%n by C- #illi$olt or #ore after they in5e!ted diphtheria to<in or other poisons into the blood strea# of a rabbit. fter a fe% #inutes one !ould obser$e %ith a #i!ros!ope that so#e poisons entered the paren!hy#a !ells %hi!h %ere repelled beforehand by the sa#e !ells. fter one-half hour a +uantity of sodiu# appeared in the li$er paren!hy#a. This e<peri#ent, #ade in 19C4, !learly sho%s that 18 into<i!ation is the first effe!t, %hi!h is follo%ed by (8 loss of ele!tri!al potentials and C8 loss of potassiu# #inerals. This test de#onstrates also the !entral position of the li$er in all these pro!esses. ?or !enturies it %as assu#ed by good !lini!ians that !hanges in the li$er %ere the beginning of al#ost all diseases. s the li$er gradually loses a part of its ele!trostati! #aintenan!e po%er for reser$es, it !annot support the entire body nor#ally any longer fro# its reser$es of gly!ogen, #any #inerals, $ita#ins and enzy#es, espe!ially during the night, but !an store the# during the dayti#e. P. '. Gauer %rote. , great progress in the proble# of !an!er de$elop#ent is the re!ognition that it belongs to the general biology. The !ells in$ol$ed are !hanged into a different life e<isten!e. The fa!t that all *inds of tu#ors !an be present in all

li$ing organis#s is the !onfir#ation of those findings. . . . "ithin all li$ing beings the !apa!ity e<ists to fall si!* %ith !an!er, %hi!h is a property of all tissues and organs.,9; To bring the syste# to nor#al or near to nor#al for healing purposes, it needs ani#ating energies besides the pure substan!es %ithout %hi!h it is unable to a!t, !ooperate and fulfill duties for #etabolis# and distribution. It is i#possible to li$e %ithout the energies %hi!h are #o$ing all substan!es all o$er the body and are supporting all !ells. The atte#pts of old and ne% #edi!al authors to abandon the #ost spe!ifi! #ethods or the sy#pto#ati! treat#ents and to rely upon and to stress the ,!on!eption of totality, ha$e #any ad$antages. 2utting the positi$e !enter of the li$er and the negati$e !enter of the thyroid #ore in the foreground is ne!essary for this therapy. There are so#e parti!ular details in the #ineral #etabolis# %hi!h !hara!terize the ne% treat#ent. ?irst, there is the artifi!ial nia!in besides the i#portant potassiu#. Aia!in sho%ed $ery good !linii!al results %hen ad#inistered in large doses, si< to eight ti#es
9;

P. '. Gauer, Das @rebsproblem, p, 471.

)- #g. a day 7it is the so-!alled pellagra pre$enti$e fa!tor, also *no%n as Qita#in G :8. The theoreti!al e<planation %as gi$en later by >r. ". Geiglboe!*, %ho pro$ed in ani#al e<peri#ents that it is a ,potential restorer, and raises the depleted li$er stores of gly!ogen. ". /. ?enn also thin*s that it restores the depleted potassiu# stores in the li$er. Aia!in is not only a $ita#in, indispensable for the protein #etabolis#, but also is, as El$eh5e# and others sho%ed, an effi!ient restorer of !ell energies in a great nu#ber of diseases fro# the !o##on !old to !an!er. nother !hara!teristi! feature of the treat#ent is the liberal use of iodine in the inorgani! for# of lugol-solution and the organi! for# of thyroid. Goth are strong restorers of the ele!tri!al potentials and !ell a!ti$ity. The thyroid gland stores only (- per !ent of all the body&s iodine !ontent. The rest of the body&s iodine is !ontained in the s*eletal #us!les, the li$er and !entral ner$ous syste#, but it is also relati$ely highly !on!entrated in the pituitary gland and in the o$aries. The thyroid gland ta*es up about :- ti#es #ore iodine than does any other tissue. To help the body in the o<idation po%er, iodine #ust be radioa!ti$e 7I1C- and I1C18. The I,1 isotope has the longest half life 7eight days8. In !an!er patients %e obser$e that the basal #etabolis# !an be $ery high, up to 4: or do%n to #inus C4. Corresponding is the iodine !ontent of the blood seru# abo$e or belo% nor#al and it !an be $ery e<!essi$e in both dire!tions, parti!ularly in #ore ad$an!ed !ases. "ith the therapy the high iodine !ontent !an be brought to nor#al or belo% nor#al in a relati$ely short ti#e, fro# 1--(- days. That #eans that the body %as losing great a#ounts of iodine at the beginning of the treat#ent and the therapy re$ersed this pro!ess. $ery lo% iodine !ontent #ay indi!ate that the body had already lost #ost of its iodine reser$es and no% absorbs iodine during the therapy in relati$ely great +uantities. Aot one e<a#ination, but the !ur$e de!ides. It is generally a!!epted that the organi! iodine of the blood, seru# is a #ore reliable inde< than the #etaboli! rate, as the latter is not !ontrolled e<!lusi$ely by the thyroid. Iodine see#s to play an i#portant role in tu#ors the#sel$es. In #ouse and rat tu#ors the iodine !on!entration %as found to e<!eed that of li$er and #us!le. The iodine deposition in tu#ors is a debated +uestion. It is reported increased by other authors, but only after the onset of regressi$e !hanges in the tu#or. n interesting report by Greenstein states that I1C1 in the blood of nor#al and tu#or bearing #i!e is the sa#e, but the decreased !apa!ity of tu#or-#i!e in !on!entration of ad#inistered I1C1 ,is probably related to so#e !hange in the physiology of the thyroid glands the#sel$es.,9) It %ould be shortsighted, e$en in!orre!t, to obser$e one of the #ineral substan!es alone, or a group of the#. <nnumerable metabolisms continue to act simultaneously, and many abnormal steps have to be made until a symptom appears. The !lini!al signs are then un!hara!teristi!, su!h as fatigue, %ea*ness, easy e<haustion, #ore e<!itabilityRall these !an be due to #any different defi!ien!ies or !auses. To sti#ulate the body %ith one or another $ita#in, or a group of the#, or

a #i<ture of the# %ith #inerals, #ay help for a short %hile. It is a diffi!ult de!ision to deter#ine %here to sti#ulate and %here only to replenish the organs. This is a diffi!ult tas* be!ause the organs #ay ha$e de$eloped so#e pathologi!al alterations in the #eanti#e. lar# sy#pto#s or spe!ial infe!tions #ay be e<!eptions but these are li#ited to a short period and re+uire sy#pto#ati! treat#ent. In #ost situations, espe!ially in !hroni! and degenerati$e diseases, it is #u!h safer and #ore fa$orable for the organis# to be helped in its totalityO this #eans the entire #etabolis# #ust be restored to nor#al or near-nor#al fun!tions. s far as the #ineral #etabolis# is !on!erned, it see#s to be the basis for the a!ti$e de$elop#ent of a #alignan!y in a poisoned body. The #ineral #etabolis# in itself is not enough to e<plain the nu#ber of fa!tors in$ol$ed in that biologi!al situation. It see#s to be the general basis on %hi!h #any different defi!ien!ies o!!ur %ith serious !onse+uen!es in the #etaboli! pro!esses of protein, fats, and, to a lesser degree, in !arbohydrates. @nder su!h !onditions the digestion and o<idation to the end produ!ts are progressi$ely da#aged. I %ill try to gi$e an appro<i#ate pi!ture about a !on!eption of nor#al life and the de$iation into !an!er.
Lesse Greenstein, 4iochemistry of #ancer, p. (-(.

ife meansD 1. =aintenan!e of the nor#al #etabolis#, its regulations and produ!tions for hor#ones, enzy#es, !oenzy#es, et!., absorption and eli#ination po%er. (. =aintaining the pre$alen!e of the potassiu# group in $ital organs and Aa-group #ainly outside in the fluids and so#e tissues. C. Peeping the positi$e ele!tri!al potentials of the !ells high as the basis for energy and fun!tion, si#ultaneously as a defense against in$asion of the Aa-group and the for#ation of ede#a. ;. =aintenan!e of !ir!ulation, tension, tonus, storage !apa!ity, reser$es. ) 6ea!ti$ation po%er of $ital substan!es, espe!ially enzy#es. 4 >efense and healing po%er.

#ancer meansD 1. 9lo% into<i!ation and alteration of the %hole body, espe!ially the li$er.

(. In$asion of the Aa-group, loss of P-group, follo%ed by tissue ede#a. C. 3o%er ele!tri!al potentials in $ital organs, #ore ede#a, a!!u#ulation of poisons, loss of tension, tonus, redu!ed rea!ti$ation and o<idation po%er, dedifferentiation of so#e !ells. ;. Can!er startsRgeneral poisoning in!reases, $ital fun!tions and energies de!rease R!an!er in!reases. ). ?urther destru!tion of the #etabolis# and li$er paren!hy# R !an!er rules R is a!ting, spreading. 4. 3oss of last defenseRhepati! !o#aRdeath.

I %ould li*e to say a %ord about the proble# of trans#iner-alization in our body. I *no% ho% diffi!ult it is for physi!ians to ta*e a positi$e stand on that proble#. Qon Gerg#ann hoped that the ti#e %ill !o#e %hen %e %ill learn to add the defi!ient substan!es therapeuti!ally. I %ould li*e to for#ulate this hope differently, as I thin* the ti#e %ill !o#e %hen %e %ill learn, a!!ording to the !on!ept of totality, to add in the right !o#position, the substan!es %hi!h %e find

to be la!*ing. t the sa#e ti#e the other substan!es and poisons %hi!h %e found to be antagonisti! or !ountera!ting ha$e to be eli#inated. The proble# of trans#ineralization is not yet re!ognized thoroughly enough to sho% all the therapeuti! diffi!ulties %hi!h ha$e to be o$er!o#e to restore the disturbed har#ony in the #ineral #etabolis#, step by step. ?ro# #y o%n !lini!al e<peri#ents I ha$e learned that it is not only ne!essary to !hange the #etabolis# in one or another substan!e, but it is also ne!essary to !hange the inta*e of proteins, enzy#es, $ita#ins, et!., si#ultaneously to a!ti$ate all natural healing for!es %hi!h %e need for our therapy,

C-APT1R =. $istri&ution of 1n@ymes in 5rgans

= AF @T'/69 !o##ent as P. '. Gauer says in his boo*. The #ancer Problem 7page 1148 translated, ,one en!ounters again and again in the literature the !on$i!tion. the riddle of !an!er !an be sol$ed by !he#istry of enzy#es . . .-. or by bio!he#istry as >r. 6ad$in reported in the 9enate 'earing 19)7. I thin* it %ill not be this %ay. It should be pointed out. the !onditions in the !ells ha$e to be basi!ally and fun!tionally !hanged firstO the %hole #etabolis# in ea!h !ell is pathologi!ally transfor#ed in its protein and fat digestion and e<!hange. That !hange transfor#s auto#ati!ally the enzy#e-#etabolis#s %hi!h are ad5ust#ents to the pre!eding pathologies. ,2ra!ti!ally all rea!tions %hi!h o!!ur in organis#s !an be attributed to the a!tion of the enzy#es.,97 The enzy#es ha$e an ,e<tre#ely spe!ifi! a!tion,, in order to #a*e a rea!tion ta*e pla!e a !ertain resistan!e in the !ell is to be o$er!o#e. That #eans. the #ole!ules %ithin the !ells #ust be a!ti$atedO a !ertain a#ount of a!ti$ation energy has to be supplied by the body. for e<a#pleRin the !ells gly!ogen is bro*en do%n to !arbon dio<ide and %ater by a large nu#ber of enzy#ati! rea!tions. This is the #ost si#ple !ell #etaboli! fun!tion and #aintained for the longer period, %hile protein and fat #etabolis#s are in the sa#e !ells and at the sa#e ti#e +ui!*er and farther rea!hing deranged. Enzy#es fun!tion as they are #ostly organized in !hain rea!tionsRso#e are ine<tri!ably !onne!ted %ith the li$ing organis#, they !an not be e<tra!ted, %ith inta!t a!ti$ity, fro# !ells or
:4 97

P. '. Gauer, Das @rebsproblem, p. 114. La#es G. 9u#ner and Parl =yrba!*, The %n:ymes, !ade#i! 2ress, 19)-, 2. 1.

tissues., Therefore t%o types of enzy#es %ere in e<isten!e 7dis!e#able8. 1.8 Enzy#es that !an be se!reted and e<tra!ted. (.8 Enzy#es %hi!h are ine<tri!able 7fi<ed in the !ells8. Enzy#es !an be rea!ti$ated in the li$er and ha$e to be supplied to the !ells. The !onse+uen!es for the !an!er therapy are, that for the restoration of enzy#ati! fun!tions the !ontent of the !ells has to be restored. That is i#possible in !an!er !ellsRpossible and ne!essary in the other !ells. ll in$estigators found that #alignant tu#ors are !hara!terized by a !onsiderable ele!tronegati$ity in the tissues and fluidsO 9tarting fro# this pre#ise, I loo*ed o$er the a!!u#ulations of #inerals in nor#al and abnor#al tissues and their ele!tropolarity. I found a !enter of high ele!tronegati$ity in the thyroid, based upon the a!!u#ulation of an e<tra!ellular group. The !lassifi!ation in e<tra!ellular 7negati$e8 and intra!ellular 7positi$e8 substan!es is !orre!t for inorganic minerals in ele!tri!al !urrents.9: In biologi!al e<peri#ents of li$ing tissue, ho%e$er, 'oeber dis!o$ered so#e stri*ing de$iations, !onfir#ed by later authors, =atsuo, "ilbrand, and others. The follo%ing table !onsists of the !lassi!al lyophile groups fro# 'ofraeister and 9piro in the

order of 'oeber&s findings. HContrary to the findings in inorgani! ele!tro!he#istry P 7potassiu#8 is negati$e, tra$eling to the anode 7"aels!h 19C;8 %hile Aa. I. Gr. is ele!tropositi$e, tra$eling to the !athode 7Peller 19C-8. In this boo* and other literature the #inerals are !hara!terized as positi$e a!!ording to the organs %here they are deposited in the #a5ority.I T!BL( )
Electropositi%e

Gorderline Co. Cl

Electronegative

3i, Aa, l, ?l CA9, I, AoC Gr

6b, C, P A'; Acetate, 9/; 2/; tartrate.

This table sho%s the antagonis# of the e<tra!ellular group-positi$ating, to the intra!ellular groupRnegati$ating 7both a!!ording to 'oeber8. 9: !andbook of "utrition, #eri!an =edi!al sso!iation, 19;C, p. 97, Table (. s the first step, it %as found that the #inerals are deposited preponderantly either in the positi$e or negati$e sense in the organs of the body. s a !onse+uen!e, one !ould differentiate the organs in pre$alent positi$e or negati$e organs, as !onfir#ed by #easure#ents #ade by Paunitz and 9!hober. s a se!ond step, it %as re$ealed that #any organi! substan!es sho% a !hara!teristi! ele!tri! !harge by being a!!u#ulated predo#inantly in #ore positi$e organs or in #ore negati$e fluids, !onne!ti$e tissue, thyroid, spleen, parietal !ells, sper#atozoas, gro%ing #alignan!ies. s a further step, I tried to study the distribution of enzy#es in different organsO there it appears to be a !hara!teristi! !lassifi!ation of one *ind of enzy#es in these and another *ind of enzy#es in other organs. ?or so#e years, '. 9. Gurr and his !ollaborators published #any signifi!ant fa!ts !on!erning the ele!tropolarity of #alignant gro%th. The first i#portant dis!o$ery %as the obser$ation that a bioele!tri!al alteration %as found to pre!ede the tu#or de$elop#ent, and the se!ond, that all #alignant tu#ors are ele!tronegati$e0 The late G. ". Crile, and his !ollaborators, =. Tel*es and . ?. 6o%land, found a de!reased ele!tri! polarization and an in!reased ele!tri! !ondu!ti$ity in #alignant tu#ors %hi!h #ay be !aused, in #y opinion, by the greater sodiu# !ontent in the gro%ing part of the tu#or 7Good#an and others8. 9e$eral in$estigators found, %ithout e<!eption, #alignant tu#or tissue negati$e by 1--(- #illi$olts %ith unpolarizable ele!trodes, %hereas by using redo< ele!trodes greater potentials %ere found %hi!h a#ounted to 1-#illi$olts and #ore, as unpolarizable ele!trode #easures the ions and #etal ele!trodes the ele!trons. s one indi!ator for ele!tropolarity, there %as found, for instan!e, the distribution bet%een blood !orpus!les 7intra!ellular, the ele!tronegati$e substan!es8 and seru# 7e<tra!ellular, positi$e substan!es8. s another fa!tor, there !ould be used the a!!u#ulation in organs su!h as the li$er, ner$e, brain, #us!le, !orte< of *idney or the a!inus of pan!reas, all preponderantly positi$e organs storing #ostly negati$e intra!ellular #atter %hereas the !utis of the s*in, #edulla of the *idney, !olloid of the thyroid and thy#us, sto#a!h and distal intestinal #u!osa, bile !apillaries and the !onne!ti$e tissues attra!t positi$e fro# e<tra!ellular #atter, repelling nor#ally the other. I ha$e sele!ted an author %ho did not use the %ord ele!tri!ity in his bio!he#i!al %or*s and does not propagate any hypothesis. The follo%ing tables are e<a#ples ta*en fro# Lesse 2. Greenstein&s tables.

If one *no%s t%o fa!tors he has indi!ations for the third one. ?or e<a#ple, if one *no%s the ele!tropolarity of the organ, %here the #inerals tra$el in the ele!tri! !urrent and !an find %here they are a!!u#ulated, he !an separate or des!ribe the# in antagonisti! groups. /r if one *no%s the ele!tropolarity of an organ and finds a !ertain #ineral or enzy#e a!!u#ulated there, he !an designate their ele!tropolarity si#ultaneously %ith the antagonis# of the t%o groups. /ne group of #inerals has a spe!ifi! ele!tropolarity biologi!ally, si#ultaneously it has another en:yme9 system 7third fa!tor8. /ne #ay learn fro# these figures that there is a distin!t tenden!y of a !ertain type of enzy#e to tra$el %ith the intra!ellular substan!es %hile the other type prefers the e<tra!ellular route. 'o%e$er, there are suffi!ient !ontradi!tory results to de#onstrate that the ele!tri! fa!tor alone is not a de!iding fa!tor, regulating all different *inds of e<!hanges in for# of a!!u#ulation or repulsion. In Table III of the sa#e $olu#e there is #ore fa$orable e$iden!e for the ele!tri!al $ie%point. ?or instan!e, the !atalase in the nor#al adult li$er is 4.:. In the regenerating fi$er, %hi!h is also $ery positi$e, it is also 4.:. In the fetal li$er, %hi!h is al%ays found to be #ore negati$e, it is -.; and in hepato#a it is -.-. "ith al*aline phosphatase, ho%e$er, the order is re$ersed99l

Lesse Greenstein of the 19C.

#eri!an

sso!iation for lie

d$an!e#ent of 9!ien!e of

ugust ;, 19;;, p.

This biologi!ally positi$e enzy#e-al*aline phosphatase, is usually one to four, for nor#al adult li$er, (7 for fetal fi$er and );( for hepato#a.1-The sur$ey of Lesse 2. Greenstein is not too unfa$orable to the ele!trostati! theory. There the figures are again in the order of the #ore negati$e and #ore positi$e organs.1-1 The #alignant tu#ors beha$e al%ays as negati$e stru!tures. The e<a#ple ta*en fro# this table is the !yto!hro#e C Ssee Table (, this !hapter8 %hi!h is found defi!ient in all #alignant tissues li*e the identi!al #inerals in the positi$e or negati$e organsO %e #ay assu#e that it is #o$ing about in the !ells li*e the positi$e and negati$e #inerals 7see Table 1, this !hapter8. 9u!h a perfect agree#ent bet%een #inerals and enzy#es is probably the e<!eption and not the rule.

