Bone morphogenetic protein 3

From Wikipedia, the free encyclopedia

Not to be confused with BMP-3.
Bone morphogenetic protein 3
Available structures
PDB Ortholog search: PDBe, RCSB
[show]List of PDB id codes

Identifiers
Symbols BMP3; BMP-3A
External IDs OMIM: 112263 MGI: 88179 HomoloGene: 927GeneCards: BMP3
Gene
[show]Gene Ontology
RNA expression pattern

More reference expression data
Orthologs
Species Human Mouse
Entrez 651 110075
Ensembl ENSG00000152785 ENSMUSG00000029335
UniProt P12645 Q8BHE5
RefSeq
(mRNA)
NM_001201 NM_173404
RefSeq
(protein)
NP_001192 NP_775580
Location
(UCSC)
Chr 4:
81.95 81.98 Mb
Chr 5:
98.85 98.88 Mb

PubMedsearch [1] [2]
This box:
view

talk

edit
Bone morphogenetic protein 3 is a protein in humans that is encoded by the BMP3 gene.
[1]

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like
other bone morphogenetic proteins(BMP's) is known for its ability to induce bone and cartilage development. It
is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in
the differentiation of osteogenic progenitors.
It is highly expressed in fractured tissues.
References[edit]
1. Jump up^ "Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".
Further reading[edit]
Dickinson ME, Kobrin MS, Silan CM et al. (1990). "Chromosomal localization of seven members of the murine
TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci".Genomics 6 (3): 505
20. doi:10.1016/0888-7543(90)90480-I.PMID 1970330.
Tabas JA, Zasloff M, Wasmuth JJ et al. (1991). "Bone morphogenetic protein: chromosomal localization of
human genes for BMP1, BMP2A, and BMP3". Genomics 9 (2): 2839. doi:10.1016/0888-7543(91)90254-
C. PMID 2004778.
Paralkar VM, Nandedkar AK, Pointer RH et al. (1990). "Interaction of osteogenin, a heparin binding bone
morphogenetic protein, with type IV collagen". J. Biol. Chem. 265 (28): 172814. PMID 2211625.
Rosen V, Wozney JM, Wang EA et al. (1990). "Purification and molecular cloning of a novel group of BMPs and
localization of BMP mRNA in developing bone". Connect. Tissue Res. 20 (14): 313
9.doi:10.3109/03008208909023902. PMID 2612162.
Wozney JM, Rosen V, Celeste AJ et al. (1989). "Novel regulators of bone formation: molecular clones and
activities". Science 242 (4885): 152834. doi:10.1126/science.3201241. PMID 3201241.
Faucheux C, Ulysse F, Bareille R et al. (1998). "Opposing actions of BMP3 and TGF beta 1 in human bone
marrow stromal cell growth and differentiation". Biochem. Biophys. Res. Commun. 241 (3): 787
93.doi:10.1006/bbrc.1997.7792. PMID 9434787.
Daluiski A, Engstrand T, Bahamonde ME et al. (2001). "Bone morphogenetic protein-3 is a negative regulator of
bone density". Nat. Genet. 27 (1): 848. doi:10.1038/83810. PMID 11138004.
Jin Y, Lu HB, Liong E et al. (2002). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and
malignant peripheral nerve sheath tumors". Histol. Histopathol. 16 (4): 10139.PMID 11642720.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-
length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899
903.doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kloen P, Di Paola M, Borens O et al. (2004). "BMP signaling components are expressed in human fracture
callus". Bone 33 (3): 36271. doi:10.1016/S8756-3282(03)00191-1. PMID 13678778.
Kang Q, Sun MH, Cheng H et al. (2004). "Characterization of the distinct orthotopic bone-forming activity of 14
BMPs using recombinant adenovirus-mediated gene delivery". Gene Ther. 11 (17): 1312
20.doi:10.1038/sj.gt.3302298. PMID 15269709.
Chen AL, Fang C, Liu C et al. (2004). "Expression of bone morphogenetic proteins, receptors, and tissue
inhibitors in human fetal, adult, and osteoarthritic articular cartilage". J. Orthop. Res. 22 (6): 1188
92. doi:10.1016/j.orthres.2004.02.013. PMID 15475196.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length
cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121
7.doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.