?or a !o#parison, here is a sur$ey of the potassiu# of the organs of a rabbit, a!!ording to the analyses of ". /. ?enn 7see Table C, this !hapter8 %ho analyzed the organs first !he#i!ally and !o#pared %hat he dis!o$ered %ith their !ontents in radioa!ti$e potassiu#. This table sho%s that

the proportion of the a!ti$ity of the organs for ne%ly in5e!ted potassiu# is not identi!al %ith their !ontents in another stage, and it is also not perfe!tly identi!al %ith other analyses of the sa#e ani#al in other stages or %ith the !ontents of other biologi!ally negati$e or intra!ellular #etals or organi! !o#poundsO but in all !ases there is a !lose si#ilarity of the distribution of #any enzy#es to the a$idity for radioa!ti$e isotopes.
1-1-1

5p. citG p. 19:. Lesse Greenstein, 4iochemistry of #ancer, p. (4), Table 3NNQI1. 1-( Quoted fro# 9y#posiu# on &espiratory %n:ymes, @ni$. of "is!onsin 2ress,

T$4 % <<<Rin positi$e organs

=us!le Testis 3i$er Intestine 'eart 3ung Grain *idney Aer$e Gone 9*in 2las#a Polonium 119 1-1 :7 9:9 :9 :7 4)()4 (7 ).)Radio Isotope 1.) 1.) (.; 1.9 ).4 (.1 -.1; 1.) -.( -.(( -.4 -.1)

In su!h tissues as the li$er, lung, bone, and testis, the figures for intra!ellular #atter alone do not gi$e an a!!urate pi!ture be!ause these organs !ontain large a#ounts of the antagonisti! groups. The bones, #oreo$er, are a !rystalline solid substan!e %hi!h !ontain large a#ounts out of proportion %ith the !ontents in protoplas#ati! %ater-ri!h tissues. The high P-!ontent of testis is also surprising.

9@3?I>E Ao% another e<a#ple of a positi$e #ineral tra$eling #ostly to the negati$e organs.
TABLE IV
(i%er In the positi%e &r'ans 0)*! +idney In the ne'ati%e &r'ans 030

7bile syste#8 neg Grain =us!le 6ed !ells 2an!reas 7islands Aegati$e8

-.-: -.-1 -.-1 -.;7

7!orte< positi$e, #edulla negati$e8 9pleen -.1: 3ungs -.17 Thyroid -.1) 9to#a!h -.(; Intestines -.:1 7#u! #e#brane negati$eO #us!le, ner$es positi$e8

The #ethods of deter#ination of enzy#es ha$e not yet rea!hed the a!!ura!y of the #odern deter#ination of #inerals. E$en the figures for sulfide sulphur in the $ery a!!urate radioa!ti$e !ounter #ethod gi$e rather different resultsO for instan!e, in only four rats used in e<peri#ents by >, >, >zie%ia*o%s*i

t%i!e the #a<i#u# %as found in #us!le and t%i!e in s*in, the #ini#u# t%i!e in li$er, on!e in s*in, on!e in hair.1-C The !on!entration of the enzy#es is $aried at different ti#es in different ani#als and !annot be !o#pared %ith inorgani! analyti!al results as analyzed by present #ethods. "ith regard to the great diffi!ulties in arri$ing at a !orre!t approa!h to an enzy#e distribution in !o#parison %ith the #ineral distribution, there is still a re#ar*able possibility of indi!ation in the antagonis#. /ne has to *eep in #ind that enzy#ati! a!tion is funda#entally influen!ed by !he#i!al fa!tors other than ele!tropolarity. the !o#parison %ith ele!tropolarity #ay in one or another !ase also be a help in !ontrolling enzy#e analyses. The ele!tri! fa!tor of the #o$e#ent of fer#ents is only one of #any in $arious organs.

Transaminase $ctivities ?ollo%ing are the $alues of Ht in different rat tissues of gluta#i! a!id and pyru$i! a!id.1-; heart 7 s*el. #us!le 1C brain ( li$er ;4 *idney C
=. G. Pritz#ann reported +uestionable transa#inase a!ti$ity in #alignant tissues and none in s#ooth #us!le 7!hi!*en gizzard8, lung, erythro!ytes.1-) lso Euler, Gunther, and ?ors#ann, found lo% transa#ination $alues for #alignan!y.1-: If this theoreti!al approa!h is useful, and if the distribution of the organic substan!es is predo#inantly influen!ed by their ele!tri! !harge, then %e #ay hope to find out in %hi!h organ these e<tra!ellular and intra!ellular substan!es are stored. "hen %e find in %hi!h organs to lo!ate the reser$e stores of 7a8 #inerals, 7b8 organi! substan!es, 7!8 the *ind of ele!tropolarity, then it %ill be possible to lo!alize the different enzy#es, too.
9ee The Bournal of 4iological #hemistry, 14;.14), 19;4. 2hillip 2. Cohen, 'ymposium on &espiratory %n:ymes, 19;(, p. (19. 1-) 9ee %n:ymologia, ).;;,19C:. 1-4 9ee ?eitschrift flier @rebsforschung, ;9.;4, 19C9.
1-; 1-:

Conclusions
The #ost stri*ing feature in this re$ie% of tables is that the li$er paren!hy#a is the #ost positi$ely !harged organ !ontaining $ery often #ost of the intra!ellular group, %hereas the thyroid is the #ost negati$ely !harged organ !ontaining a #ar*ed a!!u#ulation of the e<tra!ellular group 74- AaE ;- P in #illie+ui$alents8. It is re#ar*able that the enzy#es are distributed a!!ording to these interpretations, in li$er, #us!le and heart on one side, and in thyroid, spleen and #alignan!ies on the other side.

C-APT1R =.I Mineral Accumulations in the Thyroid

IA C/AAECTI/A %ith so#e proble#s of !hroni! diseases %hi!h respond to the ad#inistration of iodine but are not !lassified as iodine defi!ien!ies, it see#s ad$isable to learn %hether #inerals other than iodine in the so-!alled e<tra!ellular group 7Aa, Gr, rs, ?, et!.8 are disturbed in their #etabolis# and stored in the thyroid. s a funda#ental first step, a deter#ination of the Aa!ontent of a nor#al thyroid gland and its relation to P, the leading #ineral of the intra!ellular

group, is assu#ed to be essential. If %e *no% that Aa is pre$alent in any organ, and thus the proportion bet%een P and Aa in #illie+ui$alents is s#aller than one, %e %ill also find in this organ the other #inerals of the e<tra!ellular group Cl, Ca, '(/, and others in!reased. If %e find #ore P than Aa, then, as '. Paunitz, E. 2. ?is!her, and 6. Peller ha$e sho%n, there are also other #inerals of the intra!ellular P-group a!!u#ulated in this organ. The analyses of la#b thyroids sho%ed the follo%ing., TABLE 1
A 1 C 2 + mg % 0)-0. 0)!*0 0)!03 0)!"3 Na mg % 0)!/0 0)S00 0)!0S 0)!3" ,a In millimols 0).. 0)*0 0)/0 0).!

!!u#ulations of #inerals in the thyroid !o#pared %ith sub#a<illaris glands fro# rats.
K E<a#ined in 3aboratory of College of 2hysi!ians and 9urgeons, Ae% For*. 11C
Sex A 1 C 2 E 7 F F F 7 no) * 3 * * * 4et 4ei'th Grams /)!3/ !)0!/ -)3-! !)00/ -)/00 ,a 6 0)!33 0)!-! 0)!-! 0)0". 0)!-! + 6 0)3!0 0)300 0)33* 0)3!3 0)3*3 +5,a ratio !)30 !)S0 !)33 !)"!)3.

This is only one e<a#ple of the pre$alen!e of P, the intra!ellular group, %hi!h is found in sub#a<illaris glands and #ost of the other organs of adult ani#als. #us!les, heart, li$er, *idney !orte<, adrenals, brain, erythro!ytes, et!., %hi!h all together !o#prise about 4- per !ent of the body. The !ontent of the Aa-gronp is pre$alent in about (9 per !ent of the body and 11 per !ent are on the borderline. The abo$e-+uoted in$estigators ha$e de#onstrated that the P or intra!ellular group is ele!tronegati$e in biologi!al surroundings and the Aa or e<tra!ellular group is biologi!ally positi$e. The P-group, therefore, tra$els to the positi$e !ells and the Aa-group to the negati$e !ells and fluids. This is the reason %hy %e e<pe!t a surplus of ele!tropositi$e Aa in the thyroid after ele!tronegati$ity has been found in this organ. /n the other hand, a predo#inan!e of either Aa or P in the #ole!ular PEAa ratio gi$es us an e<!ellent indi!ation of %hat other #inerals %e #ay e<pe!t to find in an organ, su!h as the thyroid gland. The thyroid has, !ontrary to #ost of the other organs #ore sodiu# than potassiu# #ols in #illie+ui$alents per !ent. The sodiu# !ontent is greater be!ause of the #ain !ontent in the Aari!h !olloid, %hile the epitheliu# !ells !ontain !onsiderable a#ounts of P in the positi$e granula and ha$e #any P-ri!h erythro!ytes. The negati$ity is !entered in the !olloid, a parado< %hi!h !an only be e<plained by an ele!trolyti! pro!essO si#ilar findings are found in a nu#ber of plant and ani#al tissues. >. Gi!*lhorn des!ribed 719()8 that al*aline root !ells of 'inapsis alba #a*e the surrounding soil a!id, and A. 'enning found a si#ilar situation produ!ed by parietal !ells of the sto#a!h. 3i$ing !ells are apparently able to send out ele!tri!al potentials to%ard the outside into the dead spa!e of the thyroid folli!le or the open spa!e of the sto#a!h. The ele!trostati! hypothesis !lai#s that in li$ing protoplas#s the ele!tri!al !harge !annot be guessed a!!ording to the !harge in distilled %ater in the inorgani! laboratory. It has to be deter#ined e<peri#entally and !annot be !lassified a!!ording to the ioni! rule in a+ueous solution but is #ostly dependent upon the lyophile S!olloid %ith strong, %ea*, or la!*ing lyophile-sol$able !apa!ity8 series of 'of#eister and 9piro 7first published in 1:9)8. This series in!ludes the positi$e half of both a!ids and al*alis, represented by lithiu# and sodiu#, !al!iu#,

iodine as one group, and the ele!tronegati$e half of the series, !hara!terized by potassiu#, phosphate, !itrate, sulphate as the other group. These t%o groups in plants and ani#als %ere *no%n, by bio!he#ists, #ore than one hundred years ago. The t%o antagonisti! groups ha$e also been !alled e<tra!ellular and intra!ellular, a #isleading designation. The thyroid is an ele!tronegati$e !enter or !athode of the body, $ery s#all, and therefore %ith a s#all a#perage, but %ith a high $oltage in the !olloid. Table I of this !hapter sho%s that the Aa is deposited and a!!u#ulated in the thyroid. Therefore, %e ha$e to !onsider that the so-!alled e<tra!ellular Aa #ust, in this instan!e, be intra!ellular. It should be e#phasized that the %hole positi$e half of the lyophile series 7CA9, I, Gr, Aa, Ca, Cl, s , ?, l8 is a!!u#ulated in the thyroid. It is found ele!tronegati$e as a redo< potential in the !olloid, its #ain #ass, by >e6obertis and Gonzales 719;48 and by all earlier in$estigators. The thio!yanate 7CA98 %as al%ays found biologi!ally #ore positi$e than the iodine. The !lini!al signifi!an!e is that thio-!yanates and other !o#pounds of si#ilar !onstitution plus thiour-a!il 7not yet e<a#ined8, sulfa drugs, and sali!ylates ha$e a tenden!y to repla!e iodine. Therefore, iodine appears to be a $ery #obile and $ulnerable substan!e in the thyroid as de#onstrated by its easy repla!eability 7in biology8. The se!ond ele#ent in the positi$e half of the lyophile series is the iodine. There is no doubt that the iodine is attra!ted %ith parti!ular for!e by the nor#al thyroid, but less so in hypo- as %ell as hyperthyroidis#. In both, the iodine !ontent is de!reased in the thyroid, in hyperthyroidis# e$en up to lE1-th of the nor#al. The differen!e is that blood iodine is #ar*edly ele$ated in #ost !ases of hyperthyroidis# %hile it is de!reased in hypothyroidis#. nother ele#ent, %hi!h is $ery near to the positi$e head of the series is ionized !al!iu#. Cal!iu# %as al%ays found greatly a!!u#ulated in the thyroid by bio!he#i! essay and by nii!roeherai!al in!ineration. !!ording to the te<tboo* on bio!he#istry by /ppenhei#er, ron and Gral*a, nearly ,1 #g#. per !ent %as present in 1-- gra#s %hi!h #eans rather #ore in #ols than the nor#al thyroid stores I plus Aa. Then follo%s bro#ine, %hi!h Tanino has found in thyroids of !orpses of hospital patients to be a!!u#ulated in t%entyfold a#ount of iodine, if the patients had re!ei$ed bromides during their disease. The bro#ine !ontent of the thyroid is a #a<i#u# in !o#parison to other organs %ith one e<!eption. the %all of the aorta. The loss of iodine and its $arious effe!ts on the entire ner$ous syste# should be seriously !onsidered %hene$er bro#ide therapy is used !lini!ally. There re#ain fluorine and arseni!, %hi!h ha$e their #a<i#u# a!!u#ulation in the thyroid on a!!ount of their biologi!al ele!tro-positi$ity. This #a<i#u# refers to the protoplas#i! organ or paren!hy#al !ells, not to the solid !rystallized stru!tures su!h as hairs, bones and nails. The bones, for e<a#ple, ha$e a thousand ti#es #ore !al!iu# than the thyroid, but a#ong C; other *inds of protoplas#i! stru!tures, calcium is found at its #a<i#u# in the thyroid and a!ti$ated or ionized there. !!ording to the anlyses of the al*ali #etals, found deposited in the thyroid, %e #ay !on!lude that the thyroid as a %hole is relati$ely ele!tronegati$e and that the !olloid in its folli!les 74- per !ent in nor#al thyroid8 has a rather high negati$e $oltage. The !ontents of the other ele#ents or radi!als, a!!ording to the abo$e-+uoted earlier publi!ations, !onfir# this thesis or, at least, do not !ontradi!t it. If the thyroid is the strongest ele!tronegati$e !enter of the body, a!!ording to others and our o%n findings, %e ha$e to dis!uss so#e !onse+uen!es for the !lini!. The other organs %hi!h see# to !o#e $ery near to the great negati$ity of the thyroid are the bile !apillaries and the pan!reas ,3angerhans, islands. The li$er proper is supposed to be the !hief positi$e !enter of the organis# in relation to ele!trostati! theory. Aot on a!!ount of the ele!tronegati$ity of the bile !apillaries, but fro# #erely pra!ti!al e<perien!e, I ha$e gi$en bile preparations for #any years to %ea* or !a!he!ti! patients %ith !hroni! debilitating diseases. 3ater, I #ay try to apply the bile #edi!ation to this theory as it produ!ed in the #a5ority of the !ases a benefi!ial effe!t, %hate$er the reason for it %as. In !an!er there #ay be a gradual loss be!ause of less ability to be reabsorbed. The other organs %hi!h are also predo#inantly negati$ely !hargedRthe spleen, the s*in and

the !onne!ti$e tissueR!ontain proportionately #ore iodine, sodiu#, bro#ine, et!., and the other #e#bers of the lyophile series are i#portant for therapeuti!s in this respe!t. The ne<t neighbor to iodine in the lyophile series is bro#ine, %hi!h is only 1- or 1) #illi$olts less biologi!ally positi$e than iodine. "hat happens, for e<a#ple, to the thyroid, if bro#ides are ad#inisteredT ?. Tanino tried to ans%er this +uestion. 'e analyzed the thyroids of !orpses of hospital patients 7ti#e and dosage are not reported8 after the ad#inistration of bro#ides. =ost of the old people %ere +uite e#a!iated, had lost the iodine of the thyroid for the greater part and had a!!u#ulated bro#ide instead. I list here a fe% figures of Table II of Tanino %hi!h gi$es the results of thyroids, #oist glands, %ith #ediu# !olloid !ontent. table Se fe#ale =ale =ale =ale Age# (( 77 ): ;( disease Tuber!ulosis =yo!ardia 2neu#onia Aephros!lerosis mg A Br mg A I 1:.; )C.; (C.7 C9.C (.4 (.1.; 1.; Br*I normally )*+,7.1C.C 14.4 (7.C

In thyroid, bro#ine is nor#ally 1 #g#. per !ent or a little #ore 73abat8. The nor#al thyroid !ontains in #oist glands -.-C to -.-4 per !ent iodine.1-7 The figures sho% a tre#endous loss of iodine, in so#e !ases redu!ed to a #ini#u# fro# an a$erage of ;) #g#. per !ent to 1.; #g#. per !ent. These signifi!ant !lini!al findings, i#portant for !lini!al bro#ine therapy, are generally o$erloo*ed. s for an e<planation, it #ay be stated that the #ass a!tion la% of Goldberg and "aage 71:)(8 has a strong effe!t in the e<!hange of bro#ine for iodine. The nor#al blood seru# has the relation of 1E1--- of bro#ine to iodine, about one #g#. and not ga#as li*e iodine. s early as 191C, 3abat had dis!o$ered that nor#al ani#als a!!u#ulate the largest store of bro#ine in the thyroid. The study of Tanino&s figures, %hi!h sho% in all other !ases the sa#e tenden!ies #ore or less, raises so#e ne% proble#s. If %e re#e#ber that bro#ine #edi!ation #ay produ!e a !hara!teristi! e!ze#a and al#ost the sa#e rash is obser$ed by other neighbors of the lyophile series, %e as* oursel$es %hether the
*1/

9oll#ann, Pharmacology, p. 97C.

s*in affli!tion, !alled bro#ine or thio!yanate e!ze#a,1-: #ay not be partly a result of iodine defi!ien!y. /r %e #ay !onsider %hether the so#nolen!e or rather an iodine defi!ien!y is present. s a #atter of fa!t the other neighbors in the 'of#eister-9piro series produ!e a si#ilar tenden!y to sleep. fter %e had found that the thyroid is a store of Aa, Gr, I, and other #inerals of the ele!tropositi$e and lyophile series %hi!h tra$el in the biologi!al #ilieu to the !athode, %e %ere interested in the e<a#inations of . E. 6appaport, %ho e<a#ined #any body organs in their al*alinity or a!idity e<pressed in p'. 'e e<a#ined the !orpses of hospital patients C- hours after their death and still found strong differen!es in a!idity. The highest al*alinity in the thyroid %as usually one and a half units of p' higher than the brain 7e+ui$alent to 7: #illi$olts8. "e ha$e to re#e#ber that the brain is one of the !ounterparts of the thyroid !he#i!ally as %ell as ele!tri!ally and that it has re!orded the #ini#u# in iodine and other substan!es of the positi$e half of the lyophile series %hile the thyroid has the #a<i#u# !ontent. The !erebru#, so strongly influen!ed by tra!es of iodine, has only a #ini#u# of iodine in its o%n substan!e 7Qon ?ellenberg8. The p' of thyroid and brain is, a!!ording to 6appaport. Thyroid Brain

:.; 7,9 :,C 7.7 0)/ .)0 7.9

7.( 4.) 7.1 7..)S .)3 /+

In this table, four pneu#onia patients had 7.( in the thyroid and ).9 in the brain. #onclusionD The stri*ing al*alinity of the thyroid gland is pro$ed in this %ay. Ea!h !ell has its o%n #etabolis# and spe!ial fun!tion but all !ells depend upon and are supported by the %hole #etabolis#. ?or its proper inta*e and output ea!h !ell needs the eli#inating and digesti$e po%er of the general #etabolis#. E$erything is e+ually i#portant for single and total life pro!esses.
1-: 5p. cit., p. 9:7.

C-APT1R =.II The -ealing of Cancer

s EN23 IAE> pre$iously, !an!er is not a spe!ifi! illness but a general, !hroni!, degenerati$e disease. To a !ertain e<tent, it #ay be due to the inheritan!e of a predisposing fa!tor su!h as a %ea* li$er but #ore fre+uently it is !aused by outside influen!es %hi!h ha$e !o#e about by our %ay of life. noted !an!er bioiogist, 2rofessor 3ittle, e<pressed this thought as follo%s. ,Can!er de$elops %here there is a general brea*do%n of the %hole body., =ost s!ientists re5e!t this and si#ilar theories and !ontinue to adhere to the !onser$ati$e do!trine that !an!er is a lo!alized disease, at least in the beginning. They !onsider it a spe!ifi! syndro#e,1-9 despite the fa!t that they do not *no% the underlying !ause. 3ater %hen it spreads o$er the body, it is !alled a generalized disease, but it is only se!ondary. !!ordingly, the re!ognized treat#ents are local treat#entsRsurgery, N-ray, radiu#, or !he#i!al treat#ents by appli!ation of #ustard gas, ionized phosphorus, iodine, !obalt,11- !opper, or the ad#inistration of se< hor#ones. The !he#i!al and hor#one treat#ents are supple#entary treat#ents only. Contrary to the opinions of the #a5ority of the s!ientists, a nu#ber of pathologists feel that they !an no longer #aintain the do!trine of a lo!al de$elop#ent of !an!er, They, therefore, turn to a #ore general theory. To gi$e a fe% e<a#ples of these ne% approa!hes, let us !ite 2rofessor 9ieg#und 7translated8.111 ,The theory of !an!er is a +uestion of the
1-9

9ee #ancer $lerts. $ &eference and 'ource 4ook for Physicians. bstra!ts prepared b$ the Ae% For* !ade#y of =edi!ine, 19)7. 11- 9ee L = . Qol. 14), Ao, C, =ay 1:, 19)7. 111 9ee Gan:heitsbehandlung der Geschwulstcrkrankungen. 19)C, pp. (1(, (7(.

defense of the #esen!hy# 7!onne!ti$e tissue8 espe!ially a defense %or* of the %hole organis# against da#ages penetrated fro# outside or de$eloped fro# inside. In the end, the therapy is a so-!alled parenteral digestion. Autrition is originally an e<ternal fa!tor but the organis# a!+uires a disposition gro%ing into pre#orbidity through !onstant inta*e of denaturalized food., 2rofessor 2is!hinger pla!es the a!ti$ation of the #esen!hy# #ore pre!isely into the foreground.11( ,The #esen!hy# !onsists #ostly of !onne!ti$e tissue !ells %hi!h are distributed all o$er the body, espe!ially bet%een all organs and tissues. It !ontains so#e different types of !ells. This tissue %as long ignored until a fe% s!ientists dis!o$ered the i#portan!e of this so-!alled &filling tissue,& no% !hara!terized #ore pre!isely as the &reti!ular syste#,& !ontaining the #esen!hy#al defense and parenteral digesti$e apparatus, ?ro# the pathology %e learn that

-.

al#ost e$ery tu#or is surrounded by su!h tissue, and the sa#e tissue also e#bra!es all ne% !an!er establish#ents. This !onne!ti$e tissue is al#ost ina!ti$e and paralyzed in !an!er, in!apable of helping or prote!ting the body any longer in defense or healing., nu#ber of s!ientists ha$e tried $arious #ethods to sti#ulate the reti!ular syste# as %ell as the reti!ulo-endothelial syste#, %hi!h see# to !ontrol and regulate the gro%th of !ells. ?ailure of these syste#s #ay !ause the un!ontrolled gro%th, %hi!h is a !hara!teristi! part of !an!er. I ha$e found that this i#portant syste# !annot fun!tion suffi!iently and satisfa!torily be!ause the entire body is poisoned and has lost part of the ionized #inerals of the P-group and si#ultaneously so#e of the ele!tri!al potentials, et!. =any s!ientists regard these syste#s as part of the healing apparatus.,C 2rofessor G. $on Gerg#ann des!ribed this #ethod of !an!er de$elop#ent by %riting 7translated8. ,Can!er #etabolis# ta*es pla!e on!e the body is no longer !apable of produ!ing an a!ti$e &infla##ation #etabolis#& ... the !an!erous organis# is anergi! in respe!t to infla##ation.,,; The e<peri#ents of his assistants, 6uth 3oh#ann and 2es!hel de#onstrated, as refle!ted in the follo%ing tables, that !an!er !ells !an be *illed in fluid fro# a
5p. tit., 19)C, pp. 1-4, 117. 11C 9ee Gan:heitsbehandlung der Geschwtilsterkrankungen 7Totality Treat#ent of Tu#or >iseases8 edited by 2rof. "erner Mabel. 9tuttgart, 19)C. 11; 9ee $on Gerg#ann&s ?un!tionelle Pathologie, Lulius 9pringer, Gerlin, 19C(, p. '>+#
11(

nor#al infla##ation #etabolis#, not in blood seru#. This indi!ates the fa!t a nor#al body !an *ill !an!er by produ!ing an infla##ation.

The papers of ?riedri!h Pauf#an on non-ba!terial infla##ation re$ealed that these infla##ations are follo%ed by #esen!hy#al infla##atory rea!tions of genuine nature, %ith !apillary a!ti$ity, !ell a!ti$ation and loss of %hite blood !ells. In the sa#e ani#als, !hanges in the li$er %ere found at the sa#e ti#e, on the epithelian paren!hy#, in !onne!tion %ith the fi$er !ells the#sel$es as %ell as by infla##atory rea!tions on the #esen!hy#al tissue. fe% of #y o%n e<peri#ents %ith !antharidin plasters ha$e !onfir#ed the fa!t that !an!er patients !ould not produ!e an infla##atory rea!tion after irritation by !antharidin !he#i!al. The only e<!eption %as a !ase of beginning s*in !ar!ino#a, %hi!h produ!ed about a third of the nor#al rea!tionO but the blister fluid !ould no longer *ill !an!er !ells. fter se$eral #onths or longer of deto<i!ation, diet and #edi!ation, patients sho%ing fa$orable response %ere able to produ!e a nor#al infla##ation #etabolis#, !apable of *illing !an!er !ells. In this !ountry, I %as
11) 11:

5p. cit., p. '>*# 5p. at., p. '>'#

not in a position %here I !ould !arry out enough e<peri#ents to !onstitute a s!ientifi! proof of the fa!t that general deto<i!ation and restoration of the #etabolis# are basi! parts of the

healing of !an!er. G. $on Gerg#ann %idens the !on!eption of infla##ation as an allergi! rea!tion by %riting. ,The si!*nesses %hi!h are in our do!trine of diseases separated a!!ording to the different organs ha$e !o##on biologi!al rea!tions %ith !ellular pro!edures surpassing the defense of the reti!uloendothelial apparatus. In!luded in the allergi! rea!ting organs are. the diseases of the sto#a!h as %ell as the !olon, the great glandular paren!hy#atous organs of the li$er, pan!reas, #eninges, endo!ard, peri!ard, syno$ia of the 5ointsRfinally the #us!les, not the least being the heart #us!le, in parti!ular the $essels, the arterioles, $enules as %ell as the !apillariesRall of the# rea!ting %ith in$isible biologi!al stru!tural !hanges of the !ells and tissues and in the &hu#ural !ondition.& I**/ The theory of the fun!tional part of the diseases $on Gerg#ann !alls ,pathology of the fun!tion,, %hi!h !an lead in both dire!tions either to the ad$antage or disad$antage of the organis#. Ao% %e !o#e to the !ore of the proble# as to %hether %e !an influen!e these biologi!al or allergi! rea!tions, and ho% far and in %hat #anner one !an dire!t the#. The !an!erous body presents in general an ,anergi!, rea!tion, as far as the !an!er #ass and its #etaboli! poisons are !on!erned. Therefore, in #ore ad$an!ed !ases, light infe!tions #ay be fatal. ll atte#pts to sti#ulate the syste# by $irulent s*in infe!tions or !o#binations of their to<ins to an allergi! response against the !an!er !onsistently failed. 3ater the unspe!ifi! allergi! rea!tions be!a#e !lini!ally #ore i#portant sy#pto#s regarding the progress of the do!trine of the infla##ation. ?irst $on 2ir+uet and later 9!hi!* studied the internal infla##atory !onditions #ore intensely. It %as found that the cantharidin blister fluid !an be used as a #easure#ent indi!ating the degree of infla##atory preparedness 7!alled allergy8 of the total body, its $ariability during the !ourse of the infe!tions and other noninfe!tious diseases, and, I %ould li*e to add, for the !onfir#ation of the healing in !hroni!
117 5p. cit., p. 144.

diseases and !an!er although not enough e<peri#ents ha$e been !arried out to date. The de!isi$e step for%ard !a#e %hen the Gerlin pathologist, 2rofessor 6oessle, published his e<peri#ents. 'e sho%ed that guinea pigs rea!ted %ith different types of %hite blood !ells disappearing fro# the irritating !apillaries by the sa#e sti#ulus but after different *inds of pre$ious treat#ents %ere applied to the ani#als in using in5e!tions of $arious protein solutions. /n su!h a basis, #ore and #ore authors !a#e to the !on!lusion that the body and its present state of infla##atory preparedness de!ide the degree and type of infla##atory-rea!tion, not the degree or type of the applied sti#ulus. 3i*e%ise, Qir!ho%&s !ellular pathology is no longer $alid in this respe!t, but the predo#inant fun!tions of the !ells and their !hanges are effe!ti$e. The sa#e dis!o$ery %as #ade in the field of tuber!ulosis by P. E. 6an*e %hen he stated that not the $irulen!e nor the a#ount of tuber!ulosis ba!illi deter#ine %hether there %ill be an e<udati$e or produ!ti$e type of lung tuber!ulosis, but rather the !hara!ter of the rea!tion of the organis# against the sti#ulus is de!isi$e. The re!ipro!al effe!t bet%een reagens and rea!tor !an be so great that any !o##on $irulent strepto!o!!us sto!*, for e<a#ple, !an be !hanged to a %ea*er type su!h as strepto!o!!us $iridans %hi!h o!!urs in sepsis lenta 7older obser$ations8. To see the ad$antages of the allergi! infla##ation %e ha$e to loo* into the anato#i!al and biologi!al findings of this fun!tion. This sub5e!t is des!ribed at length in #y tuber!ulosis boo*,11: %hi!h also in!ludes an e<planation of the rthus pheno#enon in li#iting the spot and sa$ing the body. "e learn fro# pathologi!al and e<peri#ental findings that in !an!er there is no suffi!ient blo!*ade around the tu#or. The %ay is free for ne% settle#ents to spread and thus poison the body and *eep it under its destru!ti$e rule. The degree of the barrier and the !apa!ity of the eli#ination organs, parti!ularly the li$er, deter#ine the progress of poisoning and brea*do%n of

the body, %hile the defense apparatus be!o#es #ore and #ore ina!ti$e.
11: Gerson, =a<, =.>.. Dietary Therapy of ung Tuberculosis, pp. 1):, 14), 144, pursuant to the tests of 6oessle %ith respe!t to the rea!tion pro!eedings In the allergi! tissues.

The fa!t that %e regard the body in its entirety should not lead us to assu#e that the tu#or, the glands and the #etastases !an be influen!ed at one ti#e or e$en !ured all together. The !on!ept of totality should not let us forget that ea!h si!* organ, e$en ea!h node and gland, has its o%n pathologi!al anato#i!al !onditions, on %hi!h the #ethod of healing essentially depends. /steolyti! and osteoplasti! pro!esses !an e<ist in the sa#e organ or e$en in the sa#e $ertebra nearby and it appears that ea!h single spot, node, tu#or or destru!ti$e pro!ess has so#e biologi!al la%sO despite this, it re#ains the tas* of the treat#ent to subordinate all the pathologi!al and healthy organs, tissues, and !ells for the benefit of the %hole. This is the natural %ay for the #etabolis# to be supported by the autono#ous ner$ous syste# %ith the reti!ulo and reti!uloendothelial syste#. The !lose !ooperation of the li$er is essential. Ge!ause of the !ontinuous failures in the e<tensi$e e<peri#ental resear!h, #ost of the authors are unsu!!essful in sol$ing the !an!er proble#. In #y opinion, pri#arily be!ause !o#prehension of the deto<i!ation has al%ays been o$erloo*ed in !lini!s, %e are not suffi!iently trained in that dire!tion. In addition %e ha$e to ta*e into a!!ount that %e ha$e $ery little or transient or sy#pto#ati! results in other !hroni! diseases. fter su!h e<perien!es, it is $ery diffi!ult for the physi!ian to a!!ept the idea that a !an!er patient !an be !o#pletely restored. G. $on Gerg-#ann %rote. , syste#ati! therapeutic de$elop#ent of this theory #ay not be possible, . . .,119. This #eans that he, as #ost other authors, ne$er e<pe!ted that it #ight be possible to restore #etabolis# in a !an!erous organis# to an e<tent suffi!ient for healing purposes. I repeat. The !an!erous body is anergi!, %hi!h #eans that it !annot pre$ent !an!erous gro%th nor respond and defend itself against it. The treat#ent, therefore, has the tas* of restoring these nor#al fun!tions so that the defense apparatus, li$er %ith reti!ulo and reti!ulo-endothelial syste# !an fun!tion and that finally, the !onditions are restored for produ!tion, a!ti$ation and rea!ti$ation of o<idizing enzy#es. "e ha$e $ery often seen, in the #ore ad$an!ed !an!er !ases, that there are only a fe% ly#pho!ytes 7on the a$erage C-1- in
119 $on Gerg#aan, 7unctionelle Pathologie,

the so-!alled ,differential !ount,8. This sho%s that the body is no longer !apable of produ!ing the ne!essary a#ount of ly#pho!ytes for its nor#al need or for its healing po%er. "e see not only in !an!er, but also in other !hroni! diseases, that the body has lost the a!ti$ity of the $aluable and ne!essary #other-tissue of ly#pho!ytes. If %e follo% the suggestions of so#e authors, %e #ay assu#e that the reti!ular and the reti!ulo-endothelial syste#s both are the ter#inals of the $is!eral ner$ous syste#. These authors also thin* that the fun!tions of our internal organs depend, to a greater degree, on the fun!tions of that autono#ous syste#. 2rofessor 2is!hinger re#inds us in his arti!le that these tissues also play a !entral role in the ,budget of the o<ygen,, thus helping to bring o<ygen into the !ells. ?ro# 2rofessor 9!hade&s %or* %e *no% that the !onne!ti$e tissue is interposed bet%een the !apillary and the epithelial !ell, or any other !ell, in the body. If %e assu#e that the $is!eral ner$ous syste#, the reti!uloendothelial syste#, the interposed !onne!ti$e tissue and, on the other hand, the rea!ti$ation also of the o<idizing enzy#es is #ore or less da#aged in the !an!er body, %e #ay understand that so#e abnor#al !ells are for!ed to go o$er fro# the use of o<ygen to the use of fer#entation, %hi!h !hanges the life !onditions of these !ells and their gro%th and penetrates the surrounding tissue to the greatest degree. In all e<peri#ents e<!ept for one %hi!h !ould not be !onfir#ed, it %as found that !an!er !ells !annot be sti#ulated or for!ed to !hange their abnor#al fun!tions ba!* to nor#al ones. There is no other %ay but to *ill these !ells to dissol$e and absorb the#. I belie$e the surest %ay to

a!hie$e this end is to restore to the body its ability to produ!e non-ba!terial infla##atory rea!tions. The idea of produ!ing ba!terial infla##ations in a !an!erous body %as !orre!t in prin!iple. 'o%e$er, it is not enough to introdu!e a te#porary infla##ation into the body. The body itself #ust be able to do it and do it !ontinuously, be!ause #any !an!er !ells re#ain hidden in so#e areas %here e$en the blood strea# !annot rea!h the#. In order to #aintain this healing pro!ess, it is, of !ourse, ne!essary to apply the treat#ent long enough to restore all $ital organs to nor#al fun!tion 7li$er, reti!ular syste#, ner$ous syste#, et!.8 to reprodu!e the sa#e rea!ti$e pro!esses as used by the body itself, for healing purposes. ?ro# obser$ation of the s*in, I !ould learn %hat types of proteins and fats are fa$orable, at %hat ti#e the reser$es of the tissues #ust be refilled, and %hat is ne!essary to produ!e the best healing rea!tions and, finally, ho% to *eep the# at the le$el ne!essary for healing purposes. ?or these tests, therefore, %e had to sele!t !ases %hi!h had s*in !an!er, or, better still, su!h !ases %hi!h had internal !an!ers and s*in eruptions of a!ute or !hroni! nature, or !an!ers %ith additional s*in #etastases or additional s*in !an!ers. It #ay be generally !on!luded that !rea#, fatty !heese, all ani#al fats, so#e oils, egg yol*s, stra%berries, and all fat $arieties of #eats indi!ated their har#fulness on the s*in, probably be!ause they %ere only partially digested, %hereas lean #eats, fresh butter and so#e different types of oil %ere not har#ful. In all !ases %here the #etabolis# %as abo$e plus () per !ent, al#ost all proteins and fats %ere unfa$orable. In !ases %here the #etabolis# %as #inus 1- per !ent and lo%er, all fats and oils %ere har#ful, %hereas lean #eat and egg %hites %ere so to a lesser degree. In +uite ad$an!ed !ases there %as no ti#e for su!h e<a#inations as the treat#ent had to be applied i##ediately and #ost intensely. In a fe% su!h !ases the !ontent of !holesterol in the blood %as greatly in!reased, %hile trypsin and lipase %ere al#ost la!*ing. The #ilder !ases had less !holesterol and at least so#e trypsin and lipase !ontent. l#ost all !an!er !ases sho%ed an a!!eleration of the healing pro!esses %hen thyroid and lugol solution drops %ere in!reased, %hile hor#one therapy %as generally har#ful in the beginning. "here there %as hardening of the arteries, thyroid and lugol %ere espe!ially fa$orable. lso in su!h !ases %here %e !ould not $erify the i#pro$e#ent on the rea!tions of the s*in, longer, intensi$e and #ore fre+uent treat#ents %ith iodine 7thyroid plus lugol8 and potassiu# !o#pound %ere re+uired. It is our assu#ption that e$ery defense and healing po%er of the body depends on the !apa!ity of the body to produ!e a so-!alled ,allergi! infla##ation.,1(- E$ery healing is introdu!ed by a *ind of infla##ation as %e learn in surgery. It is also true in #edi!ine. ll different types of foreign bodies, su!h as ba!teria and in5uries, ha$e the !apa!ity to bring about su!h a healing infla##ation in a healthy body. It presents an afflu< of blood %ith redness and s%elling. The redness is !aused by the opening of the !apillaries and so#e spe!ial !ells. The fluid of the s%elling is not identi!al %ith ede#a fluidO it is a produ!t of hypere#ia and infla##ationO it is an e<tra$asate through finely da#aged !apillaries. The different *inds of fluid in ede#a and infla##ation are not yet fully *no%n. /tto "arburg de#onstrated that the !an!er !ell has good li$ing !onditions in blood seru# and in the infla##ation fluid these !onditions are la!*ing, for this fluid is !o#posed in su!h a %ay that the !an!er !ell %ill not find enough sugar in it for gly!olysis. "arburg sho%ed that %hen the sugar le$el sin*s to (- #g, per !ent, the la!ti! a!id produ!tion falls to half and that the lo% le$el is lo%ered still further in the infla##ation. In !hroni! or degenerati$e diseases su!h as tuber!ulosis, arthritis, arterios!lerosis, et!., the body has lost the !apa!ity to bring about su!h an ,infla##ation rea!tion., In !an!er so#e authors1(1 say %here the body has been si!* before, !an!er !ould de$elop. G. $on Gerg#ann e<plains the i#possibility to pre$ent or !ure !an!er. ,Can!er sets in %here the body is in!apable to produ!e an a!ti$e infla##atory #etabolis#., 7p. 17C.8 9trong denies 719;-8 that ,up to the present there is not yet one !an!er atta!*ing defense #e!hanis# re$ealed., >r. L. 3. libert and se$eral students S1:-:8 %ere ino!ulated %ith !an!erous #aterial fro# a fe#ale breast tu#or. It produ!ed $iolent infla##atory rea!tions. Then E#il "eiss of the 2eoples

'ospital, >epart#ent of 2athology, Chi!ago, ino!ulated an e<tra!t of hu#an !an!er into patients affe!ted %ith !an!er. The ai# of that !lini!al trial %as to find %hat therapeuti! effe!t su!h treat#ents ha$e. fter in5e!tions, !hill and te#perature lasted for t%o hours and #ore. The results %ere a #ar*ed in!rease in appetite, #ore strength, and a slight in!rease in %eight. The ly#ph nodes di#inished and be!a#e #u!h harder. Ao !ure %as obtainedRonly te#porary i#pro$e#ent. >r. ?ehleisen 71::C, Gerlin Charite8 ino!ulated real erysipelas infe!tion into !an!erous areas. This resulted in #any failures and a fe% re#ar*able su!!esses. G. $on Gerg#ann thin*s that e$ery e<perien!ed !lini!ian *no%s of a fe% !ar!ino#as !ured by inter$ening infla##atory pro!esses. '98 I id.
1(1

9ee Gon:heitsbehandlung der Geschwulsterkrankungen.

>r. "illia# G. Coley, Ae% For* 71:918, de$oted his life to this dra#ati! treat#ent %ith erysipelas ino!ulations, later %ith pyogeni! #i<tures su!h as strepto!o!!us, staphylo!o!!us and pyo!yaneus, still later adding ba!illus prodigiosus. Coley&s results and those of others re#ained +uite un!ertain and sparing. The great #a5ority of the #edi!al profession re#ained $ery s*epti!al about this #ethod of !an!er treat#ent. The idea of helping the !an!erous organis# through a strong infla##ation is old but %as !orre!t fro# the beginning. The proble# is to find the surest and #ost effe!ti$e %ay to do this. Can!er patients ha$e different types of allergi! rea!tions. 9o#e patients %ith 'odg*in&s disease responded %ith al!ohol-indu!ed pain due to #alignan!y. 1(( The pain %as regarded as an allergi! rea!tion brought about by a !ar!ino#a, as it %as not [ present before the disease. The patient had apparently enough po%er for an allergi! rea!tion but not enough for an ,allergi! infla##ation,Rnot intensi$e and a!ti$e enough for an ,allergi! infla##ation, %hi!h is the de!isi$e part of the body&s ,%eapon of healing po%er., Conse+uently, it appears that there #ust be a !hara!teristi! differen!e bet%een allergi! rea!tions and allergi! infla##ations, sin!e both are not +uite separated in their li#itation and !ausation. t the beginning of the !an!er %e !an assu#e that %ith the allergi! rea!tion there is still a part of an allergi! infla##ation present and effe!ti$e, too %ea*, of !ourse, for healing po%er, but to a !ertain degree suffi!ient to restri!t the tu#or and to *eep it te#porarily lo!alized. It is reported in the sa#e arti!le that the patient %ith allergi! rea!tion to al!ohol 7(- #l.8 had only a slight dis!o#fort !aused by the allergi! rea!tion to al!ohol %hen the roentgenogra# sho%ed that the tu#or %as larger and better defined. 3ater, the ,anergia, in!reased %hen the tu#or gre% faster, and there %as no longer pain after drin*ing the +uadruple a#ount of gin 7:- #l.8. 9u!h obser$ation indi!ates #ost probably that the in!rease of into<i!ation de!reases gradually the allergi! rea!tion to nil. These and other obser$ations are signifi!ant signs of the redu!tion of allergi! rea!tions by progressing into<i!ation i##inent in a !an!erous body. <t therefore appears that the bodyJs capacity to produce
++ 9ee L. .=. ., =ay 1:, 19)7, Qol. 14;, Ao. C, p. CCC.

an allergic inflammation Khealing power3 depends on a most complete detoxication and an e2uilibrium in the metabolism to near normal. The healing apparatus see#s to ha$e retained part of its e#bryoni! !apa!ity and healing purpose for a type of regeneration,1(C %hen it falls ba!* into the e#bryoni! state te#porarily and is a!ti$ated abo$e the degree of its nor#al fun!tion. The !o#pletely deto<ified body is then able to produ!e an allergi! infla##ation if the healing apparatus Sli$er, $is!eral ner$ous syste# and reti!ulo-#esen!hy#al syste#8 !an be a!ti$ated suffi!iently. E$erything that !an help to bring it about and strengthen the ne!essary allergi! infla##ation #ay be used for that purpose after the general deto<i!ation has ta*en pla!e, Ga!terial preparations 7Coley and others8 or 2yrifer, or any si#ilar preparations are effe!ti$e, as

far as they !an sti#ulate the $is!eral ner$ous syste# in !onne!tion %ith the li$er and the #esen!hy#al defense and healing apparatus. "e ha$e to bear in #ind that there are $ery different rea!tions a!!ording to the state and energy-!apa!ity of the healing apparatus. It #ay be ad$isable to sti#ulate, in addition to #y treat#ent, the liberated $is!eral ner$ous syste# and the reti!ulo-endothe&ial apparatus %ith a #easured ba!terial reagens. 'o%e$er, I ha$e had no e<perien!e %ith it. "e do not *no% %hat sti#ulus a!ts first and %hat tissue should be a!ti$ated. G. $on Gerg#ann 7p. 1718 +uotes the des!ription of the !ourse of the infla##ation fro# an arti!le by Pe#pner 7translated8. , t any sti#ulus an e<udation and i##igration of %hite blood !ells sets in. The !he#i!al !o#position of the e<udate is the sa#e as that of the seru# 7in the beginning8. s soon as the e<udate and the infla##atory !ells are present, there starts an o%n life separated fro# nor#al tissue %ithin the infla##ation area, in the !enter of %hi!h is the #etabolis# of the infla##atory !ells. The $elo!ity of the infla##atory rea!tions depends upon the presen!e of infla##ation !ells. These !ells ha$e an o<idati$e and digesti$e #etabolis# and by #eans of tin&s #etabolis# !ause an a!idosis of the infla#ed tissue and redu!tion of the infla#ed spa!e of o<ygen and energy-produ!ing substan!e 7sugar8. !id for#ation and defi!it of energyprodu!ing substan!e
George ". Crile, 19(4, p. 144
1(C

4ipolar Theory of iving Processes. =a!=illan Co.,

bring about da#age or destru!tion of infla#ed tissue, a *ind of s%elling, degeneration and ne!rosis.,1(; fter the infla##ation has *illed the tu#or #ass, 7see Tables I and II, this !hapter8 ne!rosis sets in. In ne!rosis of !ir!u#s!ribed lo!alized areas the i#portant fun!tion is the digesti$e po%er of leu*o!yti! enzy#es of fibrin and debris in infla#ed areas, for indigested fibrin a!ts as a foreign body and leads to fibrosis. ,The ter# ne!rosis is used to des!ribe the !hanges %hi!h the dead tissue and !ells undergo after their death. The ter# ne!robiosis is used in referen!e to the physiologi! death and repla!e#ent of !ertain !ells %hi!h are !onstantly o!!urring, e.g., blood !ells and in epider#is.,1, =y o%n obser$ations ha$e sho%n that far ad$an!ed !an!er patients ha$e lost their allergi! #igraine rea!tion and other *inds of allergi! rea!tions. >uring the healing ti#e the #igraine sy#pto#s re!ur partially but disappear %hen the patient is !ured entirely, as the !o#bined dietary regi#e is enough to !ure allergi! #igraine sy#pto#s in #ost !ases %ithout !o#bination %ith !an!erO I also #ade si#ilar obser$ations %ith other allergi! #anifestations. In all these instan!es it %as found that the degree of allergi! rea!tions $aries in$ersely %ith the degree and period of shorter or longer lasting into<i!ations. Can!er patients %ith allergi! syndro#es are for!ed to #aintain part of the diet %ithout salt and %ith lo% ani#al fats and proteins for #any years. I do not belie$e that there is funda#entally #ore than one healing apparatus in the body. 9trong said 719;-8. ,@p to the present there is not yet one !an!er atta!*ing defense-#e!hanis# re$ealed., The treat#ent is, of !ourse, unspe!ifi!. To re5e!t any dietary regi#e be!ause of insuffi!ient physiologi!al proof is not sound.0(9 /n the s*in %here %e had been able to study the healing of lupus 7see #y Tuber!ulosis boo*, p. (--8 %e !ould also obser$e the follo%ing in !an!er. fter the body is deto<ified, infla##ation %ith redness and slight s%elling of the in$ol$ed spot starts. fe% days later the redu!tion of the ede#a and infiltration sets in. The abnor#al spot and the se!ondary infe!tions %ill be dissol$ed by the digesti$e enzy#es and finally absorbed into the blood
1(; 1()

$on Gerg#ann, 7unctionelle Pathologie, p. 171. ". . >. ndersen, Pathology, p. 9). 1(4 P. '. Gauer, >as @rebsproblem, pp. 4-)-4-7.

strea#. @nder the #i!ros!ope, %e see the !reation of ne% !apillaries %hi!h penetrate into the infiltrate and the ne!roti! #ass and build the so-!alled granulation tissue. They se!rete all different hor#ones and probably also enzy#es, si#ilar to the pla!enta tissue in !ooperation %ith the o<idation pro!esses 7it is the fun!tion of leu*o!ytes, ly#pho!ytes, histio!ytes8. The healing pro!ess starts %ith hypere#ia and then the different stages of reabsorption follo%. The blood pi!tures sho% at that ti#e an in!rease in leu*o!ytes and ly#pho!ytes and a s#all in!rease in #ono!ytes. >uring the healing ti#e a s#all in!rease in lipase %as !onfir#ed, a ne!essary de$elop#ent for the digestion of the fatty !ell frag#ents. t the beginning of the dietary regi#e, %e sa% and learned that so#e nutrients hinder the healing pro!ess, %hereas others further it. These obser$ations %ere used as indi!ators to point out %hat substan!es da#age or %hi!h other ones are ne!essary for the healing pro!ess in that period. >espite the obser$ation that %e !an see the healing pro!esses in s*in !an!er under the #i!ros!ope, the fa!t re#ains that %e do not *no% e<a!tly the organ or organs %hi!h ha$e to be sti#ulated and %e do not *no% %hat part of the treat#ent a!ti$ates the#. "e do know that a healing apparatus is present and functions in a healthy bodyEand we learned, in addition, by means of this treatment that it can be reactivated if the body can be sufficiently detoxified 8in degenerative diseases and cancer3. "e ha$e the distin!t i#pression that the internal organs present si#ilar or e+ual situations under treat#ent %hi!h the s*in !an!er refle!ts. The N-rays pro$e it on the bones, lungs and other organs. >eep rea!hing !an!erous ul!erations need se$eral !orresponding infla##ations 7so-!alled ,flare-ups,8 until the larger area is !o$ered %ith #ore granulation tissue or ne% s*in. These ,flare-ups, !o#e at inter$als and %ith so#e %o#en 5ust before their #enstruation. =y idea is that the deto<i!ation obtained by fre+uent ene#as, by the dietary regi#e and so#e #edi!ation pa$e the %ay for the first allergi! healing infla##ationO the body #ust be #aintained deto<ified and in a #etaboli! e+uilibriu# e$en %ith a partially fun!tioning li$er for the follo%ing ,flare-ups., "e should not forget that after the *illing of the tu#or #ass and its dissolution, the absorption, until re!o$ery is a !onstant hea$y burden on the eli#ination apparatus, in parti!ular on the li$er and *idneys. If %e do not help the patient intensi$ely day and night to eli#inate these additional poisonous substan!es, as I ha$e seen it at the beginning of this treat#ent, there is a serious danger that the patient #ay fall into a hepati! !o#a. In the first t%o %ee*s of this treat#ent %e obser$e that the patient a%a*es fro# the half !o#atous #ood, !aused partly by a pre$ious high sedation therapy and partly by the to<ins fro# the gro%ing tu#or #asses a!!u#ulated and no% a!ti$ated in the body. In the first ten days the urine sho%s #u!h eli#ination of AaCl, up to eight gra#s per day, rarely ten gra#s. !etone plus t%o to three, disappears in about one %ee*, often together %ith a tra!e of albu#in and hyaline !asts. The red blood pi!ture re!o$ers steadily in four to si< %ee*sO the %hite differential !ount sho%s that its produ!tion apparatus has to !arry the burden. "ithin a fe% days all %hite !ells ha$e to<i! granules, the ly#pho!ytes in!rease slo%ly, the nu#ber of leu*o!ytes re#ains in!reased for a fe% %ee*s also the per!entage of neutrophiles. "e learned that the stronger the deto<i!ation, the +ui!*er and #ore surprising are the results, as long as %e are able to *eep the #etabolis# free of poison and e+ualized in #any respe!ts despite the fa!t that %e ha$e to handle other hea$ily da#aged or e$en partly destroyed organs. In this %ay it is possible to bring the !an!er-#ass or #asses out of their partial se!lusions or hiding pla!es ba!* into the e<!hange of the general #etabolis#, into its support and regulation. 'o%e$er, the deto<i!ation is only a part of the healing pro!ess though an i#portant part. 9i#ultaneously, the #etabolis# has to be balan!ed at least to a !ertain degree. The si!* organs are unable to do so the#sel$es for a long period, espe!ially in ad$an!ed !ases.

The body needs essentially. the i#portant #inerals 7P., I., 2.8, the o<idizing enzy#es and !oenzy#es, and the hor#ones. ll of the# #ust be!o#e a!ti$ated in the body and #ust be re-a!ti$ated there, other%ise they are lost. E+ually i#portant is the restoration of the p' 7#inerals in the !ells8 so that the enzy#es !an fun!tion again step by step. $ll the explanations in this book about the healing of cancer as well as other presentations would be not much more than words, if we were not able to demonstrate the corresponding clinical facts of real healings. 4ut after these facts are achieved, these conceptions are explanations for our clinical observations. /ur #odern !i$ilization has brought about su!h %idespread !hanges in our nutrition that so#e !an!er authors spea* about a so-!alled pre-!an!erous !ondition. I feel it #ust be e<pressed #ore generally as a ryre9morbid pathology. ?or our tas* it is i#portant to *no% that %e ha$e no longer a natural nutritionO therefore, the therapy is #ore diffi!ult. The pre-stages probably !ould be re!ognized by e<a#ination of P, I, urea-A and uri! a!id, and !ould be #ore easily restored. The !an!erous tissues, ho%e$er, #ust be *illed, sin!e after their #i!roso#ata and #ito!hondria too* in !ertain bio!he#i!al !hanges in #inerals and ele!tri!al potentials and probably also parti!les of a ne% protein substan!e into their !ell for#ation, they !annot be retransfor#ed to nor#al. ?inally, healing of !an!er #eans the restoration of the entire #etabolis# %ith its enteral and parenteral digestion together %ith its defense and healing fun!tions. E<tirpation of !an!er gro%ths does not #ean a !ure of the disease. The i#pro$e#ent %hi!h fre+uently follo%s an operation #ay sho% that the liberation of the body fro# su!h poisonprodu!ing #ass is a great help for the syste#, and points to the dire!tion that the partial deto<i!ation of the body benefits the !an!er-bearing syste# at least to a !ertain degree, and te#porarily. The i#pro$e#ent see#s to be only in the beginning, after the operation and in lo!alized !ases only, but this is not suffi!ient for the produ!tion of an allergi! infla##ation. In the literature, the allergi! or healing infla##ation is referred to as ,!hanges in the en$iron#ental !onditions., This is an in!orre!t !on!eption.

C-APT1B =.III Role of Allergy in the -ealing Process of Cancer

IT 9EE=9 !ertain that the healing po%er in !an!er has to be introdu!ed by an allergi! rea!tion. To understand this healing po%er, one #ust ha$e a brief e<planation of the proble# of allergy itself. >r. $on 2ir+uet had e<plained allergy as a !hange in tissue rea!tions. This #eans a hypersensiti$ity de$eloped in the body !aused by an infe!tion or after in5e!tion of a protein 7allergen8. nergy is the !ontraryO it refers to a di#inished or la!* of rea!tion against an antigen. '. '. >ale e<pressed the allergi! rea!tion and !onse+uent fun!tion as follo%s. , !hange in the dispersity of protoplas#a !olloids o!!urs if the prae!ipitin fi<ed in the !ell protoplas#a en!ounters the antigen onto %hi!h it has a spe!ifi! affinity. !hange in the dispersity of the protoplas#a !olloids sets in, %hi!h indu!es an enzy#ati! dissolution, and the produ!tion of hista#ine-li*e substan!e or hista#ine itself., 1(7 The rea!ting organs at the allergi! atta!* are parti!ularly the unstriped #us!les and the !apillary endothel, both of %hi!h stay under the regulation of the auto#ati! ner$ous syste# and endo!rine apparatus.1(: "hen the tu#or #asses are in pro!ess of dissolution, there is a greater a#ount of highly a!ti$e protein9intermediary substances su!h as hista#ine, histidine, et!., %hi!h !an a!ti$ate different pathologi!al rea!tions all o$er the body. These !ountera!t the
1(7 9ee 4ulletin, Bohns 'op*ins 'ospital, C1, 1C1-, 19(-.

9ee rthur ?. Co!a, 7amilial "onreaginic 7ood !llergy, 9nd edition" '(*)" Charles C Tho#as, 9pringfield, Illinois.

1(:

healing po%er. To neutralize and eli#inate the# is the tas* of the therapy. 9#all +uantities of indole, s*atole and phenol are absorbed into the bloodstrea#, undergo deto<i!ation in the li$er by !on5ugation %ith sulphuri! a!id and potassiu# or %ith gly!uroni! a!id. "hat really happens in the body in allergi! rea!tions or stronger in anaphyla!ti! sho!*s is that nor#al enzy#ati! pro!esses are redu!ed.1(9 This idea is based on the follo%ing findings. bderhalden and "erthei#er found redu!ed a#ount of tissue, gas-e<!hange and less o<idationO 3oehr found di#inished digestion of aro#ati! proteinsO 'ashi#oto and 2i!* found pathologi!al proteolyti! pro!esses parti!ularly in the li$er !ells. 9in!e these rea!tions o!!ur in different organs and tissues, . ?. Co!a !alls the# ,spe!ies spe!ifi! sho!*organs, or ,sho!*tissues., The *ind of allergen sti#ulant does not deter#ine the type rea!tion 7$ariant8 as e$ery patient has his o%n and his indi$idual type of rea!tion %ith %hi!h he responds to ea!h sti#ulation therapy. These are #ostly gradual differen!es, 7p. 1-C, #y Tb! boo*8 It is no%here !learly e<plained %hy nor#al allergies suppressed %hen tuber!ulosis is a!ti$e and %hy they reappear %hen the tuber!ulosis pro!ess i#pro$es. Aor#al allergi! or e$] anaphyla!ti! rea!tions appear %hen the poisons ha$e obtained *ind of pea* and the body is able to neutralize, &digest and eli#inate the#, 2neu#onia healed in for#er ti#es after the body had produ!ed a deto<i!ation !risis %ith abundant perspira-tion, diarrhea and so#eti#es $o#iting. Then healing set in. The $isible syndro#es are the a!!o#panying bodily signs of that *ind of deto<i!ation or !leansing rea!tionR%ith lo!al and general sy#pto#s %hi!h !an also be regarded as the start of a healing pro!ess. The therapy has to i#itate the deto<i!ation. fter that eli#ination, patients %ith asth#a, #igraine or gout feel greatly relie$ed, s for nutrition, it is ne!essary to *eep a%ay all substan!e, fro# the si!* body %hi!h !an produ!e allergi! and other biologi!ally stronger rea!tions su!h as !aused by fats, ani#al proteins, $ita#ins 7e<!ept $ita#in C and nia!in8 and hor#ones, be!ause
1(9 3i!ht%itz, @lin, #hemte, 19C-, p. 14.

they !ountera!t the nor#al allergi! healing rea!tion %hi!h is so ne!essary in the beginning to *ill the tu#or tissue. This per!eption sho%s four !onse+uen!es !learly. 18 The strongest deto<i!ation 7not only #e!hani!ally by ene#as8 is in !an!er the conditio sine 2ua non for the start of the healing. poisoned body is anergi! and !annot rea!t to the fa$orable side. The detoxified body can. (8 The #aintenan!e of the deto<i!ation is absolutely ne!essary and the greatest therapeuti!al help for the li$er. C8 The li$er, the #ain transfor#ation and eli#ination organ, #ust be able to indu!e the pro!edure, to #aintain it, e$en if it has to undergo so#e proteolyti! pro!esses, %hi!h parti!ularly hit the li$er !ells, a!!ording to E. ?. 2i!*.1C;8 The healing is li#ited or e$en i#possible in !ases %here and %hen the li$er is no longer able to render and #aintain this $ital ser$i!e of !onstant deto<i!ation and te#porary allergi! rea!tion to the body. L. Lensen stated, ,It #ust be e#phasized that the %hole sub5e!t of allergy is $ast and !o#ple< and that it still has #any proble#s %hi!h are as yet unsol$ed., 1C1 The !onfusion be!o#es e$en greater %hen %e see the #a5ority of the !an!er authors push the allergy proble# aside as unessential or do not #ention it at all. . ?. Co!a reported that ,all of (97 persons %ith #alignant gro%ths of the breast presented sy#pto#s of idioblapti! allergyO t%o persons a!!identally in!luded in the group %ere found to be free fro# idioblapti! !onstitution and both of these had had non-#alignant gro%ths of the breast.,1C(

In his !hapter on ,>iagnosis of llergy,, Lensen !on!luded, ,The ans%er depends upon their definition of allergy.,1CC E$ery author #a*es his o%n definition. The allergy proble# is tou!hed upon here only to #a*e the healing of !an!er understandable. To eli#inate !onfusion, I suggest the follo%ing. n allergi! rea!tion #ay be thought to be a diminished
1C1:1

r!h. f. e<per. 2ath, 7-, :9, 191;. L. Lensen, Modern #oncepts in Medicine, C. Q. =osby, 19)C, p, C47. 1C( rthur ?. Coea, 7amilial "onreaginic 7ood $llergy, p. 1:). 1CC Lensen, Modern #oncepts in Medicine, p. C4C.

enzy#ati! rea!tion 73i!ht%itz8, an allergi! infla##ation to be an in!reased enzy#ati! rea!tion 7$on Gerg#ann8. Goth are enzy#ati! by nature and both are !aused by the fun!tion of the sa#e apparatus, 7!apillary endothelRor reti!uloendothelial syste#-s#all arteries, $is!eral ner$ous syste# and enzy#es a!ti$ated and supported by the li$er8. Therefore, the na#e ,allergy, is 5ustified in des!ribing these different rea!tion !o#ple<es. In reality, the degree only is different as %ell as the pla!e of response. Giologi!ally, it !an be regarded as an unspe!ifi!, healing-indu!ing infla##ation. It is a stru!tural response to an i##une pro!ess beyond the li#its of physiologi!al fun!tion. "hether or not the body !an a!!o#plish the healing pro!ess re#ains still +uestionable. ?urther de$elop#ent during the treat#ent %ill sho% if the body !an be restored suffi!iently to a!!o#plish it. The tas* of the therapy is to pre$ent all i#peding infe!tious or poisonous rea!tions 7in!luding those !aused by drug allergies and allergies to food %hen not digested to the end produ!ts8. These %ill hinder the allergi! healing infla##ation.

C-APT1R =I= Introduction to the $iet

>iet, in the sense of 'ippo!rates, is a !o#plete regi#e regulated by the fa#ily physi!ian a!!ording to #edi!al indi!ations. Autrition should be regarded as a re#edy, pres!ribed as to *ind and +uantity or ite#s to be forbidden. Autritional pres!riptions are a part of the total therapy only and #ust be !o#pleted by other pres!riptions. The *no%ledge of su!h additional therapy is indispensable for the pra!ti!e. fe% dire!ti$es as to the effe!ti$eness on the $arious organs of response should be des!ribed in ad$an!e. "hen I started the first treat#ent, %ee*s and #onths produ!ed an in!reased sensiti$ity to%ard $arious natural sti#uli !aused by nutrition and #edi!ation. This in!reased sensiti$ity had so#e benefi!ial effe!ts, but also so#e da#aging ones. /n the one hand, it helped to atta!* the tu#or and #etastases $ery +ui!*ly, but on the other, it #ade it diffi!ult to feed the patients, as $arious allergies de$eloped, for instan!e, against li$er in5e!tions, li$er 5ui!eJ, orange 5ui!e, #inute a#ounts of le#on, and different fruits and #edi!ations. #ong the #edi!ations the #ost stri*ing %ere opiates, !odeine, no$o!aine 7all types8, peni!illin and other antibioti!s. It be!a#e ne!essary to find #eans of e<!luding all allergi! rea!tions as far as possible. "e su!!eeded in e<!luding the nutritional allergies by adding large doses of potassiu# and si#ultaneously applying a stri!tly saltless diet, in!reasing the doses of lugol solution and thyroid and in!reasing deto<i!ation by #eans of additional !offee ene#as and #ore fre+uent !astor oil treat#ents. 2atients re#ained sensiti$e to N-rays, so that e$en fluoros!opi! e<a#inations %ere da#aging and had to be o#itted as far as possible. They also re#ained sensiti$e to prolonged e<posure to sunshine. 'ypersensiti$ity to
J 9ee ppendi< III. page ;(1

no$o!aine also persisted, so that dentists %ere ad$ised not to use #ore than a third of the nor#al dose of ( !! 7-.4--.7 !!8. nesthesia %ith this redu!ed dosage pro$ed e$en #ore effe!ti$e than that for#erly a!hie$ed %ith the nor#al a#ount 2atients also retained a hypersensiti$ity to physi!al and #ental e<ertion, so that a #a<i#u# of rest %as ne!essary during the first #onths. E$en after four or si< %ee*s of treat#ent the #ore ad$an!ed patients %ere generally unable to do #ar*eting and prepare the diet and 5ui!es by the#sel$es. If there is a !ondition of perspiration, %ea*ness and depression, the entire body should be rubbed t%o or three ti#es a day %ith a soft brush %rapped in a %ash!loth and soa*ed in the follo%ing solution. one-half glass of %ater to %hi!h is added t%o tablespoons of rubbing al!ohol and t%o tablespoons of %ine $inegar. The general fun!tion of the dietary regi#e, as de$eloped by #e originally for the treat#ent of tuber!ulosis, %as regarded in #any different %ays by $arious authors %ho had spent years of %or* %ith it. /ne !alled it anti-phlogisti!, another, dehydrating, a third, in!reasing the fa$orable infla##atory pro!ess, a fourth, a!id-for#ing, a fifth, al*alizing, and yet another, in!reasing the healing pro!esses in the syste# by unspe!ifi! sti#ulation therapy. The truth of the #atter is that #ost of the abo$e opinions are !orre!t-they are partial effe!ts %hi!h, ta*en all together, #ay be e<pressed as aid in the sense that it is a!ti$ating the healing pro!ess in the %hole syste#. In biology the study of the fun!tions of one substan!e in an organ is $ery diffi!ult and disappointing. 9zent-Gydrgyi says ,the #ore %e study and *no% the single rea!tions of the #us!les, the less %e understand its fun!tion-and the fun!tion is a part of the %hole body., In e<peri#ents on foodstuffs, s!ientists also e<a#ine single ite#s in different si!*nesses. The results are often $ery !ontradi!tory. >r. le<ander Gruns!h%ig of Ae% For* =e#orial 'ospital %as puzzled about the i##unity pheno#enon in !an!er, as #ost surgeons are. The e<isten!e of so#e bodily defense against !an!er ,!an hardly be denied., Gut ,at best, this defense is ,relati$ely feeble., "hat is #ore proper than to strengthen the defense, %hi!h, in a higher degree, #eans the healing po%erT It is %ell *no%n that #y approa!h of studying the whole #etabolis# in its rea!tion is !ontrary to the pre$ailing $ie%point of the #edi!al profession, %hi!h adheres generally to the thought that so#ething spe!ifi!, su!h as one #edi!ation, or a spe!ifi! seru#, or a !o#bination of different sera, %ill ha$e to sol$e the !an!er proble#. It has be!o#e #ore e$ident of late that the appli!ation of surgery and N-rays is en!ountering #ore s*epti!is# by so#e surgeons and the publi!. @ntil $ery re!ently, it appeared that %hate$er did not fit or agree %ith the pre$ailing pra!ti!e or do!trine %as ,not s!ientifi!, and %as pushed aside. 1C; Aone of the so-!alled ,food-fanati!s, probably assu#es that one or the other ite#, used on!e, for a %ee*, or for a year, %ill prepare the underlying !onditions for !an!er. This boo* e<plains that chronic into<i!ation and degeneration of the li$er-pan!reas apparatus and the %hole #etabolis# #ay !ause the underlying !onditions for !an!er. ll other superfi!ial presentations are #is!on!eptions and #islead the reader. The introdu!tion to the abo$e-#entioned arti!le reads as follo%s. 9ugar, %hite flour, preser$es, spi!es, !heese, !anned goods, !oo*ed foods and to#atoes all !ause !an!er, %e hear. Grapes, on the other hand, !an %ard off !an!er and e$en !ure it. These are so#e of the #is!on!eptions about !an!er %hi!h $arious food-fanati!s and !ra!*pots ha$e held throughout the ages. ,Aone of the#, of !ourse, is true. 9!ien!e has not found that any dietary ite# !an lessen one&s !han!es of getting !an!er or re!o$ering fro# !an!er. lu#inu# !oo*ing utensils %ere on!e thought by so#e to !ause !an!er. =any people still belie$e that !he#i!al fertilizers, used instead of the old-fashioned organi! *ind, #a*e people #ore sus!eptible to !an!er. nother #yth %hi!h has gro%n only in !o#parati$ely re!ent years is that %ater fluoridation !auses !an!er.,1C) "hat ,other, s!ientists and their follo%ers assu#e is so#ething entirely different. Their opinion repeated in short is, that #any different da#aging food ite#s, ta*en together, or in !o#bination %ith other da#aging fa!tors, su!h as artifi!ial fertilizer, alu#inu# *it!hen utensils, and dead food

su!h as frozen food or food

The introdu!tion to the arti!le %nvironmental #ancer in #ancer "ews 719)4, Qol. N, Ao. C, p. C8 !an be regarded as the #irror of thought of the #a5ority of leading authors in the #edi!al profession. In that arti!le all see#s to be based on ,s!ien!e, and ,s!ien!e e<peri#ents, and ,s!ientifi! *no%ledge., In reality, ho%e$er, this ,all, is tal*ing around the !ore of the issue and e$ading the real proble#. *() <bid.
1C;

!hanged by !he#i!al additions for preser$ation, and in addition other defi!ien!ies in food, !aused by refining pro!esses or poisons !aused by !anning, et!., all ta*en together, !an seriously influen!e and !ontinue to influen!e our body and its $ital organs. Aobody !an re!onstru!t su!h !onditions in ani#al e<peri#ents, but #any obser$ations in the history of peoples de#onstrate their do%nfall by influen!es of !i$ilization in a broad sense. 9u!h a!!u#ulations 7not one or another ite#8 of poisons prepare the !onditions for !an!er diseases. In #any !ases, e$en the lifespan of a physi!ian&s pra!ti!e is not suffi!ient to obser$e in #any people the a!!u#ulation of all da#ages, as it #ay ta*e si<ty to se$enty years or longer to obser$e the outbrea* of the disease in healthy people %ith a strong body, a resistant li$er and good reabsorption po%er. It goes %ithout saying that $egetarians also get !an!er. 9o#e of the# !on!ludeRho% !an su!h a treat#ent help against !an!er %hen e$en $egetarians #ay be!o#e affli!tedT 718 they do not *no% %hat !onditions are ne!essary to #aintain the nor#al #etabolis#R 7(8 that our #odern agri!ulture de!reased potassiu# and iodine in our nutrition, pre!isely the #inerals essential for pre$ention of !an!erR 7C8 that so#e people %ith %ea* organs are not suffi!iently prote!ted by diet aloneE 7;8 the therapy !o#prises #u!h more than a $egetarian diet and has been su!!essful in so#e $egetarians also. s far as I *no%, e<peri#ents %ith the %hole #etabolis# in that respe!t are not being !arried out any%here in the %orld. ll the e<peri#ents perfor#ed in that dire!tion in the past t%enty or thirty years sho% #ostly the abo$e-#entioned influen!e of single ite#s on the %hole #etabolis#. The results of these e<peri#ents are partly !ontradi!tory and partly !onfli!t %ith other ideas. This is understandable, as ani#als and hu#ans $ary !onsiderably in their #etaboli! e+uilibriu#. The a#ount of da#age done by !he#i!al fertilizers, spraying, and inse!ti!ides %hi!h lead to a !hroni! poisoning of the soil !an be esti#ated %hen %e realize ho% #any poisons go into the fruit and $egetables %e eat, into the !attle, the eggs and butter %e !onsu#e and the #il* %hi!h %e and our !hildren drin*. "e also ha$e to realize the enor#ous a#ount of food one patient needs in a single year. 'ere is a re!ord of the a$erage +uantity of inta*e of so#e patients in the !ourse of one yearO a $ery great part of %hi!h is !on$erted into 5ui!es. 1:-- pounds of !arrots 1C-- pounds of apples C)--;)- pounds of !alf&s li$er 75ui!e8J 1;) heads of red !abbage ;-- heads of lettu!e 1() pounds of green peppers, et!., et!. I a# #ore than e$er !on$in!ed that bio!he#istry and #etaboli! s!ien!e %ill be $i!torious in healing degenerati$e diseases, in!luding !an!er if the whole body or the whole metabolism %ill be atta!*ed and not the sy#pto#s.
J 9ee ppendi< III, page ;(1

C-APT1R ==

Introduction to 2utrition and $iet

To GEGIA %ith, I %ould li*e to des!ribe a fe% obser$ations and e<peri#ents %hi!h de#onstrate the i#portan!e of proper nutrition to general health and pro$e faulty nutrition as being an underlying !ause of disease. 9e$eral authors on nutrition thin* that, in #odern ti#es, !attle are better fed than people. "ithout *no%ing it, #any $egetarians today are ,star$ing., The protein !ontent of #ost $egetables and fruits %ent do%n in the last ten to t%enty years and %e %ould ha$e to #a*e great efforts to bring it ba!* to nor#al or e$en near nor#al. 'ere is an e<a#ple. Corn has been allo%ed to fall in its protein !ontent fro# 9.) to :.) per !ent in the last ten years. fe% e<a#inations of $arious $egetables ha$e sho%n that by the use of artifi!ial fertilizer and >>T spraying, the P-!ontent as %ell as the protein !ontent %ent do%n !onsiderably %hile the sodiu# !ontent in!reased. /n the other hand, agri!ultural e<perts ha$e raised the protein !ontent of !lo$er and alfalfa on a pilot far# in Qista, CaliforniaO the protein per!entage of alfalfa %as raised fro# *+.) per !ent to C( per !entRe+ual al#ost to #eat. The di#inution of proteins in fruits and $egetables ne!essitated the addition of ani#al proteins to the diet, as the patients %ea*ened after four to si< %ee*s, espe!ially those %ith !an!er in the intestinal tra!t, those in the ad$an!ed age groups and those %ho %ere $ery far redu!ed in their body substan!e, espe!ially the #us!ular syste#. I do not intend to dis!uss all proble#ati! +uestions of the dietary regi#e, su!h as, for instan!e, the inta*e of suffi!ient protein to !o$er the in!reased loss of that substan!e. In pra!ti!e, I ha$e seen that #ost of the ad$an!ed or ter#inal !ases refuse a higher inta*e of protein, espe!ially !oo*ed #eats, fish, eggs, et!. =any of the# ha$e a spe!ial desire for ra% food, but refuse e$en finely !hopped ra% #eat or fresh ra% egg stirred in orange 5ui!e. I obser$ed that al#ost all patients %ith a higher protein inta*e !ould not be sa$ed. In so#e !ases I obser$ed a #u!h +ui!*er gro%th of the !an!er or #etastases. It see#s that !attle fodder is super$ised #ore !arefully than hu#an nutrition. There are interesting e<peri#ents #ade on rats, %hi!h sho% the follo%ing. "hen rats are feeding fro# organi!ally gro%n soil, they ha$e perfe!tly healthy organs through #any generations. /ther groups of rats, li$ing on ordinary food in the @nited 9tates and Gritain de$eloped, %ithin one generation, all the degenerati$e diseases and pathology *no%n in hu#an beings.1C4 6ats feeding on large +uantities of organi!ally gro%n substan!es ha$e been found to ha$e better fur, to be #ore pea!eful a#ong the#sel$es and less aggressi$e to%ards other ani#als. /ther e<peri#ents sho%ed that rats sus!eptible to !an!er sho%ed a de!line in in!iden!e of !an!er %hen gi$en proper nutrition fro# the ti#e of their birth. >r. 2ottenger&s e<peri#ents on !ats sho%ed that !ats fed !o##on food, %ithout ra% substan!es and ra% #il*, be!a#e ner$ous, si!* and e$en ho#ose<ual. 9e$eral %ee*s& treat#ent %ith ra% #il* and ra% $egetables returned the# to nor#al!y0 >r. Gis*ind1C7 #ade a spe!ial study on >>T %here$er it is used and presented in detail the da#ages on the hu#an body. ,"e ha$e found as #u!h as 1C parts per #illion in butter on the Ae% For* #ar*et and >epart#ent of gri!ulture reports indi!ate that $ery #u!h higher $alues are not at all i#probable. In addition, I ha$e seen se$eral instan!es in %hi!h e<posures to >>T sharply in!reased the insulin re+uire#ents of diabetes., 7This refers to the i#pair#ent of li$er and pan!reas.8 #ong other !lini!al sy#pto#s of poisonings, he reported. ,one patient had signs of se$ere li$er in$ol$e#entR%as !o#pletely i#pro$ed %hen all >>T-!ontaining foods %ere re#o$ed.,
9ee Prevention Maga:ine, pril, 19)7. 1C7 7'earings before the 'ouse Co##ittee to in$estigate the @se of Che#i!als in ?ood 2rodu!ts8 '. 6es. C(C.R6eprint (-)(, 3ee ?oundation for Autritional 6esear!h, =il%au*ee C, "is!onsin.
1C4

>r. Gis*ind&s and >. ?. =. 2ottenger, Lr.&s obser$ations sho%ed that in the years fro# 19;) to 19)-, blood !holesterol in his patients ,%as in!reased,, a!tually !aused by ne%er inse!ti!ides. In e<peri#ents of the ?ederal ?ood and >rug d#inistration %ith inse!ti!ides ,fi$e days after feeding sho%ed the inse!ti!ides in the gizzard, the li$er and the *idney, the tissues of the heart and brain and s!iati! ner$e fibre., "ith larger doses, ?.>. . s!ientists ha$e also sho%n that it is possible to store #any ti#es the a#ount in the body-fat that %ould be a!utely fatal intra$enously in a single dose. 9in!e >>T #obilizes fro# the body fat into the blood strea#, the intra$enous dose is the logi!al !o#parati$e one. Cu#ulati$e into<i!ation fro# e<tre#ely s#all a#ounts in food !an thus be as dangerous as dire!t e<posure to #u!h larger a#ounts. ,The soil is the #eeting pla!e of the li$ing #atter at the surfa!e and of the #ineral #atter beneath the surfa!e, and of the at#osphere abo$e and the solid ro!* underneath. Essentially all li$ing #atter depends upon it, dire!tly or indire!tlyRis, in fa!t, a part of those $ery pro!esses that produ!e the soil upon %hi!h life depends. 2lants and soils ha$e gro%n up together, ea!h partly a !ause of the other. =an has so#e%hat the sa#e relationship to the soils. 'e finds so#e are better suited to his needs than others. 'e #ay !hange the# either for better or for %orse.,1C: 9oil s!ien!e has a !ontribution to #a*e to%ard the future, but !ertainly not by itself. 9in!e s!ien!e itself has be!o#e so spe!ialized, it is diffi!ult to see s!ien!e as a %hole and its relationship to politi!s, art, business, and agri!ulture. =ore and #ore, #ode# edu!ation see#s to #a*e people spe!ialistsR#e#bers of a group or !li+ueRand leads the# a%ay fro# the #asses, fro# real de#o!ra!y. The *ind of s!ien!e that is super-spe!ialized !annot lead people to better relationships %ith ea!h other and the land, nor !an so-!alled ,pure, s!ien!e, %hi!h is too !old or too snobbish to fa!e the real proble#s. 9o#e see a danger that far#ers as %ell as other people #ay turn their proble#s o$er to so#e spe!ial group, so#e spe!ial bureau!ra!y, rather than to thin* out the proble#s for the#sel$es and #a*e their de!isions by the de#o!rati! #ethod.
1C: Charles E. Pellog. The =!=illan Co#pany, 19)4.

There e<ist abundant supplies of nearly all natural resour!es in the @nited 9tates and espe!ially of soil. Enough in5ury to the soil has ta*en pla!e to indi!ate a pressing need for ad5ust#ents of agri!ultural people to the soil upon %hi!h they li$e. 9in!e there are #any soils these relationships are too !o#pli!ated to be resol$ed by a fe% si#ple slogans or progra#s. The #odern te!hni+ue of !anned food goes ba!* to the appli!ation of heat by the atte#pts of pperts %ho tried to gain the a%ard, established by Aapoleon in 179), for the best plan for ,food !onser$ation for his ar#y., In 1:-;, he published his %or*. In 1:1-, 2eter >urand re!ei$ed the first English patent for the #etal !an. In 1:;1 the first fa!tory for !anned food %as founded in Aor%ay. 3ater in 1:;) the first fa!tory in >essau, Ger#any, %as established. In 1:7C, 6obert Po!h introdu!ed the auto!la$e. In 1:)9, fa!tories for !anned food %ere set up in the @nited 9tates. In 1:79, the first !ans for sardines %ere #ade in 9ta$anger, Aor%ay. In 19C7, the produ!tion of !anned $egetables in the @nited 9tates a#ounted to 1:9,919,--- !ratesO there also %ere 4C,7;;,--- !rates of fruits and 1(,C--,--- !rates of fish. The te!hni+ue of frozen food %as introdu!ed by C. $on 3inde 719C18. The te!hni+ue of !onser$ation is an!ient. It begins %ith the use of salt for #eat and fish and $egetables, and the use of sugar for fruit. It be!a#e #ore de$eloped in our #odern bio!he#istry.,1C9 The !anned food industry has gro%n into an i#portant fa!tor in our #odern !i$ilization. Thus, the nutrition and feeding of fa#ilies has been put on a #ass produ!tion basis. The !ans stay in the foreground and the #ista*es in that respe!t, no #atter ho% insignifi!ant they #ay appear, be!a#e an e$er-in!reasing !ala#ity in our present day so!iety. ". C. Pinney, of Qista, California, re!ently produ!ed on his organi! far# apri!ots on !o#posted, #ineralized soil that !ontain the follo%ing analysis. =oisture :4.1)Z sh . -.7-Z

2rotein 1.;1Z P(/ ;1)pp# Aa 7;: pp# Ca/ (91 pp#

1C9 "erner Pollath, ibid., pp. 7--71.

=g/ 49.( pp# 2(/) 1C;-.- pp# 9 1).( pp# ?e (-.: pp# =n 4.9 pp# G 0.(: pp# Cu 0.49 pp# The in!reased protein !ontent also has #any disad$antages. 1J- E!ono#i! pressure, in ter#s of lo%er a!tual !ash returns for the far#er&s !rops, has brought a ne% ele#ent into the planning and thin*ing of so#e of our top agrono#ists. The gro%er&s pay for his year&s %or* is being !onsiderably redu!ed through the toll ta*en by pests and disease. 9o the e#phasis is being shifted, at least in so#e +uarters, to the de$elop#ent of resistant plants and to biological controls instead of poisons. long %ith this trend there is 5ust beginning to be a realization of the fa!t that in!reasing nu#bers of !onsu#ers are %illing to pay top pri!es for really high +uality foods. In this regard, the #ost ad$an!ed resear!h sho%s that ,high protein !ontent, by itself is not ne!essarily the ans%er. "or* %ith the a#ino a!ids has sho%n, a#ong other things, that high protein brought about by e<!essi$e nitrogen fertilizing !an a!tually lessen rather than in!rease the nutritional $alue of grains and $egetables. t the sa#e ti#e, s!ientifi!ally #anaged organic fertili:ing !an gi$e better results, in ter#s of food $alues, e$en %ith a relati$ely lower protein !ontent. In the "ew =ork ;orld9Telegram 'un, =ay :, 19)7, an arti!le reported that ,6o!*land County&s stra%berry !rop is ruined, the rest of the !ounty&s ^(,---,--- fruit !rop is threatened and $irtually e$ery bee in the !ounty has been *illed by the >epart#ent of gri!ulture&s #assi$e aerial spray of >>T, the state agri!ulture agent of the !ounty !harged today., In #y opinion, it %as not the one spraying that !aused su!h disastrous da#age, as the pre$ious 1( years of in!reased spraying %ith in!reased poisons produ!ed an a!!u#ulated to<i! and pathologi!al !ondition in soil, ani#als and hu#an beings. I !alled it. ,our E<ternal =etabolis#, 7see page 1), line 18.
1;- E. E. 2feiffer, =.>., &Galan!ed Autrition of 9oils and 2lants,, "atural 7ood 7arming, =ay 19)7, p. 4.

The arti!le !on!luded as follo%s. ,>>T is, and is re!ognized and ad#itted by the defendants to be, a delayed-a!tion, !u#ulati$e poison su!h as %ill ine$itably !ause irreparable in5ury and death to all li$ing things, in!luding hu#an beings, ani#als, birds, inse!ts and the predators and parasites of har#ful inse!ts, if ingested, inhaled or brought into !onta!t there%ith in suffi!ient +uantities or o$er a suffi!ient period. ,9o#e hu#an beings, in!luding so#e of the plaintiffs, ha$e already absorbed . . . and no% irre#ediably retain in their bodies an a!!u#ulated a#ount of >>T %hi!h is to<i! and pathologi!al, so that the threatened spraying upon their persons %ill endanger their health and li$es, and the threatened spraying on their gardens and other !ulti$ated lands %ill #a*e it unsafe for the#, this year, or e$en thereafter, to eat the produ!e therefro#.,

A@T6ITI/A S>ETE6I/6 TI/A8

The preparation of the 5ui!es is des!ribed in the pres!ription boo*let. There, the physi!ian %ill

find an outline of the diet as it is used at the present ti#e and also a des!ription of the preparation of $egetables. The pres!ription boo*let also !ontains an outline of the #edi!ation %ithout indi!ating the e<a!t doses. Instead of that, one !an!er !ase is presented in full detail, fro# beginning to end. I belie$e that the physi!ian %ill thus ha$e
T!BL( I Potassium Applet #otatoes $urnips Ca88a'e (ima 8eans,dried &atmeal !-/ **0 33-*3 !.*3 300 sodium !/ !" In !00 'rams fresh su8stance /" Ash content of the edi8le por tion -0 of some common foods 9modified from (us:; 0!

-*/

a #u!h !learer idea of ho% the #edi!al treat#ent !an be applied in the best #anner. The details of the agri!ulture of foods and $egetables !annot be gi$en in extenso in this $olu#e. 9pa!e %ill only per#it a fe% brief !hapters to deal %ith the proble#s of artifi!ial fertilizers, organi! gardening #ethods, the poisons of spraying and all other fa!tors da#aging to foods and $egetables in their preparation and distribution. K 7Chapter 9C.8 ?or the !hoi!e of fruits and $egetables, it %as #ost i#portant to *no% the potassiu# !ontent as %ell as the sodiu# !ontent.,1;1 The table sho%s that the potato has the lo%est sodiu# !ontent, of 19 #illigra#s in 1-- gra#s of fresh substan!e, %hile the potassiu# !ontent is ;;- #illigra#s, or C( ti#es as #u!h. The !ontent of the apple is fifteen to 1(), or about eight and one-half ti#es as #u!h. The a!!ura!y of this table is +uite un!ertain, as the $egetables, fruit and #il* sho% +uite different figures at different ti#es. The #ore our agri!ulture turns a%ay fro# natural #ethods, the #ore the !ontents of fruits and $egetables are !hanged. the sodiu# !ontent rises, the potassiu# !ontent di#inishes. In the near future, hospitals and !an!er !lini!s and !lini!s for !hroni! degenerati$e diseases %ill be #ore or less for!ed to use fruits and $egetables gro%n by organi! gardening #ethods, or %e physi!ians %ill see that our results and therapeuti! su!!esses of the treat#ents %ill be fe%er and fe%er. The poisoned soil %ill not only help to in!rease degenerati$e diseases, but it %ill also redu!e the healing po%er of the body %hen brought under spe!ial !onditions %here it fun!tioned fa$orably pre$iously.
9ee the Physiological 4asis of Medical Practice, )th edition, by Chas. '. Gest and Aor#an Gur*e Taylor, p. 77- 7The "illia#s and "il*ins Co., 19)-8.
1;1

C-APT1R ==I The Saltless $iet

T'E 6/3E of salt in hu#an nutrition has been a disputed sub5e!t for a long ti#e. 9o#e authors regard salt #erely as a !ondi#ent or sti#ulant %hi!h is har#less in s#all +uantities, possibly har#ful in larger +uantities, but definitely dispensable in nor#al nutrition, to the e<tent that it is not a natural !ontent of food. /thers belie$e that salt is indispensable in hu#an nutrition and that the sodiu# !hloride found in foods is not enough to #eet the re+uire#ents of the nor#al hu#an being.

The e<ponents of both $ie%s ha$e gi$en reasons in support of their respe!ti$e $ie%points. "olff-Eisner asserts that salt is !o#parable to a $ita#in, and that its !o#plete e<!lusion !ould not be tolerated any longer than the e<!lusion of food itself. 7It #ight be argued here that ,!o#plete, e<!lusion is i#possible any%ay, inas#u!h as $arying +uantities of AaCl are found in food naturally.8 "olff-Eisner adds, ho%e$er, ,. . . that !oo*ing salt is the only salt %hi!h does not o!!ur in suffi!ient +uantities in nor#al nutrition and that it, therefore, #ust be added artifi!ially.&& There are different $ie%s as to the +uantity of salt %hi!h, a!!ording to this theory, #ust be added to !o$er #an&s salt re+uire#ents. The a$erage European !onsu#es ten to fifteen gra#s of salt per day and in the @nited 9tates the a$erage !onsu#ption is ten to t%el$e gra#s per day, %hereas the $alues are +uite different in sia and fri!a. ll physiologists agree that these $alues far e<!eed the salt re+uire#ents. In other %ords, they agree that people !onsu#e salt #ostly be!ause it #a*es food #ore tasty, not be!ause the body re+uires it. Gunge !ondu!ted se$eral e<peri#ents in 19-1 on the need for salt. 'e found a s#all de#and for salt in ani#als %hi!h eat a lot of #eat, %hereas he dis!o$ered the de#and #u!h greater in those li$ing on $egetation. 'e belie$ed that the sa#e relationship %as to be found a#ong hu#an beings. 'e found that the population of !ities, in %hi!h larger +uantities of #eat %ere eaten, !onsu#ed one-third of the +uantity of salt used by the #ainly $egetarian rural population. 9i#ilarly, he found little de#and for salt a#ong the #eat-eating no#ads, /n the other hand, the salt de#and a#ong agri!ultural negroes %as so great that, in so#e tribes, salt a!tually had barter $alue. ?ro# his o%n e<peri#ents, Gunge gathered that the body eli#inates large +uantities of salt if it !onsu#es #u!h potassiu#, su!h as found in large +uantities in $egetarian nutrition. 7'is !lassi!al e<peri#ent in 19-1, ho%e$er, is not indisputable in theory, although its !on!lusions are !orre!t.8 bderhalden shared Gunge&s $ie%s as to the reasons for the in!reased de#and for salt a#ong $egetarian tribes. The higher potassiu# !ontent of nutrition leads to in!reased eli#ination of sodiu# and, therefore, !auses an in!reased de#and for salt. Gunge !onsidered the addition of four to fi$e gra#s of salt daily ne!essary for the #aintenan!e of the ,salt balan!e, 7per Qoit8O 'er#annsdorfer disputed this in his do!torate dissertation, stating that %hile #an !onsu#es up to 1) gra#s of salt per day, he !ould undoubtedly #anage on one or t%o gra#s of salt. In fasting e<peri#ents on hi#self, to test the eli#ination of salt, 'er#annsdorfer generally too* t%o gra#s of salt. These $ie%s are !onsidered one-sided in so#e respe!ts despite their ha$ing !o##on usage. =y e<peri#ents on thousands of patients, as %ell as on #yself, re$eal that the de#and for salt is so#ething to %hi!h our ner$es of taste ha$e be!o#e a!!usto#ed sin!e youth. Lust as one #ight say that all people ha$e a need for al!oholi! be$erages and that e$en ani#alsRespe!ially the hu#an-li*e apesR!an be!o#e !hroni! al!oholi!s, and, !on!luding fro# this fa!t that al!ohol is a ne!essary !o#ponent of hu#an nutrition, it %ould be 5ust as in!orre!t to base a !lai# of the in dispensability of salt on its uni$ersally pra!ti!ed use. There are !ertain tribes %hi!h do not use salt, 'o#er has #entioned the#, and 9allust tal*ed of the Au#idians %ho did not use salt. Gut apart fro# that, e$en if all the people in the %orld had eaten salt sin!e ti#e i##e#orial, this still %ould not pro$e that it %as to their ad$antage. fter all, there had al%ays been !hroni! diseases %hose etiology %e !annot as!ertain e$en todayO thus, %e !annot 5udge to %hat e<tent they #ay ha$e been !aused by an unreasonable %ay of life. Lust for the sa*e of !uriosity, %e #ight point to the fa!t that, e$en today, there are tribes %ho li$e %ithout salt. 2rofessor Qrgo! reported that tuber!ulosis %as unusually pre$alent a#ong the settled Pirghizians, %hereas it o!!urred only rarely a#ong the no#adi! ones. 1;( The no#ads use no salt, %hereas the Pirghizian peasants do use salt, %hi!h is freely a$ailable in the 9teppes, as an addition to nutrition, in the #anner of the 6ussian peasants. 7Aote. the role of @umysEstrong al!oholR%ill not be dealt %ith here.8 The Pirghizians reported to Qrgo! that they had noti!ed a

deterioration of their senses of sight and s#ell sin!e parta*ing of bread and salt. Ao#ads %ho use salt lose the ability to s!ent %ol$es. Qrgo! also reported that fishing and hunting tribes of 9iberia sho% a #ar*ed disli*e of salt. /n his e<peditions to the Aorth 2ole, Aansen used the Es*i#os& disli*e of salt to get rid of unin$ited guests by offering the# strongly salted food. 9tanley and 3i$ingstone, too, reported on finding tribes to %ho# salt %as un*no%n and %ho sho%ed !ertain to<i! sy#pto#s after ta*ing it for the first ti#e. 7 lso see lbert 9!h%eitzer&s report.8 "e obser$ed healthy nurses after se$eral #onths of unsalted nutrition and found that their first rea!tion to nor#al ho#e-!oo*ing %as diarrhea and nausea. This sho%s %hat far-rea!hing effe!ts the habitual !onsu#ption of salt #ay ha$e on the organis#. fter going si< #onths %ithout salt, a nurse %ho had belie$ed that she !ould not do %ithout it rea!ted to this spi!e as a young boy rea!ts to his first !igarette. The e$aluation of al!ohol, toba!!o and salt as parts of hu#an nutrition is !losely !onne!ted %ith national and e$en religious and politi!al #oti$es %hi!h are not al%ays related to #edi!al !onsiderations. It %ould, therefore, be %ise to o#it the ethnographi! aspe!t fro# a dis!ussion of the #eaning of salt in hu#an nutrition. "e should also a$oid the #ista*e of +uoting e<a#ples fro# the ani#al %orld to pro$e that the inta*e of salt is ,natural,
1;(

Quoted in Dtsch. $er:te:eitung. 174E1(9.

or ne!essary. "e ha$e refused to use the argu#ent of ,natural nutrition,O this ter# #ust be re5e!ted %hen usedRapparentlyRto the disad$antage of the diet. "hether a for# of nutrition is natural or not has nothing to do %ith the +uestion of %hether or not it is of therapeuti! $alue in diseases. This is the only de!isi$e +uestion in pra!ti!e. Ae$ertheless, for the sa*e of !o#pleteness, a fe% brief re#ar*s regarding the desire for salt in ani#als are in order. In areas of great e<panse, su!h as in Central India and in the >e**an, there is an enor#ous %ealth of ga#e and no a$ailability of salt. 2resu#ably, the sa#e situation e<ists else%here. It is of spe!ial i#portan!e to note that apes in parti!ular sho% no need for saltO #i<ed hu#an nutrition is offered to the# only in !apti$ity, %hen they a!!ept it as readily as they learn to drin* al!ohol, s#o*e toba!!o and eat roast #eat. !!ording to >r. Gusta$ 6iedlin, thorough e<peri#ents in the use of salt %ere !ondu!ted by 'ahne#ann, the founder of ho#eopathy, and his students. In these e<peri#ents, 'ahne#ann and his students !onsu#ed !onsiderably greater +uantities of salt for %ee*s and #onths than they %ere nor#ally a!!usto#ed to !onsu#e in food. The har#ful effe!ts are des!ribed in the boo* 7pp. 9-1)8.1;( rgu#ents against a ,saltless, diet 7,saltless, #eans %ithout addition of salt to food8 %ere enu#erated by "olff-Eisner,; appro<i#ately as follo%s. In a nutrition ri!h in $egetables, the body re+uires the addition of salt, as this does not o!!ur in suffi!ient +uantities in the food ,as the only salt., s the potassiu# !arbonate of $egetables !o#bines in the organis# %ith !hloride and sodiu# to for# sodiu# !hloride and sodiu# !arbonate, it !auses the eli#ination of !hloride and sodiu#. This #eans that sodiu# as %ell as !hloride #ust be gi$en to the body to #a*e up this lossRhen!e the addition of salt In this %or*, "olff-Eisner +uotes the %ell-*no%n e<peri#ents of Gunge, %ho asserted that regular parta*ing of potatoes, %hi!h !ontain C1-;( ti#es #ore potassiu# than sodiu#, is possible only if AaCl is added to this food.
&,Gusta$ 6iedlin, Das @ochsal: 8'alt3, Ed. 2aul 3oreoz, ?reiburg, 19(;. 1;; It should be noted here that not only salt, but also fruity a!ids parti!ipate in su!h !hanges of the #etabolis#. T'E 9 3T3E99 >IET

In the sa#e %or*, strangely enough, it is #entioned that a8 apples !ontain e$en 1-- ti#es #ore potassiu# than sodiu#, yet one #ay !onsu#e large +uantities of applesRone #ay e$en ha$e e<!lusi$e apple daysR%ithout the addition of AaCl. b8 !!ording to general opinion, the

hydro!hlori! a!id of the sto#a!h is dependent on the body&s salt inta*e. Therefore, if the inta*e of salt is #issing, the for#ation of hydro!hlori! a!id #ust de!rease, %hi!h %ould affe!t appetite, digestion, et!. for ,la!* of salt inhibits produ!tion of hydro!hlori! a!id., !8 ?inally, "olff-Eisner re#ar*s that the s%eat of tuber!ular patients !ontains up to one per !ent salt, so that perspiration depri$es the body of salt.1;) d8 ?urther#ore, it is said that the *idneys regulate the body&s ioni! stateO in fe$er and in the #a5ority of infe!tious diseases, the salt !ontent of the urine is di#inished, e$en if the patients are gi$en salt. 7Conse+uently, it is argued, there is no need to regulate the inta*e of salt, if the *idneys are healthy, as the *idneys regulate the eli#ination of salt any%ay. 9in!e, a!!ording to 6oth-Poe$esti, e$en diseased *idneys are !apable of eli#inating fi$e gra#s of salt in a liter of urine, the inta*e of fi$e gra#s of salt is unob5e!tionable for su!h *idneys.U Inas#u!h as so#e of these argu#ents are also $oi!ed by our patients, %ho see parti!ular nutriti$e $alue in salt and appre!iate the sti#ulati$e effe!t of salt upon appetite and thirst, physi!ians are so#eti#es for!ed to ta*e the# into !onsideration. s far as "olff-Eisner&s first argu#ent is !on!erned, it #ust only be said that that %hi!h appears ob5e!tionable to hi# is parti!ularly desired by #e, i.e., the in!reased eli#ination of AaCl. ?or if, "olff-Eisner&s presentation, %hi!h is based on Gunge&s $ie%, is !orre!t, i.e., if the eli#ination of AaCl fro# the body&s salt resour!es is furthered by $egetarian nutrition, it is pre!isely that %hi!h #y diet %ants to a!hie$e. The #ore salt is eli#inated by it, the #ore effe!ti$e the diet is in so#e respe!ts. It appears to us that it %ould be e+ually ine<pedient to repla!e the de!reased sodiu# and !hloride, %hi!h %e desire, by the feeding of salt, as it %ould be ine<pedient to #a*e up in!reased eli#ination of sugar in the urine of diabeti!s by in!reasing sugar inta*e. ,Ao hu#an dietaries, ho%soe$er pres!ribed, e$en %ithout added salt, are so lo% in sodiu#

that they !annot support life.,1;:

1;) Med. ;elt, 19(9, p. 1:(1. 1;4 9ee lfred T. 9hohl, Mineral Metabolism, p. 1(1.

The argu#ent for the ne!essity of the addition of salt to potatoes %as #entioned abo$e, as %ell as the fa!t that apples-!ontaining 1-- ti#es #ore potassiu# than sodiu#Rare not salted, e<!ept by spe!ial gour#ets. 7This sho%s the i#portan!e of the role of habit and taste. 2easants %ould laugh at people %ho add salt to apples, yet they add salt to potatoes the#sel$es.8 It is *no%n that there is a !onne!tion bet%een the hydro!hlori! a!id of the sto#a!h and the inta*e of salt. 'o%e$er, the dependen!e of this hydro!hlori! a!id upon salt inta*e has not been pro$en, and is !ontrary to #y e<perien!e. 1;7 !!ording to 6ose#ann, the sto#a!h 5ui!es of nor#al hu#ans !ontain ;---)-- #g. of hydro!hlori! a!id. Its p' lies bet%een -.97 and -.:-. If %e !onsider the regulation for the produ!tion of sto#a!h 5ui!e, it sho%s ho% the entire organis#, espe!ially the li$er, parti!ipates in its for#ation, 5ust as it parti!ipates in all other bodily o!!urren!es, irrespe!ti$e of the organ in %hi!h the parti!ular pro!ess ta*es pla!e.

-5/ /-IT1 MA2%S $I1T A??1CTS 2ATI.1S 5? A?RICA'*,

,I ha$e to point out a happening in the #odern !i$ilization of the 'ospital, so#ething %hi!h happened this year. ,"e had to perfor# the first appendi!itis operation on a nati$e of this region. 'o% it turned out that this so fre+uent si!*ness of %hite people did not o!!ur in the !olored of this !ountry !annot be !on$in!ingly e<plained. 2robably its still e<!eptional o!!urren!e is tra!eable to a !hange in the nutrition. =any nati$es, espe!ially those %ho are li$ing in larger !o##unities do not no% li$e the sa#e %ay as for#erlyRthey li$ed al#ost e<!lusi$ely on fruits and $egetables, bananas, !assa$a, igna#, taro, s%eet potatoes and other fruits. They no% begin to li$e on !ondensed #il*, !anned butter, #eat-and-fish preser$es and bread. ,The date of the appearan!e of !an!er, another disease of !i$ilization, !annot be tra!ed in our region %ith the sa#e !ertainty as that of appendi!itis. "e !annot state de!isi$ely that for#erly

1;7 9ee Ei#er, Deutsch. Med. ;o., 19C-, Ao. (;. 1;: ?ro# 2rofessor lbert 9!h%eitzer&s ,Griefe aus de# 3a#barenespital, S3etters fro# the 3a#barene 'ospital8 in fri!a, 19);.

there %as no !an!er at all, be!ause the #i!ros!opi! e<a#inations of all tested tu#ors, re$ealing their real nature, has only been in e<isten!e here for a fe% years. Gased upon #y o%n e<perien!e, going ba!* to 191C, I !an say, if !an!er o!!urred at all it %as $ery rare but that it be!a#e #ore fre+uent sin!e. 'o%e$er, it is not spread as #u!h as it is a#ong the %hite ra!e of Europe and #eri!a. ,It is ob$ious to !onne!t the fa!t of in!rease of !an!er %ith the in!reased use of salt by the nati$es. In for#er years there %as only a$ailable the little salt e<tra!ted fro# the o!ean, %hi!h !a#e up to the hinterland. There %as a $ery li#ited traffi! only. The salt had to be transferred by dealers of the tribe li$ing at the !oast to those tribes li$ing ne<t to the# up-strea#. In this %ay it rea!hed one tribe after another and #o$ed further and further to the interior, %here the dealers handed o$er only the portion %hi!h %as left o$er fro# distribution a#ong their o%n tribe and the !hiefs !harged hea$y !usto#s for the passage through their region. "ith this pro!edure it s!ar!ely !ould get farther than 1(- #iles inland. !!ording to infor#ation of old people here, %ho# I still *ne% at the beginning of #y a!ti$ity, for#erly there %as no salt %hatsoe$er in the interior. ,This !hanged in 1:7; %hen the %hites !a#e to this land and handled the traffi! up-strea#. The European salt %as shipped in s#all sa!*s of a fe% pounds. 9till at the ti#e of #y arri$al in 3a#barene, salt %as so pre!ious that it pre$ailed as the #ost $aluable and the #ost generous type of re#uneration. "ho e$er had to #a*e a trip on the ri$er or tra$el along the paths of the $irgin %oods did not ta*e along #oney but salt 7also toba!!o lea$es i#ported fro# #eri!a8, thus trading bananas and !assa$as for his oars#en and !arriers. Gy and by the !onsu#ption of salt in!reased. Today it is used #u!h less a#ong the !olored than a#ong the %hites. The patients %e feed in our hospital re!ei$e a fe% gra#s a #onth and are satisfied %ith this s#all a#ount. ,9o it is possible that the for#erly $ery seldo# and still infre+uent o!!urren!e of !an!er in this !ountry is !onne!ted %ith the for#er $ery little !onsu#ption of salt and the still rare use of it. Curiously enough %e did not ha$e any !an!er !ases in our hospital. ,It should be #entioned that the infe!tious diseases a#ong the %hites gradually appeared. It re#ains +uestionable if tuber!ulosis %as spread for#erly as #u!h as no%, e$en if it o!!urred at all ti#es. !!ording to #y obser$ations it be!a#e #ore fre+uent after the ?irst "orld "ar., The e<peri#ents of Pre#er1;9 ha$e also sho%n !on!lusi$ely that the $alue of sto#a!h a!ids in patients on the diet re#ained nor#al for se$eral #onths, although salt inta*e %as li#ited to salt !ontained in natural food. The appetite of patients does not suffer by la!* of saltO as a rule it e$en i#pro$es, parti!ularly in serious diseases, after the start of the treat#ent. The eli#ination of a little salt in the s%eat of so#e patients is of no i#portan!e %hate$er in therapy, for the therapy brings about a fast de!rease and early !o#plete !essation of perspiration. 9traus !orre!tly attributes this, as %ell as the de!reased #u!us se!retion, to the %ater%ithdra%ing effe!t of the saltless diet. 'e !on!ludes fro# this that the depri$ation of salt also has fa$orable therapeuti! effe!ts upon su!h diseases 7su!h as Gron!hogeni!, $aginal dis!harge and pus se!retions, et!.8. The last argu#ent, that healthy *idneys regulate the ioni! state of the organis# any%ay, and that it is therefore unne!essary to li#it salt inta*e, is phrased #u!h too generally and does not ta*e into a!!ount i#portant fa!tors apart fro# *idney fun!tion, %hi!h affe!t the eli#ination of AaCl 7hor#ones, tonus in the $is!eral ner$ous syste#, !ir!ulatory regulations8. The fa!t that diseased *idneys are still !apable of eli#inating fi$e gra#s of AaCl per liter of urine has no parti!ular #eaning for our proble# regarding the +uantity of salt inta*e. Ae$ertheless, the !hloride ion deser$es a spe!ial position a#ong the substan!es to be !on!entrated by the

*idneys. "hile the *idneys are !apable of in!reasing !on!entration of uri! substan!e ;--:- ti#es, uri! a!id ()-)- ti#es, sugar 7in diabetes8 C--)- ti#es o$er their !on!entrations in the plas#a, !hloride !on!entration !an be in!reased only t%o to fi$e ti#es 14- ?or the past ;- years, pra!ti!al e<perien!e %as gathered about the effe!ts of salt li#itation upon diseases of *idneys. It %as sho%n 5ust here that radical li#itation of salt inta*e, in the sense of 9traus& ,stri!t for#, 7%ith less than (.) g of AaCl per day8 or the ,third degree, of Aoorden 7%ith 1.)-C g of AaCl per day8 %hi!h !orresponds to the usual saltless 1;9 Med. ;elt, Ao. 11E19C-. 1)- 3i!ht%itz, @lin. #hemie, 19C-, p. )-1. T'E 9 3T3E99 >IET 141 nutrition, de!reases the burden on the diseased *idneys. , s soon as the diseased *idneys are not o$er-irritated and o$er-burdened by the e<!essi$e inta*e of !hlorides in nutrition, they re!o$er in an a#azingly short ti#e and ... eli#inate #ore AaCl on a saltless diet than on the pre$iously saltri!h diet,1)1 Aoorden also pointed out that su!h saltless nutrition !annot !ure *idney diseaseO the re#o$al of a !onstant irritation !an only i#pro$e healing !onditions. 9o#ething si#ilar applies to the effe!t of our diet. The eli#ination of salt does not ser$e to !ure $arious diseases, but it is an i#portant supporting fa!tor of the diet. da#aging irritation is re#o$ed by the eli#ination of salt. ?urther#ore, if the eli#ination of salt by nor#ally fun!tioning *idneys is li#ited by fe$er, as "olff-Eisner points out, and re#ains li#ited in spite of further salt inta*e, this should not lead to the !on!lusion that the body regulates salt distribution so %ell that physi!ians should lea$e this fun!tion to the body. This only sho%s that the organis# !annot digest the gi$en +uantities of salt in fe$er states. Therefore, a te#porary radi!al li#itation of salt nutrition 7fasting, refusal of nutrition8 is also !orre!t in a!ute diseases 7infe!tious diseases8. nd, if diseased *idneys !an eli#inate fi$e gra#s of salt, this does not #ean that fi$e gra#s of salt should be gi$en. /n the !ontrary, it %ould appear to be #ore ob$ious to !on!lude that, by sparing the *idneys and other organs, one should try to a!hie$e in all diseases si#ilar results as in *idney-therapy and, lately, also in heart diseases, !an!er, et!. Claude Gernard %as probably one of the first to in$estigate the +uestion of origin of hydro!hlori! a!id in sto#a!h 5ui!e. 'e in5e!ted potassiu# ferro!yanide and la!tate of iron into the $eins. The substan!es ga$e a 2russian blue rea!tion in the presen!e of free a!id. The #u!osa of the sto#a!h turned blue after the in5e!tion but not the parietal !ells of the fundi! glands. The ulti#ate sour!e of the !hloride is undoubtedly the sodiu# !hloride of the blood. Chlorides are ionized CI in the parietal !ells, se!reted into the sto#a!h&s free spa!eO there they !o#bine %ith free ' ions and built free ' CI %hi!h is not se!reted as su!h. The $enous blood lea$ing the gastri! #u!osa sho%s a fall in !hloride and a rise in bi!arbonate of Aa. In !on!lusion, it should be stressed that the entire #ineral
Aoorden-9alo#on, !andbuch der %rnaehrung, 19(-, p. 91C.

#etabolis# of the ani#al organis# has not been suffi!iently e<plored so far. Therefore, %e !annot as yet #a*e any definite state#ents about the roles of !hloride and sodiu#Rboth indi$iduallyRas %ell as in their !o#bination in AaCl and in other !o#binations. "e #ust be !ontent by establishing !ertain relationships and !onditions in a healthy or a si!* body.

C-APT1R ==II Salt in Cancer $iet

>6. '/??=
A

refers to the epo!h-#a*ing resear!h of "ater#an %hi!h thro%s #u!h light on

,The ele!tri!al beha$ior of !ells e<posed to salt !hanges in their en$iron#ent. In the polarization of the !ells under su!h !onditions "ater#an has found a !riterion for the dis!o$ery of the earliest !hanges and the $ery onset of abnor#al pro!esses in the tissue, at a ti#e %hen in all other respe!ts the organs appear still perfe!tly nor#al., !!ording to =eyer, ,%hen unbalan!ed, the salts be!o#e a sour!e of trouble for !ell #etabolis#., nd that, therefore, ,it thus be!o#es ob$ious that the *ind of food !onsu#ed and the regular fun!tioning and !orrelation of all these organs deter#ine in part the +uantity and the ratio to one another of the salts present in the seru#.1,( =ineral i#balan!e then be!o#es a +uestion of profound i#portan!e in all dis!ussions of the !ausati$e nature of !an!erous pro!esses. I +uote further fro# =eyer in !onne!tion %ith this +uestion as follo%s. ,Gi$ing food !redit for that #u!h of a contributory influence to%ard the de$elop#ent of !an!er, al%ays re#e#bering the s#all per!entage of a!tual !an!er !ases a#ong those predisposed, is, of !ourse, $astly different fro# saying that already e<isting !an!er !ould be benefited by spe!ial diet, a suggestion upon %hi!h %e loo*, in !o##on %ith the great #a5ority of the #edi!al profession, as ha$ing no standing in #edi!al e<perien!e and no 5ustifi!ation of being #ade the basis for !an!er #edi!ation.,

,"ith this !on!lusion, ho%e$er, I 7?rederi!* 'off#an8 a#1)( /. E. =eyer Gott#gen,

19(C.

by no #eans in agree#ent. /n the !ontrary I a# of the opinion that the diet of !an!er patients has a profound effe!t on !an!erous pro!esses %hi!h !an be in!reased or de!reased a!!ording to the food inta*e and its regulated !he#i!al !o#position.,1)C Therapeuti!ally %e find the follo%ing. the saltless diet and deto<i!ation redu!e Aa, Cl, '(/ in the %hole syste#. This is the re#o$al of !ell ede#a si#ultaneously %ith the redu!tion of the negati$e ele!tri!al potentials. Thus the %ay is pa$ed for the a!ti$ated negati$ely !harged P group #inerals and positi$ely !harged iodine !o#ponents. These !hanges see# to for!e the !an!er !ells to a higher #etaboli! rate. In #y opinion, the #ineral #etabolis# united, of !ourse, %ith a nu#ber of other re$i$ed pro!esses bring about the de!isi$e role for the death of the !an!er !ells. Can!er !ells !an fer#ent onlyO therefore they are unable to adapt to the ne% intensi$e !hangesRthey brea* do%n and die. This part of the #etabolis# #ust be properly !o#posed and !onstantly rea!ti$ated by the fun!tion of the li$er. Thus, %e #ay assu#e that al#ost all $ital fun!tions, fun!tions of the restored #ineral #etabolis#, the deto<i!ation, et!., ne!essary for healing po%er, are an!hored in the li$er. 9o#e authors regarded salt as sti#ulating neoplasti! gro%th and re!o##ended its restri!tion in the !an!er diet.1); !ontrary opinion %as e<pressed by ?. Glu#enthal and E. 'esse in 19C), %ho sa% that regi#es e<tre#ely poor in salt ha$e a rather unfa$orable influen!e on hu#an neoplasias. /ther authors found that a protein-poor and P-ri!h regi#e produ!ed fa$orable !onditions for tu#or de$elop#ent, by indu!ing an al*alosis. They e#phasized. ,Ao !an!er %ithout al*alosis., The %ell-*no%n food !he#ist, 6agnar Gerg,1, ob5e!ted strongly to that $ie%point. a diet produ!ing al*alosis #ay be responsible for the de$elop#ent of !an!er. ll of these opinions still re#ain in the !ategory of theories. The a$ailable fa!ts on the role of sodiu# and potassiu# in !an!er are not !lear. The findings of the authors and their !on!lusions are, on the %hole, $ery disappointing. =y opinion is that !an!er is not a spe!ifi! disease, has no unifor# sy#pto#s
1)C ?rederi!* 3. 'off#an, 3.3.>., #ancer and Diet, The "illia#s 1 "il*ins Co., Galti#ore, 19C7, p. C;7. 1); 9ee op. !it., p. ;1-. 1)) Meits!hrift fuer Qol*seraaehrung, 9.119,19C;.

and is not e+ually de$eloped to a !ertain degree. Can!er is an e<traordinary sy#pto# only. The underlying !ause is to be found in the poisoning of the li$er. That is #ost probably the reason

%hy the biologi!al findings are in!on!lusi$e and so !ontradi!ting. Can!er is a disease of the li$er lately !alled a ,balan!e %heel of life,R%here #ost #etaboli! fun!tions are #ore or less !on!entrated. ?ro# here the other organs !an be pathologi!ally influen!ed and da#aged or poisoned. #ong the great nu#ber of obser$ations, there are so#e %hi!h see# to be !orre!t but they are not !onfir#ed by laboratory e<peri#ents. "ater#an found. ,the sodiu# !ontent of blood seru# is un!hanged in !an!er patients., Genedi!t and Theis !on!luded that the ,blood seru# in !an!er patients !ontains the nor#al a#ount of sodiu#., 2itts and Lohnson e<a#ined the sodiu# !ontent of blood seru# and of blister fluid in !an!erous and non!an!erous patients and dis!o$ered that ,the sodiu# !ontent of these fluids %as the sa#e in !an!er patients and in nor#al patients., >r. ?ry des!ribed in the 4ritish #ancer &eview of 19(4 the fa!t that in the blood of tu#or-bearing rats the a#ount of sodiu# is () per !ent abo$e nor#al %hen the tu#or is gro%ing a!ti$ely, and 4- per !ent abo$e nor#al %hen the tu#or is re!eding. =ar%ood %ent so far as to say salt is the root !ause of !an!er.

TAS7 5? T-1 SALTL1SS $I1T I2 CA2C1R

The #ain tas* of the saltless diet is to eli#inate the retained Aa, Cl, ' (-, together %ith to<ins and poisons fro# the tissues all o$er the body. ll poisons and other substan!es diffi!ult to eli#inate are sti#ulants for the si!* tissues, espe!ially li$er and *idneys. That !ondition see#s to be the reason %hy sodiu# !hloride e<!retion in!reases in tuber!ulosis, !an!er and other !hroni! diseases after t%o to three days on a saltless diet, and this !ondition stays at that higher le$el for about eight to ten or fourteen days, !orresponding to a fa$orable de$elop#ent in the !ourse of the disease. fter that is a!!o#plished, it stays near the nor#al le$el %ith the saltless diet, but sho%s a higher Aa-Cl e<!retion, together %ith #ore fluid fro# ti#e to ti#e for t%o to three days, and later for one day. 9u!h so-!alled ,flare-ups, go along so#eti#es %ith nausea, diairhea and ner$ous disturban!es, !aused probably by greater bile se!retion and sti#ulation of the $is!eral ner$ous syste#. fter ea!h ,flare-up, the patient feels easier and #entally i#pro$ed. <ndications for 'altless Diet 7a8 Ede#a and abnor#al deposition of sodiu# and !hloride in the sub!utaneous tissue 7nephropathies8, 7b8 Cardio-renal insuffi!ien!y, 7!8 and Aa-retention, in !hroni! diseases, espe!ially in tuber!ulosis, !an!er, et!. 7d8 >eto<i!ation, the degree of %hi!h #ust be in proportion to the degree of the disease-and %hi!h #ust be #aintained during the period of restoration. P-Ioss

C-APT1R ==III Insecticides

"E ' QE learned in re!ent years that spraying %ith #odern inse!ti!ides is doing #ore and #ore da#age to our food and to our bodies. I !annot e#phasize too often that our food produ!tion represents our e<ternal #etabolis#. "hoe$er is interested in this field #ay read the !earings 4efore the !ouse 'elect #ommittee to <nvestigate the 6se of #hemicals in 7ood Products, !ouse of &epresentatives %ighty97irst #ongress, 'econd 'ession. *). There is !learly des!ribed in the hearing of >r. Gis*ind %hat he obser$ed in this field and %hat he re!o##ended ought to be done.

The follo%ing is a brief sur$ey of this hearing. ,The introdu!tion for un!ontrolled general use by the publi! of the inse!ti!ide >>T, or !hlorophenothane, and the series of e$en #ore deadly substan!es that follo%ed, has no pre$ious !ounterpart in history. Geyond +uestion, no other substan!e *no%n to #an %as e$er before de$eloped so rapidly and spread indis!ri#inately o$er so large a portion of the earth in so short a ti#e. This is the #ore surprising as, at the ti#e >>T %as released for publi! use, a large a#ount of data %as already a$ailable in the #edi!al literature sho%ing that this agent %as e<tre#ely to<i! for #any different spe!ies of ani#als, that it %as !u#ulati$ely stored in the body fat and that it appeared in the #il*. t this ti#e a fe% !ases of >>T poisoning in hu#an beings had also been reported. These obser$ations %ere al#ost !o#pletely ignored or #isinterpreted. ,In the subse+uent #ass use of >>T and related !o#pounds a $ast a#ount of additional infor#ation on the to<i!ity of these #aterials, both in ani#als and in #an, has be!o#e a$ailable.
1)4 Created 2ursuant to '. 6es. C(C 76eprint _(-)( 3ee ?oundation for Autritional 6esear!h, =il%au*ee C, "is!onsin8.

9o#eho% a fantasti! #yth of hu#an in$ulnerability has gro%n up %ith referen!e to the use of these substan!es. Ge!ause their effe!ts are !u#ulati$e and #ay be insidious and be!ause they rese#ble those of so #any other !onditions, physi!ians for the #ost part ha$e been una%are of the danger. Else%here, the e$iden!e has been treated %ith disbelief, ignored, #isinterpreted, distorted, suppressed or sub5e!ted to so#e of the fan!iest double-tal* e$er perpetrated. ,Early last year I published a series of obser$ations on >>T poisoning in #an. 9in!e shortly after the last %ar a large nu#ber of !ases had been obser$ed by physi!ians all o$er the !ountry in %hi!h a group of sy#pto#s o!!urred, the #ost pro#inent feature of %hi!h %as gastroenteritis, persistently re!urrent ner$ous sy#pto#s, and e<tre#e #us!ular %ea*ness. The !ondition %as of un*no%n origin and, follo%ing an outbrea* in 3os ngeles in 19;7, %as thereafter %idely attributed to a ,$irus N., s %ith all other physi!ians, a large nu#ber of #y patients had this !ondition. ,I, li*e others, found it e<tre#ely puzzlingO it rese#bled no infe!tious pro!ess I %as a!+uainted %ith, and it had features strongly suggesting so#e *ind of into<i!ation. I had *no%n that >>T %as far #ore to<i! than !urrent #ythology ad#itted, but it %as only %hen I !a#e a!ross an ite# in the literature indi!ating the $ast a#ount of >>T already in use in our agri!ultural e!ono#y that the possibility that this agent %as in$ol$ed o!!urred to #e. I i##ediately !onsulted a$ailable te<tboo*s and found that the signs and sy#pto#s of *no%n >>T poisoning %ere suffi!iently si#ilar to the !ases I had seen to %arrant further in$estigation. In fa!t, in 19;) t%o Gritish authors had des!ribed %ith great a!!ura!y part of the disorder follo%ing e<posure to >>T in three hu#an sub5e!ts. ,The syndro#e !onsists of a group of or all of the follo%ing. !ute gastroenteritis o!!urs, %ith nausea, $o#iting, abdo#inal pain, and diarrhea. running nose, !ough, and persistent sore throat are !o##on, often follo%ed by a persistent or re!urrent feeling of !onstri!tion or a lu#p in the throat. o!!asionally the sensation of !onstri!tion e<tends into the !hest and to the ba!* and shoulders and #ay be asso!iated %ith se$ere pain in either ar# and #ay easily be !onfused %ith a heart or gall-bladder atta!*. 2ain in the 5oints, general #us!le %ea*ness, and e<hausting fatigue are usualO the latter are often so se$ere in the a!ute stage as to be des!ribed by so#e patients as paralysis. 9o#eti#es the initial atta!* is ushered in by dizziness and fainting. Inso#nia, intra!table heada!he, and giddiness are not un!o##on. >isturbed sensations of $arious *inds o!!ur in #ost !asesO areas of s*in be!o#e e<+uisitely hypersensiti$e and after a fe% days this disappears, only to re!ur else%here, or irregular nu#bness, tingling sensations, it!hing or !ra%ling sensations, or a feeling of lo!alized heat #ay ta*e pla!e. Errati! t%it!hing of $oluntary #us!les is !o##on. @sually there is di#inution of ability to feel $ibration in the e<tre#ities. 3oss of %eight is not un!o##on. ,>isturban!es of e+uilibriu# #ay o!!ur. There #ay be atta!*s of rapid pulse and palpitation asso!iated %ith !ontra!tion of blood $essels in the s*in, s%eating of the pal#s and a sense of

i#pending loss of !ons!iousness, follo%ed by slo% pulse, flushing of the s*in, rela<ation and !essation of pal#ar perspiration. ,The sub5e!ti$e rea!tions tend to re!ur in &%a$es,& as nu#erous patients ha$e des!ribed the#. 9o#e ha$e a!tually been able to !lo!* the rea!tion %ith !onsiderable pre!ision fro# day to day. The rea!tions appear #ost li*ely to o!!ur during periods of lo% blood sugar. dditionally, !onsu#ption of al!oholi! be$erages or a!ute e#otional stress #ay pro$o*e a se$ere e<a!erbation. ,/ften, patients %ith this disorder !o#plain of a ,hollo% feeling, in the epigastriu# %hi!h bears no !onstant !hronologi! relation to the ingestion of food, and in fa!t #ay ta*e pla!e i##ediately after a full #eal. tte#pts to eat further #ay pro$o*e sharp repugnan!e for food and o!!asionally #ay lead to an atta!* of hi!!ups or nausea. In other patients, a!tual o$ereating indistinguishable fro# the !o#pulsi$e types seen in !ertain psy!hogeni! disturban!es #ay result. ,'ardly a single sensory ner$e appears to be i##une to in$ol$e#ent in this disorder. disorders of $ision, s#ell, taste and hearing #ay o!!ur. 2ain of $arying intensity and duration #ay in$ol$e any area of the s*in and #ay lo!alize in a 5oint or e$en in a tooth. 9e$ere peripheral neuritis in$ol$ing intense, protra!ted pain in one or #ore of the e<tre#ities is fre+uent. 2ain in the groin, usually bilateral, is a fre+uent !o#plaint. In the a!ute stages, #ild !on$ulsions in$ol$ing #ainly the legs, #ay o!!ur. , fter subsiden!e of the a!ute atta!*, irregular spas# throughout the gastrointestinal tra!t often persists for %ee*s or #onths asso!iated %ith in!reased fatiguability, %hi!h only gradually regresses. ?e$er o!!urs o!!asionally during the initial stages but is not the rule. E<!ept for a tenden!y for ane#ia, and in so#e !ases a relati$e in!rease in !ertain %hite blood !ells, no !onstant !hanges are obser$able in the blood. =any of the patients ha$e an a!ute bout of apprehension asso!iated %ith the foregoing sy#pto# !o#ple< and rarely is this relie$ed by reassuran!e as to the absen!e of physi!al findings suffi!ient to a!!ount for the se$erity of the disturban!e. ,=ost stri*ing about the syndro#e is the persisten!e of so#e of the sy#pto#s, the tenden!y to repeated re!urren!e of others o$er a period of #any #onthsRso#e patients fail to sho% !o#plete re!o$ery e$en after a yearRand the la!* of dete!table lesions suffi!ient to a!!ount for the se$erity of the sub5e!ti$e rea!tion. ,The high in!iden!e, the usual absen!e of a febrile rea!tion, the persisten!e and errati! re!urren!e of the sy#pto#s, the la!* of obser$able infla##atory lesions, and the resistan!e e$en to palliati$e therapy, as I ha$e already indi!ated, suggested an into<i!ation rather than an infe!tion. The epide#i! first appeared at about the ti#e >>T !a#e into %idespread use by the !i$ilian population. The signs and sy#pto#s des!ribed in the phar#a!ologi! and to<ilogi! literature as !hara!teristi! of >>T poisoning turned out to be identi!al %ith those appearing in patients %ith the affli!tion des!ribed. ,Gy far the #ost disturbing of all the #anifestations are the sub5e!ti$e rea!tions and the extreme muscular weakness. In the se$ere, a!ute !ases, patient after patient has used identi!al %ords, 1 felt li*e I %as going to die.& ,I found si#ilar des!riptions in reading about the so-!alled &I!eland disease,& the #ost !hara!teristi! sy#pto# of %hi!h is e<tre#e #us!ular %ea*ness, %hi!h begins in the legs, then spreads to both ar#s and handsO patients e$en ha$e diffi!ulty in s%allo%ing. 8"ewsweek, =ay 19)78 ,The sensation !an perhaps best be des!ribed as one of unbearable e#otional turbulen!e. There are at $arious ti#es e<!ite#ent, hyper-irritability, an<iety, !onfusion, inability to !on!entrate, inattenti$eness, forgetfulness, depression, and espe!ially e<tre#e apprehensi$eness. These episodes !an easily be !onfused %ith an<iety atta!*s ha$ing a psy!hiatri! basis. The !o#bination of apprehensi$eness, !onfusion, and depression has led to sui!idal i#pulses in a nu#ber of #y patients. 9e$eral insisted after a %ee* or t%o of a #ore or less !ontinuous disturban!e that they did not %ant to li$e if the rea!tion persisted. This rea!tion %as the #ore diffi!ult to bear be!ause its sour!e %as un*no%n and, %hen the !ause be!a#e apparent, e<planation as to the etiology

%as usually of great help in tiding the patient o$er this diffi!ult period. /ne su!h patient %ho had been hea$ily e<posed to >>T %as treated psy!hiatri!ally for his sui!idal depression for #onths %ithout su!!ess. This depression $anished %ithin a fe% %ee*s %hen e<posure to >>T %as redu!ed to a #ini#u# by re#o$ing it fro# the i##ediate en$iron#ent and restri!ting the foods #ost hea$ily !onta#inated. 2arentheti!ally, one !annot help but %onder ho% often e<posure to the >>T group of !o#pounds has been i#pli!ated in other%ise ine<pli!able sui!ides. Certainly in a person already #entally disturbed the additional stress of >>T poisoning !ould be disastrous. In addition, the #ental effe!ts of >>T #ay easily lead to a!!idents. , !hara!teristi! history is that of a personRand in a nu#ber of !ases, an entire fa#ily si#ultaneously in$ol$edR%ho, pre$iously %ell and able to #a*e satisfa!tory e#otional ad5ust#ent to his en$iron#ent, suddenly is affe!ted %ith the syndro#e des!ribed and re#ains partially disabled for #any #onths. @sually, the !ondition re#ains undiagnosed and fre+uently these patients #a*e the rounds of do!tor after do!tor and institution after institution see*ing at least a diagnosis, if not relief. The e<tent to %hi!h this !an go is illustrated in the !ase of an e<ter#inator %ho had used both >>T and !hlordane. , t the ti#e I first sa% this patient he had spent t%o and one-half years $isiting $arious physi!ians and institutions see*ing relief fro# his disabling sy#pto#s, %hi!h !onsisted of pain and sense of !onstri!tion in the throat and !hest, irregular heada!hes, and pain in his head, ne!*, and shoulders, #us!ular t%it!hing all o$er his body, inso#nia, inability to !on!entrate, forgetfulness and inattenti$eness, disturbing sensations in $arious parts of the s*in, repeated gastroenteritis and re!urrent e<tre#e #us!ular %ea*ness. In the pro!ess of see*ing a diagnosis he as*ed do!tor after do!tor %hether the inse!ti!ides %ere responsible for his ail#ent and %as repeatedly assured they !ould not be. 'e %as sub5e!ted to $irtually e$ery test *no%n to #edi!al s!ien!e and e$en had his s*ull opened for in5e!tion of air into his !erebral $entri!les for N-ray purposes to #a*e sure he had no brain tu#or. Aone of the #any tests and e<a#inations !ould a!!ount for his sy#pto#s. ?inally one of the psy!hiatrists to %ho# he %as referred re!ognized the ail#ent as ha$ing a to<i! basis. ,"hen I sa% the patient he had an enlarged li$er, signs of nutritional i#pair#ent, redu!ed ability to feel $ibration in his legs and a redu!tion in his pulse pressure. @nder ordinary !ir!u#stan!es none of these signs, nor all together, !ould a!!ount for all his sy#pto#s. "hen he %as ad$ised to gi$e up his 5ob and see* less to<i! e#ploy#ent, to re#o$e all tra!es of >>T and !hlordane fro# his en$iron#ent, %as gi$en nutritional therapy to alle$iate the li$er da#age and put on a diet lo% in inse!ti!ide residues, he sho%ed pro#pt i#pro$e#ent %ithin a %ee*. ?our #onths later he %as al#ost free of sy#pto#s. 'e %as then un*no%ingly e<posed to >>T in a restaurant *it!hen %hi!h had 5ust pre$iously been aerosoled %ith >>T. "ithin half an hour the entire syndro#e returned and re+uired #ore than a %ee* to subside. , gain, t%o #onths later he %as inad$ertently e<posed to !hlordane fro# an old *it he had pre$iously used. This ti#e there %as a $ery se$ere e<a!erbation %hi!h re+uired nearly t%o #onths for subsiden!e. ?ortunately, this patient no% is al#ost !o#pletely %ell for the first ti#e sin!e 19;7., The sy#pto# of an enlarged li$er is +uite non-!hara!teristi! as %e see it in #any a!ute and infe!tious diseases, as %ell as in degenerati$e diseases, in!luding !an!er. I had not yet had the opportunity to study all different poisons present in a !an!er body %here they produ!e the destru!ti$e %or* #ost stri*ingly e<pressed in the li$er, the $is!eral ner$ous syste# and the !ir!ulatory apparatus, parti!ularly the !apillaries. These are 5ust the organs needed for healing purposes. Espe!ially interesting is an obser$ation #ade in England. "hen %heat %as #illed about onethird of the >>T residue %as found in the flour thus sho%ing that the inse!ti!ide had +ui!*ly penetrated the grain hus*s. 6ats fed %ith the bread #ade fro# this flour, li*e hens fed %ith the un#illed grain, sho%ed %ide and rapid distribution of the inse!ti!ide in their bodies. "e are espe!ially interested here in the proble# that, in asso!iation %ith li$er da#age, there often is an in!reased fragi-bility of the %alls of the s#all blood $essels and the !apillaries.

3ater they #ay ha$e a tenden!y to rupture easily. >r. ?. =. 2ottenger in California has repeatedly obser$ed a rise in blood !holesterol in hu#an beings, #ore fre+uently than he e$er sa% before. 'e has seen that syndro#e in about one-third of his patients and assu#ed that it #ay be !aused by >>T poisoning of the li$er. E$en if #ost of these obser$ations are the personal %or* of >r. Gis*ind, they are partly !onfir#ed by a fe% other !lini!al %or*ers in this field. "hat has been done to date to pre$ent these unfa$orable !onse+uen!es, is not $ery en!ouraging. n arti!le in the "ew =ork Times, ?ebruary 1, 19)(, stated that the Gee!hnut 2a!*ing Co#pany spent about ^44:,--- in the past si< years to *eep residues of ne% pesti!ides out of baby food and peanut butter. I hope that in the follo%ing years #ore substantial and !riti!al %or* %ill be done in this dire!tion.

C-APT1R ==I. The Significance of the Content of the Soil to -uman $isease
T'E ? =I3I 6 e<pression ,#other earth, is 5ustified. "hen %e ta*e fro# and rob the earth %e disturb the natural e+uilibriu# and har#ony, produ!ing si!*ness of the soil, si!*ness of the plants and fruits Sthe !o##on nutrition8, and finally si!*ness of both ani#als and hu#an beings. s a physi!ian %ho has spent #u!h of his life in$estigating the nutritional aspe!ts of disease, I ha$e often had o!!asion to obser$e a definite !onne!tion bet%een dietary defi!ien!ies and diseases, and bet%een dietary defi!ien!ies and a si!* or poor +uality soil. The relationship bet%een soil and plants on the one hand and ani#al and hu#an nutrition on the other is to #e a fas!inating sub5e!t. This relationship is a natural !y!le in %hi!h one #ay distinguish t%o great parts. I. The first part, %hi!h #ay be !alled ,e<ternal #etabolis#,, is !o#prised of the follo%ing. 7a8 2lants and their fruits. 7b8 Co#position of the soil in %hi!h they gro%Rthus being the real basis of all nutrition. 7!8 Transportation, storage and preparation of these foodstuffs. II. The se!ond part, *no%n as ,internal #etabolis#,, !onsists of all the bio!he#i!al transfor#ations that ta*e pla!e %hen su!h foodstuffs enter the ani#al body and support the nutrition and gro%th of its !ells and tissues. "hen foodstuffs are ingested, their #etabolis# is influen!ed dire!tly by the bio!he#i!al !hanges of the indi$idual body and indire!tly by the !ondition of the soil fro# %hi!h they !a#e. The type of #etaboli! !hange thus dire!tly affe!ts the nutrition and gro%th of the body tissues. There is an e<ternal and an internal #etabolis# upon %hi!h all life dependsO both are !losely and ine<tri!ably !onne!ted %ith ea!h otherO further#ore, the reser$es of both are not ine<haustible. There are, of !ourse, so#e e<!eptions, about fi$e to ten per !ent of the population %ho ha$e an e<traordinarily %ell-fun!tioning reabsorption and good storage !apa!ity apparatus. This is to e#phasize the great i#portan!e of #etabolis# to hu#an health, i.e., the soil as the basis of life %hi!h is generally negle!ted to a great e<tent. I thin* it %as !orre!t for the >epart#ent of gri!ulture to ha$e gi$en its 19C: yearboo* the short but e<pressi$e title ,9oils and =en,, and that of the 19C9 yearboo*, ,?ood and 3ife., "e #ay !o#pare the %or* of the soil to a #other feeding her baby.

C. . Gro%ne stated that ,the plant is the great inter#ediary by %hi!h !ertain ele#ents of the ro!*s, after their !on$ersion into soil, are assi#ilated and #ade a$ailable for the $ital pro!esses of ani#als and #an. The si#ple inorgani! !onstituents of the at#osphere and soil are sele!ted and built up by the plants into protein, sugar, star!h, fat, organi! salts and other substan!es of #ar$elous !o#ple<ity.1)7 Table 1 %ill gi$e the reader a good pi!ture of the great losses in #ineral nutrients sustained by soils as a result of !ropping and lea!hing. The a#ount of #inerals dissol$ed ea!h year fro# the soils of the drainage basis of four #eri!an ri$ers has been esti#ated by Clar*e to a$erage 79.4 tons annually per s+uare #ile. This table sho%s. the soil needs a!ti$ity, the natural !y!le of gro%th, rest and return of %aste to #aintain its produ!ti$ityRits life. "e #ust not only ta*e, but also gi$e ba!* nitri! a!id and potassiu#.

The first part of this table #a*es it !lear that the stra% of oats sho%s a redu!tion of potash to less than a third in ten years, %hile the %hole plant of bu!*%heat s!ar!ely sho%s any differen!e in

si< years, sin!e lea$es and blosso#s !annot thri$e %ithout suffi!ient potassiu#. /ther%ise, %ith P defi!ien!y %e open the door to a!ute and !hroni! diseases. The #aintenan!e of P-pre$alen!e 74- per !ent in the #ost essential organs8 is $ery i#portant in plants, in ani#als and #en.

That defi!ien!ies in #inerals of the soil produ!e so#e !orresponding si!*nesses on plants %as %or*ed out %ith great endea$or. 3iebig&s ,la% of the #ini#u#, that ,the defi!ien!y of one nutrient in the soil %ill retard the assi#ilation of other nutrients by plants,, !ould not be #aintained, as later e<peri#ents re$ealed. /ne of the #ost interesting parts of #odern resear!h in soil, plant and ani#al nutrition is that so#e tra!e ele#entsR!opper, #anganese, !obalt, iron, iodine, boron, and zin!Rare ne!essary in parts per #illion, i.e., $ery tiny a#ountsRyet %ithout these tra!e ele#ents, plants and ani#als suffer fro# serious diseases. Iodine is uni+ue a#ong these tra!e ele#ents as its defi!ien!y has no dire!t effe!t on the plant itselfO e<peri#ents sho% the sa#e gro%th and the sa#e yield on C or ; generations %ith or %ithout iodine, but the follo%ing generations sho%ed a signifi!ant de!rease in !rop. 7These e<peri#ents %ere done by 2rof. ?al* and #yself.8 "e did not find any e<planation in the obser$ations of others about the detri#ental effe!t on #an and do#esti! ani#als.

The dependen!e of our body upon the soil is de#onstrated in the follo%ing t%o iodine tables. These sho% that fresh fruits and $egetablesRli$ing tissue enzy#esR retain iodine in the thyroid in the su##erO !ontrari%ise, in and after %inter, there is a greater loss of iodine through the urine.

T$4 % A<< R The minor9element content of some important crops in 7luorineD This table is added to show the fluorine content of fruits and vegetables, thus proving that additional fluoridation of %afer is unne!essaryRand !an be harmful. "ature uses fluorine in minimum doses in the skin to !o$er and protect fruits like cherries, peaches, apples, apri9 cots, potatoes, beets, etc.Ralso in the enamel of our teeth.

The birth of hairless pigs has been !aused e<peri#entally by feeding brood so%s diets lo% in iodine and has been pre$ented by supplying iodine !o#pounds, seen i##ediately in tie follo%ing generationsO but, iron in #i!e ta*es effe!t in the fifth or si<th generation only. This sho%s at the sa#e ti#e that so#e of the defi!ien!ies are transferred to the follo%ing or later generations by nature Rthrough the fertilization apparatus. the egg or sper#atozoonR as there is no other %ay. ?a#iliar e<a#ples of the results of a defi!ien!y of tra!e #inerals are. 7a8 'and drawn of tobacco, due to #agnesiu# defi!ien!y if the soil !ontains less than -.(Z =g/. 7b8 #hlorosis of tomatoes on ?lorida soils, %hi!h !an be !ured by #anganese additions. 7!8 The wilting of leaves in tobacco is !aused by !opper defi!ien!y. 7d8 7ailure of cattle to develop normally is often due to defi!ien!y of iron, !opper or possibly !obalt in plants. 7Iron dire!tly !onne!ted to !hlorophyll.8 7e8 The abnormal accumulated occurrence of animal and human goitre in parts of 9%itzerland, "is!onsin, =innesota and "ashington is due to iodine defi!ien!y. 7f8 ,3a#e-si!*ness, of !attle in 9outh fri!a is due to defi!ien!y of Ca. P. 2. in lea!hed areas. 7g8 ,Gush si!*ness, of sheep in Ae% Mealand is due to la!* of !obalt. 7h8 'airless pigs due to iodine defi!ien!y. 7i8 In hu#an beings so#e a!ute and !hroni! diseases are due to the follo%ing defi!ien!ies. Gad teeth, to P and Ca 6i!*ets, to Ca and 2 ne#ias, to !opper and iron =yede#a and goitre, to iodine 9tar$ation ede#a, nephriti! ede#a, !ardia! ede#a, !ardiorenal syndro#e, old age 7thyroid defi!ien!y8, et!., all #ore or less due to defi!ien!y of se$eral #inerals 9*in and bone tuber!ulosis, to P. 2. Ca, et!.